Gene Dyrk3 (Fruit Fly)

Dyrk3

Species: Fruit Fly
Alias: SFO225, Dyrk3, unknown-telomeric-protein-gene
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 102F,

Classification

Group: CMGC
Family: DYRK
Subfamily: DYRK2

Sequence

Name Sequence Type Origin Length Description Download
Dyrk3.NA RNA None 2309 None Fasta, JSON
Dyrk3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 258 Kinase domain by global Sugen HMM Fasta, JSON
Dyrk3.AA Protein Various 573 None Fasta, JSON

Protein domain

Protein domains of Dyrk3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Dyrk3.AA DYRK2 225-538 65 1.8e-230 757.26 In-house 1-318 (318) Show / Hide 
Range on Protein: 225-538
Range on HMM: 1-318/318
Sequence Identity: 65% (210 aa)

YEMLKIIGKGSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQEEIRILHHLRRHDKYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIKKNGFKGFS
||.|..|||||||||.|.|||||..|||.|..||.||||.||.||||||||.||.||.||||..||.|||.||||.||||||||.||||.|||| |.|||
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGFS

LQLVRKFAHSLLQCLDALYKNDIIHCDMKPENVLLKQQGRSGIKVIDFGSSCFENQ-RIYTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLSGHA
|||||.||||.||||..|.||.|||||.||||.||||..|||||||||||||||.| ||||||||||||||||||||||| ||||||.|||.|||..|. 
LQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYP

LFPGENESDQLACIIEVLGMPNKNILASS-----KRSKSFFSPKGYPRYCTVRTMSDGMVVLIGGQSRRGKQRGPPCSKSLSKALDGCKDPLFLNFIRGC
||||||| ||.||..||||||.|...  .     .| | ||  .....||   .|.|. ... .. ..|...|.|| |||....| ||.|..|..||. |
LFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFFNSHCFEWYC--TFMTDHSMEIPKHYKNRHGKRRPPGSKSWKSVLKGCEDENFIDFIKRC

LEWDADKRLTPSEALKHPWL
.|||...|.|||.||||||.
FEWDPSERMTPSQALKHPWI
Kinase Dyrk3.AA DYRK 225-538 57 4.3e-203 680.98 In-house 1-320 (320) Show / Hide 
Range on Protein: 225-538
Range on HMM: 1-320/320
Sequence Identity: 57% (186 aa)

YEMLKIIGKGSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQEEIRILHHLRRHDKYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIKKNGFKGF-
|| |..|||||||||.|..||||.|.||.||.||.||||||||.||.||..|...|. ......||.|||..|||.||.|||||.||||..|.|.|.|| 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGFF

SLQLVRKFAHSLLQCLDALYKN-DIIHCDMKPENVLLKQQ-GRSGIKVIDFGSSCFENQRIYTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLSG
||.||||||...|.||. |.|| .|||||.||||..|||. ..|.||||||||||||.||||||||||||||||||||..|. ||||||||||||||. |
SLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTG

HALFPGENESDQLACIIEVLGMPNKNILASS--KRSKSFFSPKGYPRYCTVRTMSDGMV------VLIGGQSRRGKQRGPPCSKSLSKALDGCKDPLFLN
. ||||||| ||||||.||||||.|... ..  .| . ||     ..||........ .      .. . ...| .||.||.....  ... |.| .|..
WPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDC---FMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQ-CDDHQFKD

FIRGCLEWDADKRLTPSEALKHPWL
||..||.|| .||.|||.||.|||.
FIKKCLQWDPHKRITPSQALQHPWF
Kinase Dyrk3.AA CMGC 225-538 22 3.6e-125 413.58 In-house 1-513 (513) Show / Hide 
Range on Protein: 225-538
Range on HMM: 1-513/513
Sequence Identity: 22% (114 aa)

YEMLKIIGKGSFGQVIKAYD--------------HKTHEHVALKIVRNEKRFHRQAQ-------------EEIRILHHLR-RHDKYN-----------TM
|| .| ||.|..|.| |..|              |.| |.||.|...|.. ...||.              ||.|| ||. .||. |             
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN

NIIHMFDYFTFRN-----------------HTCITFELLSINLYELIKKNG--------------------------FKGFSLQLVRKFAHSLLQCLD--
||....|.|...|                 | .. ||..  .||..||.|                            | |.. ..| ... .|..|.  
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

ALYKND--IIHCDMKPENVLLKQQGRS------------------GIKVIDFGSSCFENQR------------------------IYTYIQSRFYRAPEV
 . ...  |||.|.||||.|. .....                   .|..|||........                        ...|...|.|||||.
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI

ILGGK----------YGRAIDMWSLGCILAELLSG--------HALFPGENE-----------SDQLACIIEVLGMPNKNILASSK-------RSKSFFS
.|| |          |. .|||||.|||.||.. |        . ||||..|            |||..|..|||.|. ... ..|       ... ...
LLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPN

PKGYPRYCT---------VRTMSDGMVVLIGGQSRRGKQRGPPCSKSLSKALDG-------------------------------CKDPLFLNFIRGCLE
 ...|.| .         ...  .  . .   . .| ... |.  |.| . ..                                | ||...... ..|.
MIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQ

WDADKRLTPSEALKHPWL
.| |||.|...||.||..
YDPDKRITAEQALQHPYF
Kinase Dyrk3.AA DYRK1 225-538 46 1.2e-112 380.48 In-house 1-321 (321) Show / Hide 
Range on Protein: 225-538
Range on HMM: 1-321/321
Sequence Identity: 46% (149 aa)

YEMLKIIGKGSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQEEIRILHHLRRHDKYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIKKNGFKGFS
||.   |||||||||.|||||...|.||.||..| | |  ||| |||.|  . .||| .  .|.|.   | |||| |. ||||| |||.|..   |.| |
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS

LQLVRKFAHSLLQCLDALYKN--DIIHCDMKPENVLLKQQGRSGIKVIDFGSSCFENQRIYTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLSGH
| |.||||. ... |  .     ||||||.||||.||    || ||.|||||||  .|||| ||||||||.|||.|| .|  ||||||||||| |.  | 
LNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGE

ALFPGENESDQLACIIEVLGMPNKNILASSKRSKSFFSPKGYPRYCTVRTMSDGMVVLIGGQSRR-----GKQRGPPCSKSLSKALDGCKDPL-FLNFIR
 || | || ||.  |.|||||| |... .. ... .|  |   .  ...   |.         |.     | . | | .. .  .    .|.| |   |.
PLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFE-KDPDNTWYCKKTRDKKKHYKEPCTRKLHEILGVETGGPGGRRKGEPGHSVEDYLKFKDLIK

GCLEWDADKRLTPSEALKHPWL
  |..|  .|.|| .||.|...
RMLQYDPKQRITPYYALQHSFF
Kinase Dyrk3.AA S_TKc 225-538 27 8.6e-92 312.17 SMART 1-231 (231) Show / Hide 
Range on Protein: 225-538
Range on HMM: 1-231/231
Sequence Identity: 27% (89 aa)

YEMLKIIGKGSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQEEIRILHHLRRHDKYNTMNIIHMFDYFTFRNHTCITFELLSI---NLYELIKKNGFK
||.|..||||.||.| |....||...||.||..      .... ||.||..       .  ||....|.|   .| .. .|...    .|...|||.| .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

G----FSLQLVRKFAHSLLQCLDALYKNDIIHCDMKPENVLLKQQGRSGIKVIDFGSSCFENQRIYTYIQSRFYRAPEVILGGKYGR-AIDMWSLGCILA
|    |.   .|.... ... |. . .. |||.| ||||.|| .     ||..|||....     .|.. ...|.||||.   .||. ..|.||.||||.
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELLSGHALFPGENESDQLACIIEVLGMPNKNILASSKRSKSFFSPKGYPRYCTVRTMSDGMVVLIGGQSRRGKQRGPPCSKSLSKALDGCKDPLFLNFIR
|.|.|  .||      |.. .....|                                                                 .| ...|||
EMLCGYPPFP------QMQMMFKKIG-----------------------------------------------------------------SPEAKDFIR

GCLEWDADKRLTPSEALK-------HPWL
.||..| .||.|  |||.       |||.
KCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Dyrk3.AA YAK 225-459 44 3.3e-91 309.31 In-house 1-239 (347) Show / Hide 
Range on Protein: 225-459
Range on HMM: 1-239/347
Sequence Identity: 44% (106 aa)

YEMLKIIGKGSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQEEIRILHHL-RRHDKYNTM---NIIHMFDYFTFRNHTCITFELLSINLYELIKKNGF
|  | . |.| ||||.|     | | .| |.. |   .  ||  ||.||  |  .||  |      |. | |.| ..|| |. ||.||.||||..| | |
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

KGFSLQLVRKFAHSLLQCLDALYKNDIIHCDMKPENVLLKQQGRSGIKVIDFGSSCFENQRIYTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLS
.||| ||.| .  . |  .  |    ||||| ||||..|..  .  ||.||||||| | . .|||||.|.||.||.|..  |  .|||||||||.|||  
CGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAELFL

GHALFPGENESDQLACIIEVLGMPNKNILASSKRSKSFF
|  .|||  | .|.  ||..|| |   ..   . .  .|
GLPIFPGNSEYNQIKRIIDMLGYPPSWMIDQGRFKNKYF
Kinase Dyrk3.AA HIPK 225-459 40 2e-73 230.48 In-house 1-237 (329) Show / Hide 
Range on Protein: 225-459
Range on HMM: 1-237/329
Sequence Identity: 40% (96 aa)

YEMLKIIGKGSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQEEIRILHHLRRHDKYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIKKNGFKGFS
|| | ..|.| ||||.|.  . |.| ||.|| .|.  . || | |..||| |.  .  . .... ....|  .||||. ||.|  |||.  |.| |    
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENA-DEYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPLP

LQLVRKFAHSLLQCLDALYKNDIIHCDMKPENVLLKQQGRSG--IKVIDFGS-SCFENQRIYTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLSG
|. .|      |  |  | .  .|| |.||||..|  . |    .||||||| | . .    ||.|||.|||||.||| ..  ..|||||||..|||  |
LKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFLG

HALFPGENESDQLACIIEVLGMPNKNILASSKRSKSFF
  |.|| .| ||   |..  . |.. .| .  ... ||
WPLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFF
Kinase Dyrk3.AA Pkinase 225-538 26 7.6e-71 246.48 Pfam 1-293 (293) Show / Hide 
Range on Protein: 225-538
Range on HMM: 1-293/293
Sequence Identity: 26% (91 aa)

YEMLKIIGKGSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQE-----EIRILHHLRRHDKYNTMNIIHMFDYFTFRNHTCITFELLSI-----NLYEL
|. ...||.||||.| |.....| . ||.||.. ... . . |.     ||.|...| .|.      |. ..|.|. ..| .. .|..        |...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPN-----IVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

IK---KNGFKGFSLQLVRKFAHSLLQCLDALYKNDIIHCDMKPENVLLKQQGRSG--IKVIDFGSSCF---ENQRIYTYIQSRFYRAPEVIL-GGKYGRA
|.   ...|  || . .....  .|. |. .... |||.|.||||.|....|  .  .|..|||....    |.  .|.  ...|.|||||. | .||..
ISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDYNNS-MTTFCGTPWYMAPEVIRGGQYYGPK

IDMWSLGCILAELLSGHALFPGE----NESDQLACIIEVLGMPNKNILA--SSKRSKSFFSPKGYPRYCTVRTMSDGMVVLIGGQSRRGKQRGPPCSKSL
.||||.||||.|.|.|. .|||.    |  ||...| ...| |..      .|..  . |..   .                               . .
VDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-------------------------------F-H

SKALDGCKDPLFLNFIRGCLEWDADKRLTPSEALKHPWL
..  .   .. .. ||..||..|  ||.|. ..|.|||.
WTF-HN-WSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase Dyrk3.AA CDK 225-538 25 1.2e-62 199.18 In-house 1-284 (284) Show / Hide 
Range on Protein: 225-538
Range on HMM: 1-284/284
Sequence Identity: 25% (89 aa)

YEMLKIIGKGSFGQVIKAYDHKTH-----EHVALKIVRNEK--------RFHRQAQEEIRILHHLRRHDKYNTMNIIHMFDYFTFR-----------NHT
||.|. || |..|.| || |..|.     . |||| .| |.         |   |  || .| .|  |.     ||.  .| ..             |  
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL--HP-----NIVKLHDVCHTKNMDRNNKDKHENKL

CITFELLSINLYELIKKNGFKGFSLQLVRKFAHSLLQCLDALYKNDIIHCDMKPENVLLKQQG---RSGIKVIDFGSSCFEN--------QRIYT-YIQS
 . || .   |.....           .. . . ||. |. . .| |.| |.|| | |.  .|   .  .|. ||| ..  .        .| ||  .  
YMVFEYMDHDLKKYMD-----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVT

RFYRAPEVILGGK-YG--RAIDMWSLGCILAELLS---GHALFPGENESDQLACIIEVLGMPNKNILASSKRSKSFFSPKGYPRYCTVRTMSDGMVVLIG
. |||||. || | |.   .|||||.|||.||..    . .||||..| ||| .|....| |. ..  . .    .                        
LWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY------------------------

GQSRRGKQRGPPCSKSLSKALDGCKDPLFLNFIRGCLEWDADKRLTPSEALKHPWL
                              ... ..|  | .||.. ..||.||..
------------------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase Dyrk3.AA DyrkP 225-442 39 2.7e-57 186.98 In-house 1-222 (323) Show / Hide 
Range on Protein: 225-442
Range on HMM: 1-222/323
Sequence Identity: 39% (88 aa)

YEMLKIIGKGSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQEEIRILHHLRRHDKYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIKKN----GF
| ..  .|   | . |.  | .|   . .||. | | .  |. .||..|. .         |.....|||  . |  |  |||  ||||  | |      
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYYDYFYHKEHLFIITELLKDNLYEFYKFNRENEQQ

KGFSLQLVRKFAHSLLQCLDALYKNDIIHCDMKPENVLLKQQGRSGIKVIDFGSSCFENQRIYTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLS
. | .  . |    .|  || .    .||||.||||.|.| . .  .|.||||||||    .  |.||| |||||||.| ||   |||||||||||||  
RYFTVGRLQKITQQILIALDYIHSLRLIHCDLKPENILMKSYPKCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWT

GHALFPGENESDQLACIIEVLG
|  ||  .|    || .| ..|
GNVLFQNDNIQGLLARVIGIIG
Kinase Dyrk3.AA PRP4 225-427 39 5.7e-55 188.94 In-house 1-207 (320) Show / Hide 
Range on Protein: 225-427
Range on HMM: 1-207/320
Sequence Identity: 39% (83 aa)

YEMLKIIGKGSFGQVIKAY-DHKTHEHVALKIVRNEKRFHRQAQEEIRILHHLRRH--DKYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIKKNG-F
|.    .|.| |. |...    .. | || ||.||    |.    |. ||  |     ||     .. ||. | .|.| |. || .| || |..|| |  
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD

KGFSLQLVRKFAHSLLQCLDALYKNDIIHCDMKPENVLLKQQGRSGIKVIDFGS-SCFENQRIYTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELL
.|..|  || .|  |.  |  | |..|.| |.|| |.|     .. .| .|||| |  . . |  | .||||||||.|.| .|  .||||| || |.|| 
VGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDNILVNES-KNTLKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYELY

SGHALFPG
 |  .|||
TGKIMFPG
Kinase Dyrk3.AA CLK 225-359 30 3.9e-42 123.67 In-house 1-147 (350) Show / Hide 
Range on Protein: 225-359
Range on HMM: 1-147/350
Sequence Identity: 30% (45 aa)

YEMLKIIGKGSFGQVIKAYDHKT-HEHVALKIVRNEKRFHRQAQEEIR-ILHHLRRH-DKYNTMN--IIHMFDYFTF-RNHTCITFELLSINLYELIKKN
|| ..  | | || | .  |||    .|||||.|| ...  .|. ||. |. ..    |. |.    ...|.|.| .  .| || |||.  ..|...|.|
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

G------FKGFSLQLVRKFAHSLLQCLDALYKNDIIHCDMKPENVLL
.      .... .. .|..|. |.. .  | .. ..| | |||| ..
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICF
Kinase Dyrk3.AA CLK 367-444 44 8.3e-26 73.75 In-house 186-266 (350) Show / Hide 
Range on Protein: 367-444
Range on HMM: 186-266/350
Sequence Identity: 44% (36 aa)

IKVIDFGSSC---FENQRIYTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLSGHALFPGENESDQLACIIEVLGMP
|.||||||     |..   .| ...| |||||||||  .    | || |||| || .|  ||.. .... || . ...|||
ICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMP
Kinase Dyrk3.AA TyrKc 225-542 15 2.1e-10 -54.31 SMART 1-280 (280) Show / Hide 
Range on Protein: 225-542
Range on HMM: 1-280/280
Sequence Identity: 15% (55 aa)

YEMLKIIGKGSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQEEIRILHHL-RRHDKYNTMNIIHMFDYFTFR-------NHTCITFELLS-INLYELI
 ...|..| | ||.| |.      . || | .....  ..   .|.||...|  .|.     ||. .. . |            .| .|. .  .| . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHP-----NIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KKNGFKGFSLQLVRKFAHSLLQCLDALYKNDIIHCDMKPENVLLKQQGRSGIKVIDFGSSCFENQR-------IYTYI----QSR-----FYRAPEVILG
.|.. | ....   .|..   .  . | .. .|| |    |.|.. ..   .|. ||| | .            |       ...        |||.|  
RKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

GKYGRAIDMWSLGCILAELLSGHALFPGE-----NESDQLACIIEVLGMPNKNIL----ASSKRSKSFFSPKGYPRYCTVRTMSDGMVVLIGGQSRRGKQ
||.  . | || |  . |...  .  . .      . ...   ..  ... .       .                                        
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------------------------

RGPPCSKSLSKALDGCKDPLFLNFIRGCLEWDADKRLTPSEALKHPWLRRRL
         .    .| | ..   .. | . |...| | ||       ....
---------F---VCCPDEMYQ-IMKQCWHEDPEDRPTFSEI------HECF
Kinase Dyrk3.AA DyrkP 508-538 48 1.9e-09 26.53 In-house 293-323 (323) Show / Hide 
Range on Protein: 508-538
Range on HMM: 293-323/323
Sequence Identity: 48% (15 aa)

DPLFLNFIRGCLEWDADKRLTPSEALKHPWL
| .|. |.| ||  |  .| |  |||.|||.
DHMFIDFVRQCLQIDFTRRPTAKEALQHPWF
Kinase Dyrk3.AA CLK 515-538 50 4e-06 13.53 In-house 327-350 (350) Show / Hide 
Range on Protein: 515-538
Range on HMM: 327-350/350
Sequence Identity: 50% (12 aa)

IRGCLEWDADKRLTPSEALKHPWL
|| .|| |  ||.| ..||.||. 
IRKMLEYDPSKRITCKDALQHPFF
Kinase Dyrk3.AA YAK 510-538 31 5e-06 16.13 In-house 319-347 (347) Show / Hide 
Range on Protein: 510-538
Range on HMM: 319-347/347
Sequence Identity: 31% (9 aa)

LFLNFIRGCLEWDADKRLTPSEALKHPWL
.|. || . |. .  .| .|. | .|| .
CFIDFINQLLQLNPRERWKPMQAMQHPFI
Kinase Dyrk3.AA PRP4 514-538 48 1e-05 17.01 In-house 296-320 (320) Show / Hide 
Range on Protein: 514-538
Range on HMM: 296-320/320
Sequence Identity: 48% (12 aa)

FIRGCLEWDADKRLTPSEALKHPWL
.. .||  |  || |. |||||| .
LLDKCLMLDPKKRITCNEALKHPFI
Kinase Dyrk3.AA HIPK 519-538 60 1e-05 13.46 In-house 310-329 (329) Show / Hide 
Range on Protein: 519-538
Range on HMM: 310-329/329
Sequence Identity: 60% (12 aa)

LEWDADKRLTPSEALKHPWL
. |||.||.||.|||.||. 
CTWDAHKRITPCEALNHPFV
Kinase Dyrk3.AA Pkinase_Tyr 225-258 28 0.000297 15.03 Pfam 1-38 (270) Show / Hide 
Range on Protein: 225-258
Range on HMM: 1-38/270
Sequence Identity: 28% (11 aa)

YEMLKIIGKGSFGQVIKAYDH----KTHEHVALKIVRN
 ...| .|.|.||.| |.. .    .|. .|| |....
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE