Gene GK088b (G.lamblia)
GK088b
Species: G.lamblia
Alias: GK088b
External Links:
Annotation:
Sequence
Protein domains of GK088b.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Pkinase | GK088b.AA | Pkinase | 10-267 | 23 | 3.8e-34 | 121.82 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 10-267 Range on HMM: 1-293/293 Sequence Identity: 23% (72 aa) EDLGAELGSGAHGTVYGLKSAPDR---AVKEIPTDGLPPDAQASLEL--ELRTLPRLRHPNVVEYGRVVRHEGYIYVEMRRYAG-----SLDGAIRSLRR .| .|||. |.|| . .. |||.|. .. .. . .. . |.. . ||.|||.|.. .... ...||. | | .| |. .| YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-WR RRQL--ALREMVVAVLRQVGAGLAYLHRPGKTDAAGAPLPALTHCDLRPANVLLDEAGAE---FAISDFGLCR---EGPGGLASMAV--PVYAAPEVLR- .. . .| . ...|. ||.|.|. |.|| |.|.|.|. | . |.||||.. . ... .. . | |.||||.| HGCFYFSEWE-CKFYMYQILRGLEYCHSM-----------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRG GGSHTPAADMWSLGMVAYELAAGGRPPFLSG-----RAPAEVYVAGWRPDLGAVGD-----------------------PVVRGVLAHLLVLEPERRLTA | ..|..||||.| . ||.. ||||| . . . .... .|.| . . . .. .| . |..|.|| GQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTA AALVEL--L . ... . EQILQHPWF |
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| S_TKc | GK088b.AA | S_TKc | 10-267 | 24 | 3.6e-27 | 97.49 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 10-267 Range on HMM: 1-231/231 Sequence Identity: 24% (67 aa) EDLGAELGSGAHGTVYGLKSAP---DRAVKEIPTDGLPPDAQASLELELRTLPRLRHPNVVEYGRVVRHEGYIYVEMRRYAG---SLDGAIRSLRR-RRQ ... ..|.|| |.|| . |.|.|. ... |.. | . .|||.| . | .. ...|. | | .| |.. .| ... YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR LALREMVVAVLRQVGAGLAYLHRPGKTDAAGAPLPALTHCDLRPANVLLDEAGAEFAISDFGLCREGPGGLASMAVPVYAAPEVLRGGSHTP-AADMWSL . |.. ...|. .|.|.|. | |.|| |.|.|||| . |.||||.|. | | ||||| .... ..|.||. FPFPEHARFYMYQICCALEYCHSHG-----------IIHRDLKPENILLDE---HIKICDFGLARQL---TTFCGTPWYMAPEVL---GYGKCKCDWWSC GMVAYELAAGGRPPFLSGRAPAEVYVAGWRPDLGAVGDPVVRGVLAHLLVLEPERRLTAAALVE---------LL | . ||... |.||| ..... .| .. . ..|. .||.|.|| . . . GCILYEMLC-GYPPFP---QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | GK088b.AA | TKL | 114-267 | 18 | 2.4e-20 | 70.0 | In-house | 139-364 (364) | Show / Hide |
Range on Protein: 114-267
Range on HMM: 139-364/364
Sequence Identity: 18% (43 aa)
RQVGAGLAYLHR--P--GKTDAAGAPLPALTHCDLRPANVLLDEAGAE-------------FAISDFGLCREGPGG---------------------LAS
... |..||| | .. |.. |.|| ..|.|.|| . |.||||.|. . .
LDIARGMNYLHSMNPKWCT-------KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTM
MAV--PVYAAPEVLRGG----------------SHTPAADMWSLGMVAYELAAGGRPPFLSGRAP------------AEVYVAGWRPDLG----------
. . | . ||||||| . ....|..| |.| .|.... | |. . . |.. | || .
TQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMC
--AVGDPVVRGVLAHLLVLEPERRLTAAALVELL
.| .. . . .|| |... ... |
PCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
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| Kinase | GK088b.AA | TK | 10-267 | 14 | 1.5e-18 | 58.12 | In-house | 1-486 (486) | Show / Hide |
Range on Protein: 10-267
Range on HMM: 1-486/486
Sequence Identity: 14% (71 aa)
EDLGAELGSGAHG---TVY-G---------------------------LKSAPDRAVKEIPTDGLPPDAQASL--------------ELELRTLPR---L
|| .||.|. | .|| | . . ||| . . ... . |.| . . . .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG
RHPNVVEYGRVVRHEG--------------YIYVEMRRYA---GSLDGAIRSLRR---------------------------------------------
.|||.| |. ... .| .|. . |||. |. |.
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY
----------------------------RRQLALREMVVAVLRQVGAGLAYLHRP---GKTDAAGAPLPALTHCDLRPANVLLDEAGA----------EF
..|| ..... .|. .|..|||. . . . | || |.|..| .
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL--MCWQIACGMEYLHSKNCEF--------IQNFVHRDLAARNCLVGENNVCKWHFDGCGPVC
AISDFGLCREGPGGLASMAVPV---------------------------------------YAAPEVLRGGS---------HTPAADMWSLGMVAYELAA
|.||||.|.| |. . ... . |||.|... .|.. |.||.| . .|.
KIADFGLSRQGS-GVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT
GG-RPPF--LSG---------RAPAEVYVAG---------------WRPDLGAVGD-------------PVVRGVLAHLLVLEPERRLTAAALVELL
| |. .| . | ..| .| | ... .. ..||.| | ..|.| |
YGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
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| Kinase | GK088b.AA | AGC | 141-214 | 24 | 4.8e-18 | 41.81 | In-house | 177-304 (395) | Show / Hide |
Range on Protein: 141-214 Range on HMM: 177-304/395 Sequence Identity: 24% (32 aa) HCD-LRPANVLLDEAGAEFAISDFGLCREGPGG----------------------------------------------------LASMAV----PVYAA | | | | |.|||| ..||||| ||... ... . | | | HRDYLKPENILLDED-GHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMA PEVLRGGSHTPAADMWS--LGMVAYELAAGGRP ||.| ...|.| || || . ||. .| | PEIL----YGKACDWWSFGLGCLMYEMLTGYPP |
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| Kinase | GK088b.AA | Ciliate-E2-Unclassified | 143-218 | 26 | 9.2e-14 | 44.13 | In-house | 169-272 (352) | Show / Hide |
Range on Protein: 143-218 Range on HMM: 169-272/352 Sequence Identity: 26% (28 aa) DLRPANVLLDEAGA--EFAISDFGLCR-------EGPGG------------LASMA-VPVYA----APEVLRGGSHT----PAADMWSLGMVAYELAAGG |. | |.|.|. | . |.|||... . . . ... | | |||||.| . ..|.||||...||. | DIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGY RPPFLS .|| . -YPFYD |
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| Kinase | GK088b.AA | UTK | 11-216 | 22 | 1.2e-13 | 43.03 | In-house | 2-241 (296) | Show / Hide |
Range on Protein: 11-216 Range on HMM: 2-241/296 Sequence Identity: 22% (56 aa) DLGAELGSGAHGTVYGLKSAP--------DRAVKEIPTDGLPPDAQA---SLELELR---TLPRLR-HPNVVE-YGRVVRHEGYIYVEMRRYA-GSLDGA ||..||.|| |.|. . . |.|||. ... ..... . .| | . ... ||||. .| ... |. ... .. .. |.|. QLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP-WMIVTEYMENGDLRSY IRSLRRR---RQLALREM-VVAVLRQVGAGLAYLHRPGKTDAAGAPLPALTHCDLRPANVLLDEAG------AEFAISDFG---LCREGP---------G |. |. ....|.. . ... .|..|||. | . |.|| |.|... . ..|.||| ..|. . . LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCG-----------FVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWE GLASMAVPVYA------APEVLRGG-SHTPAADMWSLGMVAYELAAGGRPPF . .|| .. . |||.| . .| . |.||.| | .|. ..|| |. SYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPY |
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| Kinase | GK088b.AA | MSK | 141-214 | 31 | 3e-13 | 41.14 | In-house | 124-209 (277) | Show / Hide |
Range on Protein: 141-214 Range on HMM: 124-209/277 Sequence Identity: 31% (27 aa) HCDLRPANVLLDEA--GAEFAISDFGLCREGPGGLASMAVP-----VYAAPEVLR----GGS-HTPAADMWSLGMVAYELAAGGRP | || | |.|.|. ... ..|||. |. | . . . . |.|||.|| . . . .| |.|||| . |.. | .| HRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVILYTMLTGQVP |
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| Kinase | GK088b.AA | RSK | 143-214 | 32 | 3e-13 | 45.13 | In-house | 129-211 (278) | Show / Hide |
Range on Protein: 143-214 Range on HMM: 129-211/278 Sequence Identity: 32% (27 aa) DLRPANVLLDE--AGAEFAISDFGLCREGPGG-LASMAVPV----YAAPEVLR----GGSHTPAADMWSLGMVAYELAAGGRP || | |.|.|. .. ..|||.|.... . .. |.|||.|. .| |. |.| |||| . ||. .| .| DLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPP |
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| Kinase | GK088b.AA | TyrKc | 10-267 | 23 | 3.8e-13 | -10.13 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 10-267 Range on HMM: 1-280/280 Sequence Identity: 23% (70 aa) EDLGAELGSGAHGTVYG--LKSAPDRAVKEIPTDGLPPDAQASLELELRTLPRL--RHPNVVEYGRVVRHEG---------YIYVEMRRYAGSLDGAIRS || .||.|| |.|| .| . ||| . | .. . |.| . .| .|||.| |....| .| .| . |.|. .|. ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLRK LRRRRQLALREMVVAVLRQVGAGLAYLHRPGKTDAAGAPLPALTHCDLRPANVLLDEAGAEFAISDFGLCREGPGG----------LA-----SMA-VPV |.. | .... . |. .| .|||. . | || |.|..| . ||||||.|.. . . . . .|. HRPK--LCMKDL-LSFCWQIACGMEYLHSK-----------NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI -YAAPEVLRGGSHTPAADMWSLGMVAYELAAGGRPPF-------LSGRAPAEVYVAGWRPDLGAV--------GDPVVRGVLAHLLVLEPERRLTAAALV |||... | |.. | || | . .|. | .| .| . | .| |.. . . . . .|| | | .... RWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIH ELL |.. ECF |
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| Kinase | GK088b.AA | ULK | 141-216 | 22 | 1e-12 | 40.79 | In-house | 153-257 (329) | Show / Hide |
Range on Protein: 141-216 Range on HMM: 153-257/329 Sequence Identity: 22% (24 aa) HCDLRPANVLLDEAGAE-----------FAISDFGLCRE-GPG----GLASMAV--------PVYAAPEVLR----GGSHTPA-ADMWSLGMVAYELAAG |.|. |.|.|... . . |.|||... . .. .| | | ||..| . .. . .|.||||.. ||. | HRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYG GRPPF |.. KPPFY |
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| Kinase | GK088b.AA | CAMK | 141-211 | 22 | 1.8e-12 | 35.8 | In-house | 202-330 (425) | Show / Hide |
Range on Protein: 141-211
Range on HMM: 202-330/425
Sequence Identity: 22% (29 aa)
HCDLRPANVLLDEAG----------------AEFAISDFGLCREGPGGL---------------------------ASMAVPVYAA-PEVLRGGS-----
|.|| | |.|||. . . |.|||. .. ..| . | |.| ||||.| .
HRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQ
---------HTPAADMWSLGMVAYELAAG
..|..||||.| . | . |
NATDEEKPYYGPKCDMWSCGVILYIMLCG
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| Kinase | GK088b.AA | STE | 143-211 | 25 | 5.6e-09 | 27.98 | In-house | 177-264 (359) | Show / Hide |
Range on Protein: 143-211 Range on HMM: 177-264/359 Sequence Identity: 25% (24 aa) DLRPANVLLDEAGAEFAISDFGLCREGPGGLA-------------------SMA-VPVYAAPEVLRG------GSHTPAADMWSLGMVAYELAAG |. |||.|| ..|||.| .| ... | . ||||... . .. .|.|||| .. |.| | DIKPANILL------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATG |
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| Kinase | GK088b.AA | CAMK | 15-67 | 14 | 1.3e-07 | 19.84 | In-house | 1-101 (425) | Show / Hide |
Range on Protein: 15-67 Range on HMM: 1-101/425 Sequence Identity: 14% (15 aa) ELGSGAHGTVYGLKSAPDR---------------AVKEIPTDGLP--------------------------PDAQASLELELRTLPR-------LRHPNV .||.|. |.|. . . |.| |... |. | ..... |.. . . |.|||. TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI V . I |
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| Kinase | GK088b.AA | STE | 10-69 | 12 | 1e-06 | 19.8 | In-house | 1-95 (359) | Show / Hide |
Range on Protein: 10-69 Range on HMM: 1-95/359 Sequence Identity: 12% (12 aa) EDLGAELGSGAHG-TVYGLKSAPD-----------------RAVKEIPTDGLPP---------------DAQASLELELRTLPRLR--HPNVVEY .. ..|.|| | ...... .. |.|... . . . . ... |.... ... |||.|.| WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKY |
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| Kinase | GK088b.AA | TKL | 16-69 | 21 | 0.010053 | 5.65 | In-house | 1-90 (364) | Show / Hide |
Range on Protein: 16-69 Range on HMM: 1-90/364 Sequence Identity: 21% (19 aa) LGSGAHGTVYGLKSA-----------PDRAVKEIPTDGLPP----------------------DAQASLELELRTLPR---LRHPNVVEY .|||. |.|| | | ||| .... .|. . | . . |||||.| . IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQF |
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| Kinase | GK088b.AA | ULK | 15-69 | 20 | 0.058597 | 2.73 | In-house | 6-83 (329) | Show / Hide |
Range on Protein: 15-69 Range on HMM: 6-83/329 Sequence Identity: 20% (16 aa) ELGSGAHGTVYGLK---S----APDRAVKEIPTDGLPPDAQA--------SLELELRTLPRLR--------HPNVVEY .||.|. |.|| . . . . |.| |. . . . . .|. | ... .| |||.|.. CLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKL |
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