Gene CaMKII (Fruit Fly)

CaMKII

Species: Fruit Fly
Alias: CAMKIId, Ca2+/calmodulin-dependent protei, camKII, Ca2+/calmodulin-dependent protein kinase II, CaMK II, DCK, CamKII, calcium/calmodulin-dependent protein kinase II, CG18069, CaM kinase II, CaM kinase, CaM KII, CaM II, Cam, calcium/calmodulin-dependent pro, CaMKII, dCaMKII, SFO223, calmodulin-dependent kinase, CamKIIalpha, CaM, CDPK1
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 102F3,

Classification

Group: CAMK
Family: CAMK2

Sequence

Name Sequence Type Origin Length Description Download
CaMKII.AA Protein Various 493 None Fasta, JSON
CaMKII.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 259 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of CaMKII.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CaMKII.AA CAMK2 14-272 90 3.1e-222 744.59 In-house 1-259 (259) Show / Hide 
Range on Protein: 14-272
Range on HMM: 1-259/259
Sequence Identity: 90% (234 aa)

YDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHPNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADA
|...|||||||||.|.|||.|.||.|.||||||||||.|||.|||||||||||||.||||||||||||||..|||||||||||||||||||||.||||||
YQLFEELGKGAFSVVRRCVKKCTGQEYAAKIINTKKLSARDHQKLEREARICRKLKHPNIVRLHDSIQEEGFHYLVFDLVTGGELFEDIVAREYYSEADA

SHCIQQILESVNHCHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVDIWACGVILYILLVGYPP
||||||||||||||||||.|||||||||||||||.|||||||||||||||||||.||||||||||||||||||.|.||||.|||||||||||||||||||
SHCIQQILESVNHCHQNGIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPP

FWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEALKHPWI
||||||||||.||||||||||||||||||||||||||||||.||.|||||.||||||||
FWDEDQHRLYQQIKAGAYDYPSPEWDTVTPEAKNLINQMLTINPKKRITADEALKHPWI
Kinase CaMKII.AA CAMK1 14-272 44 1.2e-154 453.06 In-house 1-276 (276) Show / Hide 
Range on Protein: 14-272
Range on HMM: 1-276/276
Sequence Identity: 44% (122 aa)

YDIKEELGKGAFSIVKRCVQKST---GFEFAAKIIN-TKKLTARDF---QKLEREARICRK---LHHPNIVRLHDSIQEENYHYLVFDLVTGGELFEDIV
| ...|.|.||||.|..|..|.|   | ..| |.|.  | .   |    ..||.|  | .|   ..||||. ...  ...|. ||| .||||||||. ||
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIV

AREFYSEADASHCIQQILESVNHCHQNGVVHRDLKPENLLLASKAKGAAVK--LADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKK---EPYGKSVDIW
 ...|.| ||.|...|||. |...|..|.|||||||||||...|  .. .|  .|||||.  . .|    .   |||||  ||||.    .||.|..|.|
EKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDMW

ACGVILYILLVGYPPFWDED-QHRLYSQIKAGAYDYPSPEWDTVTPE-AKNLINQMLTVNPNKRITAAEALKHPWI
 .|||.||||.|||||.||. .. |...|| . |..|||.|| .  . ||..|..||.|.|.||.|....|.||||
SIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase CaMKII.AA CAMK 19-272 25 1.5e-136 442.87 In-house 1-425 (425) Show / Hide 
Range on Protein: 19-272
Range on HMM: 1-425/425
Sequence Identity: 25% (110 aa)

ELGKGAFSIVKRCVQKSTG------------FEFAAKIINTKKLT--------------------------ARDFQKLEREARICRK-------LHHPNI
.||.|.|..||.|..|.|.             ..|.|||..|||.                          ..| ....|| .|..|       |.||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRLHDSIQE-------------------ENYHYLVF---DLVTGGEL----FEDIVAREF---------------YSEADASHCIQQILESVNHCHQNGV
..|.. ..                    ... |.|.   ....||||    |. ||...                ..|..|.....||.. |..||....
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDLKPENLLLASKAKG--------------AAVKLADFGLAIEVQGDH-----------------------QAWFGFAGTPGYLS-PEVLKK------
|||||||||.|| .. ..              . .|..|||.|.......                       |    | |||.| . ||||..      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------EPYGKSVDIWACGVILYILLVGYPPFWDE-------------DQHRLYSQIKAGAYDYPSPE------------WDTVTPE--------AKN
        ..||...|.|.|||||||.|.|||||...             ....|. .|..| ||.|.|.            || .. |        .|.
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LINQMLTVNPNKRITAAEALKHPWI
||..||.|.|.||.|....|.|||.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase CaMKII.AA CDPK 14-272 40 4.7e-121 372.93 In-house 1-271 (271) Show / Hide 
Range on Protein: 14-272
Range on HMM: 1-271/271
Sequence Identity: 40% (110 aa)

YDIKEELGKGAFSIVKRCVQK-STGFEF-AAKIINTKKLTARDF-QKLEREARICRKLHHPNIVRLHDSIQEENYHYLVFD--LVTGGELFEDIVAREFY
|.||..||||.|. |.....| .|. |  | |||. ...   .  |.. .|  | ..| ||||...    | |...|.|.   ..||||||. |...  .
YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQQQQFFNEIEILKQLDHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGHF

SEADASHCIQQILESVNHCHQNGVVHRDLKPENLLLASKAKGA----AVKLADFGLAIEVQGD----HQAWFGFAGTPGYLSPEVLKKEPYGKSVDIWAC
.| .|.  ..|||  ||.||.|..|||||||||.|. || ...     .|. |.|.. . ...     .    ..||| |..||||.|  | ...||| |
TEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGTPYYIAPEVLQKK-YNEKCDIWSC

GVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEALKHPWI
||||||||.|||||. . .   . ..| | |..  |||| .. |||.||..||...|.||..|..||.|||.
GVILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF
Kinase CaMKII.AA RAD53 14-272 36 3.2e-119 356.9 In-house 1-305 (305) Show / Hide 
Range on Protein: 14-272
Range on HMM: 1-305/305
Sequence Identity: 36% (112 aa)

YDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLT---ARDFQK---LEREARICRKLHHPNIVRLHDSIQE-ENYHYLVFDLVTGGELFEDIVARE
|.. .|||.|.|..||... |.|.  .| |||..||..    ... |   ...|..| .||.||.|.|..|.... . | |.|  |.||||||..||...
YYMSKELGSGNFGTVKLAYEKKTCQKVAIKIIDKKKFFIRCMHTIKKMDQVMNEVEILKKLNHPCIIRIYDIFDTPQKYYYMVLELMTGGELFNKIVSNK

F----YSEADASHCIQQILESVNHCHQNGVVHRDLKPENLLLASKAKGA---------------AVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLK
     ..|...     |....|.  | || .|||||||| |.......                ..|..||||.  ..|. .    . ||| |. |||. 
RCQMGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDFGLS-KFVGEGSFMKTMCGTPQYVAPEVIT

KE---------------PYGKSVDIWACGVILYILLVGYPPFWDE-DQ----HRLYSQIKA-GAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEA
..                |.|.||.|  |.||||.| ||||| |. .|      |. |||  | | .|.|.|| .. |||.||..||.|.|.||.|..||
SKGHNCYHENEERQVQVGYTKKVDCWSMGCILYICLCGYPPFSDDYTQEMHCMQLFEQIKNQGKYHFPHPYWDRISEEAKDLIKWMLCVDPEKRYTIDEA

LKHPWI
| |||.
LNHPWM
Kinase CaMKII.AA S_TKc 14-272 37 1.3e-111 378.06 SMART 1-231 (231) Show / Hide 
Range on Protein: 14-272
Range on HMM: 1-231/231
Sequence Identity: 37% (103 aa)

YDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHPNIVRLHDSIQEENYHYLVFDLVTG--GELFEDIVAREF----
|.| ...|||||. |..|. |.|| ..| |||.         ....|| .|..| ||||||.|.|..|. .. |.|.... |  |.||. |. |      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--YSEADASHCIQQILESVNHCHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGK-SVDIWACGVIL
  ..| .| . ..||.. ...||..|..||||||||.|| .      .|..||||| ..         | ||| |..||||   .||| ..|.|.||.||
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL

YILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEALK-------HPWI
|..|.|||||.  ...... .|.              .||||..|...|...|.||.|| |||.       |||.
YEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CaMKII.AA DCAMKL 14-272 37 3.8e-106 331.28 In-house 1-279 (279) Show / Hide 
Range on Protein: 14-272
Range on HMM: 1-279/279
Sequence Identity: 37% (106 aa)

YDIKEELGKGAFSIVKRCVQKSTG-FEFAAKI-----------------INTKKLTARDFQKLEREARICRKLHHPNIVRLHDSIQEENYHYLVFDLVTG
|.|    |.| |..|. |....||  ..| ||                 |. .|.    .   . | .| .|. ||.|..|...   |.  |||. .|.|
YQIGRIIGDGNFAVVHECRHRETGDHKYAMKIRYQSTLQFSFPSKFFQQIDKRKCKGKEHM-IDNEVSIMQKIKHPHIIQLYEHWDTETHYYLVMEYVQG

GELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVVHRDLKPENLLLAS-KAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKS
| ||. |.    ..| ||.  . .. .  .. |  ..||||.||||||.     .   .||.||||| .|.||    .   ||| |  ||.|..  ||  
GDLFDAITENTKFTERDAAIMMTCLCKALKYLHEMNIVHRDIKPENLLVCKHEDGEKSLKLCDFGLACHVNGDFGPLYTVCGTPTYVAPEILMETGYGCK

VDIWACGVILYILLVGYPPFWDE--DQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEALKHPWI
||||| ||||||||.|.|||  .  || .| .|| .|....|.|.|| ..  ||.||..|| |.| || || . ..|||.
VDIWAAGVILYILLCGFPPFRSPDNDQEELFDQIMQGKFEFPMPYWDNISDSAKDLISHMLQVDPEKRYTAEQIMQHPWV
Kinase CaMKII.AA Pkinase 14-272 33 9.6e-98 335.82 Pfam 1-293 (293) Show / Hide 
Range on Protein: 14-272
Range on HMM: 1-293/293
Sequence Identity: 33% (100 aa)

YDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLER--EARICRKLHHPNIVRLHDSIQEENYHYLVFDLVTGG----ELFEDIV--AR
| |.. .|.|.|. |..|. |.|| ..| |||. ..      | . |  |..| ..|.|||||||.|. ..... |.|.... ||    .||. |   ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

EFY--SEADASHCIQQILESVNHCHQNGVVHRDLKPENLLLA-SKAKGAAVKLADFGLAIEV-QGDHQAWFGFAGTPGYLSPEVLK-KEPYGKSVDIWAC
  .  || .. ... |||. ...||..|..||||||||.|.      .| ||..|||||  .     .   .|.|||.|..|||..  ..||..||.|.|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVILYILLVGYPPFWDE------DQHRLYSQIKAGAYDYPSPEWDTVT-----------------PEAKNLINQMLTVNPNKRITAAEALKHPWI
|.|||..| |.|||...      ||  .. .|. . .....|.|...                  .|.| .|. .|...|.||.||...|.|||.
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase CaMKII.AA CAMKL 14-272 35 1.9e-97 311.53 In-house 1-297 (297) Show / Hide 
Range on Protein: 14-272
Range on HMM: 1-297/297
Sequence Identity: 35% (107 aa)

YDIKEELGKGAFSIVKRCVQ-KSTGFEFAAKIINTKKLTARDFQK-------------LEREARICRKLH---HPNIVRLHDSIQEENY------HYLVF
|.| ..||||.|. || ..  . || . | |||. ||.. ... |             ..||..| ..|.   ||||..|.. |. ...       ||| 
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

DLVTGGE--LFEDIVAREF----YSEADASHCIQQILESVNHCHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIE---V-QGDHQAWFGFAGTPGY
 .. |||  ||. ||...      .| .| .  .||.. ||.||..|.||||.||||.|| .. .   .|..|||....   .  |. |    | |.| |
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY

LSPEVLKK--EPYG-KSVDIWACGVILYILLVGYPPFWDE--------DQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEALKH
 .||....  .||  . ||||.|||||| ...|| || |.        .. .|| .|. | | .|   |  |  ....|| .||.|||.||.|. . ..|
MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPP--IWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNH

PWI
|| 
PWM
Kinase CaMKII.AA Ciliate-E2 14-272 24 1.8e-91 310.16 In-house 1-365 (365) Show / Hide 
Range on Protein: 14-272
Range on HMM: 1-365/365
Sequence Identity: 24% (92 aa)

YDIKEELGKGAFSIVKRCVQKSTGFEF------------------AAKIINTKKLTARDFQKLEREARICRKLH----------------HPNIVRLHDS
|.. . .|.|.|..|..| ..... .|                  ..||.. | .  .. . ...| .|.|...                ||||......
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

IQ--EENYHYLVFDLVTGGELFEDIVAREFYS-----------EADASHCIQQILE---------------SVNHCHQNG-VVHRDLKPENLLLASKAKG
 |   .|. |||.... ||.||. |  .   .           |  ... ..|||.                ....|... ..|||.||||.|.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

AAVKLADFGLAIEVQGDHQAWFG-------------------------------FAGTPGYLSPEVLKKEP---------YGKSVDIWACGVILYILLVG
  .|..||||. ... |.|  ..                               ..|||||..||.|....         |....|||..|||||..| |
--IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG

YPPFWDEDQHRLYSQIKAGAYDYPSPE--------------WDTVTPEAKNLINQ----MLTVNPNKRIT-AAEALKHPWI
.|||        . ||| . .|.|.||              |. ...|.|.||..    || ..|.|||| . ..|.|||.
KPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase CaMKII.AA CAMK-Unique 14-272 24 2e-91 302.09 In-house 1-363 (363) Show / Hide 
Range on Protein: 14-272
Range on HMM: 1-363/363
Sequence Identity: 24% (90 aa)

YDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLT-ARDFQ-----------------KLEREARICRKLHHPNIVRLHDS----IQEEN-------
|.  . .|.|.|..|..|  ..|| ..| |... ..    .  |                 ||.||..| ... ||||..| |      . ..       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------YHYLVFDLVTGGELFEDIVA--------------------REFYSE--ADASHCIQQILESVNHCHQNGVVHRDLKPENLLLASKAK-----
        | |.| ....||.||. |..                    .  .||  .|..  .|..|. |.. |....||||||.||... .  |     
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

--------GAAVKLADFGLAIEVQGDHQA--WFGFAGTPGYLSP--------------EVLKKEPYGKSV----DIWACGVILYILLVGYPPFWDEDQH-
           .||.||||. .... .       . ||| |..|              ||..  .|.  .    |||..|||.|..|.|.|||  |.   
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDR

-------RLYSQIKAGAY-DYPSPEWDT---VTPEAKNLINQMLTVNPNKRITAAEALKHPWI
       .... |..| | ..... |.    ...|||... . .|| |..|..|.|.|.|.||
DYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase CaMKII.AA RSK 16-272 31 2.2e-90 306.57 In-house 1-278 (278) Show / Hide 
Range on Protein: 16-272
Range on HMM: 1-278/278
Sequence Identity: 31% (89 aa)

IKEE--LGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTAR--DFQKLEREARICRKLH-HPNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREF---
.|.   .|.|.......|... || ..| |... .|. .|  |     .| .|      ||.||.||.. |.| . ||. ... |||||. .  ...   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

YSEADASHCIQQILESVNHCHQNGVVHRDLKPENLLLASKAKG-AAVKLADFGLAIE-VQGDHQAWFGFAGTPGYLSPEVLK---KEP-YGKSVDIWACG
 || .|.  . .|   | | || |..|||||||| |....  . . .|| |||.. . .  . |    | .|  |. ||.||   ..  ..|..|.|  |
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLG

VILYILLVGYPPFWD---EDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRIT-----AAEALKHPWI
|..| .|.|.|||     .... .  .|. | .. ..|.|.....|||.||..||...|.||..     |.| ..|||.
VLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase CaMKII.AA TyrKc 14-272 22 6.2e-15 18.82 SMART 1-280 (280) Show / Hide 
Range on Protein: 14-272
Range on HMM: 1-280/280
Sequence Identity: 22% (65 aa)

YDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKL--HHPNIVRLHDSIQEE-------NYHYLVFDLVTGGELFEDI-V
   ...|| ||| .| ... |    . | | ..  .      . . ||||| .||  ||||||||.  . ..         ...|. .. .| | . .  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

AREFYSEADASHCIQQILESVNHCHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGD------HQAWFGFA--GTPG-----YLSPEVLKKEP
 |.  . .|  .   || .  .. |.....||||   | |....     || .||||. ..  |      ..        |. .      ..||....  
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YGKSVDIWACGVILY-ILLVGYPPFWD-----EDQHRLYSQIKAGAYDYPSPE-----WDTVTPEAKNLINQMLTVNPNKRITAAEALKHPWI
.    |.|. || .. |.  | .| ..      .  ... ..|.| .  . |.       . ..|  ... |    .|..| | .|   |  .
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase CaMKII.AA Pkinase_Tyr 14-98 28 1.8e-08 29.28 Pfam 1-94 (270) Show / Hide 
Range on Protein: 14-98
Range on HMM: 1-94/270
Sequence Identity: 28% (27 aa)

YDIKEELGKGAFSIVKRCVQK----STGFEFAAKIINTKKLTARD--FQKLEREARICRKL-HHPNIVRLHDSIQ-EENY--HYLVFDLVTGGEL
  . ..||.|||  |.... |    .|. . | |..   . . ..   ... |||.| ..| ||||||||.  .  ..    .|.|. .. .| |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL
Kinase CaMKII.AA Pkinase_Tyr 128-167 35 0.126916 6.12 Pfam 128-164 (270) Show / Hide 
Range on Protein: 128-167
Range on HMM: 128-164/270
Sequence Identity: 35% (14 aa)

HQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGD
.... .||||   | |...   .  || .|||||  .. |
ESKNCIHRDLAARNCLVTE---NNVVKICDFGLARDIYND
CaMKII_AD CaMKII.AA CaMKII_AD 352-479 66 2.6e-92 317.78 Pfam 1-128 (128) Show / Hide 
Range on Protein: 352-479
Range on HMM: 1-128/128
Sequence Identity: 66% (85 aa)

RRQEIIKITEQLIEAINSGDFDGYTKICDPHLTAFEPEALGNLVEGIDFHKFYFENVLGKNCKAINTTILNPHVHLLGEEAACIAYVRLTQYIDKQGHAH
..|||.|.||..||||..||.. |||.|.|..|.||.||.||||||..||.||||....|.|||..||.||||||..|..|||.||||||||.||.|.||
EKQEIWKVTERWIEAIYCGDWHTYTKLCHPDMTCFEWEACGNLVEGMEFHRFYFEMHWTKRCKAVHTTMLNPHVHMYGDDAACCAYVRLTQYMDKNGMAH

THQSEETRVWHKRDNKWQNVHFHRSASA
|.||||||||||||.|||.||.||||..
TRQSEETRVWHKRDGKWQCVHHHRSAMP