Gene CG14030 (Fruit Fly)
CG14030
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| CG14030.kin_dom | Protein Kinase Domain | Sugen global kinase HMM prediction | 276 | Kinase domain by global Sugen HMM | Fasta, JSON |
| CG14030.AA | Protein | Various | 1099 | None | Fasta, JSON |
Protein domains of CG14030.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Mad3_BUB1_I | CG14030.AA | Mad3_BUB1_I | 36-159 | 30 | 2.6e-58 | 204.84 | Pfam | 1-134 (134) | Show / Hide |
Range on Protein: 36-159 Range on HMM: 1-134/134 Sequence Identity: 30% (41 aa) FLNDKQAWEHAISLYQ---GPDPLDHWYNYICWYENHAQS---DPELKYRETLERCLTVYEHNDYYRQDVRLVRLWLKYIAMQT----DPLHFYQVLFQR ... .|..|..| |. | |||..||.||.|.|.. .. ... .....||||.. ..|...|..|.|....||.|. ... .|....| .... LQQQRQQFEEEIQNYECEEGDDPLQPWYRYIKWMEEAYPQGGGTKQSGLPTLLERCVKYFWHDERYKNDPRYLKIWLWYMNYCNNNFDEPRDIFQYMYNQ GTGRQVAAFYIGWAAYYESREEYKDAEAVFNLAF | |...|.||. ||.|.||......|..||.|.. GIGTKCALFYEEWAQYLESMGKWQKADEVFQLGI |
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| Mad3_BUB1_I | CG14030.AA | Mad3_BUB1_I | 36-159 | 30 | 1.2e-57 | 198.76 | SMART | 1-133 (133) | Show / Hide |
Range on Protein: 36-159 Range on HMM: 1-133/133 Sequence Identity: 30% (40 aa) FLNDKQAWEHAI--SLYQGPDPLDHWYNYICWYENHAQS---DPELKYRETLERCLTVYEHNDYYRQDVRLVRLWLKYIAMQ----TDPLHFYQVLFQRG . ...|..|..| ..|.| ||||.||.||.|.|.. . ... .....||||.. ..... |..|.|....|..|. |. .|....| ....| LEQQRQEFEQEIQDDSYEGDDPLDVWYRYIKWTEQNYPQGQQTKQSGLQTLLERCTRYFWDDERYKNDPRYLKIWIWYMDMCYNYFDEPREIFQYMYRHG TGRQVAAFYIGWAAYYESREEYKDAEAVFNLAF | |.|.||. ||..||....|..|.....|.. IGTQCALFYEEWAQWYENMGNYQKADEIYQLGI |
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| Kinase | CG14030.AA | BUB | 814-1074 | 40 | 2.8e-159 | 535.46 | In-house | 1-311 (311) | Show / Hide |
Range on Protein: 814-1074 Range on HMM: 1-311/311 Sequence Identity: 40% (127 aa) FSIDKEVGRGSYGSVYKATDSRTG-------------NVVALKYQKPPNTWEIYICDQVLKRIKEP---EVLPGVMDISTAIIAPNASLIATEFS-PFGS |.|.||.|.|||..||||..|..| ..||.|.|||||.||.|||||. .|.||. ......|.|.........|....|.. ..|. FCIQKEIGEGSYAYVYKAEHSDCGDYRLFWVAPRKSAHWVACKVQKPPNPWEFYICDQMHERLKERSETMMHCCFMHICSCHYYQDKSCMWMEYHIDYGT LLDINNKIR---QATTKVMHESLVMHFSAQICNIVDHLHRQHIIHADIKPDNFLLMRVPNVDSPLPS------------LRLIDFGCAIDMTLFPDGEKT |||..|... |...|||||..||.|..|....|.||||..|||.|||||||.||.....|.. .. |.|||||..|||||||||... LLDVINHMKEKAQVNNKVMHEYWVMFFCCQMLKMVEHLHRCEIIHGDIKPDNFMLMNRIHDDWDCWHKMSCGEAWKNKGLKLIDFGRSIDMTLFPDGQRF KFRKVVQTDGFTCIEMQ----EGRSWSYETDLFCIAATVHVMLFGDYMQPQKKGSS--WEIRQKLPRYLKKH-------VWTKFFGDLLN----MQADK- ||....|.|.|.|.||| ....|.|..|.|.||||.|.||||.|||...|... |...|...||..|. .|.|||...|| ..... KFNCETQQDPFECWEMQQSSTTNCPWTYQVDYFGIAATMHCMLFGKYMQVKQKWDGQYWKLEQNFRRYWQKDSFSELDTMWNKFFHRMLNHNGEIPDCQT LPALHEMRLIF ||..||.| .| LPMWHELRQQF |
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| Kinase | CG14030.AA | S_TKc | 814-1079 | 20 | 6.8e-16 | 56.16 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 814-1079 Range on HMM: 1-231/231 Sequence Identity: 20% (56 aa) FSIDKEVGRGSYGSVYKATDSRTGNVVALKYQKPPNTWEIYICD--QVLKRIKEPEVLPGVMDISTAIIAPNASLIATEFSPF--GSLLD-INNKIRQAT . | ...|.|..|.|||... .|| .||.| | . |. |.||. | . . .. . . .|. . |.|.| | .. |. . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL TKVMHESLVMHFSAQICNIVDHLHRQHIIHADIKPDNFLLMRVPNVDSPLPSLRLIDFGCAIDMTLFPDGEKTKFRKVVQTDGFTCIEMQEGRSWSY-ET ....| . .. .|||. ....|...||| |.||.| || . . ..||| | . . .. | . |. .... . RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---------HIKICDFGLARQL-----------TTFCGTPWYMAPEVL---GYGKCKC DLFCIAATVHVMLFGDYMQPQKKGSSWEIRQKLPRYLKKHVWTKFFGDLLNMQADKLPALHEMRL----IFEEEAY | . .. || | | .. .|. . .. | .|.. .| | | | . DWWSCGCILYEMLCGYPPFP----QMQMMFKKIG---SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | CG14030.AA | Ciliate-E2 | 887-1022 | 18 | 8.6e-15 | 47.18 | In-house | 111-292 (365) | Show / Hide |
Range on Protein: 887-1022 Range on HMM: 111-292/365 Sequence Identity: 18% (36 aa) IATEFSPFGSLLD-INNKIRQATTK-----VMHESLVMHFSAQICN---------------IVDHLHRQH-IIHADIKPDNFLLMRVPNVDSPLPSLRLI . .|. |.|.| |.|. . . . . | . ....||.. . .|| .. ||| ||||.| |. . .| LVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------------IKII DFGCAIDMTLFPD-------GEKTKFRK---------------------VVQTDGFTCIEMQEGRS---------WSYETDLFCIAATVHVMLFG ||| . . . . . .. .| | .. | |. . |. .| . ..|. |.... . . |||| DFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG |
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| Kinase | CG14030.AA | Pkinase | 910-969 | 27 | 1e-11 | 42.55 | Pfam | 101-159 (293) | Show / Hide |
Range on Protein: 910-969 Range on HMM: 101-159/293 Sequence Identity: 27% (17 aa) KVM--HESLVMHFSAQICNIVDHLHRQHIIHADIKPDNFLLMRVPNVDSPLPSLRLIDFGCA ... | . .. ||. ....|.. ||| |.||.|.|. . ...|. .....|||.| GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA---CVKICDFGLA |
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| Kinase | CG14030.AA | CDK | 814-843 | 42 | 1.8e-11 | 32.82 | In-house | 1-35 (284) | Show / Hide |
Range on Protein: 814-843 Range on HMM: 1-35/284 Sequence Identity: 42% (15 aa) FSIDKEVGRGSYGSVYKATDSRTG-----NVVALK . . ...|.|.|| |||| | .|| ..|||| YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALK |
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| Kinase | CG14030.AA | AGC | 914-948 | 31 | 3.5e-11 | 23.65 | In-house | 145-188 (395) | Show / Hide |
Range on Protein: 914-948 Range on HMM: 145-188/395 Sequence Identity: 31% (14 aa) ESLVMHFSAQ-------ICNIVDHLHR-QHIIHAD-IKPDNFLL |. . .. |. |. ...||. ..||| | .||.| || EERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILL |
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| Kinase | CG14030.AA | PDK1 | 814-843 | 35 | 5.6e-11 | 29.33 | In-house | 166-199 (307) | Show / Hide |
Range on Protein: 814-843 Range on HMM: 166-199/307 Sequence Identity: 35% (12 aa) FSIDKEVGRGSYGSVYKATDSRT----GNVVALK |.. |..|.|||..||.|.. | .. .|.| FIFGKNIGEGSYSTVYLAREKETKNDENKMYAIK |
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| Kinase | CG14030.AA | STE20 | 814-843 | 41 | 6e-11 | 36.54 | In-house | 1-34 (288) | Show / Hide |
Range on Protein: 814-843 Range on HMM: 1-34/288 Sequence Identity: 41% (14 aa) FSIDKEVGRGSYGSVYKATDSRTGNV----VALK . . ...|.||||.||||.. .||.. || | YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIK |
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| Kinase | CG14030.AA | STE | 887-973 | 29 | 6.6e-11 | 34.87 | In-house | 114-198 (359) | Show / Hide |
Range on Protein: 887-973 Range on HMM: 114-198/359 Sequence Identity: 29% (29 aa) IATEFSPFGSLLDINN---KIRQ-------ATTKVMHESLVMHFSAQICNI-VDHLHRQHIIHADIKPDNFLLMRVPNVDSPLPSLRLIDFGCAIDMT |. |. . ||| || . .. . . ... ||.. .. ||. ..||..|||| ||||.| || |.|||.. .| ICMEYMDGGSLDDIIKHKYGCGKPLNHNRQH-QHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------------VKLCDFGVCGQLT |
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| Kinase | CG14030.AA | CMGC | 814-843 | 34 | 1.9e-10 | 29.62 | In-house | 232-275 (513) | Show / Hide |
Range on Protein: 814-843 Range on HMM: 232-275/513 Sequence Identity: 34% (15 aa) FSIDKEVGRGSYGSVYKATDSRTG--------------NVVALK . |.| .|.|.|| |||..| ||. ..||.| YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIK |
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| Kinase | CG14030.AA | DYRK2 | 814-843 | 40 | 6e-10 | 28.2 | In-house | 1-30 (318) | Show / Hide |
Range on Protein: 814-843 Range on HMM: 1-30/318 Sequence Identity: 40% (12 aa) FSIDKEVGRGSYGSVYKATDSRTGNVVALK ..|.. |.||.|.| |..| |. ||.| YEILEVIGKGSFGQVVKCYDHKTKQHVAIK |
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| Kinase | CG14030.AA | CAMK | 898-973 | 22 | 3.2e-09 | 25.11 | In-house | 147-247 (425) | Show / Hide |
Range on Protein: 898-973 Range on HMM: 147-247/425 Sequence Identity: 22% (23 aa) L--DINNKIRQATT-------------KVMHESLVMHFSAQICNIVDHLHRQHIIHADIKPDNFLLMRVPNVDSPLP-----------SLRLIDFGCAID | |. ..|.. . . ..|. . .. ||| |...| ..|.| |.||.| || . ..| . . .|||| |. LFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDP-VEHDEIFDWNNNNIKIIDFGFANK MT .. FD |
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| Kinase | CG14030.AA | AGC | 814-846 | 33 | 4.5e-09 | 18.06 | In-house | 1-39 (395) | Show / Hide |
Range on Protein: 814-846 Range on HMM: 1-39/395 Sequence Identity: 33% (13 aa) FSIDKEVGRGSYGSVYKATDS------RTGNVVALKYQK | . | .|.||.| || . . || . |.| | FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLK |
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| Kinase | CG14030.AA | STE | 814-843 | 26 | 2.4e-08 | 25.7 | In-house | 1-45 (359) | Show / Hide |
Range on Protein: 814-843 Range on HMM: 1-45/359 Sequence Identity: 26% (12 aa) FSIDKEVGRGSYGSVYKATDS------RTGNV---------VALK . . ...|.|..|.|||| . .||.| .| | WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIK |
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| Kinase | CG14030.AA | PDK1 | 919-948 | 46 | 2.7e-08 | 20.95 | In-house | 114-143 (307) | Show / Hide |
Range on Protein: 919-948 Range on HMM: 114-143/307 Sequence Identity: 46% (14 aa) HFSAQICNIVDHLHRQHIIHADIKPDNFLL .. |.| ...|||. ||| |.||.| || FYAAEIIDALEHLHSNGIIHRDLKPENILL |
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| Kinase | CG14030.AA | Pkinase | 814-843 | 43 | 8e-08 | 28.74 | Pfam | 1-30 (293) | Show / Hide |
Range on Protein: 814-843 Range on HMM: 1-30/293 Sequence Identity: 43% (13 aa) FSIDKEVGRGSYGSVYKATDSRTGNVVALK . | . .|.||.|.|||... || .||.| YHIGRKIGSGSFGCVYKCHHKGTGKIVAVK |
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| Kinase | CG14030.AA | CAMK | 819-843 | 27 | 7.3e-07 | 17.38 | In-house | 1-37 (425) | Show / Hide |
Range on Protein: 819-843 Range on HMM: 1-37/425 Sequence Identity: 27% (10 aa) EVGRGSYGSVYKATDSRTG------------NVVALK . ||||.| |..... .|. || | TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIK |
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| Kinase | CG14030.AA | Ciliate-E2 | 814-843 | 33 | 7.8e-07 | 19.47 | In-house | 1-30 (365) | Show / Hide |
Range on Protein: 814-843 Range on HMM: 1-30/365 Sequence Identity: 33% (10 aa) FSIDKEVGRGSYGSVYKATDSRTGNVVALK . . | |.|..|||||... .... .|.| YKFIKKIGQGNFGSVYKCKVWKVQKQFAIK |
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| Kinase | CG14030.AA | CMGC | 904-967 | 21 | 1e-06 | 16.95 | In-house | 169-249 (513) | Show / Hide |
Range on Protein: 904-967 Range on HMM: 169-249/513 Sequence Identity: 21% (18 aa) IRQ--ATTKVMHESLVMHFSAQICNIVD--HLHRQH--IIHADIKPDNFLLMR--------------VPNVDSPLPSLRLIDFG .|. . | . .. .. ||.. .. ..|.. ||| |.|| | |. . |... |...||| HRRPPHNIKYFMI-HIR-YMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDW-NPCQKNGRLKICDFG |
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| Kinase | CG14030.AA | DYRK2 | 915-948 | 44 | 6e-06 | 14.98 | In-house | 102-135 (318) | Show / Hide |
Range on Protein: 915-948 Range on HMM: 102-135/318 Sequence Identity: 44% (15 aa) SLVMHFSAQICNIVDHLHRQHIIHADIKPDNFLL .|| | ..| . . ||. |||.| || | || QLVRRFAHSILQCLRFLHKNNIIHCDLKPENILL |
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| Kinase | CG14030.AA | TyrKc | 814-1040 | 15 | 1.8e-05 | -134.14 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 814-1040
Range on HMM: 1-280/280
Sequence Identity: 15% (47 aa)
FSIDKEVGRGSYGSVYKATDSRTGNVVALKYQKPPNTWEIYICD--QVLKRI--KEPEVLPGVMDISTAIIAP-------NASLIATEFSPFGSLLDINN
. .|. |.| .| |||.| . || | |. . ... ...... . | .. . ... . .| .|. | |.|.|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVR----LYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR
KIRQATTKVMHESLVMHFSAQICNIVDHLHRQHIIHADIKPDNFLLMRVPNVDSPLPSLRLIDFGCAIDMTLFPD-------GEKTK----FRK------
| | . .|. ||.. ..||....|| |. | |. . . ||| . | . | ..| .|
KHRPK----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-------TVKISDFGLSRD--IYDDDQQGESKDYYRKKEHKGGKTMLPIR
-----VVQTD-----------GFTCIEMQEGRSWSYETDLF--CIAATVHVMLFGDYMQPQKKG-----------------------------SSWEIRQ
. .. | .. |. |. . . . .. |. . |. || . . .||..
WMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHE
KL
..
CF
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| Kinase | CG14030.AA | STE20 | 929-948 | 70 | 0.000872 | 10.06 | In-house | 131-150 (288) | Show / Hide |
Range on Protein: 929-948 Range on HMM: 131-150/288 Sequence Identity: 70% (14 aa) DHLHRQHIIHADIKPDNFLL |.||..|||| ||| || || DYLHSNHIIHRDIKADNILL |
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| Kinase | CG14030.AA | CDK | 910-950 | 26 | 0.001637 | 6.92 | In-house | 106-143 (284) | Show / Hide |
Range on Protein: 910-950 Range on HMM: 106-143/284 Sequence Identity: 26% (11 aa) KVMHESLVMHFSAQICNIVDHLHRQHIIHADIKPDNFLLMR |.|. . .. |. . ....|...|.| |.|| | |... KYMD---IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINN |
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