Gene ik2 (Fruit Fly)
ik2
Sequence
Protein domains of ik2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | ik2.AA | IKK | 12-295 | 51 | 1.4e-178 | 599.6 | In-house | 1-297 (297) | Show / Hide |
Range on Protein: 12-295 Range on HMM: 1-297/297 Sequence Identity: 51% (152 aa) WCTTSVLGKGATGSVFQGVNKITGESVAVKTFNPYSHMRPADVQMREFEALKKVNHE-------NIVKLLAIEED---QEGRGKVIVMELCTGGSLFNIL |.....||.||.|.|.....|.||..||||..|..|.||...|..||||..|..||. ||..|..|||| |. . .|||||.||||.|...| WEMCDRLGQGAFGNVYHWRHKKTGRKVAVKHCNHMSWMRCRWVWCREFEWMKRLNHQRQFVWFPNIWCLCDIEEDMQWQICKQPVIVMEYCTGGDLYKYL DDPENSYGLPE-HEFLLVLEHLCAGMKHLR-DNKLVHRDLKPGNIMKFISEDGQTIYKLTDFGAARELEDNQPFASLYGTEEYLHPDLYERAVLRKSIQR ..|.|..||.| ||||.|....||||.||. .|..||||.||||||....|||.||||.||||.|||..|...|.|.||||||||||.||||||||..|. NSPWNCCGLKEGHEFLQVCRDCCAGMHHLHSQNGIVHRDIKPGNIMCQKGEDGKTIYKITDFGYAREWDDDEMFMSFYGTEEYLHPDMYERAVLRKPHQK SFTANVDLWSIGVTLYHVATGNLPFRPFGG-RKNRETMHQITTKKASGVISGTQLSENGPIEWSTTLPPHAHLSQGLKTLVTPLLAGLLEENREKTW ...|.||.||.|||.||.|||.|||.|... |...|.|..|||.|.|||..|.| ..|||.|||..||...||.|.......|... .||......| PYCATVDYWSFGVTFYHCATGELPFMPHWQPRRWHEKMKHITTEKPSGVCIGVQEEMNGPVEWSSHLPQYCHLCQIIHEQMEPWCIMMLEWHQDQCW |
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Kinase | ik2.AA | S_TKc | 12-306 | 22 | 1.6e-41 | 145.14 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 12-306 Range on HMM: 1-231/231 Sequence Identity: 22% (68 aa) WCTTSVLGKGATGSVFQGVNKITGESVAVKTFNPYSHMRPADVQMREFEALKKVNHENIVKLLAIEEDQEGRGKVIVMELCTG--GSLFNILDDPENS-- . ..|||| |.|.....| ||. ||.| . . .|| . ||| .|.|||||. . .| .|||.| | |.|| .... YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGL -YGLPEHEFLLVLEHLCAGMKHLRDNKLVHRDLKPGNIMKFISEDGQTIYKLTDFGAARELEDNQPFASLYGTEEYLHPDLYERAVLRKSIQRSFTA-NV ...|| . .. .| ..... ... .|||||| ||. ..| |..||| ||.| .. || .|. | . ... . RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENIL--LDE----HIKICDFGLARQL------TTFCGTPWYMAPEVL-----------GYGKCKC DLWSIGVTLYHVATGNLPFRPFGGRKNRETMHQITTKKASGVISGTQLSENGPIEWSTTLPPHAHLSQGLKTLVTPLLAGLLEENREKTWSFDRFFH--- | ||.|..|| ..| ||. .....| . . .. ..|. . || .. .. DWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG----------------------------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEW ----EVTL . DIKCHPWF |
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Kinase | ik2.AA | Pkinase | 12-225 | 28 | 3.2e-41 | 146.82 | Pfam | 1-213 (293) | Show / Hide |
Range on Protein: 12-225 Range on HMM: 1-213/293 Sequence Identity: 28% (64 aa) WCTTSVLGKGATGSVFQGVNKITGESVAVKTFNPYSHMRPADVQMR---EFEALKKVNHENIVKLLAIEEDQEGRGKVIVMELCTGG----SLFNILD-D ... ...|.|. |.|.....| ||. ||||... . |.. | | . .|..||.|||.|. . || .. .|||.| || .|| .. . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTW PENSYGLPEHEFLLVLEHLCAGMKHLRDNKLVHRDLKPGNIMKFISEDGQT--IYKLTDFGAARE--LEDNQPFASLYGTEEYLHPDLYERAVLRKSI-Q .... ..|.| .. .. |.... ... .|||||| ||. |...|.. . |..||| |. . |. . .. || .|. | . . RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENIL--IDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV--------IRGG RSFTANVDLWSIGVTLYHVATGNLPFR . . || ||.|..|| ...|..||. QYYGPKVDMWSCGCILYEMLCGRPPFP |
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Kinase | ik2.AA | CAMK | 17-225 | 19 | 1.5e-39 | 124.64 | In-house | 1-335 (425) | Show / Hide |
Range on Protein: 17-225 Range on HMM: 1-335/425 Sequence Identity: 19% (67 aa) VLGKGATGSVFQGVNKITG------------ESVAVKTFNPY-------------------------SHMRPADVQ--MREFEALKK-------VNHENI .||.|. | |. ...| |. . ||.| . ...|| | . .|| | .|| ..|.|| TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VKLLAIEED-----------QEGRG-------KVIVM---ELCTGG----SLFNILDDPEN------------SYGLPEHEFLLVLEHLCAGMKHLRDNK .||. . || .. ..|| |.|.|| ||. . . .. . ..|.| . .| ..... ... IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN LVHRDLKPGNIMKFISEDGQ-------------TIYKLTDFGAARELED------------------------NQPFASLYGTEEYLH-PDLYER----A ||||||| ||. ..|.. |..||| |..... .|.. || || | . .. . IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN VLRKSI----QRSFTANVDLWSIGVTLYHVATGNLPFR . .. . .| ||.|| || .| .||. MQ-N-ATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFY |
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Kinase | ik2.AA | ULK | 12-179 | 25 | 4.8e-34 | 116.27 | In-house | 1-214 (329) | Show / Hide |
Range on Protein: 12-179 Range on HMM: 1-214/329 Sequence Identity: 25% (55 aa) WCTTSVLGKGATGSVFQGVNKIT----GESVAVKT-----FNPYSHMRP----ADVQMREFEALKKVN--------HENIVKLLAIEEDQ-EGRGKVIVM .| .||||. | |..| ||.| .| ||.| .| ..... . ..| . .|| . |.|||||. . |.. . |.| YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNH-NNIYIIM ELCTGGSLFNILD-DPE------NSYGLPEHEFLLVLEHLCAGMKHLRDNKLVHRDLKPGNIMKFISEDGQT----------IYKLTDFGAARELEDN-- |.| || |.... . . . |.| | . .. ....|.|.|.... .|||.|| ||. |... . ..|..||| |. .... EYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNIL--IHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNM --QPFASLY------GT | . . || EQQMMMTCVNEKRLCGT |
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Kinase | ik2.AA | ULK | 12-179 | 26 | 2.7e-33 | 115.5 | In-house | 1-210 (324) | Show / Hide |
Range on Protein: 12-179 Range on HMM: 1-210/324 Sequence Identity: 26% (57 aa) WCTTSVLGKGATG-SVFQGVNKIT---GESVAVKTFN-----PYSHMRP----ADVQMREFEALKKVN---HEN--IVKLLAIEEDQEGRGKVIVMELCT .| .||||. | |..| ||.| .. ||.| . ..... . ...| . .|| . |.| ||||. . |.. |.||.| YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN GGSLFNILD----DPENS---YGLPEHEFLLVLEHLCAGMKHLRDNKLVHRDLKPGNIMKFISEDGQT----------IYKLTDFGAARELEDN----QP || |.... || |.| | . .. ..|.|.|.|.... .|||.|| ||. |... . ..|..||| |. ...| | GGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNIL--IHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQM FASLY------GT . .. || CQTCVNEKRIKGT |
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Kinase | ik2.AA | STE | 12-227 | 22 | 1.6e-28 | 97.89 | In-house | 1-274 (359) | Show / Hide |
Range on Protein: 12-227 Range on HMM: 1-274/359 Sequence Identity: 22% (64 aa) WCTTSVLGKGATGSVFQGVNK------ITGES---------VAVKTFNP--------------YSHMRPADVQ--MREFEALKKVN--HENIVKLLAIEE | ...||||.|.|....|. ||| .|.| | .. . . ..| ..| . .|| | |.|||| . .. WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF -----DQEGRGKVIVMELCTGGSLFNILD---DPENS--------YGLPEHEFLLVLEHLCAG-MKHLRDNKLVHRDLKPGNIMKFISEDGQTIYKLTDF .... |.||.. |||| |.. . .. .||.. .. .. | ...| ... .|||.||.||. ||.|| KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKLCDF GAARELED----------------NQPFA-SLYGTEEYLHPDLYERAVLRKSIQRSFTANVDLWSIGVTLYHVATGNLPF---RPF | . |.| .| .. || . | .. . .. .| ||.| |. . |||. |. |. GVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-R-DKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPM |
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Kinase | ik2.AA | CAMK-Unique | 12-224 | 20 | 4.4e-27 | 86.28 | In-house | 1-293 (363) | Show / Hide |
Range on Protein: 12-224 Range on HMM: 1-293/363 Sequence Identity: 20% (61 aa) WCTTSVLGKGATGSVFQGVNKITGESVAVKTFNPYSHMRPADVQ-------------------MREFEALKKVNHENIVKLLAI----EEDQE------- . . ..|.|. | |. . .. || |.| .. . | . . .| .|| . .|.|.|.||.||. . .| . YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI ------GRGKVIVMELCTGGSLFNILDDPEN-----------------SYGLPE--HEFLLVLEHLCAGMKHLRDNKLVHRDLKPGNIMKFISEDG---- .||||.|.|| || .... . | . ... | ... ... ||||||. ||| |.. IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH --------QTIYKLTDFGAARELEDNQPFA---SLYGTEEYLHP---------DLYERAVLRKSIQRSFTANV----DLWSIGVTLYHVATGNLPF .. ||.||| ..... |. . . ||..|. | .. .|. .. . |.||.||..| ..|..|| RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVIN---MQCYDQQCSPASDIWSLGVIMYYMLCGCPPF |
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Kinase | ik2.AA | Ciliate-E2 | 17-243 | 18 | 2.7e-26 | 87.26 | In-house | 6-304 (365) | Show / Hide |
Range on Protein: 17-243 Range on HMM: 6-304/365 Sequence Identity: 18% (60 aa) VLGKGATGSVFQGVNKITGE-----------------------SVAVKTF--NPYSHMRPADVQMREFE----------ALKKVNHENIVKLLAIEEDQE ..|.|. |||... .. ... .|.|.. | .. . .||| . |...|| ||.|. ... KIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKD GRGKVIVMELCTGGSLFNIL---DDPENSY-----GLPEHEFLLVLEHLCA---------------GMKHLRDNK-LVHRDLKPGNIMKFISEDGQTIYK .|||.| ||.|| .. . .|. . | | . . .... ....| .. .|||.|| ||. | DNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IK LTDFGAARELEDN--------------------------------QPFASLYGTEEYLHPDLYE-RAVLRKSIQRSFTANVDLWSIGVTLYHVATGNLPF ..||| .... |. . | ...|| .|. | .. . | . .|.||.||.|| .|..|| IIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF RPFGGRKNRETMHQITTKK . || .| -----------QQQIKQCK |
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Kinase | ik2.AA | CAMKL | 10-182 | 27 | 3.6e-26 | 80.39 | In-house | 1-199 (297) | Show / Hide |
Range on Protein: 10-182 Range on HMM: 1-199/297 Sequence Identity: 27% (56 aa) YVWCTTSVLGKGATGSVFQGVN-KITGESVAVKTFN-------PYSHMR------PADV-QMREFEALKKVN---HENIVKLLAIEEDQEG----RGKVI | . .||||. | | ... ..||| ||.| . |..... ..|. || . .|..| |.||.||. . |..| .. YRIGK--TLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYL VMELCTGGS--LFNILDDPENSY-GLPEHEFLLVLEHLCAGMKHLRDNKLVHRDLKPGNIMKFISEDGQ-TIYKLTDFGAARELED-----NQPFASLYG |||.| ||. ||. .. .. .|||| ........ ... ||||.|| ||. ..|.| .| |..||| . . .. .| . | VMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENIL--LDENGNNNI-KIIDFGFSNMYRPCIFGPGQKLKTFCG TEEY . .| SPPY |
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Kinase | ik2.AA | TKL | 18-225 | 17 | 3.3e-24 | 84.05 | In-house | 1-290 (364) | Show / Hide |
Range on Protein: 18-225 Range on HMM: 1-290/364 Sequence Identity: 17% (54 aa) LGKGATGSVFQGVNKI--------TGESVAVKTFNPYS-----------------------HMRPADVQMREFEALKKVN---HENIVKLLAIEEDQEGR .|.|. | |..|. . ||. ||||.|. . . . . .| | .. . |.|||..... . ... IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG G-----------KVIVMELCTGGSLFNILDDPENSYGLPEHEFLLVLEHLCAGMKHLRDNK--------LVHRDLKPGNIMKFISED----------GQT . ||||.| ||||...| | .. . || .| .. ..|||||. ||. . . CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW IYKLTDFGAARELEDN-QPFASLYGTEEYLHPD---------LYERA---------VLRKSIQ-------------RSFTANVDLWSIGVTLYHVATGNL |..||| .|... . . .. ... | .. . |||.... .... .| .| |. |. ..|. . CCKICDFGLSRFMSQSGNMNDTMTTMME----SAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR PFR |.. PYY |
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Kinase | ik2.AA | RSK | 15-243 | 28 | 1.7e-20 | 71.84 | In-house | 1-231 (278) | Show / Hide |
Range on Protein: 15-243 Range on HMM: 1-231/278 Sequence Identity: 28% (69 aa) TSVLGKGATGSVFQGVNKI----TGESVAVKTFNPYSHMRPADV----QMREFEALKKVN-HENIVKLLAIEEDQEGRGKVIVMELCTGGSLFNILDDPE .|||.|. |.||. . |. || |.| . . ...... |.| . |. .. | .||.| . |.. ..||.| || || | . LKVLGQGGYGKVFL-CRKCTHHDTGQIYAMKVLK-KAKIVQRQKDTRHTMTERNILERCQQHPFIVTL--HYAFQTEGKLYLIMEYCRGGELFTHLQKEK NSYGLPEHEFLLVLEHLCAGMKHLRDNKLVHRDLKPGNIMKFISEDGQ-TIYKLTDFGAARE--LEDNQPFASLYGTEEYLHPDLYERAVLRKSIQRS-F . |.| .. . ..|| . . .|||||| ||. . .|. . |||||| ... ...||. . .| ||. | .|.. |.. HFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENIL-YDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPE-----MLKRANQQGGH TANVDLWSIGVTLYHVATGNLPFRPFGGR-KNRETMHQITTKK ....|.|| || .| ||..||. ... |.| .| ..| DKACDWWSLGVLMYEMLTGCPPFQG-PNDNNRKEIMKRIQKGK |
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Kinase | ik2.AA | Pkinase_Tyr | 17-139 | 30 | 3.4e-18 | 62.26 | Pfam | 6-137 (270) | Show / Hide |
Range on Protein: 17-139 Range on HMM: 6-137/270 Sequence Identity: 30% (40 aa) VLGKGATGSVFQGVNK----ITGESVAVKTFNPYSHMR---PADVQMREFEALKKV-NHENIVKLLAIEEDQEGR-GKVIVMELCTGGSLFNILDDP-EN .||.|| |.|..|. | |. ||||. ..... . .| | . .|. .|.|||.|... ||.. ||||.. .|.| . | .. |. KLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHRED SYGLPEHEFLLVLEHLCAGMKHLRDNKLVHRDL |. .. | ..|| .| .....|||| KQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL |
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Kinase | ik2.AA | TyrKc | 12-275 | 21 | 1.5e-13 | -3.42 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 12-275 Range on HMM: 1-280/280 Sequence Identity: 21% (67 aa) WCTTSVLGKGATGSVFQGVNKITGESVAVKTFNPYSHMRPADVQMREFEALKKV--NHENIVKLLAIEEDQEG-----RGKVIVMELCTGGSLFNILDDP .|| || | |..|. | . ||||. .... .| ||| . ..|. .|.|||.|... .|.. ||||.. .|.| . | .. ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDF-MREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH ENSYGLPEHEFLLVLEHLCAGMKHLRDNKLVHRDLKPGNIMKFISEDGQTIYKLTDFGAARELEDN---QPFASLYGTEEYLHPDLYERAV--LRK---- .. |. ..| ..|| .| .....|||| |.. ..|.. . | .||| .|...| | | . .| RPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCL--VGENH--TVKISDFGLSRDIYDDDQQG-----------ESKDYYRKKEHKGGKTMLP -------SIQRS-FTANVDLWSIGVTLYHVATGNLPFRPFGG-----RKNRETMHQITTKKASGVISGTQLSEN--------GPIEWSTTL--------- .|. . || | || ||... . | . | | .|.| .... . . .| | | . IRWMAPECINYGKFTTKSDVWSFGVCMWEIFT--YGQQPYPGMIQQMMSNQEVIEYVKQGYR------MPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPE --PPHAHLSQGL | . . . . DRPTFSEIHECF |
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Kinase | ik2.AA | CAMKL | 205-225 | 57 | 6e-06 | 14.81 | In-house | 217-237 (297) | Show / Hide |
Range on Protein: 205-225 Range on HMM: 217-237/297 Sequence Identity: 57% (12 aa) VDLWSIGVTLYHVATGNLPFR || ||.||.|| .|.|||. VDIWSCGVILYAMVCGYLPFD |
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Kinase | ik2.AA | ULK | 205-225 | 38 | 0.006455 | 6.12 | In-house | 237-257 (329) | Show / Hide |
Range on Protein: 205-225 Range on HMM: 237-257/329 Sequence Identity: 38% (8 aa) VDLWSIGVTLYHVATGNLPFR .|.||.|. .| .| ||. CDIWSLGCIFYEMLYGKPPFY |
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Kinase | ik2.AA | ULK | 205-225 | 38 | 0.014258 | 5.02 | In-house | 233-253 (324) | Show / Hide |
Range on Protein: 205-225 Range on HMM: 233-253/324 Sequence Identity: 38% (8 aa) VDLWSIGVTLYHVATGNLPFR .|.||.|. .| .| ||. CDIWSLGCIFYEMLYGKYPFF |