Gene GL50803_96878 (G.lamblia)
GL50803_96878
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| GL50803_96878.AA | Protein | None | 999 | None | Fasta, JSON |
| GL50803_96878.kin_dom | Protein Kinase Domain | None | 266 | None | Fasta, JSON |
Protein domains of GL50803_96878.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | GL50803_96878.AA | AGC | 175-261 | 23 | 4.1e-11 | 23.47 | In-house | 273-374 (395) | Show / Hide |
Range on Protein: 175-261 Range on HMM: 273-374/395 Sequence Identity: 23% (27 aa) YAPPELLHAVAKSELQGTLTEKADLWS--LGCLIYEFITGLKPLRVSP----------VMEAYNMSM----TIMETISLP----------PSYDKDIKPV | .|| | . .| || ||||.||..||. | . . || .. | .|.. . .| .. ... | YMAPEIL-----------YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDL LSILLSPIPARRL .. || . |..|| IKKLLCKDPEKRL |
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| S_TKc | GL50803_96878.AA | S_TKc | 7-272 | 17 | 1.6e-08 | -51.87 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 7-272
Range on HMM: 1-231/231
Sequence Identity: 17% (51 aa)
YEPGALWGQGLDRCLYTVEAKRDKARYICRELSYACLTPTQQERLSARISGARKMVCQHVGQIADVICDEGEQKHYIL--YSAG--QTLAELRALKKP--
|| . . |.| . | . |... .. . ... ...|. . . .. .. ||. | .. |. | | .| .. ...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK------HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG
-----SLDDVHSSLMQLLKALAYLHSKVKPDSDVGVVLAGI----LTPERILCSKGLLKVVDY----VLPDSLSIGEALLDNQEMYC----YAPPELLHA
. .. . . |...||.|.|| || | || ||... .|. | .| .| | .||.|
LRFPFPE-HARFYMYQICCALEYCHS------------HGIIHRDLKPENILLDE-HIKICDFGLARQL--------------TTFCGTPWYMAPEVL--
VAKSELQGTLTE-KADLWSLGCLIYEFITGLKPLRVSPVMEAYNMSMTIMETISLPPSYDKDIKPVLSILLSPIPARRLPAMALQN-------NPRI
. |.| ||.||..||...| | . ... ... . ... | .. .| |..|. | . . | .
--------GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | GL50803_96878.AA | Aur | 195-212 | 50 | 1.8e-07 | 15.21 | In-house | 180-197 (257) | Show / Hide |
Range on Protein: 195-212 Range on HMM: 180-197/257 Sequence Identity: 50% (9 aa) EKADLWSLGCLIYEFITG .| |.|.|| |.||...| HKVDIWCLGVLCYELCHG |
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| Kinase | GL50803_96878.AA | PDK1 | 194-215 | 45 | 7.1e-07 | 16.53 | In-house | 217-238 (307) | Show / Hide |
Range on Protein: 194-215 Range on HMM: 217-238/307 Sequence Identity: 45% (10 aa) TEKADLWSLGCLIYEFITGLKP | .|.|.|||.|| ...|. | TPSCDIWALGCIIYQMVAGQPP |
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| Kinase | GL50803_96878.AA | GEK | 175-239 | 29 | 3e-06 | 16.31 | In-house | 167-229 (269) | Show / Hide |
Range on Protein: 175-239 Range on HMM: 167-229/269 Sequence Identity: 29% (19 aa) YAPPELLHAVAKSELQGTLTEKADLWSLGCLIYEFITGLKPLRVSPVMEAYNMSMTIMETISLPP | ||.|.|. .| .. | |||| ..||.. | | ..| | | . ...|. YISPEILQAMEDG--KGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKDHFQFPS |
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| Kinase | GL50803_96878.AA | Akt | 194-213 | 42 | 3e-06 | 15.86 | In-house | 180-200 (264) | Show / Hide |
Range on Protein: 194-213 Range on HMM: 180-200/264 Sequence Identity: 42% (9 aa) TEKADLWS-LGCLIYEFITGL | ..| |. |||..||...|. TKAVDWWGSLGCVMYEMMCGR |
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| Kinase | GL50803_96878.AA | CMGC | 194-216 | 40 | 4e-06 | 15.09 | In-house | 313-342 (513) | Show / Hide |
Range on Protein: 194-216 Range on HMM: 313-342/513 Sequence Identity: 40% (12 aa) TEKADLWSLGCLIYEFITG-------LKPL |.. | ||.|| ..| .|| .||| TTPIDMWSVGCIFAEMYTGYQSLIFRGKPL |
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| Kinase | GL50803_96878.AA | Ciliate-E2 | 194-215 | 45 | 5e-06 | 16.79 | In-house | 274-295 (365) | Show / Hide |
Range on Protein: 194-215 Range on HMM: 274-295/365 Sequence Identity: 45% (10 aa) TEKADLWSLGCLIYEFITGLKP ..|.|.||||...||...| | DYKCDIWSLGVILYEMLFGKPP |
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| Kinase | GL50803_96878.AA | SCY1 | 192-217 | 42 | 8e-06 | 16.18 | In-house | 249-274 (337) | Show / Hide |
Range on Protein: 192-217 Range on HMM: 249-274/337 Sequence Identity: 42% (11 aa) TLTEKADLWSLGCLIYEFITGLKPLR ..| ..|..||||||.. ..|.||.. KCTWASDMFSLGCLIWWVYNGKKPQI |
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| Kinase | GL50803_96878.AA | Ciliate-D1 | 198-216 | 47 | 8e-06 | 20.38 | In-house | 1-19 (19) | Show / Hide |
Range on Protein: 198-216 Range on HMM: 1-19/19 Sequence Identity: 47% (9 aa) DLWSLGCLIYEFITGLKPL |.||.||..|| ..| .| DIWSFGCILYEMLFGQPPF |
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| Kinase | GL50803_96878.AA | ULK | 196-215 | 55 | 1.9e-05 | 15.1 | In-house | 236-255 (329) | Show / Hide |
Range on Protein: 196-215 Range on HMM: 236-255/329 Sequence Identity: 55% (11 aa) KADLWSLGCLIYEFITGLKP |.|.|||||..|| ..| | KCDIWSLGCIFYEMLYGKPP |
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| Kinase | GL50803_96878.AA | Pkinase | 194-212 | 47 | 0.001915 | 13.26 | Pfam | 190-208 (293) | Show / Hide |
Range on Protein: 194-212 Range on HMM: 190-208/293 Sequence Identity: 47% (9 aa) TEKADLWSLGCLIYEFITG . |.| ||.||..||...| GPKVDMWSCGCILYEMLCG |
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| Kinase | GL50803_96878.AA | CMGC | 98-122 | 19 | 0.019717 | 2.76 | In-house | 156-201 (513) | Show / Hide |
Range on Protein: 98-122 Range on HMM: 156-201/513 Sequence Identity: 19% (9 aa) KKPSLDDVH-------------SSLM-------QLLKALA--YLHSK .. |.. | ..| |.|..|. |.||. RPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSH |
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| Kinase | GL50803_96878.AA | Aur | 111-153 | 29 | 0.062202 | 0.32 | In-house | 109-145 (257) | Show / Hide |
Range on Protein: 111-153 Range on HMM: 109-145/257 Sequence Identity: 29% (15 aa) QLLKALAYLHSK------VKPDSDVGVVLAGILTPERILCS--KGLLKVVD |. || |.||| | || || . .| .|. | QICNALDYCHSKNIIHRDIK--------------PENILLDQCNGNIKICD |
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| Kinase | GL50803_96878.AA | SCY1 | 109-124 | 37 | 0.071944 | 2.37 | In-house | 130-145 (337) | Show / Hide |
Range on Protein: 109-124 Range on HMM: 130-145/337 Sequence Identity: 37% (6 aa) LMQLLKALAYLHSKVK . |.|.|| .||.... IFQILDALSFLHNDCH |
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| Kinase | GL50803_96878.AA | Ciliate-D1 | 83-101 | 26 | 2.216389 | 1.12 | In-house | 1-19 (19) | Show / Hide |
Range on Protein: 83-101 Range on HMM: 1-19/19 Sequence Identity: 26% (5 aa) ILYSAGQTLAELRALKKPS ..| | .| |. ..| DIWSFGCILYEMLFGQPPF |
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| Kinase | GL50803_96878.AA | Pkinase | 111-122 | 50 | 5.127027 | 1.14 | Pfam | 116-127 (293) | Show / Hide |
Range on Protein: 111-122 Range on HMM: 116-127/293 Sequence Identity: 50% (6 aa) QLLKALAYLHSK |.|..|.|.||. QILRGLEYCHSM |
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| Ank | GL50803_96878.AA | Ank | 394-414 | 42 | 0.000455 | 18.93 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 394-414 Range on HMM: 1-21/33 Sequence Identity: 42% (9 aa) TGRTALMHAAICGHSAIAKLL |.|.|. |..||| ..|.| DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_96878.AA | Ank | 426-446 | 33 | 5.6e-05 | 22.2 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 426-446 Range on HMM: 1-21/33 Sequence Identity: 33% (7 aa) RGWTALMYAACHNNADVCKVL |.|.|..|.......|.| | DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_96878.AA | Ank | 457-477 | 28 | 0.013599 | 13.61 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 457-477 Range on HMM: 1-21/33 Sequence Identity: 28% (6 aa) NGFTALMIATQQNSIDAIAEL .|||.|..| . .... . .| DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_96878.AA | Ank | 488-508 | 33 | 0.091735 | 10.62 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 488-508 Range on HMM: 1-21/33 Sequence Identity: 33% (7 aa) TGTTALMMAAKIGSKDAVRHL | |.|..|.. |... |. | DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_96878.AA | Ank | 519-544 | 23 | 0.012279 | 13.77 | Pfam | 1-26 (33) | Show / Hide |
Range on Protein: 519-544 Range on HMM: 1-26/33 Sequence Identity: 23% (6 aa) NGYAAIHIAAEENKADVLSFLIKREA .|. . |.|.. . ..|...|... | DGFTPLHLACRCGHTEVVKMLLQHGA |
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| Ank | GL50803_96878.AA | Ank | 550-572 | 39 | 0.000759 | 18.13 | Pfam | 1-23 (33) | Show / Hide |
Range on Protein: 550-572 Range on HMM: 1-23/33 Sequence Identity: 39% (9 aa) GGLTALHVAALNDSTDSIRYLLQ | |.||.|.....|. ...||| DGFTPLHLACRCGHTEVVKMLLQ |
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| Ank | GL50803_96878.AA | Ank | 612-633 | 40 | 0.000192 | 20.28 | Pfam | 1-22 (33) | Show / Hide |
Range on Protein: 612-633 Range on HMM: 1-22/33 Sequence Identity: 40% (9 aa) DGCTALMHAAQKNSFGVVRDLL ||.|.|. |..... ||..|| DGFTPLHLACRCGHTEVVKMLL |
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| Ank | GL50803_96878.AA | Ank | 581-611 | 24 | 0.002489 | 16.27 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 581-611 Range on HMM: 1-33/33 Sequence Identity: 24% (8 aa) RGYTALMLAAMADLPDAVELLVK--EEARMRDN |.|.|.||.. . .. |..|.. . ..|. DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_96878.AA | Ank | 643-663 | 42 | 0.000857 | 17.94 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 643-663 Range on HMM: 1-21/33 Sequence Identity: 42% (9 aa) TGSTALHHAVRCNSKDCVRIL | |.|| |.||.....|. | DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_96878.AA | Ank | 747-776 | 23 | 0.061749 | 11.24 | Pfam | 1-30 (33) | Show / Hide |
Range on Protein: 747-776 Range on HMM: 1-30/33 Sequence Identity: 23% (7 aa) TGYTALAYAAVLNYADLAALLIEKEAGLQA |.|.| .|. .... . .|... | . | DGFTPLHLACRCGHTEVVKMLLQHGADVNA |
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| Ank | GL50803_96878.AA | Ank | 788-811 | 58 | 9.4e-07 | 28.62 | Pfam | 1-24 (33) | Show / Hide |
Range on Protein: 788-811 Range on HMM: 1-24/33 Sequence Identity: 58% (14 aa) EGSTALMLAAWHGHIEVVRLLLQH .| |.|.||. .||.|||..|||| DGFTPLHLACRCGHTEVVKMLLQH |
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| Ank | GL50803_96878.AA | Ank | 819-840 | 50 | 6e-06 | 25.84 | Pfam | 1-22 (33) | Show / Hide |
Range on Protein: 819-840 Range on HMM: 1-22/33 Sequence Identity: 50% (11 aa) DGRTALMLASVKGHEEIVSLLI ||.|.|.||. .||.|.|..|. DGFTPLHLACRCGHTEVVKMLL |
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| Ank | GL50803_96878.AA | Ank | 850-871 | 36 | 0.012201 | 13.78 | Pfam | 1-22 (33) | Show / Hide |
Range on Protein: 850-871 Range on HMM: 1-22/33 Sequence Identity: 36% (8 aa) RRYTALALAAQRGNLAVIKLLV .|.| ||...|.. |.|.|. DGFTPLHLACRCGHTEVVKMLL |
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| Ank | GL50803_96878.AA | Ank | 881-901 | 42 | 0.185149 | 9.52 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 881-901 Range on HMM: 1-21/33 Sequence Identity: 42% (9 aa) RGFSALMFAVQEGHTKSVGYL ||..|. |.. |||. | .| DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_96878.AA | Ank | 912-933 | 31 | 0.00661 | 14.74 | Pfam | 1-22 (33) | Show / Hide |
Range on Protein: 912-933 Range on HMM: 1-22/33 Sequence Identity: 31% (7 aa) NGQTALMSAASHGFIKCLSILL .|.|.|. |...| ..... || DGFTPLHLACRCGHTEVVKMLL |
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| Ank | GL50803_96878.AA | Ank | 943-973 | 27 | 2.5e-05 | 23.45 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 943-973 Range on HMM: 1-33/33 Sequence Identity: 27% (9 aa) DGYTALMSACKHAHAEAITLLVD--HELGLRTK ||.|.|. ||.. |.| ...|.. .. .... DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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