Gene GL50803_9658 (G.lamblia)
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| GL50803_9658.AA | Protein | None | 303 | None | Fasta, JSON |
| GL50803_9658.kin_dom | Protein Kinase Domain | None | 277 | None | Fasta, JSON |
Protein domains of GL50803_9658.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | GL50803_9658.AA | Ciliate-E2-Unclassified | 70-284 | 20 | 1.7e-26 | 88.9 | In-house | 76-352 (352) | Show / Hide |
Range on Protein: 70-284 Range on HMM: 76-352/352 Sequence Identity: 20% (59 aa) LSHKNLVKYYDVYYNDTKNLGHFVMEYYERCCLMDVI------------LFYRMKERV-IPEETVW-----YILSHLAEALLYYHSPQKDNTDMGPLVHR |.|.........|. .|. .|||| | |.. | || .||.| ..|. . ... .. ..| |.|. .. .|| LNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNN-------IIHR NIKPSKVFLAADG---YCKLADSGTFRLLDNV----------------ILSSTIFGTLGFC----PPEVLKMERYT----EESDLWSLGALVYCVCALKP .|||. ... .| |.|..| | .. ... ...|. ||... .||||. . | ...| |||| . |. . .. DIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYY PAYSANPEE----------------LLKKLQGFEVDVNELRE----REYSEELI----GTLQSMLNYDPKQRIDLSKLNAIPQI | |. | |. |... . ...... . |.| . ||.||...|..||..... | . PFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
|||||||||
| S_TKc | GL50803_9658.AA | S_TKc | 9-284 | 22 | 1.8e-26 | 95.22 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 9-284 Range on HMM: 1-231/231 Sequence Identity: 22% (65 aa) VSTGPVLAKTALGHVEVVRSLDPACNDGSQGQDYAVKVVNITSIPNRYRSVVRNDFIKLCSLSHKNLVKYYDVYYNDTKNLGHFVMEYYER--CCLMDVI . .. | | | | .| . |. .|.|... .|. | . |.|.||.|||... . ..|||| . |.|.| YEILRKIGKGAFGKVYKCRHKK-------TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYI LFYRM--KERVIPEETVWYILSHLAEALLYYHSPQKDNTDMGPLVHRNIKPSKVFLAADGYCKLADSGTFRLLDNVILSSTIFGTLGFCPPEVLKMERYT .. . ...|| ...... ...|| | || . .|| .||. ..| |..| | |.| .|. ||. ...|||| |. KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHG--------IIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYG E-ESDLWSLGALVYCVCALKPPAYSANPEELLKKLQGFEVDVNELREREYSEELIGTLQSMLNYDPKQRIDLSKLNA-------IPQI ..| ||.| ..| .. .|| . ......||. |.|.. .. .|..||..|. .. . | . KCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
|||||||||
| Kinase | GL50803_9658.AA | Pkinase | 69-284 | 20 | 2.2e-25 | 90.84 | Pfam | 56-293 (293) | Show / Hide |
Range on Protein: 69-284 Range on HMM: 56-293/293 Sequence Identity: 20% (52 aa) SLSHKNLVKYYDVYYNDTKNLGHFVMEYYERC----CLMDVILFYRMKERVI--PEETVWYILSHLAEALLYYHSPQKDNTDMGPLVHRNIKPSKVFLAA .|.|.| |..||....... .|||| | |.|.| ...... .|... .. ....| | || . .|| .||. ... RLNHPNIVRLYDWFEDKDHIY--MVMEYCEGGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHS-M-------GIIHRDLKPENILIDN DGYC----KLADSGTFRL--LDNVILSSTIFGTLGFCPPEVLK-MERYTEESDLWSLGALVYCVCALKPPAYSA------NPEELLKKLQGFEVDVNELR .|.. |..| | .. . | .|. ||.....|||.. . |. ..| ||.| ..|... .|| ... .. ..... | ... .. NGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPW EREYS-----------------EELIGTLQSMLNYDPKQRIDLSKLNAIPQI ... | ||.. . ..|..|||.|. . | . WCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
|||||||||
| Kinase | GL50803_9658.AA | NEK6 | 67-275 | 31 | 1.7e-24 | 77.34 | In-house | 53-252 (252) | Show / Hide |
Range on Protein: 67-275 Range on HMM: 53-252/252 Sequence Identity: 31% (67 aa) LCSLSHKNLVKYYDVYYNDTKNLGHFVMEYYERCCLMDVILFYRMKERVIPEETVWYILSHLAEALLYYHSPQKDNTDMGPLVHRNIKPSKVFLAADGYC | .| |.|..|||. . .. | |.| . . .| ... ..|.||| |.| |. || || ..|| ||| ||. |.| LKQLNHPNVIKYYASFIEN--NELNIVLELADAGDMSRMIKHFKKQKRLIPERTIWKYFVQLCSALEHMHSKR--------VMHRDIKPANVFITANGIV KLADSGTFRLL-DNVILSSTIFGTLGFCPPEVLKMERYTEESDLWSLGALVYCVCALKPPAYS--ANPEELLKKLQGFEVDVNELREREYSEELIGTLQS || | | | . . || . || .. . | ||.|||| |.| . ||. | | | | ||.. . | | |||.| . KLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIE--QCDYPPLPADHYSEQLRQLVCM MLNYDPKQRIDL ... ||..| |. CIHPDPEWRPDI |
|||||||||
| Kinase | GL50803_9658.AA | Ciliate-E2 | 67-278 | 20 | 2.2e-24 | 80.62 | In-house | 86-359 (365) | Show / Hide |
Range on Protein: 67-278 Range on HMM: 86-359/365 Sequence Identity: 20% (59 aa) LCSLSHKNLVKYYDVYYNDTKNLGHFVMEYYERCCLMDVILFYRMKERVIPE-------ETVWYILSHLAE---------------ALLYYHSPQKDNTD | .|.|.|..|.|..... ..| .||||.. |.| | . |. ..| . . || .... || | || LEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHS------- MGPLVHRNIKPSKVFLAADGYCKLADSGTFRLLDNV--------------------------------ILSSTIFGTLGFCPPEVLKMER---------Y .. .||.|||. ... .|..| |. . .|. . || ||.|. .||.|... | KNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGY TEESDLWSLGALVYCVCALKPPAYSANPEELLKKLQGFEVDVNELR--------------EREYSEELIGTLQS----MLNYDPKQRID-LSKL ....|.|||| . |. . ||| ... . ..| .. . |.| . .. ||..||..||. ... DYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQI |
|||||||||
| Kinase | GL50803_9658.AA | NEK | 69-284 | 29 | 9.1e-22 | 73.72 | In-house | 60-286 (286) | Show / Hide |
Range on Protein: 69-284 Range on HMM: 60-286/286 Sequence Identity: 29% (68 aa) SLSHKNLVKYYDVYYNDTKNLGHFVMEYYE-RCCLMDV---ILFYRMKERVIPEETVWYILSHLAEALLYYHSP--QKDNTDMGPLVHRNIKPSKVFLAA .| | | ||||| .. . .| . |||| | |.. | .. | ..||..| .. ... || | |. . .|| |||. .|| . QLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGP-----QRKILHRDIKPQNIFLTK DGY----CKLADSGTFRLLD-NVILSST-IFGTLGFCPPEVLKMERYTEESDLWSLGALVYCVCAL--KPPAYSA--NPEELL-KKLQGFEVDVNELRER .. |. | | ..|. .. . .| || . |||.. . |.. || |||| ..| |.| |.| .. | ..| | .| . . . .. NNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKPYNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKG--PQYPPIPSH E-YSEELIGTLQSMLNYDPKQRIDLSKLNAIPQI ||..| ...||. ||.|| . ... . |.| RMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI |
|||||||||
| Kinase | GL50803_9658.AA | CAMK | 39-276 | 16 | 1.1e-21 | 66.02 | In-house | 31-417 (425) | Show / Hide |
Range on Protein: 39-276
Range on HMM: 31-417/425
Sequence Identity: 16% (64 aa)
GQDYAVKVVNITSIPNRY----------------------RSVVRN------DFIKLCS-----LSHKNLVKYYDVYYNDT-----------------KN
|| .|.|... . ... | . | . |... |.|.|..| |.|| ... ..
GQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDK
LGHFVM---EYYERCCL----MDVILFYRMKE-----------RVIPEETVWYILSHLAEALLYYHSPQKDNTDMGPLVHRNIKPSKVFLAADG------
..|| || . .| | | . . . ..|. . .. ...|. | || .. ||| .|| . | ..
HMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHS-------HN-IVHRDLKPENILLDDNNDDSDPV
----------Y-CKLADSGTFRLLDN------------------------VILSSTIFGTLGFCP-PEVLKM--------------ERYTEESDLWSLGA
. |..| | . .| . .| .||..... ||||. . |....| ||.|
EHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGV
LVYCVCALKPPAYSA-------------NPEELLKKLQGFEVDVNELR------------EREYSEE--------LIGTLQSMLNYDPKQRIDLS
. | .|| |. |..||..| . . | . . |.| . ...||..||..|. ..
ILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIE
|
|||||||||
| Kinase | GL50803_9658.AA | STE | 34-278 | 19 | 4e-21 | 71.42 | In-house | 34-351 (359) | Show / Hide |
Range on Protein: 34-278 Range on HMM: 34-351/359 Sequence Identity: 19% (66 aa) NDGSQGQDYAVKVVNITSIPN---------------RYRSVVRNDFIKLCSLS--HKNLVKYYDVYYND---TKN--LGHFVMEYYERCCLMDVIL-FYR |.|..|. .|.|..|. . | . . .. . .. |.| ||||. |... .|| . .||| . .| |.| | NNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYG MKE---------RVIPEETVWYILSHLAEALLYYHSPQKDNTDMGPLVHRNIKPSKVFLAADGYCKLADSGTFRLLDN-----------------VILSS ... ..||. . ||. . ..||||. .. .|| |||. ..| .||.| |. |.. . . CGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH-------IIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRN TIFGTLGFCPPEVLKMER------YTEESDLWSLGALVYCVCALKPPAYS-ANPEELLKKLQGF------------EVDVNELRE--------------- |. || . |||.. .. |.. .| |||| .. . ||| ... .. ..... . . | . TFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGT ---REYSEELIGTLQSMLNYDPKQRIDLSKL ...|.|.. .. |..||..| . |.| TYPHKWSPEFKDFINKCLQKDPNKRPTASQL |
|||||||||
| Kinase | GL50803_9658.AA | NEK10 | 70-286 | 26 | 9.2e-16 | 48.21 | In-house | 70-279 (279) | Show / Hide |
Range on Protein: 70-286 Range on HMM: 70-279/279 Sequence Identity: 26% (58 aa) LSHKNLVKYYDVYYNDTKNLGHFVMEYYERCCLMDVILFYRMKERVIPEETVWYILSHLAEALLYYHSPQKDNTDMGPLVHRNIKPSKVFLAADGYCKLA . | | | || .. . ||| | | | . . . |. || .| .. . || | | . ||| .| . . . MRHPNIVRYYRTFVEPQNHRMYIVMELIEGCPLYEHFNSMKEKHHHFEEERIWHMFIQMCLALRYLHKEKQ-------IVHRDLTPNNIMMGDKDRVTIT DSGTFRLLD--NVILSSTIFGTLGFCPPEVLKMERYTEESDLWSLGALVYCVCALKPPAYSANPEELLKKLQGFEVDVNELREREYSEELIGTLQSMLNY | | . . . | . || . ||... | | | | |. | .| | |.|| ||.| | | | . . | .|... |... | DFGLAKQKQPDPSKMTSVV-GTILYSCPEIVQSEPYGEKADVWAFGCCLYQMCTLQPPFYSTNMLTLAMKIV--EHFYDPVNEGMWSDDVRFTITRCLTP DPKQRIDLSKLNA-IPQIVD ||. | |. | . . .| | DPEARPDIVKVSSVLRMIQD |
|||||||||
| Kinase | GL50803_9658.AA | TKL | 39-272 | 13 | 2e-15 | 52.04 | In-house | 26-354 (364) | Show / Hide |
Range on Protein: 39-272
Range on HMM: 26-354/364
Sequence Identity: 13% (48 aa)
GQDYAVKVVNITS-------------------------IPNRYRSVVRNDFIKLCSLSHKNLVKYYD---------VYYN--DTKNLGHFVMEYYERCCL
|.| |||. .... . ..| .. . .|.| |.|... | .. .... ..||||... .|
GKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSL
MDVILFYRMKERVIPEETVWYILSHLAEALLYYHS--P---QKDNTDMGP--LVHRNIKPSKVFLAADGY--------------CKLADSGTFRLLDNVI
.... . . | .. | || | . . ..||..|.. ... .. ||..| |. | ...
LHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCT-------KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSG
--------------------LSSTIFGTLGFCPPEVLKME----------------RYTEESDLWSLGALVYCVCALKPPAYSANPEELLKK---LQGFE
..|. ||.....||||... |.| .| .| | . . ... ..| | .... . . |.
NMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFM
VDVNELRE----------------REYSEELIGTLQSMLNYDPKQR
..... . .... .| ..||..|
MVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKR
|
|||||||||
| Kinase | GL50803_9658.AA | Ciliate-E2b | 149-217 | 30 | 8.3e-14 | 38.5 | In-house | 124-201 (272) | Show / Hide |
Range on Protein: 149-217 Range on HMM: 124-201/272 Sequence Identity: 30% (24 aa) VHRNIKPSKVFLAADGYCKLADSGTFRLLDNVIL----SSTIFGTLGFCPPEVLK-----MERYTEESDLWSLGALVY ..| |||. . . .||.||.| || ... || ||. . ||... || ..|.||.| | IYRDIKPENIMVDHKGYMKLIDMGTAKHMYKKNEQMTRTFTIIGTPHYMAPEIIQSLQPGGKGYTYKVDIWSVGICLY |
|||||||||
| Kinase | GL50803_9658.AA | NEK2 | 195-284 | 32 | 6.1e-11 | 32.96 | In-house | 233-319 (319) | Show / Hide |
Range on Protein: 195-284 Range on HMM: 233-319/319 Sequence Identity: 32% (29 aa) PEVLKMERYTEESDLWSLGALVYCVCALKPPAYSANPEELLKKLQGFEVDVNELREREYSEELIGTLQSMLNYDPKQRIDLSKLNAIPQI ||... | | || ||.| |.| |||.|| | .| | .. . . . .. ||..| .|.| |...| . . ||| PEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFR--RIPYQ-YSRHLNEIIHFMINVDHYHRPSIEEILQHPQI |
|||||||||
| TyrKc | GL50803_9658.AA | TyrKc | 9-284 | 16 | 3.1e-09 | -73.35 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 9-284 Range on HMM: 1-280/280 Sequence Identity: 16% (51 aa) VSTGPVLAKTALGHVEVVRSLDPACNDGSQGQDYAVKVVNITSIPNRYRSVVRNDFIK----LCSL--SHKNLVKYYDVYYNDTK-----NLGHFVMEYY .. | .| | | | . .. |||... . | ||.. .|.| .|.|.|. | | . |||| ITLGKKLGEGAFGEVYKGTWK----------IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYM ERCCLMDVILFYRMKERVIPEETVWYILSHLAEALLYYHSPQKDNTDMGPLVHRNIKPSKVFLAADGYCKLADSGTFRLLDNV--------ILS-----S . .| | . .| | .. .. .. |. | || ...|| . . ..... .| .| | | ... . . PHGDLKDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSK--------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKG TIF-GTLGFCPPEVLKMERYTEESDLWSLGALVYCVCAL-KPPAYS-----ANPEELLKKLQGFEVDVNELREREY---------SEELIGTLQSMLNYD . . . ..||... ..|..|| || | . . .. . ..| . ...|...... . .. .. ..|. .. ..| GKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYR----MPQPPNDYPMSFVCCPDEMYQIMKQCWHED PKQRIDLSKLNAIPQI |..| | . . .. PEDRPTFSEI--HECF |
|||||||||
| Kinase | GL50803_9658.AA | NEK2 | 70-164 | 30 | 4.2e-08 | 23.24 | In-house | 55-162 (319) | Show / Hide |
Range on Protein: 70-164 Range on HMM: 55-162/319 Sequence Identity: 30% (33 aa) LSHKNLVKYYDVYYNDTKNLGHFVMEYYERCCLMDVILFYRMKERVIPEETVWYILSHLAEALLYYHS---------------PQKDNTDMGPLVHRNIK | | | |.||| . .. |||| |. | .| .| . ..|| .| |. | || | | .|. || || LKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQYMEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHT--ILHRDIK PSKVFLAADG | .|| .|. PANIFLDYDH |
|||||||||