Gene Gprk2 (Fruit Fly)

Gprk2

Species: Fruit Fly
Alias: SFO218, Gprk2, CG17998, Gprk-2, gprk2
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 100C6--D1,

Classification

Group: AGC
Family: GRK
Subfamily: GRK

Sequence

Name Sequence Type Origin Length Description Download
Gprk2.AA Protein Various 714 None Fasta, JSON
Gprk2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 266 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of Gprk2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
RGS Gprk2.AA RGS 52-294 11 4.3e-31 110.53 SMART 1-121 (121) Show / Hide 
Range on Protein: 52-294
Range on HMM: 1-121/121
Sequence Identity: 11% (28 aa)

SYGYVIDQQPIGRELFRLFCENKRPVYFRYITFLDEVVKYEIEYISNRIFIGHDIGRRFLDVEAQLELRNGSGGDALDAETQEELLLNSSNANPTETAET
|. ...|..||||..|| |..... .|.... |.... ...  . . |.  ...|  ......|  |                                 
SFHHLCDNDPIGRRYFREFLKQEFCEYKENLEFWLACEEFKKMEDEERRQKAREIYDKYISPNAPCE---------------------------------

EHCNNTTANNCNNINNSNNSQHSSDINHKKLDTRNHNGDDATGNGSSHQDDGDESVKCQEGHDDAEKGGGGEGGGGGKCVPVGGYPDELVLDVLNDDLIA
                                                                             .|| .  .. | . . |..    
-----------------------------------------------------------------------------HCVNIDHHTREQCQQCLCN----

QVRNKLNSGGKDIFAQCVNAVKAFLAGEPFREFESSMYFHRYL
         ..|.| .. ..|  .........| .|.|..|||
--------PHPDCFDEAQRHVYQLMEKDSYPRFLRSDYYKRYL
RGS Gprk2.AA RGS 52-92 34 6.5e-08 28.13 Pfam 1-40 (124) Show / Hide 
Range on Protein: 52-92
Range on HMM: 1-40/124
Sequence Identity: 34% (14 aa)

SYGYVIDQQPIGRELFRLFCENKRPVYFRYITFLDEVVKYE
|.  ... |||||.||| |.|.  . | ..| |.... ...
SFHHLCNDQPIGRRLFRQFLESEFCEY-ENIEFWLACEDFK
RGS Gprk2.AA RGS 245-293 15 1.4e-07 27.08 Pfam 74-124 (124) Show / Hide 
Range on Protein: 245-293
Range on HMM: 74-124/124
Sequence Identity: 15% (8 aa)

LNDDLIAQVRNKLNS--GGKDIFAQCVNAVKAFLAGEPFREFESSMYFHRY
. .|. ......|.    ..|.| ..   .. .........|  |.|..|.
IDHDTREHCQDNLEQAQPTPDCFDEAQRHIYTLMEKDSYPRFLKSDYYQRF
Kinase Gprk2.AA GRK 309-574 73 2.2e-230 733.91 In-house 1-272 (272) Show / Hide 
Range on Protein: 309-574
Range on HMM: 1-272/272
Sequence Identity: 73% (201 aa)

FRMYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQKINSP---FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGG-E
||.|||||||||||||||||||||||||||.|.||||||||||.|.|.|||||.|..|.   |.|..|||||||||||||.||||||||..||||||  |
FRQYRVLGKGGFGEVCACQVRATGKMYACKCLDKKRIKKRKGETMALNEKQILEKVHSRDCPFIVCMAYAYETKDALCLVMTIMNGGDLHYHIYNMGNNE

PGFELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDHGHVRISDLGLAVEIPEGE-MVRGRVGTVGYMAPEVIDNEK-YAFSPDWFSFGCLLYEM
|||. ||.||||||..|||.|.|...|||||.|||||||||||||||||||||.|||||. |..|||||.|||||||..||. |.|||||.|.||..|||
PGFDEERMRFYAAEICCGLEHMHRRRIVYRDLKPENILLDDHGHVRISDLGLACEIPEGQPMIHGRVGTHGYMAPEVLQNERAYDFSPDWWSLGCMIYEM

IEGQAPFRMRKEKVKREEVDRRVKEDPEKYSSKFNDEAKSMCQQLLAKSIKQRLGCRNGRMGGQDVMAHPFF
|||..|||..|||||||||||||||||.||..||..|||..|..||.|...||||||.|..|.|.|..||||
IEGHSPFRQHKEKVKREEVDRRVKEDPVKYPDKFSEEAKDICEMLLQKDPEQRLGCRGGTCGAQEVKEHPFF
Kinase Gprk2.AA GRK 309-574 78 1.7e-226 758.72 In-house 1-265 (265) Show / Hide 
Range on Protein: 309-574
Range on HMM: 1-265/265
Sequence Identity: 78% (210 aa)

FRMYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQKINSPFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGGEPGFE
||.||||||||||||||||||||||||||||||||||||||||.|.|.|||||.|..|.|||.||||||||||||||.||||||||||||||||..|||.
FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEQMALNEKQILEKVHSRFVVSLAYAYETKDALCLVMTIMNGGDLKFHIYNMGENPGFD

LERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDHGHVRISDLGLAVEIPEGEMVRGRVGTVGYMAPEVIDNEKYAFSPDWFSFGCLLYEMIEGQAP
.|||.|||||..|||.|||...|||||.||||||||||||.||||||||||||||.|.||||||||||||||..||.|.|||||...|||.||||||..|
EERAIFYAAEICCGLEHLHRERIVYRDMKPENILLDDHGHIRISDLGLAVEIPEGQMIRGRVGTVGYMAPEVVKNERYTFSPDWWGLGCLIYEMIEGRSP

FRMRKEKVKREEVDRRVKEDPEKYS-SKFNDEAKSMCQQLLAKSIKQRLGCRNGRMGGQDVMAHPFF
||.|||||||||||||||||||||| .||..|||..|..||.|...||||||..  |...|..||||
FRQRKEKVKREEVDRRVKEDPEKYSHEKFSEEAKDICRMLLHKDPEQRLGCREE--GCDEVRQHPFF
Kinase Gprk2.AA AGC 309-574 26 3.4e-155 404.63 In-house 1-395 (395) Show / Hide 
Range on Protein: 309-574
Range on HMM: 1-395/395
Sequence Identity: 26% (107 aa)

FRMYRVLGKGGFGEVCACQVR------ATGKMYACKKLEKKR-IKKRK--GESMVLIE------------KQILQKIN----------SPFVVN-LAYAY
|....|.|||.||.|. .. .      .|||.||.|.|.||. |...|   . ....|            ..||.|.|          .||.|. | |..
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ETKDA--LCLVLTIMN--------GGDLKFHIYNMG--GEPGFELERARFYAAE-------VACGLQHLHK-QGIVYRD-CKPENILLDDHGHVRISDLG
..||   |..|.  |.        ||.. ......|  .|  |. |||||||||       ....|..||. .||..||  ||||||||..||....| |
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LAVEIP---------------------------------------------------EGEMVRGRVG--TVGYMAPEVIDNEKYAFSPDWFS--FGCLLY
|. |..                                                   ....    .|  |  |||||..    | .. || |  .|||.|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMIEGQAPFRM------------RKEKVKREEVDRRVKEDPEKYS----------SKFNDEAKSMCQQLLAKSIKQRLGCRNGRM---GGQDVMAHPFF
||. |. ||.             ..|. .. . .|.......|.           ..| .|||. ...|| |  ..||||... .   | .....||.|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase Gprk2.AA S_TKc 309-574 31 1.4e-87 298.16 SMART 1-231 (231) Show / Hide 
Range on Protein: 309-574
Range on HMM: 1-231/231
Sequence Identity: 31% (86 aa)

FRMYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQKINSPFVVNLAYAYETKDALCLVLTIMNG--GDLKFHIYNMGGEPG
... |..|||.||.|. |. . ||. .|.|..            ... | |||.| . |..|.| ..... | |..|.  ..|  |||. .| ..|....
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDHGHVRISDLGLAVEIPEGEMVRGRVGTVGYMAPEVIDNEKYAF-SPDWFSFGCLLYEM
   |   .||||.....|.|...|..||..|| ||||||||.  |. |.| ||| ..      .  .||  ||||||.   .| . . || |.||.||||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

IEGQAPFRMRKEKVKREEVDRRVKEDPEKYSSKFNDEAKSMCQQLLAKSIKQRLGCRNGRMGGQDVMAHPFF
. |. ||.   ... .  .                .|||.. ...| |  ..|...     ...|...||.|
LCGYPPFP-QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Gprk2.AA BARK 309-574 45 9.6e-85 287.85 In-house 1-264 (264) Show / Hide 
Range on Protein: 309-574
Range on HMM: 1-264/264
Sequence Identity: 45% (124 aa)

FRMYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQKI----NSPFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGGE
| . |..|.||||||  |    |||||| | |.||||| ..|| . | |. .|. .      ||.| ..||..| | || .| .|||||| .|.   |  
FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGQDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHG--

PGFELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDHGHVRISDLGLAVEIPEGEMVRGRVGTVGYMAPEVIDN-EKYAFSPDWFSFGCLLYEMI
  |  .  ||||||.  || |.|.. .|||| || |||||..||||||||||| .  .       ||| |||||||.     |  | ||||.||.|| ..
-VFSEQEMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDENGHVRISDLGLACDFSK-KKPHASVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLYKLL

EGQAPFRMRKEKVKREEVDRRVKEDPEKYSSKFNDEAKSMCQQLLAKSIKQRLGCRNGRMGGQDVMAHPFF
 | .|||  | | | .|.||       .   .| .| ... . || . ...||||.    | |.|  ||||
RGHSPFRQHKTKDK-HEIDRMTLTMNVELPDSFSKEMRDLLEGLLQRDVSKRLGCMG--RGAQEVKEHPFF
Kinase Gprk2.AA SGK 309-574 34 1.6e-78 241.99 In-house 1-283 (283) Show / Hide 
Range on Protein: 309-574
Range on HMM: 1-283/283
Sequence Identity: 34% (100 aa)

FRMYRVLGKGGFGEVCACQVRAT------------------GKMYACKKLEKKRIK-------KRKGESMVLIEK-QILQKINSPFVVNLAYAYETKDAL
|.   |.|||.||.|   .  ..                  .|.|| | | |. |        |.| .  ...|.  ||.....|| ||| ||  ||. |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

CLVLTIMNGGDLKFHIYNMGGEPGFELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDHGHVRISDLGLAV-EIPEGEMVRGRVGTVGYMAPEVI
 .|.  .|||.. .|.     |  |   ||||||||..| | .||.| |.||| ||||||||. ||... | ||.  .| . .      ||. |.||||.
YFVMDYVNGGEMFYHLQR---EKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVL

DNEKYAFSPDWFSFGCLLYEMIEGQAPFRMRKEKVKREEVDRRVKEDPEKYSSKFNDEAKSMCQQLLAKSIKQRLGCRNGRMGGQDVMAHPFF
  . .  . ||.. ||.||||. |  ||    .   ...        | .    .  .|... |.||.|  |.||| ..   .. ..  ||||
RKQPHDRTVDWWCLGCVLYEMMYGLPPF----YSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKR---DFMEIKNHPFF
Kinase Gprk2.AA RSK 312-574 32 3.4e-76 259.43 In-house 1-278 (278) Show / Hide 
Range on Protein: 312-574
Range on HMM: 1-278/278
Sequence Identity: 32% (92 aa)

YRVLGKGGFGEVCACQVR---ATGKMYACKKLEKKRIKKR-KGESMVLIEKQILQKIN-SPFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGGEPG
 .|||.||.|.|  |.     .||. || | |.|. |..| |    .. | .||. .. .||.|.| ||..|.. | |..  ..||.|  |... .    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDD---HGHVRISDLGLAVE-IPE-GEMVRGRVGTVGYMAPEVID---NEK-YAFSPDWFSFGC
|  ..|.||.||... ..|||.|||..|| ||||||.||   .||....| |.. .  .. ...    ..|. |||||..     .. .  . ||.|.|.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LLYEMIEGQAPFRMRKEKVKREEVDRRVKEDP--EKYS--SKFNDEAKSMCQQLLAKSIKQRLGCRNGRMGGQDVMAHPFF
|.|||  |. ||..  ..  |.|. .|...     .    ..  .|||.  ...| .  ..||||  |... ... .||.|
LMYEMLTGCPPFQG-PNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGC--GPQDAEEIKQHPWF
Kinase Gprk2.AA AktR 309-574 35 1.5e-74 254.01 In-house 1-268 (268) Show / Hide 
Range on Protein: 309-574
Range on HMM: 1-268/268
Sequence Identity: 35% (98 aa)

FRMYRVLGKGGFGEVCACQVR-ATGKMYACKKLEKKRIKKRKGESMVLIEKQILQ-KINSPFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGGEPG
|. |..||||.||.|  .| .  ..|.|| | . || |..|. .. .. |..|.. ..| || |.| |. .||. | ... .. ||.| .|. . .    
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKK---K

FELERARFYAAEVACGLQHLHKQ-GIVYRDCKPENILLDDHGHVRISDLGLAV-EIP--EGEMVRGRVGTVGYMAPEVIDN-EKYAFSPDWFSFGCLLYE
|. |.||||.|..  .|..||..  |.||| |||||||| .|||.|.| ||.  ..   . |. .  .||. |||||.| . . . .| || .||...||
FSEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYE

MIEGQAPFRMRKEKVKREEVDRRVKED--PEKYSSKFNDEAKSMCQ-QLLAKSIKQRLGCRNGRMGGQDVMAHPFF
|. |. ||     | .......  ...  . .|.|.| ...|. .| .|| |  ..|||   ...| ...  ||.|
MVTGCPPF---YHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGY--YCNGWEEIKSHPWF
Kinase Gprk2.AA PKC 309-574 38 1.8e-74 240.74 In-house 1-262 (262) Show / Hide 
Range on Protein: 309-574
Range on HMM: 1-262/262
Sequence Identity: 38% (104 aa)

FRMYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGESMVLIEKQIL-QKINSPFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGGEPGF
|.. .||||| || |     . | ..|| | | |  | .      ...|| .| .  . || ..|     |.| |  |.   ||||| ||| ...    |
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQR---RF

ELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDHGHVRISDLGLA-VEIPEGEMVRGRVGTVGYMAPEVIDNEKYAFSPDWFSFGCLLYEMIEGQ
..|.|||||||..|.|| ||..||.||| | .|.|||  ||..| | |..  .. .|.. .   ||  |.|||..  ..| .| || .|| |.|||  ||
KEEHARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQ

APFRMRKEKVKREEVDRRVKEDPEKYSSKFNDEAKSMCQQLLAKSIKQRLGC-RNGRMGGQDVMAHPFF
.||    |    .|. . . .|   |   .  ||.|.|.... |  ..|||| . .. | ||...||||
SPFHGEDE----DELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase Gprk2.AA Delta 309-574 37 3.3e-70 239.55 In-house 1-259 (259) Show / Hide 
Range on Protein: 309-574
Range on HMM: 1-259/259
Sequence Identity: 37% (100 aa)

FRMYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQ-KINSPFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGGEPGF
| . .||||| || |    .. . | || | | |  . .       ..|...|    ..||.  |  .. ||. |  |.  .||||| .|| ...    |
FHFHKVLGKGSFGKVMLAELKGKNKYYAIKCLKKDVVLEDDDVECTMVERRVLALAWEHPFLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCH---RF

ELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDHGHVRISDLGLA-VEIPEGEMVRGRVGTVGYMAPEVIDNEKYAFSPDWFSFGCLLYEMIEGQ
...||||||.|. |||| |||.||.||| | .|.|||  ||..| | |..  ..   ..     ||  |.|||.|  .||..| ||.||| |.|||. ||
DEKRARFYACEIICGLQFLHKKGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQ

APFRMRKEKVKREEVDRRVKEDPEKYSSKFNDEAKSMCQQLLAKSIKQRLGCRNGRMGGQDVMAHPFF
.||  . |    .|. . . .|   |    . |||.. ..|. .  ..||| ..   |  |. .|.||
SPFHGEDE----DELFWSICNDRPWYPRWITKEAKDCLKKLFERDPEKRLGVQYCPKG--DIRQHCFF
Kinase Gprk2.AA Pkinase 309-574 28 6.3e-69 240.09 Pfam 1-293 (293) Show / Hide 
Range on Protein: 309-574
Range on HMM: 1-293/293
Sequence Identity: 28% (87 aa)

FRMYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGESMVL-IEKQILQKINSPFVVNLAYAYETKDALCLVLTIMNGG----DLKFHIY--NM
..  |..|.|.||.|. |. . |||..|.|...|...|. | .. ..  | ||....|.|..| | ...|.|| ...|.  ..||    ||. .|   . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GGEPGFELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDHGHV----RISDLGLAVE--IPEGEMVRGRVGTVGYMAPEVID-NEKYAFSPDWFS
|.   |. . ..||. ....||...|..||..|| ||||||.|..||.    .|.| |||    .  ..   ...|| .|||||||  ...|  . |..|
GCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

FGCLLYEMIEGQAPFRMR----KEKVKREEVDRRVKEDPEKYSSKFN--------------------DEAKSMCQQLLAKSIKQRLGCRNGRMGGQDVMA
.||.||||. |. ||. .    .   ... ..|. . ...  ... .                    .|.|. .  .|.|  |.|..        .... 
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-------AEQILQ

HPFF
||.|
HPWF
Kinase Gprk2.AA Akt 309-509 39 1.4e-66 211.84 In-house 1-203 (264) Show / Hide 
Range on Protein: 309-509
Range on HMM: 1-203/264
Sequence Identity: 39% (81 aa)

FRMYRVLGKGGFGEVCACQVRATGKMY-ACKKLEKKRIKKRKGESMVLIEKQILQKINSPFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGGEPGF
|.. .||||| || |  ..  .|.|.| | | | |..| ...    .. |. |||..|.||.||| |.  |.| |..|.  .|||.| .|..    .. |
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQR---KRRF

ELERARFYAAEVACGLQHLHKQGIVYRD-CKPENILLDDHGHVRISDLGLAV-E-IPEGEMVRGRVGTVGYMAPEVIDNEKYAFSPDWFS-FGCLLYEMI
  .|||||.||. ....|||...|.|||  ||||||.| .||... | ||.  . | ....     ||  |.|||....  .  . || . .||..|||.
SEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMM

EGQAPF
 |. ||
CGRPPF
Kinase Gprk2.AA TyrKc 309-556 20 6e-16 35.2 SMART 1-280 (280) Show / Hide 
Range on Protein: 309-556
Range on HMM: 1-280/280
Sequence Identity: 20% (60 aa)

FRMYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQKI--NSPFVVNLAYAYETK-------DALCLVLTIMNGGDLKFHIY
 .. ..|| | ||||. .. .    . | |.| .        . . . | .|. |.  . | .|.|  .  ..       . |..|.  | .|||| .. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

NMGGEPGFELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDHGHVRISDLGLAVEIPEG-------EMVR------GR-VGTVGYMAPEVIDNEK
. ...  . ..    ..  .||| ..||..... ||    |.|... ..|.||| ||. .| ..       .. |      |. .  .  ||||.|.  |
KHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YAFSPDWFSFGCLLYEMIE-GQAPFR------MRKEKVKREEVDRRVKEDPEK--------YSSKFNDEAKSMCQQ-----LLAKSIKQRL
. .  | .||| ...|.   || |        |  . | .   ...  . |.          ...  .  |. ..         . |....
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase Gprk2.AA Pkinase_Tyr 309-509 23 3.3e-08 28.42 Pfam 1-216 (270) Show / Hide 
Range on Protein: 309-509
Range on HMM: 1-216/270
Sequence Identity: 23% (52 aa)

FRMYRVLGKGGFGEVCACQVR----ATGKMYACKKLEKKRIKKRK--GESMVLIEKQILQKI-NSPFVVNLAYAYE-TKDA--LCLVLTIMNGGDLKFHI
 .. ..||.| ||||. .  .     |.   | |.| |    ..    |..   | .|. .. . | .|.|  .    ..   ...|.  | .|||. . 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

YNM-GGEPGFELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDHGHVRISDLGLAVEI-PEGEM-V--RGRVGTVGYMAPEVIDNEKYAFSPDWF
 .   ... . ...   .....|.|...|. .... ||    |.|... ..|.|.| |||  | ....  .   |    .  ||||.| . |.    |  
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVW

SFGCLLYEMIE-GQAP-F
||| |..|..  |. | .
SFGVLMWEIFTYGEQPTY
Kinase Gprk2.AA Akt 534-574 34 5.9e-07 18.19 In-house 226-264 (264) Show / Hide 
Range on Protein: 534-574
Range on HMM: 226-264/264
Sequence Identity: 34% (14 aa)

SKFNDEAKSMCQQLLAKSIKQRLGCRNGRMGGQDVMAHPFF
... .|.|.   .|| |  |.|||  .|  . |....||.|
DWISPECKDLISGLLNKDPKKRLG--GGPNDAQEIKRHPWF
S_TK_X Gprk2.AA S_TK_X 577-656 26 5.5e-17 63.67 SMART 1-79 (79) Show / Hide 
Range on Protein: 577-656
Range on HMM: 1-79/79
Sequence Identity: 26% (23 aa)

TQLNWRRLEA--GMLEPPFVPDPHAVYAKDVLDIEQFS--TVKGVNIDESDTNFYTKFNTGSVSISWQNEMMETE----CFRELNVFG
 ...|..|..  ...||||.|....||| .  |...|     ...         .| .........|||| ||||    .||... . 
RGIDWDKLYNQQKEIEPPFKPKIKEVYA-SPTDTSNFDPEFTEETPM-------LTPDDPPLSNSMWQNE-METEIPPDPFRGFTYVF