Gene ial (Fruit Fly)

ial

Species: Fruit Fly
Alias: ial, AURORA-like, DmAurB, Aurora B, auroraB, CG6620, IplI-aurora-like kinase, DmAuroraB, aurB, DmAIRK2, aurora B, IAL, SFO104, aurora B kinase
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 32B1,

Classification

Group: Other
Family: Aur

Sequence

Name Sequence Type Origin Length Description Download
ial.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 253 Kinase domain by global Sugen HMM Fasta, JSON
ial.AA Protein Various 329 None Fasta, JSON

Protein domain

Protein domains of ial.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase ial.AA Aur 53-305 55 5.9e-226 603.67 In-house 1-257 (257) Show / Hide 
Range on Protein: 53-305
Range on HMM: 1-257/257
Sequence Identity: 55% (143 aa)

FEMGAHLGRGKFGRVYLARERHSHYLVAMKVMFKEELRKGCVQRQVLREIEIQSRLKHPHILRLLTWFHDESRIYLALEIASEGELFKHLRGAPNHRFDE
||.|..||.||||.|||||....|...|.||||||...| |...|. |||.|||.|.||.||.. ..|||. |||| || |. |||.|.|. .||.||||
FEIGKPLGKGKFGNVYLARHKKTHFIFALKVMFKEQIKKYCMEHQLRREIKIQSHLNHPNILKMYGYFHDDQRIYLILEYAPGGELYKELQKQPNKRFDE

PRSAKYTYQVANALNYCHLNNVIHRDLKPENILLT-STDDLKLADFGWSAHTP-NNKRRTLCGTLDYLPPEMVDGNSYDDSVDQWCLGILCYEFVVGCPP
.|.|||.||..|||.||| .|.||||.|||||||  . ...|..|||||.|.| ||.|.|.||||||.||||| |...|..|| ||||.||||...||||
QRAAKYMYQICNALDYCHSKNIIHRDIKPENILLDQCNGNIKICDFGWSVHCPNNNRRMTFCGTLDYMPPEMVEGQMHDHKVDIWCLGVLCYELCHGCPP

FES-NSTESTYSKIR-RMEISYPSHLSKGCKELIGGLLRKESKGRITLVDVMTHYWV
||| ...  ||..|. ...|..|||.||..|.|| ..|....| |.||...| |.|.
FESNENHDETYDRIKNKVDIQFPSHISKEAKDLISKILQHDPKQRMTLDQIMNHPWI
Kinase ial.AA AGC 53-305 23 5e-99 256.05 In-house 1-395 (395) Show / Hide 
Range on Protein: 53-305
Range on HMM: 1-395/395
Sequence Identity: 23% (93 aa)

FEMGAHLGRGKFGRVYLARERHSH------YLVAMKVMFKEE---LRKGCVQRQVLRE------------IEIQSRLK----------HPHILR-LLTWF
||.  ..|.| ||.|||.|.....       . ||||. |..   ..|   ......|             .| ....          || | . |   |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

HDESR--IYLALEIAS---------EG-ELFKHLRGA-PNHRFDEPRSAKYTYQ-------VANALNYCHL-NNVIHRD-LKPENILLTSTDDLKLADFG
.|...  .|. .| ..          | ||| ||.|   . ||||.|.  |. .       .. || | |  ...|||| ||||||||..   .||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

WSAHTPN----------------------------------------------------NKRRTLCG--TLDYLPPEMVDGNSYDDSVDQWC--LGILCY
 .   .|                                                    ..  |.||  | .|..||..    |. ..| |.  ||.| |
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EFVVGCPPFESNSTE----------STYSKIR------RMEISYP----------SHLSKGCKELIGGLLRKESKGRIT----------LVDVMTHYWV
|...|.||| .....           .. ||.        .. .|          ...|. .| || .|| |. . |..            ... | | 
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase ial.AA S_TKc 53-305 30 1e-88 301.97 SMART 1-231 (231) Show / Hide 
Range on Protein: 53-305
Range on HMM: 1-231/231
Sequence Identity: 30% (81 aa)

FEMGAHLGRGKFGRVYLARERHSHYLVAMKVMFKEELRKGCVQRQVLREIEIQSRLKHPHILRLLTWFHDESRIYLALEIASE--GELFKHLRGAPNHR-
.|.. ..|.| ||.||..|..... .||.|..           ....|||.| .. .||.| .|. .|.| ...|. .| ..   |.||....  . |. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FDEPRSAKYTYQVANALNYCHLNNVIHRDLKPENILLTSTDDLKLADFGWSAHTPNNKRRTLCGTLDYLPPEMVDGNSYDD-SVDQWCLGILCYEFV
   |.| . ..|.||...||.||| ...||||||||||||..   .|..||| ...      .|.|||..|..||..   .|.  ..| | .|.. ||..
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

VGCPPFESNSTESTYSKIRRMEISYPSHLSKGCKELIGGLLRKESKGRITLVDVMT-------HYWV
.|.|||.    . .. ||.          |. .|..| ..|.|. . |.|  ....       | |.
CGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ial.AA CAMK 58-305 20 4.5e-85 273.98 In-house 1-425 (425) Show / Hide 
Range on Protein: 58-305
Range on HMM: 1-425/425
Sequence Identity: 20% (89 aa)

HLGRGKFGRVYLARERHSH------------YLVAMKVMFKEELRK-------------------------GCVQRQVLREIEIQSR-------LKHPHI
 |||| || |.|......               ||.|.. |. |..                         .. ...|.||||| ..       |.||.|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LRLLTWFHD-------------------ESRIYLAL---EIASEGEL----FKHLRGAPN-------------HRFDEPRSAKYTYQVANALNYCHLNNV
..|. .. |                   ....|. .   | .| |||    | ...  ..             .||.|   ..|  |.. |..||| .|.
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDLKPENILLTSTD-----------------DLKLADFGWSAH-------------------------TPNNKRRTLCGTLDYLP-PEMVDGNS----
.|||||||||||.. .                 ..|..||| ...                         |.. | .| |||. | . ||.. |..    
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

----------YDDSVDQWCLGILCYEFVVGCPPFESN-------------STESTYSKIRRMEIS-YPSH-----------------------LSKGCKE
          |. ..| | .|...|  ..|.|||..              . . .. ||.. . . .|..                       .|. || 
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LIGGLLRKESKGRITLVDVMTHYWV
|| ..|... . |.|. ... | |.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase ial.AA CAMKL 53-305 30 1.3e-77 247.17 In-house 1-297 (297) Show / Hide 
Range on Protein: 53-305
Range on HMM: 1-297/297
Sequence Identity: 30% (91 aa)

FEMGAHLGRGKFGRVYLARE-RHSHYLVAMKVMFKEELRKGCVQRQ------------VLREIEIQSRLK---HPHILRLLTWFHDESR------IYLAL
...|  ||.| || | ||.  |.    ||.|.. |. ... .. ..            . |||.|...|.   ||.| .|.  . ...       ||| .
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EIASEGE--LFKHLRGAPNHR--FDEPRSAKYTYQVANALNYCHLNNVIHRDLKPENILLTSTDD--LKLADFGWSAH-TP-----NNKRRTLCGTLDYL
| .| ||  || ...  ...|  ..|.   .|  |.  |.|||| ....|||.|||||||.. ..  .|..||| |.. .|     ..| .| ||.. | 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

PPEMVDG--NSYD-DSVDQWCLGILCYEFVVGCPPFESN--------STESTYSKIRRMEISYP--SHLSKGCKELIGGLLRKESKGRITLVDVMTHYWV
.||.. |   .||   || | .|.. |  |.|  ||.           .   | ||..    .|  .|.|  |. || ..| .  . |.|. ..| | |.
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase ial.AA Pkinase 53-305 29 1.9e-77 268.39 Pfam 1-293 (293) Show / Hide 
Range on Protein: 53-305
Range on HMM: 1-293/293
Sequence Identity: 29% (86 aa)

FEMGAHLGRGKFGRVYLARERHSHYLVAMKVMFKEELRKGCVQRQVL-REIEIQSRLKHPHILRLLTWFHDESRIYLALEIASEG----ELFKHLRGAPN
.. |  .|.| ||.||..... .  .||.|.. |.. .... |. .. .||.|  ||.||.|.||. ||.|...||. .| .  |    .|| ....  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

HRF--DEPRSAKYTYQVANALNYCHLNNVIHRDLKPENILLTSTDDL----KLADFGWSA---HTPNNKRRTLCGTLDYLPPEMVD-GNSYDDSVDQWCL
 .|  .|    .| ||.. .|.||| ...|||||||||||. .....    |..||| ..   . .|    |.|||..|..|| .  |. |. .|| | .
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GILCYEFVVGCPPFESN------STESTYSKIRRMEISYPSHLS---------------------KGCKELIGGLLRKESKGRITLVDVMTHYWV
|...||.. | ||| .       .    . .|.. ......  .                     . ||..| ..|.|  | |.|  ... | |.
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase ial.AA MARK 53-305 37 6.5e-76 247.65 In-house 1-262 (262) Show / Hide 
Range on Protein: 53-305
Range on HMM: 1-262/262
Sequence Identity: 37% (97 aa)

FEMGAHLGRGKFGRVYLARERHSHYLVAMKVMFKEELRKGCVQRQVLREIEIQSRLKHPHILRLLTWFH--DESR-IYLALEIASEGELFKHLRGAPNHR
..|.  .| | .. |.||. .|..  || |.. |. | . .  . | ||||| ..|.||.| .|.  .   .|.. ||| .| ||.|||. ... .||.|
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

FDEPRSAKYTYQVANALNYCHLNNVIHRDLKPENILLTSTD--DLKLADFGWSAHT-PNNKRRTLCGTLDYLPPEMVDGNSYD-DSVDQWCLGILCYEFV
  |.   ..  |.  |.|||| .|..|||.||||||. .    . |..|||.|..  |..|  | |||. | .||.. .  ||   || | ||.. |  |
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMV

VGCPPFE--SNSTESTYSKIRRMEISYPSHLSKGCKELIGGLLRKESKGRITLVDVMTHYWV
.|. ||.  ... .  | ||.| . ..|.|.||.|. ||  ||    . |.|. ..| | |.
CGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase ial.AA PLK 53-305 32 7.1e-66 213.54 In-house 1-258 (258) Show / Hide 
Range on Protein: 53-305
Range on HMM: 1-258/258
Sequence Identity: 32% (84 aa)

FEMGAHLGRGKFGRVYLARERHSHYLVAMKVMFKEELRKGCVQRQVLREIEIQSRLKHPHILRLLTWFHDESRIYLALEIASEGELFKHLRGAPNHRFDE
.| |  ||.| | ..| ... |... .| ||  |. . |      . .||||...|.||.|... . | |.. .|. ||... ..|. |.  .  .|. |
YERGHFLGKGGFAKCYEMTDIHTKQVYAIKVVPKSLMQKPHQREKMKQEIEIHRQLHHPNIVKFHHFFEDHENVYIVLEYCHNRSLM-HYHKRRAKRLTE

PRSAKYTYQVANALNYCHLNNVIHRDLKPENILLTSTDDLKLADFGWSAHTPNN--KRRTLCGTLDYLPPEMVDGNS--YDDSVDQWCLGILCYEFVVGC
|    |.||....| | | ...||||||. |..|..   .|..||| ..   ..  ...|.|||  |  || .|||   ..  || | ||.  | . .| 
PEVRYYMYQIVQGLKYLHQHRIIHRDLKLGNLFLNDNMHVKIGDFGLATRLEYDGERKKTMCGTPNYIAPEVLDGNKQGHSYEVDCWSLGCIMYTLLIGK

PPFESNSTESTYSKIRRMEISYPSH--LSKGCKELIGGLLRKESKGRITLVDVMTHYWV
||||... ..||..|.  . |.|.|  .|.  |.||  .|..    |.|.  .. | . 
PPFETKDVKETYKRIKHNHYSFPEHCPISDEAKDLIQKMLNWNPDERPTIDQILQHPFF
Kinase ial.AA Ciliate-E2 53-305 23 5e-62 211.72 In-house 1-365 (365) Show / Hide 
Range on Protein: 53-305
Range on HMM: 1-365/365
Sequence Identity: 23% (89 aa)

FEMGAHLGRGKFGRVYLARERHSHY-----------------------LVAMKVMFKEELRKGCVQRQVLREIE----------IQSRLKHPHILRLLTW
..    .|.| || ||... .   .                       ..|||.| | ...      ...|||.          |...|.||.|...  .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FH--DESRIYLALEIASEGELFKHLR---GAPNHR------FDEPRSAKYTYQVAN---------------ALNYCHLNN-VIHRDLKPENILLTSTDDL
|   |.. ||| .| .. |.||....      ||       |.|   .....|...               ||.|.| .| .||||.||||||.     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLADFGW--SAHTPNNKRR-------------------------------TLCGTLDYLPPEMVDGNS---------YDDSVDQWCLGILCYEFVVGCPP
|..|||    ....|..|.                               |.|||. |..||.. | .         || ..| |.||.. ||.. | ||
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FESNSTESTYSKIRRMEISYP------------------SHLSKGCKELIGG----LLRKESKGRIT-LVDVMTHYWV
|        . .|   .|..|                   ..|. || ||      .| |. . |||   ... | | 
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase ial.AA Ciliate-E2-Unclassified 53-305 23 8.1e-62 211.68 In-house 1-352 (352) Show / Hide 
Range on Protein: 53-305
Range on HMM: 1-352/352
Sequence Identity: 23% (83 aa)

FEMGAHLGRGKFGRVYLARERHSHYLVAMKVMFKEELRKGCVQRQV----LREIEIQSR------------------LKHPHILRLLTWFHDESRIYLAL
....  .|.| || ||.....   .. ||| | |   .| . ....    . ..|....                  ..||.|.... .| |.  ||. .
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EIASEGELFKHLRGAPN---------------HRFDEPRSA-----KYTYQVANALNYCHLNN-VIHRDLKPENILLTSTD---DLKLADFGWSA-----
| .  |.|.....  ..               ..|.|  ..     .|..|. ..|.|.| .| .||||.||||||...      .|..||| |      
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

------------HTPNNKRRTLCGTLDYL----PPEMVDGNSYDDS----VDQWCLGILCYEFVVGCPPFESNSTES----------------TYSKIRR
             .....  | |||. |.    .||. .|. ||.|    .| |.||...||.. | .||..|. |.                 |..|  
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

MEISYPS--------HLSKGCKELIG----GLLRKESKGRITLVDVMTHYWV
 .|..|.        |.|. .|..|      .| |  . |||. ... | | 
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase ial.AA SAK 53-305 34 1.6e-61 208.18 In-house 1-254 (254) Show / Hide 
Range on Protein: 53-305
Range on HMM: 1-254/254
Sequence Identity: 34% (88 aa)

FEMGAHLGRGKFGRVYLARERHSHYLVAMKVMFKEELRKGCVQRQVLREIEIQSRLKHPHILRLLTWFHDESRIYLALEIASEGELFKHLRGAPNHRFDE
....  ||.| |  || |.  | |  ||.|.. |  ..|  . . | .|.|| ..|||| || | ..|.|.  .|| ||..  ||. . ..    . | |
YQVQHLLGKGGFACVYRAKCIHTHQEVAIKMIDKKLMQKTGMVQRVRNEVEIHCQLKHPSILELYNYFEDNNYVYLVLEMCHNGEMHRYMKHR-MRPFTE

PRSAKYTYQVANALNYCHLNNVIHRDLKPENILLTSTDDLKLADFGWSA--HTPNNKRRTLCGTLDYLPPEMVDGNSYDDSVDQWCLGILCYEFVVGCPP
   ...  |.   . | |  ...||||   |||||   ..|.||||  .  . |. |  |.|||  |. ||..   .     | | || . | ...| ||
EEARHFMHQIVIGMLYLHSHGIMHRDLTLSNILLTRDMHCKIADFGLATQLKMPHEKHYTMCGTPNYISPEIATRTAHGLQSDVWSLGCMLYTLLIGRPP

FESNSTESTYSKIRRMEISYPSHLSKGCKELIGGLLRKESKGRITLVDVMTHYWV
|. .. ..|  |.   |   |.|||   ..||  .|||. . ||||  |. | ..
FDTDAVKNTLNKVMMAEYIMPAHLSMEAQDLIHKMLRKNPHERITLSTVLCHPFM
Kinase ial.AA PKA 53-286 38 9.8e-60 204.77 In-house 1-239 (263) Show / Hide 
Range on Protein: 53-286
Range on HMM: 1-239/263
Sequence Identity: 38% (92 aa)

FEMGAHLGRGKFGRVYLARERHSHYLVAMKVMFKEELRKGCVQRQVLREIEIQSRLKHPHILR-LLTWFHDESRIYLALEIASEGELFKHLRGAPNHRFD
||  . ||.| ||||.|.|..||   .|||.. |.|  .   .  |. |. | . .||| | . .   |.|.. .|. .| .. ||.|..||   . ||.
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRK--SGRFS

EPRSAKYTY-QVANALNYCHLNNVIHRDLKPENILLTSTDDLKLADFGWSAHTPNNKRRTLCGTLDYLPPEMVDGN-SYDDSVDQWCLGILCYEFVVGCP
.| .  |   |.  || | |  | |.|||||||||. .   .|..||| .  . .    ||||| .||.||.. .   .  ||| |.|||| ||...| |
NPHAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD-RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYP

PFESN--STESTYSKIRRMEISYPSHLSKGC---KELIGGLL
||. .  .. ..| ||.  .| .|.|...     | ||  ||
PFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLL
Kinase ial.AA Pkinase_Tyr 53-198 29 1e-19 67.4 Pfam 1-156 (270) Show / Hide 
Range on Protein: 53-198
Range on HMM: 1-156/270
Sequence Identity: 29% (47 aa)

FEMGAHLGRGKFGRVYLARER----HSHYLVAMKVMFKEELRKGCVQRQ-----VLREIEIQSRL-KHPHILRLLTWFH-DESR--IYLALEIASEGELF
 ..|  ||.| ||.||... .      .. || |.. ||    |. ..|      .||..| . | .||.|.||.     ..    ||. .| .  | | 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE----GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL

KHLRGA--PNHRFDEPRSAKYTYQVANALNYCHLNNVIHRDLKPENILLTSTDDLKLADFG
..||    ...... ..  .. .|.|....| . .| |||||   |.|.|..   | .|||
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase ial.AA TyrKc 53-303 18 3.8e-15 22.11 SMART 1-280 (280) Show / Hide 
Range on Protein: 53-303
Range on HMM: 1-280/280
Sequence Identity: 18% (53 aa)

FEMGAHLGRGKFGRVYLARERHSHYLVAMKVMFKEELRKGCVQRQVLREIEIQSRL--KHPHILRLLTWFHDE-------SRIYLALEIASEGELFKHLR
 ..|  ||.| ||.||... .   . || |.. ..       ..  .||..| ..|  .||.|.||.    ..         ... .| .. | | ..||
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

GAPNHRFDEPRSAKYTYQVANALNYCHLNNVIHRDLKPENILLTSTDDLKLADFGWSAHTPNN------KRRTLCGT---LD------YLPPEMVDGNSY
   .. .  .   .. .|.|.  .| | .|.|||||   |.|...    | .||| |    .       |      .    .       ..||  . . .
KHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

DDSVDQWCLGILCYEFVVGC-PPFES-----NSTESTYSKIRRMEISYPSHL---------SKGCKELIGGLLRKESKGRITLVDVMTHY
    | |  |....|    . .| .       | .  . .... .   . .          ..   ...    . . . | |  ..    
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF