Gene GL50803_91220 (G.lamblia)

GL50803_91220

Species: G.lamblia
Alias: GK188, GL50803_91220
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_91220.AA Protein None 1144 None Fasta, JSON
GL50803_91220.kin_dom Protein Kinase Domain None 266 None Fasta, JSON

Protein domain

Protein domains of GL50803_91220.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc GL50803_91220.AA S_TKc 11-276 32 1.7e-75 258.03 SMART 1-231 (231) Show / Hide 
Range on Protein: 11-276
Range on HMM: 1-231/231
Sequence Identity: 32% (89 aa)

YEKLIMIECGGFGKVFKCKENTTGIIYAVKEVDYAGVPADAVKKVKNEVHLMLKLAHDNILKPIEFFDDTENEILYIVMDFYER--GDLSKLIRESRKKK
||.|  |  |.||||.||... || |.|.|...         .....|. .. |  |.|| | ...|.|   . ||.||.. .   ||| ..|.. ....
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

TP--IPEDTVWFYLRQSLSALAYLHSPKKGGNVPIGIIIHRDIKPQNILIGNDDVIKVMDFGISRESASFMTTNTTMGTPSYLAPEVLNDKPFSI-KSDI
..  .|| ...||..| ..||.|.|| .         |||||.||.|||. .  .||. |||..|.       .|  ||| |.|||||   ...  |.|.
LRFPFPE-HARFYMYQICCALEYCHSHG---------IIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDW

WALGLTILELCTRNRTFVGEPVMVLKQHREFSNKISLPDYSQDLCDAIGMMLIKDPQRRPSAGELLE-------HALI
|..| .. |....   |  .. |..|. .           |....| |  .| |||..||.| |.|.       |  .
WSCGCILYEMLCGYPPFP-QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_91220.AA NEK 11-276 34 4.1e-68 232.61 In-house 1-286 (286) Show / Hide 
Range on Protein: 11-276
Range on HMM: 1-286/286
Sequence Identity: 34% (99 aa)

YEKLIMIECGGFGKVFKCKENTTGII-----YAVKEVDYAGVPADAVKKVK-NEVHLMLKLAHDNILKPIEFFDDTENEILYIVMDFYE-RGDLSKL---
||.. .|  | ||||.|..   .| .     |. |.... .      ..   |||..  .| |.|| | .. | . .|. |.|||.. |  |||...   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IRESRKKKTPIPEDTVWFYLRQSLSALAYLHSPKKGGNVPIGIIIHRDIKPQNILIGNDDV----IKVMDFGISRESA-S--FMTTNTTMGTPSYLAPEV
| . ..|.....|...| .. | ..|| |.|. | |.    . |.||||||||| . ...     .|. |||||..   .  . .| |  ||| |..|||
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRK-GP---QRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYT-TQVGTPYYMSPEV

LNDKPFSIKSDIWALGLTILELCTR--NRTFVGE----PVMVLKQHRE-FSNKISLPD-YSQDLCDAIGMMLIKDPQRRPSAGELLEHALI
...|| . |||||.||  . |.||   .. | ..    |  ..|  .. . ..|.    ||||| . | .|| |||. |||. ..||. .|
CQNKPYNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase GL50803_91220.AA Pkinase 20-276 27 3.4e-60 211.1 Pfam 10-293 (293) Show / Hide 
Range on Protein: 20-276
Range on HMM: 10-293/293
Sequence Identity: 27% (82 aa)

GGFGKVFKCKENTTGIIYAVKEVDYAGVPADAVKKVKN--EVHLMLKLAHDNILKPIEFFDDTENEILYIVMDFYERG----DLSKLIRESRKKKTPI--
|.||.|.||..  ||.|.|||.... .   .  .   .  |...|..| |.||.. ...| |  .  .|.||.. | |    ||. .|.   ......  
GSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST--WRHGCFYF

PEDTVWFYLRQSLSALAYLHSPKKGGNVPIGIIIHRDIKPQNILIGNDDVI----KVMDFGISRE--SASFMTTNTTMGTPSYLAPEVLN-DKPFSIKSD
.|... ||..| |..|.|.|| .         |||||.||.|||| |...|    |. |||...     .   ..|  ||| |.||||.. ... . |.|
SEWECKFYMYQILRGLEYCHS-M--------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

IWALGLTILELCTRNRTFVGE---------PVMVLKQHREFSNKISLPDY------------------SQDLCDAIGMMLIKDPQRRPSAGELLEHALI
.|..|... |.....  | |.          ..... .....  .. ..                   |....| |  .| |||..||.| ..|.|  .
MWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase GL50803_91220.AA STE 11-276 24 8.6e-60 204.95 In-house 1-359 (359) Show / Hide 
Range on Protein: 11-276
Range on HMM: 1-359/359
Sequence Identity: 24% (92 aa)

YEKLIMIECGGFGKVFKCKENT---------------TGIIYAVKEVDYAGVPA---------------DAVKKVKNEVHLMLKLA--HDNILKPIEFFD
.|.. .|  |.||.|.|.. .                || |.|.|....    .               . ......|. .| |.   |.|| | .  . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

-----DTENEILYIVMDFYERGDLSKLIRESRKKKTP----------IPEDTVWFYLRQSLSA-LAYLHSPKKGGNVPIGIIIHRDIKPQNILIGNDDVI
     . ... |.|.| . . | |...|..  ... |          .||. . ...|| | . |.|||| .         ||||||||.|||.     .
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---------IIHRDIKPANILL-----V

KVMDFGISRESASFM-----------------TTNTTMGTPSYLAPEVLN------DKPFSIKSDIWALGLTILELCTRNRTFVG-EPV----MVLKQHR
|  |||..   .. |                  .||  ||| . ||||..      ||. ..|.||| ||.||.|..| .  .    |     | .. ..
KLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYH

EFS----------NKISLPD--------------------YSQDLCDAIGMMLIKDPQRRPSAGELLE--HALI
 ..          .  .|||                    .|....| |   |.|||. ||.| .||.  |  |
MQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase GL50803_91220.AA Ciliate-E2 11-276 23 1.8e-55 188.9 In-house 1-365 (365) Show / Hide 
Range on Protein: 11-276
Range on HMM: 1-365/365
Sequence Identity: 23% (90 aa)

YEKLIMIECGGFGKVFKCKENTTGIIY------------------AVKEVDYAGVPADAVKKVKNEVHLM----------------LKLAHDNILKPIEF
|... .|  |.||.|.|||   ..  .                  ..|..    .  . .. .|.| |.|                 .| |.||.| .|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FDDTENEILYIVMDFYERGDLSKLIRESRKKKTPIPE-------DTVWFYLRQSLS---------------ALAYLHSPKKGGNVPIGIIIHRDIKPQNI
| .. .. .|.||.... ||| ..|....||.. ..|         . .. .| |.               || |||| .         ||||||||.||
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKN--------NIIHRDIKPENI

LIGNDDVIKVMDFGISRESASF--------------------------------MTTNTTMGTPSYLAPEVLNDKP---------FSIKSDIWALGLTIL
|.     ||. |||.|..   .                                ...||. ||| |.|||.|| |.          . |.|||.|| .. 
LF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILY

ELCTRNRTFVGEPVMVLKQHREFSNKISLPD-----------------YSQDLCDAIGM----MLIKDPQRRPS-AGELLEHALI
|... .. |       ..|. .   ... |.                  ||.  | |      || |||. |.. . ..|.|  .
EMLFGKPPF-------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase GL50803_91220.AA NEK1 11-276 32 2.5e-49 169.26 In-house 1-276 (276) Show / Hide 
Range on Protein: 11-276
Range on HMM: 1-276/276
Sequence Identity: 32% (92 aa)

YEKLIMIECGGFGKVFKCKENTTGIIYAVKEVDYAGVPADAVKKVKNEVHLMLKLAHDNILKPIEFFDDTENEILYIVMDFYERGDLSKLIRESRKKKTP
|... .|  | |||... |.   |  |. ||      .     ...||| .  |. | || |  | |    . ||||||.. . ||| . | . . |  .
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

IPEDTVWFYLRQSLSALAYLHSPKKGGNVPIGIIIHRDIKPQNILIG--NDD---------------VIKVMDFGISRE-SASFMTTNTTMGTPSYLAPE
..||.   .  |   || . |. |         |.|||||.|||     ...               ..|. ||||.|  . .    .|. ||| || ||
FSEDQIMHWFCQICLALNHIHDRK---------ILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPE

VLNDKPFSIKSDIWALGLTILELCTRNRTFVG--EPVMVLKQHREFSNKISLPDYSQDLCDAIGMMLIKDPQRRPSAGELLEHALI
  . ||   |||||.||    ||||  . | .  ....|||. .    .|. | ||..|   .  |. ..|. |||.  .||   |
ICQNKPYNNKSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIP-PHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase GL50803_91220.AA Ciliate-E2-Unclassified 11-276 24 9.7e-47 160.15 In-house 1-352 (352) Show / Hide 
Range on Protein: 11-276
Range on HMM: 1-352/352
Sequence Identity: 24% (87 aa)

YEKLIMIECGGFGKVFKCKENTTGIIYAVKEVDYAGVPADAVKKVK----------NEVH-------------LMLKLAHDNILKPIEFFDDTENEILYI
|...  |  ||||||.||... .. .|| |.   . . ..  .. |          |.               ..| . | .|.| .. | |..|  .||
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQN--IYI

VMDFYERGDLSKLIR-------------ESRKKKTPIPEDTVW-----FYLRQSLSALAYLHSPKKGGNVPIGIIIHRDIKPQNILIGNDD---VIKVMD
||.. | |||.. |.             ...|..  ..|  .      ||..| |..| |||. ..        ||||||||.|||. |.     ||. |
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNN--------IIHRDIKPENILFDNNGKNYYIKIID

FGISRESASF----------------MTTNTTMGTPSYL----APEVLNDKPFS----IKSDIWALGLTILELCTRNRTFVGEPVMVLK-----------
||||... ..                . ..|..|||.|.    |||||  .  .    .|.|||.||  . |... .. | ..     .           
FGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAY

---QHREFSNK-------------ISLPDYSQDLCD-AIGMMLIKDPQRRPSAGELLEHALI
   ..... .|               ...  .|..   .  || |.|  |... ..|.| ..
RKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase GL50803_91220.AA CAMK 16-209 21 1.1e-44 141.52 In-house 1-321 (425) Show / Hide 
Range on Protein: 16-209
Range on HMM: 1-321/425
Sequence Identity: 21% (71 aa)

MIECGGFGKVFKCKEN-TTG-----------IIYAVKEVDYAGVP--------------------------ADAVKKVKNEVHLMLKLA-------HDNI
 .  |.||||..|..  |||             .|.| .|   ..                          .   |.|..|...| ||        | ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LKPIEFFDD-----------TENE-------ILYIVM---DFYERG----DLSKLIRESRKKK-----------TPIPEDTVWFYLRQSLSALAYLHSPK
.| .|...|           | .         .|.||   .. . |    ||   |.| ...              ..|. . .| || .||..|.||  
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHS--

KGGNVPIGIIIHRDIKPQNILIGNDD-----------------VIKVMDFGISRESAS------------------------FMTTNTTMGTPSYLA-PE
       . |.|||.|| |||. ...                  ||. ||| ...  .                            .|  |||.| | ||
------HN-IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPE

VLND--------------KPFSIKSDIWALG
|||               .. . |.|.|..|
VLNGKGHCNMQNATDEEKPYYGPKCDMWSCG
Kinase GL50803_91220.AA CAMK-Unique 11-209 22 4.2e-43 140.0 In-house 1-280 (363) Show / Hide 
Range on Protein: 11-209
Range on HMM: 1-280/363
Sequence Identity: 22% (66 aa)

YEKLIMIECGGFGKVFKCKENTTGIIYAVKEVDYAGVPADAVKK------------------VKNEVHLMLKLAHDNILKPIEF----FDDTEN------
|...  |. |.||.|..|.  .|| ..|.| |  ...  .. |                    |.|. ..... | ||.|  ..    | | ..      
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

-------EILYIVMDFYERGDLSKLIRE-SRKK---------------KTPIPE--DTVWFYLRQSLSALAYLHSPKKGGNVPIGIIIHRDIKPQNILIG
         .||||.. . |||...| . .  .               ...  |    . |. .. |||.||.|| .         |.|||.|. ||.. 
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQD---------IVHRDLKLENIMVC

ND--D--------------VIKVMDFGISRESASFMTTN---TTMGTPSYLAP--------------EVLNDKPFSIKS----DIWALG
.   |               ||. |||....  .        |. |||.|.||              ||.|  . . ..    |||.||
YSFKDNNHHRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLG
Kinase GL50803_91220.AA ULK 20-276 26 3.7e-41 141.45 In-house 10-329 (329) Show / Hide 
Range on Protein: 20-276
Range on HMM: 10-329/329
Sequence Identity: 26% (86 aa)

GGFGKVFKCKENTT----GIIYAVKEVDYAGVPADAVK--------KVKNEVHLMLKLA----HDN----ILKPIEFFDDTENEILYIVMDFYERGDLSK
| ||||.| . . |    ....|.| .|      .            .|||. .| ||     | |    | | ...| .. .  .||.|.. . |||..
GSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQ

LIRESRK------KKTPIPEDTVWFYLRQSLSALAYLHSPKKGGNVPIGIIIHRDIKPQNILIGNDD------------VIKVMDFGISRESASF----M
.| . .|      .|  ..|. .  ...| |... .||. .         ||||||||||||| |..            |.|. ||| ..   ..     
YIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHN---------IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

TTNTTM------GTPSYLAPEVLN----DKPFS-IKSDIWALGLTILELCTRNRTFVGE-PVMVLKQHREFSNK------------ISLPD------YSQ
 . |.       ||| | ||..|.     ||..  |.||| ||  . |. .    |..     .|.....  |.            .  |.       |.
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISP

DLCDAIGMMLIKDPQRRPSAGELLEHALI
.. | |  ||..|.  | |  ||..| ..
ECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase GL50803_91220.AA TKL 17-274 20 2.2e-40 140.47 In-house 1-364 (364) Show / Hide 
Range on Protein: 17-274
Range on HMM: 1-364/364
Sequence Identity: 20% (78 aa)

IECGGFGKVFKCKENT--------TGIIYAVKEVDY-------------------------AGVPADAVKKVKNEVHLMLKLAHDNILKPIEFFDDTENE
|  ||||.|.| | .         ||   |||                             .  .  . .. ..|. .|..| |.||.. . .  . .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

I-----------LYIVMDFYERGD-LSKLIRESRKKKTPIPEDTVWFYLRQSLSALAYLHS--PKKGGNVPIGIIIHRDIKPQNILIGNDDV--------
            |.|||.....|. |. |.            .      ..  ....||||  || ..      |||||.|..|||. ..          
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCT---KPPIIHRDLKSKNILVDENWTNVSNYMYN

------IKVMDFGISRESASFM--------------------TTNTTMGTPSYLAPEVLNDK----------------PFSIKSDIWALGLTILELCTRN
      .|. |||.||.    .                    ||.|  ||| ..|||||...                ..| |.|... |. . |..|| 
PNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRC

RTFVGEPVM------------VLKQHREFSNKIS-----------LPDYSQDLCDAIGMMLIKDPQRRPSAGELLEHA
| . ..| |            ..  ..     |             ||  ..... . .    ||. |||. |.|.. 
RPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase GL50803_91220.AA STE-Unique 81-276 23 1.1e-34 120.36 In-house 365-616 (616) Show / Hide 
Range on Protein: 81-276
Range on HMM: 365-616/616
Sequence Identity: 23% (62 aa)

ENEILYIVMDFYERGDLSKLIRESRKKKTP---------IPEDTVWFYLRQSLSALAYLHSPKKGGNVPIGIIIHRDIKPQNILIGNDD-----VIKVMD
| . ..|.| ..| | |. .|    |   .         .||. |  |..| | .| |||| .         |||||.|| ||.. .|.      .|. |
EQNWVWIFMEYCEHGTLQQII----KRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHN-------PIIHRDLKPHNIFCMQDGKGRVCKVKICD

FGISRESASF---------------------------------------MTTNTTMGTPSYLAPEVLNDK-----PFSIKSDIWALGLTILELCTRNRTF
||.. ...                                          |  .  ||| | .|||.| .     |.. |.||| || .....|.   ..
FGHATCCQPDHFEKDNNSKNSNTWININNNSSTNSTAQQTPMWDLNINNYTMKYCCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPW

VGEPVM-VLKQHREFSNKISL--------PDYSQDLCDAIGMMLIKDPQRRPSAGELLEHALI
.   .|  . . .  .... .        |...... ..|   | ..|  |||| .||.| . 
HQRYHMQAYIEMCIHIHCQPPQCPIENIPPKCQPEQQQFIEKCLERNPHHRPSAHQLLHHFWL
Kinase GL50803_91220.AA TyrKc 11-274 22 6e-16 35.18 SMART 1-280 (280) Show / Hide 
Range on Protein: 11-274
Range on HMM: 1-280/280
Sequence Identity: 22% (69 aa)

YEKLIMIECGGFGKVFKCKENTTGIIYAVKEVD-YAGVPADAVKKVKNEVHLMLKL--AHDNILKPIEFFDDT-EN----EILYIVMDFYERGDLSKLIR
 ... .. .| ||.|.|.. .   |  ||| .  .|      ..   .|  .| ||   |.||.. .    .  .|    | |.||| . . ||| . .|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

ESRKKKTPIPEDTVWFYLRQSLSALAYLHSPKKGGNVPIGIIIHRDIKPQNILIGNDDVIKVMDFGISRESASF-----MTTNTTM----GTPS-----Y
..|.|   .. ..   .  |  .  .||||           .||||.   |.|.|.. ..|. ||| ||.  .       .   ..    |. .      
KHRPK---LCMKDLLSFCWQIACGMEYLHSK---------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW

LAPEVLNDKPFSIKSDIWALGLTILELCTRNRTFVGEPV---MVLKQHREFSNKI---SLPDY---------SQDLCDAIGMMLIKDPQRRPSAGELLEH
.|||..|.. |..|||.|. | .. |..|.  .   ...   |  .. .|.  .      |..         .... . . .    ||  ||.  |. | 
MAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC

A
 
F
Kinase GL50803_91220.AA Pkinase_Tyr 11-218 26 7.1e-12 40.84 Pfam 1-210 (270) Show / Hide 
Range on Protein: 11-218
Range on HMM: 1-210/270
Sequence Identity: 26% (58 aa)

YEKLIMIECGGFGKVFKCKEN----TTGIIYAVKEVDYAGVPADA--VKKVKNEVHLMLKL-AHDNILKPIEFFD-DTE-NEILYIVMDFYERGDLSKLI
 ... ..  | ||.|.|.. .     |.|  ||| .   |   ..   ..  .|. .| .|  |.||.. .     . | |  .|||| . . ||| .  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGDLLDYL

RESRKKKTPIPEDTVWFYLRQSLSALAYLHSPKKGGNVPIGIIIHRDIKPQNILIGNDDVIKVMDFGISRESASFMTTNT-TMGT-----PSYLAPEVLN
|. |  | |..  .   . .|  ....||.| .         .||||.   |.|.... |.|. ||| .|    . . .  ....        .|||..|
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---------CIHRDLAARNCLVTENNVVKICDFGLARDI--YNDDYYYRKRGGGKLPIKWMAPECIN

DKPFSIKSDIWALGLTILELCTR
.. |..|||.|. | .. |..|.
YGKFTTKSDVWSFGVLMWEIFTY
Kinase GL50803_91220.AA CAMK 246-276 35 1e-06 16.49 In-house 395-425 (425) Show / Hide 
Range on Protein: 246-276
Range on HMM: 395-425/425
Sequence Identity: 35% (11 aa)

SQDLCDAIGMMLIKDPQRRPSAGELLEHALI
||.  | |  || .||..|... . |.|  .
SQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase GL50803_91220.AA STE-Unique 12-72 26 3e-06 17.4 In-house 1-65 (616) Show / Hide 
Range on Protein: 12-72
Range on HMM: 1-65/616
Sequence Identity: 26% (17 aa)

EKLIMIECGGFGKVFKCKENTTGIIYAVKEVDYAGVPADA----VKKVKNEVHLMLKLAHDNILK
.  .||  |.||.|..|. . ..  .|.| .   .         |..  .|. .| .| | || |
NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLHHQNIVK
Kinase GL50803_91220.AA CAMK-Unique 243-276 48 0.176112 0.42 In-house 329-363 (363) Show / Hide 
Range on Protein: 243-276
Range on HMM: 329-363/363
Sequence Identity: 48% (17 aa)

PDY-SQDLCDAIGMMLIKDPQRRPSAGELLEHALI
||| || . |..   .  ||  | || |||||  |
PDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Ank GL50803_91220.AA Ank 323-347 40 0.001383 17.19 Pfam 1-25 (33) Show / Hide 
Range on Protein: 323-347
Range on HMM: 1-25/33
Sequence Identity: 40% (10 aa)

EGKTALMLAAENGHCHIASTLLPYG
.| |.|.||...||  ... || .|
DGFTPLHLACRCGHTEVVKMLLQHG
Ank GL50803_91220.AA Ank 354-374 33 2.319765 5.56 Pfam 1-21 (33) Show / Hide 
Range on Protein: 354-374
Range on HMM: 1-21/33
Sequence Identity: 33% (7 aa)

DGTTALKIALQNANWDVASIL
|| |.| .| .. . .|.. |
DGFTPLHLACRCGHTEVVKML
Ank GL50803_91220.AA Ank 434-464 24 0.007136 14.62 Pfam 1-33 (33) Show / Hide 
Range on Protein: 434-464
Range on HMM: 1-33/33
Sequence Identity: 24% (8 aa)

KGYTALMICARTNYFEIGRMLID--AESKIINN
 |.|.|.. .| .. |. .||..  |.  . ..
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank GL50803_91220.AA Ank 465-492 17 9.327171 3.38 Pfam 1-28 (33) Show / Hide 
Range on Protein: 465-492
Range on HMM: 1-28/33
Sequence Identity: 17% (5 aa)

EGYGAIHIATMNNSLDILPSLVKNEAKL
.|. . |.| ........  |... | .
DGFTPLHLACRCGHTEVVKMLLQHGADV
Ank GL50803_91220.AA Ank 496-517 40 0.012677 13.72 Pfam 1-22 (33) Show / Hide 
Range on Protein: 496-517
Range on HMM: 1-22/33
Sequence Identity: 40% (9 aa)

KGLTALHLAAAANLTDAAQILL
 | |.||||.  . |. .. ||
DGFTPLHLACRCGHTEVVKMLL
Ank GL50803_91220.AA Ank 748-780 27 1.1e-05 24.72 Pfam 1-33 (33) Show / Hide 
Range on Protein: 748-780
Range on HMM: 1-33/33
Sequence Identity: 27% (9 aa)

CGKTALMYAAESGNLEICKLLAPKEANMQYKTY
.| |.|..|...|..|..|.|  . |.   .. 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank GL50803_91220.AA Ank 843-864 36 4.9e-05 22.42 Pfam 1-22 (33) Show / Hide 
Range on Protein: 843-864
Range on HMM: 1-22/33
Sequence Identity: 36% (8 aa)

DGTTALMIAAKAGYADIVQILI
|| |.|..|.. |....|. |.
DGFTPLHLACRCGHTEVVKMLL
Ank GL50803_91220.AA Ank 935-956 40 0.000685 18.29 Pfam 1-22 (33) Show / Hide 
Range on Protein: 935-956
Range on HMM: 1-22/33
Sequence Identity: 40% (9 aa)

LGKTALMVAAEHGHLEAARLLL
 | |.|..|...||.| ...||
DGFTPLHLACRCGHTEVVKMLL
Ank GL50803_91220.AA Ank 970-992 47 0.002653 16.17 Pfam 1-23 (33) Show / Hide 
Range on Protein: 970-992
Range on HMM: 1-23/33
Sequence Identity: 47% (11 aa)

NGATALILATRAGYLDVVKVLVD
.| |.| || | |...||| |..
DGFTPLHLACRCGHTEVVKMLLQ
Ank GL50803_91220.AA Ank 1001-1022 27 0.416525 8.25 Pfam 1-22 (33) Show / Hide 
Range on Protein: 1001-1022
Range on HMM: 1-22/33
Sequence Identity: 27% (6 aa)

KGWFALAIASQRGYLDILNVLL
 |. .| .|...|.....  ||
DGFTPLHLACRCGHTEVVKMLL
Ank GL50803_91220.AA Ank 1032-1053 54 0.001085 17.57 Pfam 1-22 (33) Show / Hide 
Range on Protein: 1032-1053
Range on HMM: 1-22/33
Sequence Identity: 54% (12 aa)

DGATALPIAAQYGQTEIVKALL
|| |.| .|...|.||.|| ||
DGFTPLHLACRCGHTEVVKMLL
Ank GL50803_91220.AA Ank 1063-1085 43 0.000286 19.66 Pfam 1-23 (33) Show / Hide 
Range on Protein: 1063-1085
Range on HMM: 1-23/33
Sequence Identity: 43% (10 aa)

DGETALIRAAAYGRVECVKLLVD
||.|.|  |. .|..|.||.|..
DGFTPLHLACRCGHTEVVKMLLQ
Ank GL50803_91220.AA Ank 1094-1126 33 0.00019 20.3 Pfam 1-33 (33) Show / Hide 
Range on Protein: 1094-1126
Range on HMM: 1-33/33
Sequence Identity: 33% (11 aa)

DGKTALMLAAARGYEDCMNILLPYERDIKTVDG
|| |.|.||. .|.....  || .  |.  .| 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD