Gene PR2 (Fruit Fly)

PR2

Species: Fruit Fly
Alias: Rp2, DPR2, DRODPR2, SFO018, PR2/ACK, DmHD-11, PR2, focal adhesion kinase, HD-11, CG3969
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 49F10--11,

Classification

Group: TK
Family: Ack

Sequence

Name Sequence Type Origin Length Description Download
PR2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 264 Kinase domain by global Sugen HMM Fasta, JSON
PR2.AA Protein Various 1238 None Fasta, JSON

Protein domain

Protein domains of PR2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PR2.AA Ack 51-314 57 2.6e-199 668.44 In-house 1-266 (266) Show / Hide 
Range on Protein: 51-314
Range on HMM: 1-266/266
Sequence Identity: 57% (154 aa)

ISVNKQLGTGEFGIVQQGVWSN-GNERIQVAIKCLCRERMQSN--PMEFLKEAAIMHSIEHENIVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRV
|.....||.|.||.|..|.|.| |...||||.|||....||..  ...||.|.|||||..|...||||||||....||.|||||...|||.||.. ..|.
ITLCEKLGDGCFGVVWRGEWTNPGGKHIQVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVVLDQPMLMMVTELAPCGSLLDCLRK-HCRT

SFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKD-KVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFGV
.|..|.|||.|..||..||||||.||.|||||||||||.||.| ||||.||||.||||...|||...|..|||.|.|||||||.....|..|||||.|||
AFFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWMFGV

CLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEIYDQL
.||||||||..|||...|.|||..||. ...||..|||||...|..||.|||...|.||.|..|.|||
TLWEMFSYGEEPWAGCNGYQILQKIDK-EGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL
Kinase PR2.AA TyrKc 51-314 39 4e-127 429.53 SMART 1-280 (280) Show / Hide 
Range on Protein: 51-314
Range on HMM: 1-280/280
Sequence Identity: 39% (115 aa)

ISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSI--EHENIVRLYGVVLAT-------DSLMLVTELAHLRSLLECLK
|. .|.|| |.||.| .|.|.     ||||.|.|  .      ..|..|| ||...  .|.||||||||..         . ||.|.|.. . .|.. |.
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

DSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVG------KDYYKTNFNVNLK--LPIAWCAPECINYL
... .   |. ..|..|..||..||.||..|..|||||||||.|| ..  ||||||||||... .      ||||..    . |  ||| |.||||||| 
KHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

RFTNASDVWAFGVCLWEMFSYGFQPWAA-----LTGLQILEAIDAPNYQRLEQPDC------CPSEYYTLMMKCWQDDAAKRPRFGEIYDQL
.|| .||||.||||.||.|.|| ||.       ..  ...| ... .. .  . |.      ||.| |..| .||. |...||.| ||....
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase PR2.AA Pkinase_Tyr 51-314 42 2.9e-114 387.61 Pfam 1-270 (270) Show / Hide 
Range on Protein: 51-314
Range on HMM: 1-270/270
Sequence Identity: 42% (117 aa)

ISVNKQLGTGEFGIVQQGVWS--NGNERIQVAIKCLCRERMQSN--PMEFLKEAAIMHSI-EHENIVRLYGVVL-ATDS--LMLVTELAHLRSLLECLKD
|. .|.|| |.|| | .|.|    .|..|.||.|.|    |...    .|..||.||...  |.||||||||..   ..  ...|.|.. . .||. |..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

SGLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVW
       ||...|.....||..|| |||.|..|||||||||.|| .. .|||.||||.|..   .||| .    . |||| |.||||||| .|| .||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVW

AFGVCLWEMFSYGFQP-WAALTGLQILEAI-DAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEIYDQL
.|||..||.|.|| || .. ..  ...|.| .    .|...|. || | |.||..||. |...||.| ||. ||
SFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYED--GYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase PR2.AA TK 51-314 22 5.1e-107 359.9 In-house 1-486 (486) Show / Hide 
Range on Protein: 51-314
Range on HMM: 1-486/486
Sequence Identity: 22% (108 aa)

ISVNKQLGTGEFG---IVQQGVWSNGN-----------------------ERIQVAIKCLCRERMQSNPMEFL----------------KEAAIMHS--I
| . |.|| |.||    | .| | ..|                       ....||.|.|  .  .|  ..|.                 |...|..   
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

EHENIVRLYGVVLATDS------------LMLVTELAHLRS----LLECLKDSGLRVSF-----------------------------------------
.|.||||||||..  ..            .|.|.|.... .    |.. |...  . .                                          
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LTIPTLCEFALQICNGMRYLEQK------RLIHRDLAARNILVFSKDK-----------VKISDFG---
                               || ..|. ...||..||.||..|      ...||||||||.||.....           .||.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LSRALGVGKDYYKTNFNV---------------------NLKLPIAWCAPECIN---------YLRFTNASDVWAFGVCLWEMFSYGFQPWAA-L
     |.|... ..|||...                        . |||| |.||||.|         | .|| .||||.|||..||.|.|| .|..  .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

TG---------LQILEAIDAPNY------------QRLEQPDCCP--------------SEYYTLMMKCWQDDAAKRPRFGEIYDQL
.           ...| . .                |..||. ||               ||| ||..||. |...||.| ....||
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase PR2.AA UTK 51-314 30 3.2e-90 306.05 In-house 1-296 (296) Show / Hide 
Range on Protein: 51-314
Range on HMM: 1-296/296
Sequence Identity: 30% (90 aa)

ISVNKQLGTGEFGIVQQGVWSNGN---ERIQVAIKCLCRERM-QSNPM---EFLKEAA---IMHSIE-HENIVRLYGVVLATDSLMLVTELAHLRSLLEC
.   .||| |.||.|. . . . .   .  .||.| . .. . | .|    .|..||.   .|   . |.|..||.||...   .|.|||..   .|. .
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LKDSGL----RVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSK-------DKVKISDFG---LSRALGV--------GKDYYKTNFNVN
| ...     .  .||  .. ..|..| .|| ||......||||||||.||..         ..||.|||   .||...         . .||. .  ..
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQ--HQ

LKLPIAWCAPECINYL-RFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEIYDQL
 ..||.|.|||....  |||..||||.||| .||....| .|.. ..  |..... . ...|...|. || . |.||..||. | ..||.| ....|.
DRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase PR2.AA Syk 51-308 38 4.4e-87 295.62 In-house 1-257 (257) Show / Hide 
Range on Protein: 51-308
Range on HMM: 1-257/257
Sequence Identity: 38% (101 aa)

ISVNKQLGTGEFGIVQQGVWSNG-----NERIQVAIKCLCRERMQSN-PMEFLKEAAIMHSIEHENIVRLYGVVLATDSLMLVTELAHLRSLLECLKDSG
.   ...| |.|| | .|.           .|.|||| |  .  | .   ||. || .|.  .|  |||. |. .|  ..|.| |.| | ...  |.. .
LVQDNEIGCGNFGSVHKGWYMMKSGAGEKQWIKVAIKMLKADHNQPADKQEFMREAQVMCQLDHPCIVRMIGICHA-EMMMMVMEMAELGPMHKYLQQHR

LRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAF
  ..   .  |   . |.  || ||| |  .||||||||.|   .   ||||||.|.||| . .||.  .    | |. | |||||.|  |  .|||| |
HEITANNVLEL--WHTQVAMGMCYLEEKHFVHRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQ--ATTHGKWPVKWYAPECIYYYKFSHKSDVWSF

GVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFG
|| .||||||| .| .  .|  ... |.  |  |...|. || | | || |||  ..  || |.
GVTMWEMFSYGQKPYGEMKGQEVMKFIE--NGHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV
Kinase PR2.AA SFK-Src 51-318 38 7.5e-82 242.24 In-house 1-259 (259) Show / Hide 
Range on Protein: 51-318
Range on HMM: 1-259/259
Sequence Identity: 38% (103 aa)

ISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHENIVRLYGVVLATDSLMLVTELAHLRSLLECLKD-SGLRVSF
|   |.|| | || | .|.|   |.  .||.| |    | ..  |||.||..|    |.| ..|| |      .  .|||    |||  |..  |     
IRLEKKLGSGQFGDVWKGRW---NNTTEVAVKTLKPGAMSAE--EFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHG---RS

LTIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFGVCLW
|..|.|   | |.  || ||| .  .||||||||.||     .|. |||.|| |.     |        | || | |||  |. ||   ||||.||. . 
LRMPQLVDMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGA--KFPIKWTAPEAMNMNRFSIKSDVWSFGILMM

EMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEIYDQLPDMK
|.  ||  |.  .|   .|  .| |.  |.. |  || ||| .|. |||  .  || |.    |. |  
EIVTYGRIPYPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase PR2.AA Src 51-314 40 5.5e-78 264.53 In-house 1-255 (255) Show / Hide 
Range on Protein: 51-314
Range on HMM: 1-255/255
Sequence Identity: 40% (108 aa)

ISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHENIVRLYGVVLATDSLMLVTELAHLRSLLECLK-DSGLRVSF
|   ..||.| || | .|.|   | ...||.| | .  |.  |  ||.|| || .  ||..|.|| |.   .    |||.    |||. || |.  |   
IKLCRKLGQGQFGEVWMGYW---NGNTKVAVKTLKPGTMS--PEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRH--

LTIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFGVCLW
| .|.| ..| |. .|| |||....|||||||||.||  .  .|. |||| | . ...| |        |.|| | |||.||| |||  |||| ||. |.
LHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARH--GAKFPIKWTAPEAINYGRFTIKSDVWSFGILLT

EMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYT-LMMKCWQDDAAKRPRFGEIYDQL
|...||  |    |  . |..... .| |. .|. || | |  .|..||. |. .|| |  ... |
EIVTYGRVPYPGMTNHEVLQQVER-GY-RMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase PR2.AA FAK 51-319 38 5.5e-76 254.08 In-house 1-285 (285) Show / Hide 
Range on Protein: 51-319
Range on HMM: 1-285/285
Sequence Identity: 38% (114 aa)

ISVNKQLGTGEFGIVQQGVWSNGNE-------------------------RIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHENIVRLYGVVLATDS--
|  |. .| | || | |||. |                             ||||||   ..  ..|  .|..|| ||. . |  ||.| |..       
ITLNRCIGEGQFGDVYQGVYTNHKNGKGKNLAGNGKNSNSDQRNADSRPDKIQVAIKTCKKCCDDDNKEKFMQEAYIMKQFDHPHIVKLIGICEEMPIWI

LMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIA
.|   ..  ||. |.  |.|      |...||  ...|.|  | ||| |. .||| ||||.|| |.| ||  |||||| .   ..|||    .  |||| 
IMELCKYGELRHYLQRNKNS------LKHATLILYCYQLCMAMAYLESKKFVHRDIAARNVLVSSPDCVKLGDFGLSRWM-HDHSYYKASPKG--KLPIK

WCAPECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEIYDQLPDMKP
| .|| ||. ||| ||||| ||||.||  .|| .|   .    .   |   |  ||  |. ||   |.|| .||  |  ||||| |.  || |.. 
WMSPESINFRRFTTASDVWMFGVCMWEILMYGVKPFQWVKNNDVIGRIE--NGERLPMPPNCPPTLYSLMTRCWAYDPSKRPRFKELKCQLKDIYQ
Kinase PR2.AA EGFR 51-315 36 3.3e-73 242.4 In-house 1-258 (258) Show / Hide 
Range on Protein: 51-315
Range on HMM: 1-258/258
Sequence Identity: 36% (97 aa)

ISVNKQLGTGEFGIVQQGVWSNGNERIQ--VAIKCLCRERMQSNPMEFLKEAAIMHSIEHENIVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVS
.   | || | || |  |.|    | ..  |||| |  .  ..   |.| || .| |..|...||| || .. . ..||| .  . .||. ..       
LKKVKVLGSGAFGTVYKGIWIPEGENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQ-MQLVTQYMPYGCLLDYVR---QHKD

FLTIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFGVCL
 .    |  ...||  || |||..|..||||||||.|| |  .||| ||||.. | . .. |. .     |.|| | | ||| . ..| .||||..|| .
NIGSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQ---GGKMPIKWMALECIHHRCYTHQSDVWSYGVTC

WEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEIYDQLP
||.  .| .|.. .   .| . ..  .  ||.||. |    | .|.|||  |.. ||.| |.| .. 
WELMTFGQKPYDGIPAREIPDLLEKGE--RLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase PR2.AA Frk 51-318 37 6.8e-72 245.16 In-house 1-260 (260) Show / Hide 
Range on Protein: 51-318
Range on HMM: 1-260/260
Sequence Identity: 37% (102 aa)

ISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHENIVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFL
| . ..||.| || |  | |   |  . ||.| |    |  .| .||.|| || .. |  ...|| |    . ....||| .  ||.| |.    . . .
IQLIRRLGSGQFGEVWEGLW---NNTTPVAVKTLKPGTM--DPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQC

TIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKD-YYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFGVCLW
 ...| . | |.  || |||..  |||||||||.||  .  .|| |||| | | . .   | .   .. ..|| | ||| .|| .||  ||||.||. | 
QMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYES--RHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLT

EMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEIYDQLPDMK
|.  ||  |.. .|. ..|. .|. .| |. ||  || ..| .|..||. |. ||| |  .  .| |  
EIITYGRMPYPGMTNAEVLQMVDH-GY-RMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase PR2.AA Fer 51-315 31 1.3e-71 243.13 In-house 1-283 (283) Show / Hide 
Range on Protein: 51-315
Range on HMM: 1-283/283
Sequence Identity: 31% (91 aa)

ISVNKQLGTGEFGIVQQG--VWSNGN------ERIQVAIKCL-CRERMQSNPMEFLKEAAIMHS-IEHENIVRLYGVVLATDSLMLVTELAHLRSLLECL
.  .|.|| | ||.| .|  .   ..      . . |. | . |      .  ||..|| || .   | |.|..|||      .|.| |..   ||.. |
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

KDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFS-KDKVK--ISDFGLSRA-LGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFT
| .. .  .... .. ....|...||.||..|  ||||.||||.|.   |.|.|  |||||.||.  ..|.||..       |.|| | |||....  ..
KKNKNK--TVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKE--KACKVPIRWLAPETWQTGIYS

NASDVWAFGVCLWEMFSYGFQPWAA------LTGL-QILEAIDAPNYQRLEQPDCCPSEYYTLMM-KCWQDDAAKRPRFGEIYDQLP
 ..|||.||| .|| |. | .|...      .| .   . . .. .. ..  |. .|.| . .|| .||| |  .|| . ||. .| 
PKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase PR2.AA S_TKc 51-317 24 1.4e-48 168.65 SMART 1-231 (231) Show / Hide 
Range on Protein: 51-317
Range on HMM: 1-231/231
Sequence Identity: 24% (67 aa)

ISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHENIVRLYGVVLATDSLMLVTELAHL--RSLLECLKDSGLRVS
  . ...| | || | .... .     .||||..           ...| .|...  |.|||.||.|    |.| .|.|..     .|.. .|. | .  
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

F--LTIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTN-ASDVWAFG
   ..  . . .. |||... |. ... |||||   |||. .   .||.||||.| |              .     ..||| .    ..  ..|.|..|
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG

VCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEIYD------QLPDM
..|.||.. |  |.   .  .... |              ..|   ...||.| | .|||   |.        . | .
CILYEMLC-GYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PR2.AA Pkinase 51-314 21 3.4e-39 139.67 Pfam 1-293 (293) Show / Hide 
Range on Protein: 51-314
Range on HMM: 1-293/293
Sequence Identity: 21% (65 aa)

ISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQS-NPMEFLK--EAAIMHSIEHENIVRLYGVVLATDSLMLVTELAHLR----SLLECLK-D
. . ...| | || | .... . ..  .||.|......  |  ... ..  |..||... |.||||||...   |.. .|.|..       .| . .. .
YHIGRKIGSGSFGCVYKCHHKGTGK--IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

SGLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDKV----KISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECIN-YLRFTN
.. ... ..  ... ...||. |. |. ... |||||   |||. ... .    ||.||||.. .     | .   .  .   . ..||| |. .   . 
RHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

ASDVWAFGVCLWEMFSYGFQPWAAL------TGLQILEAIDAPNYQRLEQPDCC------------------PSEYYTLMMKCWQDDAAKRPRFGEIYDQ
..|.|..|. |.||.. |  |.         . .|... |  | . . .. .|.                  ..|   .. .|.. | .||| . .|   
KVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

--L
  .
PWF
Kinase PR2.AA SH3 320-378 33 5e-06 27.35 SMART 1-58 (58) Show / Hide 
Range on Protein: 320-378
Range on HMM: 1-58/58
Sequence Identity: 33% (20 aa)

EQLKAVVNCTEPKKDHLLYRQGDIISVLDRNTGTPFWKGVLS-TGKTGYFNPSNTVAFLE
.. .|. ...    |.|  ..|||| ||... .   ||| .  ||..|.| ||| |. ..
PYVRALYDYQAQNPDELSFKKGDIITVLEKD-DDGWWKGRCNRTGQEGWF-PSNYVEEID
PBD PR2.AA PBD 405-451 25 3.4e-11 41.84 Pfam 1-60 (60) Show / Hide 
Range on Protein: 405-451
Range on HMM: 1-60/60
Sequence Identity: 25% (16 aa)

MISKPQNDFKHTGHVGIDGATFGDIAFLGSSQNYNHVPKQI----------------VTPYKP
|||.|. .|||| |||.|| |....   |  .. ......                 |.....
MISTPLTNFKHTMHVGWDGQTGFFT---GMPPEWQKLLQSSGISKPEQKHNPQAVFDVVQFYQ
PBD PR2.AA PBD 406-440 31 7.9e-11 43.22 SMART 1-38 (38) Show / Hide 
Range on Protein: 406-440
Range on HMM: 1-38/38
Sequence Identity: 31% (12 aa)

ISKPQNDFKHTGHVG-IDG--ATFGDIAFLGSSQNYNH
|| | ..|||. ||| .||   .|... .. ... ...
ISTPTGNFKHIVHVGPWDGQTGEFTGLPHQWQHLLKHC