Gene GL50803_7653 (G.lamblia)
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| GL50803_7653.AA | Protein | None | 634 | None | Fasta, JSON |
| GL50803_7653.kin_dom | Protein Kinase Domain | None | 284 | None | Fasta, JSON |
Protein domains of GL50803_7653.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| S_TKc | GL50803_7653.AA | S_TKc | 11-298 | 18 | 2.6e-14 | 32.94 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 11-298 Range on HMM: 1-231/231 Sequence Identity: 18% (54 aa) YRITEKISDGPYDTLYLGTNAKYKDLVVFRHIVLPEARRTRTELVHSQTTLVPALRHPHIIPQLQTEQAPNNDIITTTPYYEN--GSLQLLINVLKKDRK |.| .|| | . . |.... | . .| | ...| |. . .||.|. . . | ... . | .. |.| .| .. .. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK------HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGL R--VSKSCFFSYTYQLLTALSYLHCPRKDETYQGPTGTTISIKRVVHGAIRPASVLIDNNGKKVILGNMTHCQEITNSTLTVKLAATGVNVYYSSPEQVK | . .|.||.. || |.| ....| . |. .|.|. . .. . .. . .| .|| . RFPFPE-HARFYMYQICCALEYCHS-----------------HGIIHRDLKPENILLDE---HIKICDFGLARQL---------TTFCGTPWYMAPEVL- GMPLSE-TTDIWSLGATLYEFFTLTPLTYLSQLESAGKLIMDSPDRKYPPNPDLSVITDKDVRFLLSVMLCMDPAERISAAELLT---LDAFTPYF . . |.||.| .|||... |. . |.. |.|. ..... ... .|..||..|..| |.|. . . |.| --GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | GL50803_7653.AA | Ciliate-E2 | 198-294 | 17 | 3.9e-10 | 30.97 | In-house | 252-365 (365) | Show / Hide |
Range on Protein: 198-294
Range on HMM: 252-365/365
Sequence Identity: 17% (24 aa)
YYSSPEQVKGMP---------LSETTDIWSLGATLYEFFTLTPLTYLSQLESAGKLIMDSPDRKYPPNPDLSVITDKDVRFL------------------
.| .|| ..| . .. |||||| .|||. . | . | .....|
GYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-------------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSW
----------LSV----MLCMDPAERIS-AAELLTLDAF
.. ||. || .||. . ..| |
KKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
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| Kinase | GL50803_7653.AA | NEK2 | 198-231 | 50 | 1.5e-09 | 28.2 | In-house | 229-262 (319) | Show / Hide |
Range on Protein: 198-231 Range on HMM: 229-262/319 Sequence Identity: 50% (17 aa) YYSSPEQVKGMPLSETTDIWSLGATLYEFFTLTP || ||||..|.. .| ||||.| .|| .| | YYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHP |
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| Kinase | GL50803_7653.AA | Pkinase | 198-294 | 17 | 1.8e-09 | 34.57 | Pfam | 176-293 (293) | Show / Hide |
Range on Protein: 198-294 Range on HMM: 176-293/293 Sequence Identity: 17% (21 aa) YYSSPEQVK-GMPLSETTDIWSLGATLYEFFTLTPLTYLS----QLESAGKLIMDSPDRKYPPNPDLSVITD-----------------KDVRFLLSVML .| .|| .. | . . |.||.| .|||... |. . . . ..| ..... . . . .. . ... .| WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL CMDPAERISAAELLTLDAF |.||..|..|...| . | CKDPKKRPTAEQILQHPWF |
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| Kinase | GL50803_7653.AA | ULK | 198-294 | 21 | 1.2e-08 | 26.92 | In-house | 212-324 (324) | Show / Hide |
Range on Protein: 198-294 Range on HMM: 212-324/324 Sequence Identity: 21% (25 aa) YYSSPEQVK----GMPLSET-TDIWSLGATLYEFFT-LTP---LTYLSQL----ESAGK------LIMDSPDRKYPPNPDLSVITDKDVRFLLSVMLCMD .| .|. .. ..| .. .|||||| .|| . .| . .| . . .| . | ....|. ... .... |.. ||. | LYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPP--KDPKISPECKDLIRRMLQYD PAERISAAELLTLDAF . .||| |.. | EKDRISWEEIFNHPWF |
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| Kinase | GL50803_7653.AA | TKL | 65-228 | 14 | 9.5e-08 | 23.99 | In-house | 82-284 (364) | Show / Hide |
Range on Protein: 65-228
Range on HMM: 82-284/364
Sequence Identity: 14% (33 aa)
LRHPHIIPQLQTEQAPNND------------IITTTPYYENGS-LQLLINVLKKDRKRVSKSCFFSYTYQLLTALSYLHC--P---RKDETYQGPTGTTI
||||.|.. . ..|... . . |...|| | .|. . ... .. ...||| | .
LRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCT-------------
SIKRVVHGAIRPASVLIDNNGK-------------KVILGNMTHCQEITNST----------------LTVKLAATGV-NVYYSSPEQVKGM--------
. ..| . .. .|.|.|.. .. .. . ......|. .. | | . . .. .|| .|.
-KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVG
--------PLSETTDIWSLGATLYEFFT
. || .|..| | |.| .|
IDEFCKGFEYSEKCDVYSFGIVLWEILT
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| Kinase | GL50803_7653.AA | Trio | 201-224 | 50 | 1.8e-07 | 14.55 | In-house | 168-191 (258) | Show / Hide |
Range on Protein: 201-224 Range on HMM: 168-191/258 Sequence Identity: 50% (12 aa) SPEQVKGMPLSETTDIWSLGATLY .|| ..| | |..||||| |.. | APEIIQGNPVSYGTDIWSIGVLTY |
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| TyrKc | GL50803_7653.AA | TyrKc | 11-294 | 16 | 7.5e-07 | -111.86 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 11-294 Range on HMM: 1-280/280 Sequence Identity: 16% (52 aa) YRITEKISDGPYDTLYLGTNAKYKDLVVFRHIVLPEARRTRTELVHSQTTLVPAL--RHPHIIPQL--QTEQAPN----NDIITTTPYYENGSLQLLINV . .|. | . . |.|| . | . ..| | .. . | .||.|. . |.| | . . | ..|.|. . ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK---DY LKKDRKRVSKSCFFSYTYQLLTALSYLHCPRKDETYQGPTGTTISIKRVVHGAIRPASVLIDNNGKKVILGNMTHCQEITNS--------TLTVKL--AA |.| |.... . . |. .| .||| ...| . .|...|. | . . .|.. . ..| . LRKHRPKLCMKDLLSFCWQIACGMEYLHSK-----------------NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGG TG-VNVYYSSPEQVKGMPLSETTDIWSLGATLYEFFTLTPLTYLSQLE---SAGKLIMDSPDRKYPPNPDL-----SVITDKDVRFLLSVMLCMDPAERI . . . .|| . .. .|.|| | ...| ||. | . . |. .| . .....| |. .|. ... . . ||..| KTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP SAAELLTLDAF . .|. . | TFSEI--HECF |
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| Kinase | GL50803_7653.AA | STE | 201-294 | 13 | 9.2e-07 | 20.05 | In-house | 230-359 (359) | Show / Hide |
Range on Protein: 201-294
Range on HMM: 230-359/359
Sequence Identity: 13% (18 aa)
SPEQVKGM------PLSETTDIWSLGATL-------YEFFTLTPLTYLSQLESAGKLIM----------DSPDRKYP------PNPDLSVITD-------
.|| .... . .. |||||| |. .......|. . . .. . ..| . . .. .
APEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMIS----Y--GGSGTTYP
----KDVRFLLSVMLCMDPAERISAAELLT--LDAF
.. . .. | .|| .| .| .|| .
HKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
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| Kinase | GL50803_7653.AA | NEK | 198-231 | 47 | 1e-06 | 20.09 | In-house | 189-224 (286) | Show / Hide |
Range on Protein: 198-231 Range on HMM: 189-224/286 Sequence Identity: 47% (17 aa) YYSSPEQVKGMPLSETTDIWSLGATLYEFFTL--TP || |||.... | .. |||||| ||| || . YYMSPEVCQNKPYNNKSDIWSLGCVLYEMCTLKPKH |
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| Kinase | GL50803_7653.AA | CMGC | 239-294 | 17 | 3e-06 | 15.55 | In-house | 420-513 (513) | Show / Hide |
Range on Protein: 239-294 Range on HMM: 420-513/513 Sequence Identity: 17% (16 aa) ESAGKLIMDSPDRKYPPNPDLSVI--------------------------------------TDKDVRFLLSVMLCMDPAERISAAELLTLDAF |.| . | .. . .| .... . |.. . ||. ||..||..||.|.. | . | EFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF |
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| Kinase | GL50803_7653.AA | NEK1 | 198-230 | 51 | 3.5e-05 | 14.1 | In-house | 186-218 (276) | Show / Hide |
Range on Protein: 198-230 Range on HMM: 186-218/276 Sequence Identity: 51% (17 aa) YYSSPEQVKGMPLSETTDIWSLGATLYEFFTLT || ||| | .|||||| ||| ||. YYLSPEICQNKPYNNKSDIWSLGCVLYELCTLK |
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| Kinase | GL50803_7653.AA | Ciliate-E2-Unclassified | 149-228 | 25 | 4e-05 | 13.76 | In-house | 163-265 (352) | Show / Hide |
Range on Protein: 149-228 Range on HMM: 163-265/352 Sequence Identity: 25% (26 aa) KRVVHGAIRPASVLIDNNG-----KKVILGNMTHCQEITNSTLTVK-----------LAATGVNVYYS----SPEQVKGMPLSET----TDIWSLGATLY . ..| | | .|.|||| | .|. . |. |.. | . . . .| .|| .| ... |||||| || NNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILY EFFT |. . EMLF |
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| Kinase | GL50803_7653.AA | NEK | 265-294 | 33 | 0.00048 | 10.59 | In-house | 257-286 (286) | Show / Hide |
Range on Protein: 265-294 Range on HMM: 257-286/286 Sequence Identity: 33% (10 aa) KDVRFLLSVMLCMDPAERISAAELLTLDAF .| . |.| ||. || .| |. ..| . QDLQNLISQMLQKDPEQRPSCNQILEMPFI |
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| Kinase | GL50803_7653.AA | Ciliate-E2-Unclassified | 270-294 | 36 | 0.006123 | 6.06 | In-house | 328-352 (352) | Show / Hide |
Range on Protein: 270-294 Range on HMM: 328-352/352 Sequence Identity: 36% (9 aa) LLSVMLCMDPAERISAAELLTLDAF ||. || .| .||.. ..| | LLQKMLKKNPNKRITFEQILNHPWF |
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| Kinase | GL50803_7653.AA | NEK1 | 265-294 | 23 | 0.006684 | 6.1 | In-house | 247-276 (276) | Show / Hide |
Range on Protein: 265-294 Range on HMM: 247-276/276 Sequence Identity: 23% (7 aa) KDVRFLLSVMLCMDPAERISAAELLTLDAF .....|.|.|. .| | |. .|. YELQSLVSQMFKRNPRHRPSVNQILERPFI |
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| Kinase | GL50803_7653.AA | CMGC | 118-130 | 46 | 0.016948 | 2.98 | In-house | 185-199 (513) | Show / Hide |
Range on Protein: 118-130 Range on HMM: 185-199/513 Sequence Identity: 46% (7 aa) YTYQLLTALS--YLH |.||.|..| |.| YMYQILRGLKLKYCH |
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| Kinase | GL50803_7653.AA | CMGC | 211-232 | 26 | 0.030204 | 2.14 | In-house | 313-342 (513) | Show / Hide |
Range on Protein: 211-232 Range on HMM: 313-342/513 Sequence Identity: 26% (8 aa) SETTDIWSLGATLYEFFT--------LTPL ... |.||.| ..| .| . || TTPIDMWSVGCIFAEMYTGYQSLIFRGKPL |
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| Kinase | GL50803_7653.AA | Pkinase | 65-130 | 25 | 6.917197 | 0.68 | Pfam | 57-125 (293) | Show / Hide |
Range on Protein: 65-130 Range on HMM: 57-125/293 Sequence Identity: 25% (18 aa) LRHPHIIPQLQTEQAPNNDIITTTPYYENG----SLQLLINVLKKDRKRV--SKSCFFSYTYQLLTALSYLH |.||.|. . . . ...| ..| |.| .| .| . ...... | .| ||.| .| |.| LNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCH |
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| Ank | GL50803_7653.AA | Ank | 505-530 | 34 | 0.000247 | 19.89 | Pfam | 1-26 (33) | Show / Hide |
Range on Protein: 505-530 Range on HMM: 1-26/33 Sequence Identity: 34% (9 aa) MGRTALMLAAEKNQTRTVEILINYEA .|.|.|.||.....|. |. |... | DGFTPLHLACRCGHTEVVKMLLQHGA |
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| Ank | GL50803_7653.AA | Ank | 536-568 | 24 | 0.001157 | 17.47 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 536-568 Range on HMM: 1-33/33 Sequence Identity: 24% (8 aa) HGNTALILATMNNSIESIKILCKKESNIENRAR .|.|.| || .....| .| | .. .. . . DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_7653.AA | Ank | 572-587 | 31 | 52.522331 | 0.67 | Pfam | 6-21 (33) | Show / Hide |
Range on Protein: 572-587 Range on HMM: 6-21/33 Sequence Identity: 31% (5 aa) LLIAAHKGNLEAIRLL | .|...|..| ...| LHLACRCGHTEVVKML |
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