Gene GK135 (G.lamblia)
GK135
Species: G.lamblia
Alias: GK135
External Links:
Annotation:
Sequence
Protein domains of GK135.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | GK135.AA | Pkinase | 52-295 | 22 | 7.1e-31 | 110.26 | Pfam | 11-293 (293) | Show / Hide |
Range on Protein: 52-295 Range on HMM: 11-293/293 Sequence Identity: 22% (65 aa) TMGTVYSLRGHPS---LAVKEILLDGPDKRDLGAIRL--ELAALLDLSNPGVLKHHQVVEGEGLIYVVMNRHDKTLERLLTEH----KRRKIPM--SAGV ..|.|| . . . |||.| ... .. . . |. |.. .. |. | ... . ..| .. ||.|| ....|. .. . .|. .. | . SFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYISTWRHGCFYFSEWE VLSVLRQIAAALAYLHGVNGVSVNGFVHRDLRPANVLISADGEY---FVIAGLGLC----KDALRCGSTIVSTAVYVAPEVLL-HNEASPASDVWSLGVI . ....||. .|.|.| |..|||| |.|.||. .|. . |. ||. . .|.. | |.||||.. ... .|..|.||.|.| CKFYMYQILRGLEYCHSM------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCI IYELVTLRRPDFLEGK------DPKDVFVDGWRPDLSGVTD-----------------------GFIKSVLERIFVLEPERRPTARELHET--L .||... .|| | |. |.. ... .|.|. . |....... . |..||||... . . LYEMLC-GRPPFP-GHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| S_TKc | GK135.AA | S_TKc | 42-297 | 23 | 6.4e-30 | 106.63 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 42-297 Range on HMM: 1-231/231 Sequence Identity: 23% (63 aa) RRLGSVLNESTMGTVYSLRGHP---SLAVKEILLDGPDKRDLGAIRLELAALLDLSNPGVLKHHQVVEGEGLIYVVMNRHDK---TLERLLTEHKRRK-- ... .. . ..|.|| | . |.|.| || |.. | | . | . | . . .|.|| | .| ... ...|.. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR IPMSAGVVLSVLRQIAAALAYLHGVNGVSVNGFVHRDLRPANVLISADGEYFVIAGLGLCKDALRCGSTIVSTAVYVAPEVLLHNEASP-ASDVWSLGVI |.. .. ....||. ||.|.| .|..|||| |.|.|.. |. ||.. .|.. | |.||||| .. ..|.||.|.| FPFPE-HARFYMYQICCALEYCHS------HGIIHRDLKPENILLDE---HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI IYELVTLRRPDFLEGKDPKDVFVDGWRPDLSGVTDGFIKSVLERIFVLEPERRPTARELHE-------TLAT .||... ..| | ... .| .. .. ...... .||.|||| |. . LYEMLC-GYPPFP---QMQMMFKKIG-------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | GK135.AA | TKL | 122-295 | 18 | 1.9e-23 | 81.31 | In-house | 126-364 (364) | Show / Hide |
Range on Protein: 122-295 Range on HMM: 126-364/364 Sequence Identity: 18% (46 aa) LERLLTEHKRRKIPMSAGVVLSVLRQIAAALAYLHGVN---GVSVNG--FVHRDLRPANVLISADGE------Y-------FVIAGLGLCKDA-----LR |..|. . .. ..|| ...||| | . .|||| ..|.|. ... | |. .||... LHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCT---KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMN CGST-----------------IVSTAVYVAPEVLLHN----------------EASPASDVWSLGVIIYELVTLRRPDF-LEGKDPK---------DVFV ...| .. | . ||||| . |.|...||.| |....|..| .|| . . ... . . DTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVC D-GWRPDLS------------GVTDGFIKSVLERIFVLEPERRPTARELHETL | | || . .. .|. ... .|| ||.. |. ..| DKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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| Kinase | GK135.AA | TK | 142-295 | 19 | 1.4e-22 | 71.83 | In-house | 238-486 (486) | Show / Hide |
Range on Protein: 142-295
Range on HMM: 238-486/486
Sequence Identity: 19% (50 aa)
LSVLRQIAAALAYLHGVN--GVSVNGFVHRDLRPANVLISADGE----------YFVIAGLG--------LCKDALR----CGSTIVSTAV---------
| .|||....||| | . . .|||||| |.|.. .. || | |..| . . .. .|..
L-MCWQIACGMEYLHSKNCEF--IQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDP
----------------YVAPEVLLHNE---------ASPASDVWSLGVIIYELVTLRRPDFLEGKDPKDVFVD---------------------------
. |||.|.... ...|||||.|| ..|..|. . . .| . || .|
WQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYR
GWRPDLSGVTD-------------GFIKSVLERIFVLEPERRPTARELHETL
.| . .| .. .. . . ..||.||| ..||| |
MRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
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| Kinase | GK135.AA | AGC | 147-238 | 24 | 7.4e-22 | 51.89 | In-house | 161-300 (395) | Show / Hide |
Range on Protein: 147-238
Range on HMM: 161-300/395
Sequence Identity: 24% (37 aa)
QIAAALAYLHGVNGVSVNGFVHRD-LRPANVLISADGEYFVIAGLGLCKDALRCG---------------------------------------------
.|. || ||| | .|..||| | | |.|. .| . .. |||| . |
CIVLALEYLH-----SHMGIIHRDYLKPENILLDED-GHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDT
--------STIVS--TAVYVAPEVLLHNEASPASDVWS--LGVIIYELVT
.|.. |. |.|||.| ..| | || ||...||..|
TRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLT
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| Kinase | GK135.AA | Ciliate-E2 | 86-242 | 21 | 1.9e-21 | 70.38 | In-house | 82-295 (365) | Show / Hide |
Range on Protein: 86-242 Range on HMM: 82-295/365 Sequence Identity: 21% (48 aa) ELAALLDLSNPGVLKHHQVVE--GEGLIYVVMNRHDK-TLERLLT--EHKRRKI-----PMSAGVVLSVLRQIAA---------------ALAYLHGVNG |. | |..| ..| . . . . || || . .|. .. .|| .. ... .. . .||. || ||| EKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHS--- VSVNG-FVHRDLRPANVLISADGEYFVIAGLGLCKDAL----------RCG------------------------STIVSTAVYVAPEVLL--------- .. .|||. | |.|. |. .||.|.. .|. ||. |. |.|||.| ---KNNIIHRDIKPENILF------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQK HNEASPASDVWSLGVIIYELVTLRRP ... . ..|.||||||.||... ..| QKGYDYKCDIWSLGVILYEMLFGKPP |
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| Kinase | GK135.AA | Ciliate-E2-Unclassified | 126-242 | 24 | 6.2e-20 | 65.84 | In-house | 125-269 (352) | Show / Hide |
Range on Protein: 126-242 Range on HMM: 125-269/352 Sequence Identity: 24% (37 aa) LTEHKRRKIPMSAGVVL-----SVLRQIAAALAYLHGVNGVSVNGFVHRDLRPANVLISADGE--YFVIAGLGLCKDALRC------------------G | ...... . .. ..|| .| ||| . |...|||. | |.|.. .|. | |...|..| . LFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLH-----HKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMM STIVSTAVYV----APEVLLHNEAS----PASDVWSLGVIIYELVTLRRP .|.. | | ||||| .. . ..|.||||||.||... ..| WTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYP |
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| Kinase | GK135.AA | CMGC | 111-242 | 18 | 5.3e-17 | 51.53 | In-house | 130-341 (513) | Show / Hide |
Range on Protein: 111-242 Range on HMM: 130-341/513 Sequence Identity: 18% (41 aa) IYVVMNRHDKTLERLLTEHKR-----RKIPMSAGV------------VLSVL------RQIAAALA--YLHGVNGVSVNG--FVHRDLRPANVLISADGE .| |. |..| ... .... |..|.| . . . . .|| .|. |.| .. ..|||| |.|.||. ..| LYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHS------HWGNIIHRDLKPENILINHNCE YF-------------------VIAGLGLCK--DA----------------------LRCGSTIVSTAVYVAPEVLLHNEAS----------PASDVWSLG .. |. ||.. . .| .. |.| | |||.|| . .. |.||.| LITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVG VIIYELVTL-------RRP |..|..| ..| CIFAEMYTGYQSLIFRGKP |
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| Kinase | GK135.AA | RSK | 144-238 | 30 | 7.3e-15 | 51.07 | In-house | 109-207 (278) | Show / Hide |
Range on Protein: 144-238 Range on HMM: 109-207/278 Sequence Identity: 30% (32 aa) VLRQIAAALAYLHGVNGVSVNGFVHRDLRPANVLISA--DGEYFVIAGLGLCKD-ALRCGS---TIVSTAVYVAPEVLL---HNE-ASPASDVWSLGVII ....|. |. .|| |..|||| | |.| . . .. |.|| .. .. | . |. |.|||.| ... . | |.|||||.. YMAEIVLAVEHLHQQ------GIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLM YELVT ||. | YEMLT |
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| Kinase | GK135.AA | STE | 42-242 | 17 | 1.6e-14 | 47.8 | In-house | 1-267 (359) | Show / Hide |
Range on Protein: 42-242 Range on HMM: 1-267/359 Sequence Identity: 17% (50 aa) RRLGSVLNESTMGTVYSLRGH-PS-----------------LAVKEILLDGPDK---------------RDLGAIRLELAALLDLS--NPGVLKHHQVVE .. ... . . |||| . | .. |.|.. |. .. .. | |. . ... | . | . . WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF GEG-------LIYVVMNRHD-KTLERLLTEHKRRKIPMS----------AGVVLSVLRQIAAA-LAYLHGVNGVSVNGFVHRDLRPANVLISADGEYFVI || ....| | .|. .. . . .. |.. .. ..||| . |.||| . .|||. |||.|. . KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH------IIHRDIKPANILL------VKL AGLGLCKDALR-------------------CGSTIVSTAVYVAPEVLLH------NEASPASDVWSLGVIIYELVTLRRP . |.|. |.| | . ||||.. .. . .|.|||| | |..| . | CDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPP |
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| Kinase | GK135.AA | ULK | 129-242 | 22 | 1.7e-14 | 47.86 | In-house | 109-251 (324) | Show / Hide |
Range on Protein: 129-242 Range on HMM: 109-251/324 Sequence Identity: 22% (34 aa) HKRRKIPMSAGV---------VLSVLRQIAAALAYLHGVNGVSVNGFVHRDLRPANVLISADGEY-----------FVIAGLGLCKDAL------RCGST .|..| |. ......||.... .|| .. .|||. |.| ||. . .. . || |..| | KKNKKLPE-T-EEKKRLSEQEAIQFFKQICNGFKELH------KHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT IV------STAVYVAPEVLL----HNEASPA-SDVWSLGVIIYELVTLRRP .| | | ||..| . . . . .|.||||.|.||... . | CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYP |
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| Kinase | GK135.AA | TyrKc | 42-295 | 20 | 3e-13 | -8.38 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 42-295 Range on HMM: 1-280/280 Sequence Identity: 20% (60 aa) RRLGSVLNESTMGTVYS--LRGHPSLAVKEILLDGPDKRDLGAIRLELAALLDL--SNPGVLKHHQVVEGE-------GLIYVVMN--RHDKTLERLLTE .|| .| | |.|| .. ||| . | . ... |. . | ..| ... . |. . . ...|| | ...| ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH HKRRKIPMSAGVVLSVLRQIAAALAYLHGVNGVSVNGFVHRDLRPANVLISADGEYFVIAGLGLCKDALRC------GSTIVS----TAV------YVAP ... . || |||. .||| ...|||| |.|..... |. ||..| ...... . || RPK----LCMKDLLSFCWQIACGMEYLHSK------NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP EVLLHNEASPASDVWSLGVIIYELVTLRRPDFLEG----KDPKDVF---VDGWRPDLSGV--------TDGFIKSVLERIFVLEPERRPTARELHETL |.. ... ...||||| || ..|. |. . . .....|. .| |.. . .. .. .|| ||| .|.|| . ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | GK135.AA | TK-Unique | 211-295 | 29 | 2.6e-12 | 38.87 | In-house | 204-294 (294) | Show / Hide |
Range on Protein: 211-295 Range on HMM: 204-294/294 Sequence Identity: 29% (27 aa) APEVLL--HNEA-SPASDVWSLGVIIYELVTLRRPDFLEG--KDPKDVFVDGWRPDLSGVT-DGFIKSVLERIFVLEPERRPTARELHETL |||.|. |. . .. |||||.||...|..|| ... . ||. . . || |... . ..... . .||| ||. |.. | APESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL |
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| Kinase | GK135.AA | Pkinase_Tyr | 211-239 | 41 | 8e-06 | 20.43 | Pfam | 182-210 (270) | Show / Hide |
Range on Protein: 211-239 Range on HMM: 182-210/270 Sequence Identity: 41% (12 aa) APEVLLHNEASPASDVWSLGVIIYELVTL |||.. ... . .||||| || ..|..|. APECINYGKFTTKSDVWSFGVLMWEIFTY |
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| Kinase | GK135.AA | Pkinase_Tyr | 130-182 | 26 | 0.000115 | 16.42 | Pfam | 99-148 (270) | Show / Hide |
Range on Protein: 130-182 Range on HMM: 99-148/270 Sequence Identity: 26% (15 aa) KRR---KIPMSAGVVLSVLRQIAAALAYLHGVNGVSVNGFVHRDLRPANVLISADG ... | | . |. .|||....||. | ..||||. |.|.. .. RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN------CIHRDLAARNCLVTENN |
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| Kinase | GK135.AA | TK-Unique | 141-183 | 31 | 0.000187 | 11.41 | In-house | 133-171 (294) | Show / Hide |
Range on Protein: 141-183 Range on HMM: 133-171/294 Sequence Identity: 31% (14 aa) VLSVLRQIAAALAYLHG-VNGVSVNGFVHRDLRPANVLISADGE ... . ||| ...||.. .. ||||| |||.. |.. LYHFAWQIACGMEYLASQRKKI-----VHRDLCARNVLLTEDKV |
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| Kinase | GK135.AA | Pkinase_Tyr | 281-295 | 60 | 0.021521 | 8.73 | Pfam | 256-270 (270) | Show / Hide |
Range on Protein: 281-295 Range on HMM: 256-270/270 Sequence Identity: 60% (9 aa) EPERRPTARELHETL .||.||| .|.|| | DPEDRPTFSEIHEQL |
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