Gene GK111b (G.lamblia)
GK111b
Species: G.lamblia
Alias: GK111b
External Links:
Annotation:
Sequence
Protein domains of GK111b.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | GK111b.AA | Pkinase | 130-300 | 26 | 4.4e-31 | 110.99 | Pfam | 28-205 (293) | Show / Hide |
Range on Protein: 130-300
Range on HMM: 28-205/293
Sequence Identity: 26% (49 aa)
AVKEVLLDGLDKGDLDTIRL--ELATLLDLSHPGVLKHHQVVEDDDFIYVVTDRHDKTLECLLTEH----KRRKIPV--PIAVILSVLRQVAAALAYLYG
|||.. ... ... . | |. |.. .. |.|| ... . ..||.| ||.|.. ....|. .. . .|. .. . .. ....|.. .|.|..
AVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS
LSGIGTRGLVHRDLRPANIFISADGEY---FVIAGLGLCRN--ALRGGSITAI--TRPYMAPEVLL-HNETSPASDVWSLGVIVYEL
| .|||| |.||.|. .|. . |. ||.. ... | . |..||||||.. ... .|..|.||.|.|.||.
M------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEM
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| S_TKc | GK111b.AA | S_TKc | 106-361 | 23 | 4.6e-23 | 83.85 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 106-361 Range on HMM: 1-231/231 Sequence Identity: 23% (64 aa) KQLNDVLNESPAGTVYSLKDYL---GLAVKEVLLDGLDKGDLDTIRLELATLLDLSHPGVLKHHQVVEDDDFIYVVTDRHDK---TLECLLTEHKRRK-- .. ... . |.|| .. |.|.. ..|| |.. | || . | . | .| |..|.|.. | .| .. ...|.. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR IPVPIAVILSVLRQVAAALAYLYGLSGIGTRGLVHRDLRPANIFISADGEYFVIAGLGLCRNALRGGSITAITRPYMAPEVLLHNETSP-ASDVWSLGVI | | .. ....|.. ||.|. . || .|||| |.||... |. ||.| . |. ||||||| .. ..|.||.|.| FPFPE-HARFYMYQICCALEYCHSH-GI-----IHRDLKPENILLDE---HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI VYELTILRRPDFLEGKDPKDVFVDGWRPNLSGVTDGFIKSILERIFVLEPERRPTARELHE-------TLAT .||. ..| | ... .| .. .. ....... .||.|||| |. . LYEMLC-GYPPFP---QMQMMFKKIG-------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | GK111b.AA | TK | 149-359 | 12 | 1.9e-21 | 67.97 | In-house | 89-486 (486) | Show / Hide |
Range on Protein: 149-359
Range on HMM: 89-486/486
Sequence Identity: 12% (52 aa)
LELATLLD---LSHPGVLKHHQVVEDDDF------------IYVVTDRHDKT-----LECLLTEHKRRKIP-----------------------------
.| . ... . || ... . |. ... ...|. .. | | ........
AEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSH
-------------------------------------------VPIAVILSVLRQVAAALAYLYGL--SGIGTRGLVHRDLRPANIFISADGE-------
.. . | .|.|....|| . ..| ..||||| |. .. ..
ESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI--QNFVHRDLAARNCLVGENNVCKWHFDG
---YFVIAGLG--------LCRNALRGGSITAITRPY-----------------------------MAPEVLLHNE---------TSPASDVWSLGVIVY
|| | |.| ... .. . .. ||||.|.... ...|||||.|| ..
CGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMW
ELTILRRPDFLEGKDPKDVFVD---------------------------GWRPNLSGVTD-------------GFIKSILERIFVLEPERRPTARELHET
|. . . . .| . || .| .| . .| .. .. . . ..||.||| ..|||
EIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQ
L
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L
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| Kinase | GK111b.AA | Ciliate-E2 | 150-300 | 20 | 4.7e-21 | 69.01 | In-house | 82-289 (365) | Show / Hide |
Range on Protein: 150-300 Range on HMM: 82-289/365 Sequence Identity: 20% (45 aa) ELATLLDLSHPGVLKHHQVVE--DDDFIYVVTDRHDK-TLECLLT--EHKRRKI-----PVPIAVILSVLRQVAA---------------ALAYLYGLSG |. | |.|| ..| . . . ||. || |.. . .|. .. .|| .. . . |. . .|.. || || EKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLH---- IGTRG-LVHRDLRPANIFISADGEYFVIAGLGLCRNAL-----------RGGSITAI------------------------TRPYMAPEVLL-------- .. .|||. | ||.. |. .||.... .. . | .|||||.| --SKNNIIHRDIKPENILF------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQ -HNETSPASDVWSLGVIVYEL ... . ..|.|||||| ||. KQKGYDYKCDIWSLGVILYEM |
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| Kinase | GK111b.AA | TKL | 185-359 | 17 | 5.1e-21 | 72.43 | In-house | 124-364 (364) | Show / Hide |
Range on Protein: 185-359
Range on HMM: 124-364/364
Sequence Identity: 17% (45 aa)
TLECLLTEHKRRKIPVPIAVILSVLRQVAAALAYLYGLS---GIGTRGLVHRDLRPANIFISADGE------Y-------FVIAGLGLCRNALRGG----
.|. .|. . .... ...| ...|| . .....|||| ..||.. ... | |. .||.|. . |
SLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMND
-----------------SITAI-TRPYMAPEVLLHN----------------ETSPASDVWSLGVIVYELTILRRPDF-LEGKDPK---------DVFVD
..| . | .|||||| . | |...||.| |.. .|. .|| . . ... . .|
TMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCD
-GWRPNLS------------GVTDGFIKSILERIFVLEPERRPTARELHETL
| || . .. .|..... .|| ||.. |. ..|
KGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
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| Kinase | GK111b.AA | Ciliate-E2-Unclassified | 229-300 | 27 | 3.3e-16 | 52.73 | In-house | 164-263 (352) | Show / Hide |
Range on Protein: 229-300 Range on HMM: 164-263/352 Sequence Identity: 27% (27 aa) GLVHRDLRPANIFISADGE--YFVIAGLGLCRNALRG------------------GSITAITRPYM----APEVLLHNETS----PASDVWSLGVIVYEL . .|||. | ||... .|. | |...|.... . .. | || ||||| .. . ..|.|||||| ||. NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEM |
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| Kinase | GK111b.AA | AGC | 228-300 | 22 | 3.7e-16 | 36.81 | In-house | 173-298 (395) | Show / Hide |
Range on Protein: 228-300 Range on HMM: 173-298/395 Sequence Identity: 22% (29 aa) RGLVHRD-LRPANIFISADGEYFVIAGLGLCRNALRGGSI----------------------------------------------------TAI---TR .| .||| | | || . .| . .. ||| ..|.. | | MGIIHRDYLKPENILLDED-GHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTP PYMAPEVLLHNETSPASDVWS--LGVIVYEL |||||.| ..| | || ||.. ||. EYMAPEIL----YGKACDWWSFGLGCLMYEM |
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| Kinase | GK111b.AA | CAMK | 130-298 | 15 | 8.1e-15 | 43.48 | In-house | 35-325 (425) | Show / Hide |
Range on Protein: 130-298
Range on HMM: 35-325/425
Sequence Identity: 15% (47 aa)
AVKEVLLDGLD--------------------------KGDLDTIRLELATLLDLS-------HPGVLKHHQVVED-------------------DDFIYV
|.| . . |. |.. .| |.. . |. || ..| ..| || |...|
AIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYM
VT---DRHDKT------LECLLTEHKRR----------KIPVPIAVILSVLRQVAAALAYLYGLSGIGTRGLVHRDLRPANIFISADGE-----------
|. . . .. . ... . .. . . ||.. |..|. . . ||||| | || .. ...
VMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH------NIVHRDLKPENILLDDNNDDSDPVEHDEIF
----Y-FVIAGLGLCRNALRGGS--------------------------ITAITRPYMA-PEVLLH--------------NETSPASDVWSLGVIVY
. |. |. . .| . | .||| ||||. .|..|.||.||| |
DWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILY
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| Kinase | GK111b.AA | CMGC | 118-300 | 15 | 4.6e-13 | 38.35 | In-house | 13-328 (513) | Show / Hide |
Range on Protein: 118-300
Range on HMM: 13-328/513
Sequence Identity: 15% (49 aa)
GTVYSLKDYLG-----------------LAVKEVLLDGLDKGDLD----------TIRLELATLLDLS-----------------HPGVLKHHQVVEDDD
|.||. .| . |.| . .. .. . .. |. | |. |. ..| . .. ...
GVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKN
-----------------FIYVVTDRHDKTLECLLTEHKR-----RKIPVPIAV------------ILSVL------RQVAAALA--YLYGLSGIGTRG--
.| |.. |..| .. .... |..| . . | . . .|. .|. |. ..
SDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH------SHWGN
LVHRDLRPANIFISADGEYF-------------------VIAGLGLCRNALRGGS----------------------IT--AITRPYMAPEVLLHNETS-
.|||| |.|| |. ..|.. |. ||.| . .| || | |||.|| .
IIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYT
---------PASDVWSLGVIVYEL
.. |.||.| | .|.
NHNYSMHYTTPIDMWSVGCIFAEM
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| Kinase | GK111b.AA | TyrKc | 121-359 | 18 | 5.7e-13 | -12.92 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 121-359 Range on HMM: 1-280/280 Sequence Identity: 18% (54 aa) YSLKDYLG---------------LAVKEVLLDGLDKGDLDTIRLELATLLDL--SHPGVLKHHQVVEDD-------DFIYVVTD--RHDKTLECLLTEHK .|.. || ||| . | . .. |. . | .|| ... . |. .. . ...|. | .. | .. ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP RRKIPVPIAVILSVLRQVAAALAYLYGLSGIGTRGLVHRDLRPANIFISADGEYFVIAGLGLCRNALRG-------GSITA----ITRP-----YMAPEV . .. . || |.|. .|| ...|||| |. ..... |. ||.|. . ... .. ||||. K----LCMKDLLSFCWQIACGMEYLHSK------NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC LLHNETSPASDVWSLGVIVYELTILRRPDFLEG----KDPKDVF---VDGWRPNLSGV--------TDGFIKSILERIFVLEPERRPTARELHETL . ... ...||||| || .|. . . . .....|. .| |. . .| .. .|| ||| .|.|| . INYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | GK111b.AA | Fer | 273-360 | 23 | 8.6e-13 | 40.0 | In-house | 184-283 (283) | Show / Hide |
Range on Protein: 273-360 Range on HMM: 184-283/283 Sequence Identity: 23% (23 aa) YMAPEVLLHNETSPASDVWSLGVIVYELTILRRPDFLE-----------GKDPKDVFVDGWRPNLSGVTDGFIKSILE-RIFVLEPERRPTARELHETLA ..|||.. ..||..|||| || .| .... . . | . ..| .. . . .|..|.. .... .|| |||. |....| WLAPETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK |
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| Kinase | GK111b.AA | UTK | 206-300 | 25 | 1.3e-12 | 39.43 | In-house | 121-233 (296) | Show / Hide |
Range on Protein: 206-300 Range on HMM: 121-233/296 Sequence Identity: 25% (30 aa) LSVLRQVAAALAYLYGLSGIGTRGLVHRDLRPANIFISADG------EYFVIAGLG---LCRNAL-------RGGSITAITRP-------YMAPEVLLHN |. ...|....|| ..|.||||| |... ... . ..||..| ..|.. ...| .. ||||.| |. LCMAWDIARGMQYLH------SCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHH -ETSPASDVWSLGVIVYEL . .|||||.|| ..|. TRFTTKSDVWSFGVVCWEI |
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| Kinase | GK111b.AA | RTKK | 265-359 | 38 | 1.7e-12 | 38.34 | In-house | 176-272 (272) | Show / Hide |
Range on Protein: 265-359 Range on HMM: 176-272/272 Sequence Identity: 38% (38 aa) SITAITRPYMAPEVLLHNETSPASDVWSLGVIVYELTIL-RRPDFLEGKDPKDVFVD---GWRPNLSGVTDGFIKSILERIFVLEPERRPTARELHETL | .|. | |.|| | | ||||||||||. | || ||..|.|. | || .. | |.| | ..| .|| ||. | SKVAVPFPWMSPESLIHRRFSPASDVWSLGMTAWEICSNGQRP--WEGMEPQDIMLAVHRGQRPVIQNNWPPQIQSLLRRVWERDPNKRPSARDYVSKL |
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| Kinase | GK111b.AA | Pkinase_Tyr | 194-300 | 25 | 9.2e-08 | 26.91 | Pfam | 99-207 (270) | Show / Hide |
Range on Protein: 194-300 Range on HMM: 99-207/270 Sequence Identity: 25% (29 aa) KRR---KIPVPIAVILSVLRQVAAALAYLYGLSGIGTRGLVHRDLRPANIFISADGEYFVIAGLGLCRNA-----L-RGGSITAITRPYMAPEVLLHNET ... | |... .|. .|.|....|| ....||||. |. .. .. |. ||.| | .. . . . ||||.. ... RKHREDKQPLTMKDLLQMCWQIAKGMEYL------ESKNCIHRDLAARNCLVTENN-VVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKF SPASDVWSLGVIVYEL . .||||| || .|. TTKSDVWSFGVLMWEI |
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| Kinase | GK111b.AA | Pkinase_Tyr | 345-359 | 60 | 0.021521 | 8.73 | Pfam | 256-270 (270) | Show / Hide |
Range on Protein: 345-359 Range on HMM: 256-270/270 Sequence Identity: 60% (9 aa) EPERRPTARELHETL .||.||| .|.|| | DPEDRPTFSEIHEQL |
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| Kinase | GK111b.AA | UTK | 345-359 | 26 | 0.028309 | 3.59 | In-house | 282-296 (296) | Show / Hide |
Range on Protein: 345-359 Range on HMM: 282-296/296 Sequence Identity: 26% (4 aa) EPERRPTARELHETL .|..||....| ... DPQERPDFEDLVQQM |
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| Kinase | GK111b.AA | Pkinase | 335-359 | 22 | 0.270152 | 5.66 | Pfam | 267-293 (293) | Show / Hide |
Range on Protein: 335-359 Range on HMM: 267-293/293 Sequence Identity: 22% (6 aa) KSILERIFVLEPERRPTARELHET--L |....... . |..||||... . . KDFIKWCLCKDPKKRPTAEQILQHPWF |
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