Gene GL50803_86934 (G.lamblia)

GL50803_86934

Species: G.lamblia
Alias: GK088, GL50803_86934
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-GL1

Sequence

Name Sequence Type Origin Length Description Download
GL50803_86934.AA Protein None 308 None Fasta, JSON
GL50803_86934.kin_dom Protein Kinase Domain None 259 None Fasta, JSON

Protein domain

Protein domains of GL50803_86934.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Pkinase GL50803_86934.AA Pkinase 10-267 23 1.3e-34 123.5 Pfam 1-293 (293) Show / Hide 
Range on Protein: 10-267
Range on HMM: 1-293/293
Sequence Identity: 23% (72 aa)

EDLGAELGSGAHGTVYGLKSAPDR---AVKEIPTDGLPPDAQASLEL--ELRTLPRLRHPNVVEYGRVVRHEGYIYVEMRRYAG-----SLDGAIRSLRR
  .|  .|||. |.||  .   ..   |||.|. ..  .. . .. .  |.. . ||.|||.|.. .... ...||. |    |     .|   |.  .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-WR

RRQL--APREMVVAVLRQVGAGLAYLHRPGKTDAAGAPLPALTHCDLRPANVLLDEAGAE---FAISDFGLCR---EGPGGLASMAV--PVYAAPEVLR-
.. .   ..| .  ...|.  ||.|.|.               |.|| |.|.|.|. |     . |.||||..   . ... ..  .  | |.||||.| 
HGCFYFSEWE-CKFYMYQILRGLEYCHSM-----------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRG

GGSHTPAADMWSLGMVAYELAAGGRPPFLSG-----RAPAEVYVAGWRPDLGAVGD-----------------------PVVRGVLAHLLVLEPERRLTA
|  ..|..||||.| . ||..  ||||| .      . . ....   .|.|    .                       .  . ..  .| . |..|.||
GQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTA

AALVEL--L
. ...   .
EQILQHPWF
S_TKc GL50803_86934.AA S_TKc 10-267 24 1.8e-28 101.82 SMART 1-231 (231) Show / Hide 
Range on Protein: 10-267
Range on HMM: 1-231/231
Sequence Identity: 24% (67 aa)

EDLGAELGSGAHGTVYGLKSAP---DRAVKEIPTDGLPPDAQASLELELRTLPRLRHPNVVEYGRVVRHEGYIYVEMRRYAG---SLDGAIRSLRRRR--
 ... ..|.|| |.||  .        |.|.|.          ... |.. | . .|||.| .  | .. ...|. |    |   .|   |.. .|..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

QLAPREMVVAVLRQVGAGLAYLHRPGKTDAAGAPLPALTHCDLRPANVLLDEAGAEFAISDFGLCREGPGGLASMAVPVYAAPEVLRGGSHTP-AADMWS
.  |  ..  ...|.  .|.|.|. |             |.|| |.|.||||   .  |.||||.|.          | | |||||   .... ..|.||
FPFPE-HARFYMYQICCALEYCHSHG-----------IIHRDLKPENILLDE---HIKICDFGLARQL---TTFCGTPWYMAPEVL---GYGKCKCDWWS

LGMVAYELAAGGRPPFLSGRAPAEVYVAGWRPDLGAVGDPVVRGVLAHLLVLEPERRLTAAALVE---------LL
.| . ||... |.|||     .....            .| ..  . ..|. .||.|.||  . .          .
CGCILYEMLC-GYPPFP---QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_86934.AA TKL 114-267 18 2.4e-20 70.0 In-house 139-364 (364) Show / Hide 
Range on Protein: 114-267
Range on HMM: 139-364/364
Sequence Identity: 18% (43 aa)

RQVGAGLAYLHR--P--GKTDAAGAPLPALTHCDLRPANVLLDEAGAE-------------FAISDFGLCREGPGG---------------------LAS
...  |..|||   |  ..        |.. |.|| ..|.|.|| .                 |.||||.|.  .                        .
LDIARGMNYLHSMNPKWCT-------KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTM

MAV--PVYAAPEVLRGG----------------SHTPAADMWSLGMVAYELAAGGRPPFLSGRAP------------AEVYVAGWRPDLG----------
. .  | . |||||||                 . ....|..| |.| .|.... | |.     .            . |.. | || .           
TQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMC

--AVGDPVVRGVLAHLLVLEPERRLTAAALVELL
     .| ..  . .    .|| |...  ... |
PCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase GL50803_86934.AA TK 10-267 14 2.4e-18 57.41 In-house 1-486 (486) Show / Hide 
Range on Protein: 10-267
Range on HMM: 1-486/486
Sequence Identity: 14% (71 aa)

EDLGAELGSGAHG---TVY-G---------------------------LKSAPDRAVKEIPTDGLPPDAQASL--------------ELELRTLPR---L
  || .||.|. |   .|| |                            .   . ||| .  .    ...  .              |.| . . .   .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHPNVVEYGRVVRHEG--------------YIYVEMRRYA---GSLDGAIRSLRR---------------------------------------------
.|||.|    |. ...              .| .|.  .    |||.   |. |.                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------------------------RRQLAPREMVVAVLRQVGAGLAYLHRP---GKTDAAGAPLPALTHCDLRPANVLLDEAGA----------EF
                            ..|| .....    .|. .|..|||.    .         . . | ||   |.|..| .             
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL--MCWQIACGMEYLHSKNCEF--------IQNFVHRDLAARNCLVGENNVCKWHFDGCGPVC

AISDFGLCREGPGGLASMAVPV---------------------------------------YAAPEVLRGGS---------HTPAADMWSLGMVAYELAA
 |.||||.|.|  |. . ...                                        . |||.|...          .|.. |.||.| . .|.  
KIADFGLSRQGS-GVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT

GG-RPPF--LSG---------RAPAEVYVAG---------------WRPDLGAVGD-------------PVVRGVLAHLLVLEPERRLTAAALVELL
 |  |.   .|          .   |  ..|                .|      |             ...  ..     ..||.| | ..|.| |
YGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase GL50803_86934.AA AGC 141-214 24 4.8e-18 41.81 In-house 177-304 (395) Show / Hide 
Range on Protein: 141-214
Range on HMM: 177-304/395
Sequence Identity: 24% (32 aa)

HCD-LRPANVLLDEAGAEFAISDFGLCREGPGG----------------------------------------------------LASMAV----PVYAA
| | | | |.||||      ..||||| ||...                                                    ...  .    | | |
HRDYLKPENILLDED-GHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMA

PEVLRGGSHTPAADMWS--LGMVAYELAAGGRP
||.|    ...|.| ||  || . ||. .|  |
PEIL----YGKACDWWSFGLGCLMYEMLTGYPP
Kinase GL50803_86934.AA Ciliate-E2-Unclassified 143-218 26 9.2e-14 44.13 In-house 169-272 (352) Show / Hide 
Range on Protein: 143-218
Range on HMM: 169-272/352
Sequence Identity: 26% (28 aa)

DLRPANVLLDEAGA--EFAISDFGLCR-------EGPGG------------LASMA-VPVYA----APEVLRGGSHT----PAADMWSLGMVAYELAAGG
|. | |.|.|. |   .  |.|||...       .  .             . ...  | |     |||||.|  .      ..|.||||...||.  | 
DIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGY

RPPFLS
 .|| .
-YPFYD
Kinase GL50803_86934.AA TyrKc 10-267 22 3e-13 -8.45 SMART 1-280 (280) Show / Hide 
Range on Protein: 10-267
Range on HMM: 1-280/280
Sequence Identity: 22% (69 aa)

EDLGAELGSGAHGTVYG--LKSAPDRAVKEIPTDGLPPDAQASLELELRTLPRL--RHPNVVEYGRVVRHEG---------YIYVEMRRYAGSLDGAIRS
  || .||.|| |.||   .|   . ||| .  |      .. .  |.| . .|  .|||.|    |....|         .| .|   . |.|.  .|.
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLRK

LRRRRQLAPREMVVAVLRQVGAGLAYLHRPGKTDAAGAPLPALTHCDLRPANVLLDEAGAEFAISDFGLCREGPGG----------LA-----SMA-VPV
 |..    . .  .    |. .| .|||.             . | ||   |.|..| .    ||||||.|..  .           .     . . .|.
HRPK---LCMKDLLSFCWQIACGMEYLHSK-----------NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI

-YAAPEVLRGGSHTPAADMWSLGMVAYELAAGGRPPF-------LSGRAPAEVYVAGWRPDLGAV--------GDPVVRGVLAHLLVLEPERRLTAAALV
   |||... |  |.. | || | . .|.   | .|        .| .   |   .| |..  .           . .  .       .|| | | ....
RWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIH

ELL
|..
ECF
Kinase GL50803_86934.AA MSK 141-214 31 3e-13 41.14 In-house 124-209 (277) Show / Hide 
Range on Protein: 141-214
Range on HMM: 124-209/277
Sequence Identity: 31% (27 aa)

HCDLRPANVLLDEA--GAEFAISDFGLCREGPGGLASMAVP-----VYAAPEVLR----GGS-HTPAADMWSLGMVAYELAAGGRP
| || | |.|.|.   ...  ..|||. |. | . .  . .      |.|||.||    . . . .| |.|||| . |..  | .|
HRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVILYTMLTGQVP
Kinase GL50803_86934.AA RSK 143-214 32 3e-13 45.13 In-house 129-211 (278) Show / Hide 
Range on Protein: 143-214
Range on HMM: 129-211/278
Sequence Identity: 32% (27 aa)

DLRPANVLLDE--AGAEFAISDFGLCREGPGG-LASMAVPV----YAAPEVLR----GGSHTPAADMWSLGMVAYELAAGGRP
|| | |.|.|.    ..  ..|||.|....      .  ..    |.|||.|.    .| |. |.| |||| . ||. .| .|
DLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPP
Kinase GL50803_86934.AA UTK 11-216 21 3.3e-13 41.52 In-house 2-241 (296) Show / Hide 
Range on Protein: 11-216
Range on HMM: 2-241/296
Sequence Identity: 21% (55 aa)

DLGAELGSGAHGTVYGLKSAP--------DRAVKEIPTDGLPPDAQA---SLELELR---TLPRLR-HPNVVE-YGRVVRHEGYIYVEMRRYA-GSLDGA
 ||..||.|| |.|.  .  .        |.|||.  ...  .....    . .| |    . ... ||||.  .| ... |. ... .. .. |.|.  
QLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP-WMIVTEYMENGDLRSY

IRSLRRR---RQLAPREM-VVAVLRQVGAGLAYLHRPGKTDAAGAPLPALTHCDLRPANVLLDEAG------AEFAISDFG---LCREGP---------G
 |. |.    .... ..   .   ... .|..|||. |           . |.||   |.|... .        ..|.|||   ..|. .         .
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCG-----------FVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWE

GLASMAVPVYA------APEVLRGG-SHTPAADMWSLGMVAYELAAGGRPPF
 . .|| .. .      |||.|  .  .| . |.||.| | .|. ..|| |.
SYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPY
Kinase GL50803_86934.AA ULK 141-216 22 1e-12 40.79 In-house 153-257 (329) Show / Hide 
Range on Protein: 141-216
Range on HMM: 153-257/329
Sequence Identity: 22% (24 aa)

HCDLRPANVLLDEAGAE-----------FAISDFGLCRE-GPG----GLASMAV--------PVYAAPEVLR----GGSHTPA-ADMWSLGMVAYELAAG
|.|. |.|.|...  .            . |.|||...    .     ..  .|        | | ||..|     .  .. . .|.||||.. ||.  |
HRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYG

GRPPF
  |..
KPPFY
Kinase GL50803_86934.AA CAMK 141-211 22 1.8e-12 35.8 In-house 202-330 (425) Show / Hide 
Range on Protein: 141-211
Range on HMM: 202-330/425
Sequence Identity: 22% (29 aa)

HCDLRPANVLLDEAG----------------AEFAISDFGLCREGPGGL---------------------------ASMAVPVYAA-PEVLRGGS-----
|.|| | |.|||. .                .   |.|||. .. ..|                             .   | |.| ||||.| .     
HRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQ

---------HTPAADMWSLGMVAYELAAG
         ..|..||||.| . | .  |
NATDEEKPYYGPKCDMWSCGVILYIMLCG
Kinase GL50803_86934.AA STE 143-211 25 5.6e-09 27.98 In-house 177-264 (359) Show / Hide 
Range on Protein: 143-211
Range on HMM: 177-264/359
Sequence Identity: 25% (24 aa)

DLRPANVLLDEAGAEFAISDFGLCREGPGGLA-------------------SMA-VPVYAAPEVLRG------GSHTPAADMWSLGMVAYELAAG
|. |||.||        ..|||.|      .|                   ...  | . ||||...      . ..  .|.|||| .. |.| |
DIKPANILL------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATG
Kinase GL50803_86934.AA CAMK 15-67 14 1.3e-07 19.84 In-house 1-101 (425) Show / Hide 
Range on Protein: 15-67
Range on HMM: 1-101/425
Sequence Identity: 14% (15 aa)

ELGSGAHGTVYGLKSAPDR---------------AVKEIPTDGLP--------------------------PDAQASLELELRTLPR-------LRHPNV
.||.|. |.|.  .   .                |.| |... |.                          |  ..... |.. . .       |.|||.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

V
.
I
Kinase GL50803_86934.AA STE 10-69 12 1e-06 19.8 In-house 1-95 (359) Show / Hide 
Range on Protein: 10-69
Range on HMM: 1-95/359
Sequence Identity: 12% (12 aa)

EDLGAELGSGAHG-TVYGLKSAPD-----------------RAVKEIPTDGLPP---------------DAQASLELELRTLPRLR--HPNVVEY
 ..  ..|.|| | ......  ..                  |.|... .   .               . . ... |.... ...  |||.|.|
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKY
Kinase GL50803_86934.AA TKL 16-69 21 0.010053 5.65 In-house 1-90 (364) Show / Hide 
Range on Protein: 16-69
Range on HMM: 1-90/364
Sequence Identity: 21% (19 aa)

LGSGAHGTVYGLKSA-----------PDRAVKEIPTDGLPP----------------------DAQASLELELRTLPR---LRHPNVVEY
.|||. |.||  |              | ||| ....                          .|.   . | . .     |||||.| .
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQF
Kinase GL50803_86934.AA ULK 15-69 20 0.058597 2.73 In-house 6-83 (329) Show / Hide 
Range on Protein: 15-69
Range on HMM: 6-83/329
Sequence Identity: 20% (16 aa)

ELGSGAHGTVYGLK---S----APDRAVKEIPTDGLPPDAQA--------SLELELRTLPRLR--------HPNVVEY
.||.|. |.||  .   .    . . |.| |. . .  . .         .|. | ... .|         |||.|..
CLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKL