Gene GL50803_91334 (G.lamblia)
GL50803_91334
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| GL50803_91334.AA | Protein | None | 1003 | None | Fasta, JSON |
| GL50803_91334.kin_dom | Protein Kinase Domain | None | 264 | None | Fasta, JSON |
Protein domains of GL50803_91334.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | GL50803_91334.AA | NEK6 | 54-213 | 31 | 1.5e-13 | 40.76 | In-house | 46-195 (252) | Show / Hide |
Range on Protein: 54-213 Range on HMM: 46-195/252 Sequence Identity: 31% (53 aa) CFDDIDLWSQLSHPCLLKIHEVLHEVQSKQVHIVVDEPLGQSMRDVISKNEKHNRYVDEKTQWKALSSLADALAYLHSPIRTNTRVNRRMAHRYICPDTI | .||| || || ..| . .. .. ||.. | .| | | . |.| || |. ||. .|| .|. || | | . CIKEIDLLKQLNHPNVIKYYASF--IENNELNIVLELADAGDMSRMIKHFKKQKRLIPERTIWKYFVQLCSALEHMHS---------KRVMHRDIKPANV YVLESGVAQLGPPPLLHLLGI-RQLSDMPTSAHR------YLAPEILMMRSYGDKVDIWSLGCTLFE .. |. .|| ||. | | | || |..|| . | | ||||||| |.| FITANGIVKLGD------LGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYE |
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| S_TKc | GL50803_91334.AA | S_TKc | 10-276 | 17 | 2.8e-13 | 17.86 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 10-276 Range on HMM: 1-231/231 Sequence Identity: 17% (51 aa) YELSEPVAQDPYLIIRHAIRRADHRICMCHSLSYSRLLADGESPCFDDIDLWSQLSHPCLLKIHEVLHEVQSKQVHIVVDEPLG--QSMRDVISKNEKHN ||. ... . . . .. . ..||. . .. |.. .. || . |...| .. . ...| . | ...|.| |. .| YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG --RYVDEKTQWKALSSLADALAYLHSPIRTNTRVNRRMAHR-------YICPDTIYVLESGVAQLGPPPLLHLLGIRQLSDMPTSAHRYLAPEILMMRSY .. .| . .. . ...||.|.|| .. || .. .| . |.| . . |.|||.| .| LRFPFPE-HARFYMYQICCALEYCHS---------HGIIHRDLKPENILLDE-HIKICDFGLARQL--------------TTFCGTPWYMAPEVL---GY GD-KVDIWSLGCTLFEYGSNKPFIIDTQPALIEKRCQEFYGNVAMYNLSPVMIKLLSSLLEFQEDLRISAVDLRQ-------HFRI | |.|.||.||.|.| . .| |.... |.. || .. ... .|.. . |..| .. | | . GKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | GL50803_91334.AA | Ciliate-E2 | 187-273 | 21 | 2.5e-12 | 38.62 | In-house | 253-362 (365) | Show / Hide |
Range on Protein: 187-273 Range on HMM: 253-362/365 Sequence Identity: 21% (25 aa) YLAPEILMMRS---------YGDKVDIWSLGCTLFEYGSNKP-FIIDTQPALIEKRCQEFYGNVAMYN---------------LSPVMIKLLSS----LL |.|||||.. . |. |.||||||..|.| ..|| | .... ... . . .. .|. .. |.. .| YMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRML EFQEDLRIS-AVDLRQH . ... ||. . .. .| QKDPEKRITGWEQILNH |
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| Kinase | GL50803_91334.AA | AGC | 187-213 | 51 | 2.7e-12 | 26.61 | In-house | 273-297 (395) | Show / Hide |
Range on Protein: 187-213 Range on HMM: 273-297/395 Sequence Identity: 51% (15 aa) YLAPEILMMRSYGDKVDIWS--LGCTLFE |.||||| || .|.|| ||| ..| YMAPEIL----YGKACDWWSFGLGCLMYE |
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| Kinase | GL50803_91334.AA | Ciliate-E2-Unclassified | 187-276 | 19 | 2.8e-12 | 38.94 | In-house | 232-352 (352) | Show / Hide |
Range on Protein: 187-276 Range on HMM: 232-352/352 Sequence Identity: 19% (23 aa) YLAPEILMMRSYGDK----VDIWSLGCTLFEYGSNKPFIIDTQPA-----------------LIEKRCQE-FYGNVAM-----YNLSPVMIKLLS----S |.|||.|. |... .||||||. |.| ... |.. |... .| .. . . ...|| . ... . YTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQK LLEFQEDLRISAVDLRQHFRI .|. . . ||.. .. .| . MLKKNPNKRITFEQILNHPWF |
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| Kinase | GL50803_91334.AA | ULK | 187-276 | 26 | 4.1e-12 | 38.66 | In-house | 217-329 (329) | Show / Hide |
Range on Protein: 187-276 Range on HMM: 217-329/329 Sequence Identity: 26% (30 aa) YLAPEILMMR----SYGDK-VDIWSLGCTLFEYGSNK-PFIIDTQPALIEKRCQEFYGNV------------------AMYNLSPVMIKLLSSLLEFQED | ||.||. . |.|. .||||||| ..| .| || .... .|. . | . ...|| .. |.. .|...|. YMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEK LRISAVDLRQHFRI ||| .| .|. . DRISWEELFNHPWF |
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| Kinase | GL50803_91334.AA | Ciliate-B1 | 187-213 | 57 | 3.3e-11 | 35.61 | In-house | 194-221 (290) | Show / Hide |
Range on Protein: 187-213 Range on HMM: 194-221/290 Sequence Identity: 57% (16 aa) YLAPEILM-MRSYGDKVDIWSLGCTLFE | ||||| .|. ||||||.||...| YMAPEILNFNQQYDKKVDIWSFGCIMYE |
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| Kinase | GL50803_91334.AA | ULK | 187-276 | 26 | 1.8e-10 | 33.42 | In-house | 213-324 (324) | Show / Hide |
Range on Protein: 187-276 Range on HMM: 213-324/324 Sequence Identity: 26% (30 aa) YLAPEILMMR----SYGDK-VDIWSLGCTLFEYGSNK-PF---IIDTQ-------------PALIEKRCQEFY-GNVAMYNLSPVMIKLLSSLLEFQEDL | ||.||. . |.|. .||||||| ..| .| || . |.. . .|... .|. .. . ...|| .. |.. .|...|. YMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPP-KDPKISPECKDLIRRMLQYDEKD RISAVDLRQHFRI ||| .. .|. . RISWEEIFNHPWF |
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| Kinase | GL50803_91334.AA | RAD53 | 187-212 | 31 | 2.2e-10 | 26.61 | In-house | 192-232 (305) | Show / Hide |
Range on Protein: 187-212 Range on HMM: 192-232/305 Sequence Identity: 31% (13 aa) YLAPEILM---M------------RSYGDKVDIWSLGCTLF |.|||.. . |. |||.||.||.|. YVAPEVITSKGHNCYHENEERQVQVGYTKKVDCWSMGCILY |
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| Kinase | GL50803_91334.AA | NEK | 187-213 | 51 | 3.1e-10 | 32.65 | In-house | 190-216 (286) | Show / Hide |
Range on Protein: 187-213 Range on HMM: 190-216/286 Sequence Identity: 51% (14 aa) YLAPEILMMRSYGDKVDIWSLGCTLFE |..||.. ..|. |.||||||| |.| YMSPEVCQNKPYNNKSDIWSLGCVLYE |
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| Kinase | GL50803_91334.AA | Aur | 187-208 | 45 | 9.2e-10 | 21.41 | In-house | 167-188 (257) | Show / Hide |
Range on Protein: 187-208 Range on HMM: 167-188/257 Sequence Identity: 45% (10 aa) YLAPEILMMRSYGDKVDIWSLG |..||. .....|||||.|| YMPPEMVEGQMHDHKVDIWCLG |
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| Kinase | GL50803_91334.AA | Pkinase | 186-213 | 51 | 7.3e-08 | 28.89 | Pfam | 176-204 (293) | Show / Hide |
Range on Protein: 186-213 Range on HMM: 176-204/293 Sequence Identity: 51% (15 aa) RYLAPEILM-MRSYGDKVDIWSLGCTLFE .|.|||... . || |||.||.||.|.| WYMAPEVIRGGQYYGPKVDMWSCGCILYE |
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| TyrKc | GL50803_91334.AA | TyrKc | 41-274 | 11 | 0.000226 | -151.94 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 41-274
Range on HMM: 1-280/280
Sequence Identity: 11% (38 aa)
LSYSRLLADGE-------------------SPCFDDIDLW-------SQL--SHPCLLKIHEVLHEV-----QSKQVHIVVDEPLGQSMRDVISKNEKHN
.. . | |. . . . ..| .||...... | . .... ||. . . .| . |....
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-
RYVDEKTQWKALSSLADALAYLHSPIRTNTRVNRRMAHRYICPDTIYVLESGVAQLGPPPLLH--------LLGIRQ-------------LSD-------
. |. . |. .|||| .. | |.| .. .|
--LCMKDLLSFCWQIACGMEYLHSK----------------------------------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESK
--MPT----SAH-----RYLAPEILMMRSYGDKVDIWSLGCTLFE---YGSNKPFI-ID--TQPALIEKRCQEFYGNVAMYN--------LSPVMIKLLS
. ... | .||| .. . . | |.|| | ...| || . | .. . .. .. | . | .. | .. .
DYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMK
SLLEFQEDLRISAVDLRQHF
. ... . | . .... |
QCWHEDPEDRPTFSEIHECF
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| Kinase | GL50803_91334.AA | Pkinase | 243-274 | 23 | 0.001347 | 13.8 | Pfam | 260-293 (293) | Show / Hide |
Range on Protein: 243-274 Range on HMM: 260-293/293 Sequence Identity: 23% (8 aa) YNLSPVMIKLLSSLLEFQEDLRISAVDLRQH--F .|.|. ........|.. |..| .. || | HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | GL50803_91334.AA | Ciliate-E2-Unclassified | 64-131 | 17 | 0.007648 | 5.72 | In-house | 76-161 (352) | Show / Hide |
Range on Protein: 64-131 Range on HMM: 76-161/352 Sequence Identity: 17% (15 aa) LSHPCLLKIHEVLHEVQSKQVHIVVDEPLGQSMRDVISKNEK---------HNRYV-----DEKTQW----KALSSLADALAYLHS |.||........ .. . . . || . |..... |.|..| ||.. ..... . . . ..| |||. LNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHH |
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| Kinase | GL50803_91334.AA | Ciliate-E2 | 62-131 | 23 | 0.00812 | 5.48 | In-house | 87-178 (365) | Show / Hide |
Range on Protein: 62-131 Range on HMM: 87-178/365 Sequence Identity: 23% (22 aa) SQLSHPCLLKIHEVLHEVQSKQVHIVVDEPLGQSMRDVISKN---EKHN----RYVDEKTQWKALSSLAD---------------ALAYLHS .||.|| ..|..|. | . . . .| . |....| | .| ..|. | .|| . ... || |||| EQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHS |
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| Ank | GL50803_91334.AA | Ank | 671-696 | 30 | 0.000258 | 19.82 | Pfam | 1-26 (33) | Show / Hide |
Range on Protein: 671-696 Range on HMM: 1-26/33 Sequence Identity: 30% (8 aa) CGRTALMYAAANNSIDAVEMLMRYEA .|.|.|..|. ..... |.||. . | DGFTPLHLACRCGHTEVVKMLLQHGA |
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| Ank | GL50803_91334.AA | Ank | 643-670 | 21 | 54.56854 | 0.61 | Pfam | 6-33 (33) | Show / Hide |
Range on Protein: 643-670 Range on HMM: 6-33/33 Sequence Identity: 21% (6 aa) LMRAAATNDMNTLRHLVCDERQLRAVDD |. |. .... .. |. . |.|| LHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_91334.AA | Ank | 702-729 | 42 | 8e-06 | 25.35 | Pfam | 1-28 (33) | Show / Hide |
Range on Protein: 702-729 Range on HMM: 1-28/33 Sequence Identity: 42% (12 aa) DGATALMFASQRGSNDVVKLLLHQEAQL || |.|. |...|. .|||.|| . | . DGFTPLHLACRCGHTEVVKMLLQHGADV |
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| Ank | GL50803_91334.AA | Ank | 733-755 | 26 | 1.740549 | 6.01 | Pfam | 1-23 (33) | Show / Hide |
Range on Protein: 733-755 Range on HMM: 1-23/33 Sequence Identity: 26% (6 aa) SGTTALMIAAKYYRATTAYILLD | |.|..|... .. . ||. DGFTPLHLACRCGHTEVVKMLLQ |
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| Ank | GL50803_91334.AA | Ank | 764-784 | 33 | 0.010139 | 14.07 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 764-784 Range on HMM: 1-21/33 Sequence Identity: 33% (7 aa) SGKTALMYASLNGDEEIAFLL | |.|..|...|..|.. .| DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_91334.AA | Ank | 795-815 | 28 | 0.008866 | 14.28 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 795-815 Range on HMM: 1-21/33 Sequence Identity: 28% (6 aa) NGETALMHALANGNNHIARLL .|.|.|. | .|. ....| DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_91334.AA | Ank | 826-849 | 20 | 1.740549 | 6.01 | Pfam | 1-24 (33) | Show / Hide |
Range on Protein: 826-849 Range on HMM: 1-24/33 Sequence Identity: 20% (5 aa) TKSTALMLCAKTNNLEIGRELVEK |.|.| .. ...|. ..|... DGFTPLHLACRCGHTEVVKMLLQH |
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| Ank | GL50803_91334.AA | Ank | 857-877 | 33 | 0.001522 | 17.04 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 857-877 Range on HMM: 1-21/33 Sequence Identity: 33% (7 aa) HGDTALMHAASAGNIDLVALL .|.|.|. |.. |... | .| DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_91334.AA | Ank | 919-939 | 33 | 0.0001 | 21.31 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 919-939 Range on HMM: 1-21/33 Sequence Identity: 33% (7 aa) AGNTALMYAAQNNRIDIVKYL |.|.|..|........||.| DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_91334.AA | Ank | 888-918 | 33 | 0.000476 | 18.86 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 888-918 Range on HMM: 1-33/33 Sequence Identity: 33% (11 aa) GGLTAMMIAAQKGHLDVVRMLSA--AEMRIKDY | |. ..|...||..||.|| |. ..| DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_91334.AA | Ank | 950-970 | 38 | 0.16717 | 9.68 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 950-970 Range on HMM: 1-21/33 Sequence Identity: 38% (8 aa) TGETALVDAILMNNTDIVKVL |.|.| |.....|..|| | DGFTPLHLACRCGHTEVVKML |
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