Gene GL50803_8445 (G.lamblia)

GL50803_8445

Species: G.lamblia
Alias: GL50803_8445, GK163
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_8445.AA Protein None 597 None Fasta, JSON
GL50803_8445.kin_dom Protein Kinase Domain None 268 None Fasta, JSON

Protein domain

Protein domains of GL50803_8445.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_8445.AA NEK 10-277 34 2.6e-88 299.7 In-house 1-286 (286) Show / Hide 
Range on Protein: 10-277
Range on HMM: 1-286/286
Sequence Identity: 34% (101 aa)

YRELMAIKRGHYGIVHKVEHISTKKI-----YARKTVKYGKLDQRGVELIM-REANLLSRMKHINVLGYHDVVIDEVEKVIYIFTEFCN-KGDLFQL---
|...  | .| .| |.||...|..|.     |. | ...|.....  .  .  |...|...|| |. .|.|  |.|    ..|  |.|. .|||.|.   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IDKHRYPRTNIPEERIWKLFGQLLLALEYCH---CPTKENFELGEIVIHRDIKPANILITNDDV----VKLADFGFSRSFNSS-DMLKT-QLGTPSYTAP
| |..  .....|| ||. | |..||| |.|    |          ..||||||.|| .|...     ||. ||| |. .|.. ||..| | ||| | .|
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGP-------QRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSP

EVLNKTPYNEKADIWSLGCVIFHLCSL--EFPFQAM--THADLARNVRDG-KRRPFPQGI-YSKELEELVDSMMIVDYTQRPSAAQLIRHRKF
||..  |||.|.||||||||....|.|  . ||.|    .  |. ... | .  | |. . ||..| .|. .|  .| .||||. |.. .   
EVCQNKPYNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase GL50803_8445.AA NEK2 10-277 32 2e-80 270.52 In-house 1-319 (319) Show / Hide 
Range on Protein: 10-277
Range on HMM: 1-319/319
Sequence Identity: 32% (104 aa)

YRELMAIKRGHYGIVHKVEHISTKKIYARKTVKYGKLDQRGVELIMREANLLSRMKHINVLGYHDVVIDEVEKVIYIFTEFCNKGDLFQLIDKHRYPRTN
|  | .| .| .| . || ..|..|| ..|  .||...     .   | |.|.  || |.  | | .||. ....||  |.|  ||| |.| | |  |. 
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQY

IPEERIWKLFGQLLLALEYCHC---------------PTKENFELGEIVIHRDIKPANILITNDDV----------------------------------
..|| ||. . ||..||  ||                | . .   .....|||||||||    |.                                   
MEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDG---KHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMD

-----VKLADFGFSRSFN-SSDMLKTQLGTPSYTAPEVLNKTPYNEKADIWSLGCVIFHLCSLEFPFQAMTHADLARNVRDGKRRPFPQGIYSKELEELV
     ||| |||  |. | ..   .|  ||| |  ||...  .|||| ||||.||.|. .|.|  ||||   | |.  .. |. |. |  .||..| |..
YSQVVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPY-QYSRHLNEII

DSMMIVDYTQRPSAAQLIRHRKF
 .|. ||  .|||   ...|   
HFMINVDHYHRPSIEEILQHPQI
Kinase GL50803_8445.AA S_TKc 10-277 29 1.8e-76 261.29 SMART 1-231 (231) Show / Hide 
Range on Protein: 10-277
Range on HMM: 1-231/231
Sequence Identity: 29% (82 aa)

YRELMAIKRGHYGIVHKVEHISTKKIYARKTVKYGKLDQRGVELIMREANLLSRMKHINVLGYHDVVIDEVEKVIYIFTEFCNK--GDLFQLIDKHRYPR
|. |  | .| .| |.|. |..|..|.| | .|         | |.|| ..|.. .| |.  ..||  |   . .|...|.|.   ||||..|.|.....
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

TN--IPEERIWKLFGQLLLALEYCHCPTKENFELGEIVIHRDIKPANILITNDDVVKLADFGFSRSFNSSDMLKTQLGTPSYTAPEVLNKTPYNE-KADI
..  .|| ...... |...||||||   .        .||||.||.|||...  ..|..|||..| .      .|. ||| | |||||   .|.  |.|.
LRFPFPE-HARFYMYQICCALEYCHSH-G--------IIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDW

WSLGCVIFHLCSLEFPFQAMTHADLARNVRDGKRRPFPQGIYSKELEELVDSMMIVDYTQRPSAAQLIR-------HRKF
||.||... ... . ||.  ... . ....            |.|. .... .. .| ..||.| .. .       |  |
WSCGCILYEMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_8445.AA CAMK 15-277 18 6.9e-67 214.3 In-house 1-425 (425) Show / Hide 
Range on Protein: 15-277
Range on HMM: 1-425/425
Sequence Identity: 18% (81 aa)

AIKRGHYGIVHKVEHISTK------------KIYARKTVKYGKLD--------------------------QRGVELIMREANLLSR-------MKHINV
 . || .|.|....|..|.            . .| | ..  ||.                          ..  . ..|| .....       ..| |.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LGYHDVVIDEV-----------------EKVIYIFT---EFCNKG----DLFQLIDKHRYPRTN-----------IPEERIWKLFGQLLLALEYCHCPTK
.  ..|  |.                  .| .|...   |.|  |    |||. | .|.... .           ..|.   ..| |.. |..|||    
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCH----

ENFELGEIVIHRDIKPANILITNDD-----------------VVKLADFGFSRSFNS------------------------SDMLKTQLGTPSYTA-PEV
   ...  ..|||.|| |||.....                  .|..||||.. |..                         ...||. |||.| | |||
---SHN--IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEV

LNK--------------TPYNEKADIWSLGCVIFHLCSLEFPFQAM-------------THADLARNVRDGKRR-PFP-------------QGIYSKE--
||.              ..|..|.|.||.|.. . . . ..||..              .  .| .... || . | |              .  |.|  
LNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFH

------LEELVDSMMIVDYTQRPSAAQLIRHRKF
         |. .|. || ..|....|  .|  .
HFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase GL50803_8445.AA STE 10-278 21 5.2e-61 209.01 In-house 1-359 (359) Show / Hide 
Range on Protein: 10-278
Range on HMM: 1-359/359
Sequence Identity: 21% (80 aa)

YRELMAIKRGHYGIVHKVEHIS---------------TKKIYARKTVKYGKLDQ---------------RGVELIMREANLLSRMK--HINVLGYHDVVI
.. .  | .| .| |.|  ..                |..|.| | ... . ..                 .. |..| .......  | |.  |..  .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DE-----VEKVIYIFTEFCNKGDLFQLID-KHRYPRTN---------IPEERIWKLFGQLLLA-LEYCHCPTKENFELGEIVIHRDIKPANILITNDDVV
.|      .  ..|. |... | | ..|. |.  ....         .||. | .   |.| . |.| |       ...  .|||||||||||.     |
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLH-------SHH--IIHRDIKPANILL-----V

KLADFGFSRSFNS-----------------SDMLKTQLGTPSYTAPEVLNK------TPYNEKADIWSLGCVIFHLCSLEFPF---QAM---THADLARN
||.|||.. ....                 . . .|  ||| . ||||...       .|..|.|||||||.| ...  . |.   . |    ..     
KLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYH

VRD---------GKRRPFPQG------------------IYSKELEELVDSMMIVDYTQRPSAAQLIR--HRKFI
. .         |.  |.|.                    .|.|. . ..   . |. .||.| ||..  | .||
MQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEH-PFI
Kinase GL50803_8445.AA Ciliate-E2 10-277 22 2.8e-58 198.68 In-house 1-365 (365) Show / Hide 
Range on Protein: 10-277
Range on HMM: 1-365/365
Sequence Identity: 22% (86 aa)

YRELMAIKRGHYGIVHKVEHISTK-----------------------KIYARKTVKYGKLDQRG-VELIMREAN----------LLSRMKHINVLGYHDV
|  .  | .| .|.| |.......                       |||| |..|  .. |   .. |||| |          .|....| |.. ....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

VIDEVEKVIYIFTEFCNKGDLFQLIDKHRYPRTNIPE-------ERIWKLFGQLLL---------------ALEYCHCPTKENFELGEIVIHRDIKPANI
 ... .. ||. .|.|. ||||..| ...  |....|       . | ... |.|                ||||.|       . .  .||||||| ||
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLH-------SKNN-IIHRDIKPENI

LITNDDVVKLADFGFSRSFNSS--------------------------------DMLKTQLGTPSYTAPEVLNKTP---------YNEKADIWSLGCVIF
|.     .|..|||.|. .. .                                .| .|..||| | |||.||. .         |..|.||||||....
LF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILY

HLCSLEFPFQAMTHADLARNVRDGKRRPFPQ----------------GIYSKELEELVDS----MMIVDYTQRPS-AAQLIRHRKF
 ... ..||         ..  ..| . ...                   |.|   |       |. .|  .|.. . |.. |  |
EMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase GL50803_8445.AA Pkinase 10-277 25 1.6e-57 202.22 Pfam 1-293 (293) Show / Hide 
Range on Protein: 10-277
Range on HMM: 1-293/293
Sequence Identity: 25% (80 aa)

YRELMAIKRGHYGIVHKVEHISTKKIYARKTVKYGKLDQRGVELIMR--EANLLSRMKHINVLGYHDVVIDEVEKVIYIFTEFCNKG----DLFQLIDKH
|. .  | .| .| | |  |..| ||.| |..|. . .    .   |  |. .. |..| |.. ..|.. |  .. ||. .|.|..|    ||| .|   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST-

RYPRTNI--PEERIWKLFGQLLLALEYCHCPTKENFELGEIVIHRDIKPANILITNDDVV----KLADFGFSRS--FNSSDMLKTQLGTPSYTAPEVLN-
   ....  .|. . . . |.| .|||||            .||||.||.|||| |....    |..|||...     ..  ..|  ||| | ||||.. 
-WRHGCFYFSEWECKFYMYQILRGLEYCHSM---------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRG

KTPYNEKADIWSLGCVIFHLCSLEFPFQAM----THADLARNVRDGKRRPFPQGIYS---------------------KELEELVDSMMIVDYTQRPSAA
 ..|  |.|.||.||... ... ..||.      .| .... .|......  .  ..                     .|. ......  .| ..||.|.
GQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAE

QLIRHRKF
|.  |  |
QILQHPWF
Kinase GL50803_8445.AA NEK1 10-278 32 4.4e-54 185.97 In-house 1-276 (276) Show / Hide 
Range on Protein: 10-278
Range on HMM: 1-276/276
Sequence Identity: 32% (94 aa)

YRELMAIKRGHYGIVHKVEHISTKKIYARKTVKYGKLDQRGVELIMREANLLSRMKHINVLGYHDVVIDEVEKVIYIFTEFCNKGDLFQLIDKHRYPRTN
| .. .|  | .| . .| | .  . |. |  .  |  .   |  |.|...|..||| |. .| .  . .   . ||  |.|. |||.| | . .     
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

IPEERIWKLFGQLLLALEYCHCPTKENFELGEIVIHRDIKPANILIT--NDD---------------VVKLADFGFSRSFNSSDML-KTQLGTPSYTAPE
..|  |   | |. ||| . |   ...      ..|||||. ||  |  ...               .|||.||| .|  |... . .| .||| |  ||
FSEDQIMHWFCQICLALNHIH---DRK------ILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPE

VLNKTPYNEKADIWSLGCVIFHLCSLEFPFQAMTHADLARNVRDGKRRPFPQGIYSKELEELVDSMMIVDYTQRPSAAQLIRHRKFI
  .. ||| | ||||||||   || |  ||.|     |   .  |   | |.  ||.||..|| .|  ..   |||. |.   | ||
ICQNKPYNNKSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPH-YSYELQSLVSQMFKRNPRHRPSVNQIL-ERPFI
Kinase GL50803_8445.AA CAMKL 10-277 27 1.7e-51 162.5 In-house 1-297 (297) Show / Hide 
Range on Protein: 10-277
Range on HMM: 1-297/297
Sequence Identity: 27% (86 aa)

YRELMAIKRGHYGIVHKVEH-ISTKKIYARKTVKYGKLDQRGVEL-------------IMREANLLSRMK---HINVLGYHDVVID-----EVEKVIYIF
|| .  . .|..| |   .| . |.. .| | ..  |.  . . .             | ||........   | |.   ..|. .     |  | ||..
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIET-KKIYLV

TEFCNKGD--LFQLIDKHRYPRTNIPEERIWKLFGQLLLALEYCHCPTKENFELGEIVIHRDIKPANILITNDD--VVKLADFGFS---RS--FNSSDML
.| |  |.  ||. |.||...|  .||.   ..| |.. |..|||       ..|  ..|||||| |||.....  ..|..|||||   |   |.. ..|
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCH-------SHG--IVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKL

KTQLGTPSYTAPEVLNK--TPYN-EKADIWSLGCVIFHLCSLEFPFQAMTHA-------DLARNVRDGKRRPFPQGIYSKELEELVDSMMIVDYTQRPSA
||. |.|.| |||....  .||.  |.||||.| . . .   ..|| . |..        | . .. |  .| .    | ... |  .|. |. ..||..
KTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTI

AQLIRHRKF
 |. .|. .
HQIMNHPWM
Kinase GL50803_8445.AA Ciliate-E2-Unclassified 10-277 23 4.5e-50 171.87 In-house 1-352 (352) Show / Hide 
Range on Protein: 10-277
Range on HMM: 1-352/352
Sequence Identity: 23% (85 aa)

YRELMAIKRGHYGIVHKVEHISTKKIYARKTVK----YGKLDQRGVELIMREANLLSRMK-----------------HINVLGYHDVVIDEVEKVIYIFT
|. .  | .| .|.|.|..|...|..|| |. |    | .. .. .. ||.|.. . ..|                 | . . .... ... .. ||| .
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EFCNKGDLFQLID-------------KHRYPRTNIPEERIW-----KLFGQLLLALEYCHCPTKENFELGEIVIHRDIKPANILITNDD---VVKLADFG
|.|. |||.| |              .... |  ..|. .      ..| |.|..|||.|       ..   .||||||| |||..|.     .|..|||
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLH------HKN--NIIHRDIKPENILFDNNGKNYYIKIIDFG

FSR----------------SFNSSDMLKTQLGTPSYT----APEVLNKTPYN----EKADIWSLGCVIFHLCSLEFPFQAMTHAD---------------
.|.                ......|..|. |||.|     ||||| .  |.    .|.||||||.... ..  ..||.. .  .               
ISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRK

-LARNVRDG--KRRPFPQ----GIYSKELEELVD----SMMIVDYTQRPSAAQLIRHRKF
 | .|  ..  . ..||.     . |.| ....     .|. ..  .|... |.. |  |
QLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase GL50803_8445.AA ULK 143-277 30 1.8e-41 142.52 In-house 151-329 (329) Show / Hide 
Range on Protein: 143-277
Range on HMM: 151-329/329
Sequence Identity: 30% (54 aa)

VIHRDIKPANILITNDD------------VVKLADFGFSRSFNSS----DMLKTQL------GTPSYTAPEVLN----KTPYN-EKADIWSLGCVIFHLC
.|||||||.||||.|..            |.|.|||||.......    .|..|..      ||| | ||..|.    . ||.  |.|||||||... . 
IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEML

SLEFPFQAMTHADLA-----RNVRDG---------KRRPFP----QGIYSKELEELVDSMMIVDYTQRPSAAQLIRHRKF
  . ||.|.   |.      ......         .   ||    . . |.|...|   |...| ..| |  .|. |  |
YGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase GL50803_8445.AA ULK 143-277 29 1.6e-39 137.63 In-house 147-324 (324) Show / Hide 
Range on Protein: 143-277
Range on HMM: 147-324/324
Sequence Identity: 29% (53 aa)

VIHRDIKPANILITNDD------------VVKLADFGFSRSFNSS----DMLKTQL------GTPSYTAPEVLN----KTPYN-EKADIWSLGCVIFHLC
.|||||||.||||.|..            |.|.|||||......     .|..|..      ||| | ||..|.    . ||.  |.|||||||... . 
IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEML

SLEFPFQAMTHADLA----RNVRDG---------KRRPFPQGI----YSKELEELVDSMMIVDYTQRPSAAQLIRHRKF
  . ||...   |.     . .. |         .  .|| ..     |.|...|   |...| ..| |  ... |  |
YGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase GL50803_8445.AA TyrKc 10-277 20 3.8e-16 38.36 SMART 1-280 (280) Show / Hide 
Range on Protein: 10-277
Range on HMM: 1-280/280
Sequence Identity: 20% (63 aa)

YRELMAIKRGHYGIVHKVEHISTKKIYARKTVKYGKLDQRGVELIMREANLLSRM--KHINVLGYHDVVIDEVE-----KVIYIFTEFCNKGDLFQLIDK
 . .  . .|..|.|.| . .      | |..| ..     .| .||||.....   .| |..  . |.... .     . ..| .|.. .||| . . |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

HRYPRTNIPEERIWKLFGQLLLALEYCHCPTKENFELGEIVIHRDIKPANILITNDDVVKLADFGFSRSFNSS-------DMLKTQL--GTPS-----YT
||     .. .   .   |     || |            .||||.   |.|.... .|| .||| ||   .        |. ...   |. .      .
HRPK---LCMKDLLSFCWQIACGMEYLHSK---------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM

APEVLNKTPYNEKADIWSLGCVIFHLCSLEFPFQA------MTHADLARNVRDGKRRPFPQG-------IYSKELEELVDSMMIVDYTQRPSAAQLIRHR
|||..|.  ...| |.|| | ... ....  .         |. ... ..|..|.|.| |.        . ..|. ..  .    |  .||. ...  |.
APECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HE

KF
.|
CF
Kinase GL50803_8445.AA ULK 19-128 22 1.8e-14 47.78 In-house 10-141 (324) Show / Hide 
Range on Protein: 19-128
Range on HMM: 10-141/324
Sequence Identity: 22% (30 aa)

GHYG-IVHKVEHIST---KKIYARKTVKYGKLDQRGVE--------LIMREANLLSRMK---HIN--VLGYHDVVIDEVEKVIYIFTEFCNKGDLFQLID
| .|  |.| ... |   ....| | .   |. .   |        |...| ...  .|   | |  .  ..|.  .  .. |||..|.|| |||.|.| 
GSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIK

KHRY-----PRTNIPEERIWKLFGQLLLALEY
|...        ...|. . . | |.. .. .
KNKKLPETEEKKRLSEQEAIQFFKQICNGFKE
Kinase GL50803_8445.AA ULK 19-128 24 2.3e-14 46.63 In-house 10-145 (329) Show / Hide 
Range on Protein: 19-128
Range on HMM: 10-145/329
Sequence Identity: 24% (33 aa)

GHYGIVHKVEHISTK----KIYARKTVKYGKLDQRGVE--------LIMREANLLSRMK----HIN----VLGYHDVVIDEVEKVIYIFTEFCNKGDLFQ
| .| |.| ... ||    ...| | .   |..|   |        |...|  .. ..|    |.|    .  ..|.  .  .. |||..|.|| |||.|
GSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQ

LIDKHRY------PRTNIPEERIWKLFGQLLLALEY
.| |...         ...|. . . | |.| .. .
YIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKE
Kinase GL50803_8445.AA Pkinase_Tyr 144-244 29 1.7e-12 42.96 Pfam 133-240 (270) Show / Hide 
Range on Protein: 144-244
Range on HMM: 133-240/270
Sequence Identity: 29% (32 aa)

IHRDIKPANILITNDDVVKLADFGFSRSFNSSDML-KTQLGTPS---YTAPEVLNKTPYNEKADIWSLGCVIFHLCSLE-FP-FQAMTHADLARNV-RDG
||||.   |.|.|.. ||| .||| .|   . |   ... |..     .|||..|   ...| |.|| | ... ....   | .. |. ... . . .||
IHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDG

KRRPFPQG
 | | |..
YRMPCPEN
Kinase GL50803_8445.AA Pkinase_Tyr 55-96 36 0.006077 10.59 Pfam 51-94 (270) Show / Hide 
Range on Protein: 55-96
Range on HMM: 51-94/270
Sequence Identity: 36% (16 aa)

MREANLLSRM-KHINVLGYHDVVIDEVEK-VIYIFTEFCNKGDL
||||.... . .| |.. .. |..|. |   ||| .|.. .|||
MREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL
Ank GL50803_8445.AA Ank 413-431 31 0.258046 9.0 Pfam 1-19 (33) Show / Hide 
Range on Protein: 413-431
Range on HMM: 1-19/33
Sequence Identity: 31% (6 aa)

DGMTALMRAVQMNDIAGIK
||.|.|. |......  .|
DGFTPLHLACRCGHTEVVK
Ank GL50803_8445.AA Ank 444-465 31 0.562279 7.78 Pfam 1-22 (33) Show / Hide 
Range on Protein: 444-465
Range on HMM: 1-22/33
Sequence Identity: 31% (7 aa)

KGKTALMMCSDTGKTEAAALLI
 | |.|.. .  | || . .|.
DGFTPLHLACRCGHTEVVKMLL
Ank GL50803_8445.AA Ank 475-495 47 0.00199 16.62 Pfam 1-21 (33) Show / Hide 
Range on Protein: 475-495
Range on HMM: 1-21/33
Sequence Identity: 47% (10 aa)

DGTTALILAAIAGHVDIVNIL
|| |.| ||.. ||...|  |
DGFTPLHLACRCGHTEVVKML
Ank GL50803_8445.AA Ank 506-528 43 0.01404 13.56 Pfam 1-23 (33) Show / Hide 
Range on Protein: 506-528
Range on HMM: 1-23/33
Sequence Identity: 43% (10 aa)

QGDTALINAAVTGHAEVVRALVE
 |.|.|  |.  ||.|||. |..
DGFTPLHLACRCGHTEVVKMLLQ
Ank GL50803_8445.AA Ank 537-558 50 0.003513 15.73 Pfam 1-22 (33) Show / Hide 
Range on Protein: 537-558
Range on HMM: 1-22/33
Sequence Identity: 50% (11 aa)

DGRAAIHNAAYKGHLECVKILL
||. . | |...||.|.|| ||
DGFTPLHLACRCGHTEVVKMLL