Gene GL50803_9487 (G.lamblia)
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
---|---|---|---|---|---|
GL50803_9487.AA | Protein | None | 925 | None | Fasta, JSON |
GL50803_9487.kin_dom | Protein Kinase Domain | None | 456 | None | Fasta, JSON |
Protein domains of GL50803_9487.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | GL50803_9487.AA | CAMK | 549-743 | 23 | 2.3e-43 | 137.12 | In-house | 141-425 (425) | Show / Hide |
Range on Protein: 549-743 Range on HMM: 141-425/425 Sequence Identity: 23% (67 aa) LCGGGSL----------KEYRAN----------TVVTEPMARYFFSQIMSAVLYMHLHGVAHMDLRLENCLLDNN-----------------GCVRLCDF .| || | .... . .|| ||..| || ||| |.| |...| || .|| |||.| . . ..|| YCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDF GNAMSFSMDEESK---------------QAIDTVRRGMVAGTLAHMP-PEMLLLQ------------SDYSARKVDIWCCGLILYELLTAKPAFTVAKSM | | | .|... . ... . ||.. |. ||.|. . .| .|.|.| || ||| .|. .| | . . GFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDN DGCHSDTELS-----KKLCSNICSMNYEALGFN-----------------------YSAEARDLCSRMMSYDALERPDAYEILLHPWL . | | | ..|. .|.. .|. . |.|..|| ..|. .| .|. . ..| |||. EICE-D-E-WIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM |
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S_TKc | GL50803_9487.AA | S_TKc | 288-743 | 16 | 1.6e-42 | 148.49 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 288-743 Range on HMM: 1-231/231 Sequence Identity: 16% (79 aa) YITGKTLGFGRGGIVKIAIHRSFLTADKAGRFPSTRKGALGPEAGMTISKNYASAKSLSAYIPTRSAGMVEAELRPRSRAKPGRKQSNRKSDVSTHSYAK | ....| | | |. ..|.. .. . | .. YEILRKIGKGAFGKVYKCRHKK--------------------------TGRIVAIKIIK----------------------------------------- SSAENVFDVPSVTLDVEKTQSEAMSTNLQMPTVSTSEFVTTQPPQPINQDDVPASVQVALKLIPSKPVSSLLSTLAPTVMRKKTATRKNRVVSSDTKTET ---------------------------------------------------------------------------------------------------- DGSSTECKDSSTNFDTSREAVPCPEPVALERLTGHQNIVELMDKFVYVDMKGNEWEAMALTLCGG--GSLKEYRANTV-------VTEPMARYFFSQIMS . | |.. .| ||| | | |. . | . .|.| |.|..| . .| .||... || . -------------------EHIRREIQILKK--HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICC AVLYMHLHGVAHMDLRLENCLLDNNGCVRLCDFGNAMSFSMDEESKQAIDTVRRGMVAGTLAHMPPEMLLLQSDYSARKVDIWCCGLILYELLTAKPAFT |. |.| ||. | || || |||. .. .|||| | . . ||. |.||.| |. .|.|.| || ||||.|. .| | ALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP VAKSMDGCHSDTELSKKLCSNICSMNYEALGFNYSAEARDLCSRMMSYDALERPDAYEILL-------HPWL . .. ||.. | ||.|. .... .| .|| | |.| |||. ---------QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | GL50803_9487.AA | AGC | 550-743 | 21 | 1.9e-39 | 98.43 | In-house | 124-395 (395) | Show / Hide |
Range on Protein: 550-743 Range on HMM: 124-395/395 Sequence Identity: 21% (60 aa) CGGG-SLKEYRANT----VVTEPMARYFFSQ-------IMSAVLYMHL-HGVAHMD-LRLENCLLDNNGCVRLCDFGNAMSFSMD--------------- |||| | . . . .|..||..... | .|. |.| .|. | | | .|| |||..| ..|.||| . . .| CGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHW ---------------------------EESKQAIDT--VRRGMVAG--TLAHMPPEMLLLQSDYSARKVDIWC--CGLILYELLTAKPAFTVAKSMDGC- | ..... .| | | |.||.| . .|.|. | ..||.|| .| |. . HNKKYQKSNMDTNKCNPNNWQRNNMSQE-DDTTR-KKRDRTWTFCGPCTPEYMAPEIL------YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQE-NR HSDTELSKKLCSNICSMN---YEALGFN------------YSAEARDLCSRMMSYDALERPD----------AYEILLHPWL | . . ... .|.. . . . |. | ||.||..... | .|. | || ||| H-PFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF |
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Kinase | GL50803_9487.AA | Ciliate-E2 | 549-743 | 20 | 2.6e-32 | 108.2 | In-house | 115-365 (365) | Show / Hide |
Range on Protein: 549-743 Range on HMM: 115-365/365 Sequence Identity: 20% (56 aa) LCGGGSLKEYRANT------------VVTEPMARYFFSQIMS---------------AVLYMHLHG-VAHMDLRLENCLLDNNGCVRLCDFGNAMSFS-- .| ||.|..| | || ..|.. || . |. |.| . . | |. .|| |. . ..|||.. .. YCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDD -----------MDEESKQAIDTVRRGM-----------VAGTLAHMPPEMLLLQSDY-------SARKVDIWCCGLILYELLTAKPAFTVAKSMDGCHSD . . |. ... . | ..||. |.||.| .... |.|||..| ||||.|. || | NQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF------------ TELSKKLCSN-ICSMNYEAL---------------GFNYSAEARDLCSR----MMSYDALERPD-AYEILLHPWL . . | .. .. | |. ||... |. .| .|.. . .|| |||. ------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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Kinase | GL50803_9487.AA | Pkinase | 516-677 | 32 | 5.7e-29 | 103.51 | Pfam | 54-212 (293) | Show / Hide |
Range on Protein: 516-677 Range on HMM: 54-212/293 Sequence Identity: 32% (56 aa) LERLTGHQNIVELMDKFVYVDMKGNEWEAMALTLCGGG----SLKEYRA---NTVV--TEPMARYFFSQIMSAVLYMHLHGVAHMDLRLENCLLDNNGCV . || .| |||.| | | . . . | . .|.|| .|..| .... .| .. .. || ... |.| .|. | || .||.|.|||| . MKRL-NHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHI ----RLCDFGNAMSFSMDEESKQAIDTVRRGMVAGTLAHMPPEMLLLQSDYSARKVDIWCCGLILYELLTAKPAF ..|||| | |. . ..||. |.|| .. ...|. .|||.| ||.||||.|. .| | DACVKICDFGLAKQFD-------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYG-PKVDMWSCGCILYEMLCGRPPF |
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Kinase | GL50803_9487.AA | MSK | 565-743 | 30 | 2.5e-28 | 92.88 | In-house | 99-277 (277) | Show / Hide |
Range on Protein: 565-743 Range on HMM: 99-277/277 Sequence Identity: 30% (58 aa) TEPMARYFFSQIMSAVLYMHLHGVAHMDLRLENCLLDNN---GCVRLCDFGNAMSFSMDEESKQAIDTVRRGMVAGTLAHMPPEMLL----LQSDYSARK .| .|. . .. .|| .|| |. | || .|| |.|.. | |.| ||| | | ||| . .|| |.|||| .. |.. DESECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKS-------PCFTLHYMAPEMLRRGYAQDGGYDE-A VDIWCCGLILYELLTAKPAFT-VAKSMD-GCHSDTELSKKLCSNICSMNYEALGFNYSAEARDLCSRMMSYDALERPDAYEILLHPWL .|.| | |||..|| . |. ... . .| | .|..|. | | .| | |..|.|| ... | |. . ... | |. CDWWSLGVILYTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAW-QNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK |
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Kinase | GL50803_9487.AA | Ciliate-E2-Unclassified | 549-743 | 23 | 9.8e-27 | 89.77 | In-house | 102-352 (352) | Show / Hide |
Range on Protein: 549-743 Range on HMM: 102-352/352 Sequence Identity: 23% (62 aa) LCGGGSLKEYRANT------------------VVTEPMAR-----YFFSQIMSAVLYMHLHG-VAHMDLRLENCLLDNNG---CVRLCDFGNAMSFSMDE .| ||.|..| . .|| |. ..| || .. |.| . . | |. .|| |.|||| .....|||... .. YCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNN ESK---QAIDTVRRGMV--------AGTLAHM----PPEMLLLQSDYSA--RKVDIWCCGLILYELLTAKPAFTV----------------AKSMDGCHS ... | ..... .||. | .||.| | . |.|||..| ||||.|. .. | | NCDTNQQ----QKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNA-------- DTELSKKLCSNICSMNYEALGFNY-------SAEARDLCS----RMMSYDALERPDAYEILLHPWL | | .||. |.. |. | || |... .|. .. .|... .|| |||. ---YRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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Kinase | GL50803_9487.AA | RSK | 565-743 | 28 | 2.6e-24 | 85.98 | In-house | 102-278 (278) | Show / Hide |
Range on Protein: 565-743 Range on HMM: 102-278/278 Sequence Identity: 28% (55 aa) TEPMARYFFSQIMSAVLYMHLHGVAHMDLRLENCLLDN---NGCVRLCDFGNAMSFSMD-EESKQAIDTVRRGMVAGTLAHMPPEMLL---LQSDYSARK .| |.. ...| .|| ..| .|. | || .||.|.|. .| ..|.||| . |. | .. . .|.. |.|||| |. ... SEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMT--------FCYTIEYMAPEMLKRANQQGGHDK-A VDIWCCGLILYELLTAKPAFTVAKSMDGCHSDTELSKKLCSNICSMNYEALGFNYSAEARDLCSRMMSYDALERPD-----AYEILLHPWL .|.| | ..||.|| .| |. . | . |..|. ... |.. .. . |.||.|| ..|. | |. | ||. |||. CDWWSLGVLMYEMLTGCPPFQG--PND--NNRKEIMKRIQKGKFSLTMPN-WQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF |
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Kinase | GL50803_9487.AA | TKL | 575-741 | 18 | 9.5e-22 | 75.09 | In-house | 140-364 (364) | Show / Hide |
Range on Protein: 575-741 Range on HMM: 140-364/364 Sequence Identity: 18% (41 aa) QIMSAVLYMHLHG--------VAHMDLRLENCLLDNNGC--------------VRLCDFGNAMSFSMDEESKQAIDTVR-----------RGMVAGTLAH .| ... |.| .. ..| || .|.|.|.|. . .|||| . ..|...... |.. .... ||... DIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRW MPPEMLLLQSDYSA--------------RKVDIWCCGLILYELLTAKPAFTVAKSMDGCHSDTELSKKLCSNICSMNYE-ALG------------FNYSA |.||.| | .|. |.|.. |..|.|.|| .. . ..|. .| .. . .|. .. . . MAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQD-P-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPP EARDLCSRMMSYDALERPDAYEILLHP . ..|. . ...|. .|| . ||| . SMKKLMQDCWDHDPEKRPSFQEILKRL |
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Kinase | GL50803_9487.AA | MARK | 569-672 | 33 | 1.4e-21 | 67.44 | In-house | 106-201 (262) | Show / Hide |
Range on Protein: 569-672 Range on HMM: 106-201/262 Sequence Identity: 33% (36 aa) ARYFFSQIMSAVLYMHLHGVAHMDLRLENCLLDNNG--CVRLCDFGNAMSFSMDEESKQAIDTVRRGMVAGTLAHMPPEMLLLQSDYSARKVDIWCCGLI || .|.|| ||| |.| ....| |. .|| |.| || . ..||| . . ... . ||.. |.|| ..|. .| ..||||| .| . ARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQK---------LNTFCGTPPYMAPE-IFLKKPYDGPKVDIWSLGVV LYELLT || ... LYFMVC |
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Kinase | GL50803_9487.AA | CAMKL | 565-612 | 50 | 1.3e-17 | 52.59 | In-house | 125-174 (297) | Show / Hide |
Range on Protein: 565-612 Range on HMM: 125-174/297 Sequence Identity: 50% (25 aa) TEPMARYFFSQIMSAVLYMHLHGVAHMDLRLENCLLDNNG--CVRLCDFG .|. || .| ||.||| |.| ||..| |. .|| |||.|| . ..||| PEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFG |
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Kinase | GL50803_9487.AA | AMPK | 564-612 | 46 | 3.1e-17 | 47.76 | In-house | 97-145 (254) | Show / Hide |
Range on Protein: 564-612 Range on HMM: 97-145/254 Sequence Identity: 46% (23 aa) VTEPMARYFFSQIMSAVLYMHLHGVAHMDLRLENCLLDNNGCVRLCDFG ..| |. || || |.| |.| |...| || .|| ||| | .. . ||| LQEREACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFG |
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Kinase | GL50803_9487.AA | CAMKL | 637-743 | 27 | 7.2e-16 | 46.99 | In-house | 195-297 (297) | Show / Hide |
Range on Protein: 637-743 Range on HMM: 195-297/297 Sequence Identity: 27% (30 aa) GTLAHMPPEMLLL-QSDYSARKVDIWCCGLILYELLTAKPAFTVA---KSMDGCHSDTELSKKLCSNICSMNYEALGFNYSAEARDLCSRMMSYDALERP |... |.||... . .| ..||||| || ||| ... . | . | .. ... ..| |. . | ..||| ..|. . .|| GSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNK-----QGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRP DAYEILLHPWL . .|. |||. TIHQIMNHPWM |
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Kinase | GL50803_9487.AA | MARK | 713-743 | 41 | 5.3e-08 | 22.44 | In-house | 232-262 (262) | Show / Hide |
Range on Protein: 713-743 Range on HMM: 232-262/262 Sequence Identity: 41% (13 aa) SAEARDLCSRMMSYDALERPDAYEILLHPWL |.|.|.| .|.. . |||.. ||. |||. SKECRNLIQRLLTVNPEERPTIEEIMKHPWM |
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Kinase | GL50803_9487.AA | TyrKc | 288-743 | 13 | 4e-06 | -122.84 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 288-743 Range on HMM: 1-280/280 Sequence Identity: 13% (66 aa) YITGKTLGFGRGGIVKIAIHRSFLTADKAGRFPSTRKGALGPEAGMTISKNYASAKSLSAYIPTRSAGMVEAELRPRSRAKPGRKQSNRKSDVSTHSYAK ||.|| | |.| .. . ITLGKKLGEGAFGEVYKGTWK------------------------------------------------------------------------------- SSAENVFDVPSVTLDVEKTQSEAMSTNLQMPTVSTSEFVTTQPPQPINQDDVPASVQVALKLIPSKPVSSLLSTLAPTVMRKKTATRKNRVVSSDTKTET .||| | . . -------------------------------------------------------IQVAVKMLKEDA--------------------------------- DGSSTECKDSSTNFDTSREAVPCPEPVALERL-TGHQNIVELMDKFVYVDMKGN------EWEAMALTLCGGGSLKEYRANTV--VTEPMARYFFSQIMS ||. . | . .| |.||| ... | ... | . . .. .|.||.| .. .. . .| || . -----------------REDF-MREARIMCKLGGHHPNIV----RLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIAC AVLYMHLHGVAHMDLRLENCLLDNNGCVRLCDFGNAMSFSMDEE-----SKQAIDT----VRRGMVAGTLAHMPPEMLLLQSDYSARKVDIWCCGLILYE | | ... | || |||...|..|. .||| .| ... ||. ... ...|. . |.|| . . .. | |.| | ..| GMEYLHSKNCIHRDLAARNCLVGENHTVKISDFG--LSRDIYDDDQQGESKDYYRKKEHKGGKTML--PIRWMAPECI-NYGKFTT-KSDVWSFGVCMWE LLT--AKPAFTVAKSMDGCHSDTELSKKLCSN--ICSMNY--EALGFNYSAEARDLCSRMMS----YDALERPDAYEILLHPWL ..| ..| ... |..|. ... . . . . . | .. | ..|. .|. .|| || | . IFTYGQQPYPGMIQQ---MMSNQEVIEYVKQGYRMPQPPNDYP-MSF---VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
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Kinase | GL50803_9487.AA | Pkinase | 711-743 | 39 | 1.2e-05 | 21.11 | Pfam | 261-293 (293) | Show / Hide |
Range on Protein: 711-743 Range on HMM: 261-293/293 Sequence Identity: 39% (13 aa) NYSAEARDLCSRMMSYDALERPDAYEILLHPWL | | |..|..... .| .|| | .|| |||. NWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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Kinase | GL50803_9487.AA | AMPK | 653-671 | 57 | 1.7e-05 | 12.35 | In-house | 176-194 (254) | Show / Hide |
Range on Protein: 653-671 Range on HMM: 176-194/254 Sequence Identity: 57% (11 aa) YSARKVDIWCCGLILYELL | ..|||| || ||| .| YCGPEVDIWSCGVILYAML |
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Kinase | GL50803_9487.AA | AMPK | 288-307 | 55 | 8.1e-05 | 10.3 | In-house | 1-20 (254) | Show / Hide |
Range on Protein: 288-307 Range on HMM: 1-20/254 Sequence Identity: 55% (11 aa) YITGKTLGFGRGGIVKIAIH ||.|||.| | | ||...| YIIGKTIGEGTFGKVKMGTH |
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Kinase | GL50803_9487.AA | AMPK | 713-743 | 38 | 0.000191 | 9.18 | In-house | 224-254 (254) | Show / Hide |
Range on Protein: 713-743 Range on HMM: 224-254/254 Sequence Identity: 38% (12 aa) SAEARDLCSRMMSYDALERPDAYEILLHPWL | ||.|| ..| | ..| . .| |||. SPEAKDLIKHMLQVDPMKRITIHDIRNHPWF |
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Kinase | GL50803_9487.AA | CAMKL | 288-308 | 59 | 0.001284 | 7.25 | In-house | 1-22 (297) | Show / Hide |
Range on Protein: 288-308 Range on HMM: 1-22/297 Sequence Identity: 59% (13 aa) YITGKTLGFGRGGIVKIAIH-R |. ||||| | | || |.| | YRIGKTLGKGSFGKVKLATHIR |
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Kinase | GL50803_9487.AA | CAMK | 293-308 | 56 | 0.004853 | 4.84 | In-house | 1-16 (425) | Show / Hide |
Range on Protein: 293-308 Range on HMM: 1-16/425 Sequence Identity: 56% (9 aa) TLGFGRGGIVKIAIHR ||| |. |.|| .||. TLGRGSFGKVKLCIHK |
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Kinase | GL50803_9487.AA | Pkinase | 288-309 | 31 | 0.013248 | 10.29 | Pfam | 1-22 (293) | Show / Hide |
Range on Protein: 288-309 Range on HMM: 1-22/293 Sequence Identity: 31% (7 aa) YITGKTLGFGRGGIVKIAIHRS | .|...| | | |....|.. YHIGRKIGSGSFGCVYKCHHKG |
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Kinase | GL50803_9487.AA | MARK | 288-308 | 42 | 0.038813 | 2.98 | In-house | 1-21 (262) | Show / Hide |
Range on Protein: 288-308 Range on HMM: 1-21/262 Sequence Identity: 42% (9 aa) YITGKTLGFGRGGIVKIAIHR | .||.| | . || |.|. YKMLKTIGHGSYAKVKLACHK |
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Kinase | GL50803_9487.AA | Ciliate-E2 | 288-309 | 27 | 0.075849 | 2.1 | In-house | 1-22 (365) | Show / Hide |
Range on Protein: 288-309 Range on HMM: 1-22/365 Sequence Identity: 27% (6 aa) YITGKTLGFGRGGIVKIAIHRS |. | .|.| |.|. . ... YKFIKKIGQGNFGSVYKCKVWK |