Gene GL50803_5553 (G.lamblia)

GL50803_5553

Species: G.lamblia
Alias: GK266, GL50803_5553
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_5553.AA Protein None 533 None Fasta, JSON
GL50803_5553.kin_dom Protein Kinase Domain None 265 None Fasta, JSON

Protein domain

Protein domains of GL50803_5553.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc GL50803_5553.AA S_TKc 9-273 18 2.8e-14 32.41 SMART 1-231 (231) Show / Hide 
Range on Protein: 9-273
Range on HMM: 1-231/231
Sequence Identity: 18% (52 aa)

YEILGQIARSRCSVIMLAVDSTQEEAGPVVVKKFVLPLPTEELARAFQAELLMARSLRNKYLVPYLDTFFEKQWAGYFAVMPYYKS--QSLYEQIRHRKT
|||| .| .   .. .....        | .|.           . .. |. . .. . ...| ..|.| .     .. || |      .|.. |..|..
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGR

--IQKPFEEASIWIFLASMLDLFVLLHGSSNIESLSCPHNYV---IRPDNIFVSKYGIFQLHRFHLGKYEHFRTNKPKLTPCYHAPEVIGGKNWSI-KSD
   ..|| |  .. ... ...    .|           |. .   . |.||....     .  | | .      .    || | ||||.    ..  |.|
HGLRFPFPE-HARFYMYQICCALEYCHS----------HGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCD

VWSVACIAYEMCTLRPLYELLDVSELFGLIKDARPTFNLRGYSREMQDLLSTMLDPIASSRASPEYLLK-------NSTL
.||. || |||.. .|...  .. ..| .|.           |.|. |... .|.   . | .   .|.          .
WWSCGCILYEMLCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Pkinase GL50803_5553.AA Pkinase 181-269 25 3.1e-13 47.88 Pfam 174-289 (293) Show / Hide 
Range on Protein: 181-269
Range on HMM: 174-289/293
Sequence Identity: 25% (29 aa)

TPCYHAPEVIG-GKNWSIKSDVWSVACIAYEMCTLRPLYELL------DVSELFGLIKDARPTFNLRGYS--------------------REMQDLLSTM
|| | |||||  |. .. |.|.||. || |||.. ||..         |  ... .|..... |.    .                    .|..|... .
TPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWC

LDPIASSRASPEYLLK
|..  ..| ..| .|.
LCKDPKKRPTAEQILQ
Kinase GL50803_5553.AA NEK2 181-216 52 9.2e-13 39.19 In-house 227-262 (319) Show / Hide 
Range on Protein: 181-216
Range on HMM: 227-262/319
Sequence Identity: 52% (19 aa)

TPCYHAPEVIGGKNWSIKSDVWSVACIAYEMCTLRP
|| |  ||.. |   . |||.||| |. ||||.|.|
TPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHP
Kinase GL50803_5553.AA STE 181-273 20 9.3e-13 41.49 In-house 226-359 (359) Show / Hide 
Range on Protein: 181-273
Range on HMM: 226-359/359
Sequence Identity: 20% (27 aa)

TPCYHAPEVIGG------KNWSIKSDVWSVACIAYEMCTLRPLY-ELLDVSELFGLIKD---------------ARPTFNL------------------R
|| . ||||| .      |  ..|.|.||. | . ||.| .| . .. . . .|  ..                  |..                    .
TP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPH

GYSREMQDLLSTMLDPIASSRASPEYLLK--NSTL
 .| |..| ..  |.   . |.... |||   . .
KWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase GL50803_5553.AA STE-Unique 181-273 22 1.4e-12 40.45 In-house 511-616 (616) Show / Hide 
Range on Protein: 181-273
Range on HMM: 511-616/616
Sequence Identity: 22% (24 aa)

TPCYHAPEVIGGK-----NWSIKSDVWSVACIAYEMCTLRPLYELLDVS-ELFGLIKDARPTFN-------LRGYSREMQDLLSTMLDPIASSRASPEYL
|||| .|||| ..       . |.|.|| .|.  .||.. |..  . .   .. ..       .          .. |.|... . |..  . |.|.. |
TPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPWHQRYHMQAYIEMCIHIHCQPPQCPIENIPPKCQPEQQQFIEKCLERNPHHRPSAHQL

LKNSTL
|.  .|
LHHFWL
Kinase GL50803_5553.AA NEK8 181-215 48 1.5e-12 32.0 In-house 185-219 (278) Show / Hide 
Range on Protein: 181-215
Range on HMM: 185-219/278
Sequence Identity: 48% (17 aa)

TPCYHAPEVIGGKNWSIKSDVWSVACIAYEMCTLR
||.|  ||   ||    |||.|.. |. ||||.|.
TPYYMSPEMCEGKPYNQKSDMWALGCVLYEMCCLK
Kinase GL50803_5553.AA ULK 181-273 27 9.6e-12 37.35 In-house 214-329 (329) Show / Hide 
Range on Protein: 181-273
Range on HMM: 214-329/329
Sequence Identity: 27% (32 aa)

TPCYHAPEVIG----GKNWS-IKSDVWSVACIAYEMCTLR-P--LYELLDVS-----ELFGL-------IKDARPTFNLRG----YSREMQDLLSTMLDP
|| | ||...     .|. .  |.|.||. || ||| . . |   .   |       .|. .       ||.  . |.  |     | |..||.. ||  
TPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQY

IASSRASPEYLLKNSTL
  . | | | |...  .
DEKDRISWEELFNHPWF
Kinase GL50803_5553.AA NEK 181-216 50 2e-11 36.87 In-house 187-224 (286) Show / Hide 
Range on Protein: 181-216
Range on HMM: 187-224/286
Sequence Identity: 50% (19 aa)

TPCYHAPEVIGGKNWSIKSDVWSVACIAYEMCTL--RP
||.| .|||. .|  . |||.||. |. ||||||  ..
TPYYMSPEVCQNKPYNNKSDIWSLGCVLYEMCTLKPKH
Kinase GL50803_5553.AA NEK4 181-255 36 3.8e-11 36.45 In-house 165-239 (257) Show / Hide 
Range on Protein: 181-255
Range on HMM: 165-239/257
Sequence Identity: 36% (27 aa)

TPCYHAPEVIGGKNWSIKSDVWSVACIAYEMCTLRPLYELLDVSELFGLIKDARPTFNLRGYSREMQDLLSTMLD
|| |  ||. | . .  |||.||  |  ||| ||.  ..  |   |   | . .|    . || ..|.|. .||.
TPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITLKHAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLE
Kinase GL50803_5553.AA Ciliate-E2 181-273 23 1.1e-10 32.91 In-house 250-365 (365) Show / Hide 
Range on Protein: 181-273
Range on HMM: 250-365/365
Sequence Identity: 23% (29 aa)

TPCYHAPEVIGGKN---------WSIKSDVWSVACIAYEMCTLRPLYELLDVSELFGLIKDARPTFN-----------------LRGYSREMQDLLST--
|| | |||...||.         .. |.|.||. .| |||.. .| .        .  ||.    |.                     | |..||..   
TPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFG

--MLDPIASSRAS-PEYLLKNSTL
  ||.   . | . .| .|..  .
KRMLQKDPEKRITGWEQILNHPWF
Kinase GL50803_5553.AA Ciliate-E2-Unclassified 181-273 22 1.4e-10 32.93 In-house 225-352 (352) Show / Hide 
Range on Protein: 181-273
Range on HMM: 225-352/352
Sequence Identity: 22% (29 aa)

TPCYH----APEVIGGKNWS----IKSDVWSVACIAYEMCTLRPLYELLDVSE----------------LFGLIKDARPTFNL-------RGYSREMQDL
||.|     ||||..|.| .    .|.|.||. .|.|||.. .. ..  .  .                |.  ||.  . |.         . | | .|.
TPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDF

LS----TMLDPIASSRASPEYLLKNSTL
..     ||.   ..| ..| .|.   .
INDLLQKMLKKNPNKRITFEQILNHPWF
Kinase GL50803_5553.AA NEK-Unclassified 181-254 36 1.9e-10 30.49 In-house 160-239 (258) Show / Hide 
Range on Protein: 181-254
Range on HMM: 160-239/258
Sequence Identity: 36% (29 aa)

TPCYHAPEVIGGKNWSIKSDVWSVACIAYEMCTLRPLYELLDVSELFGLIK--DARPTFNL----RGYSREMQDLLSTML
|.|. .|||.  . .  .|||||  || |||||  |        |..  ||  |.|    |    . ||  .|... .||
TMCWMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCEPFFDTHNMGEVYMKIKQDDNRLEEALEPVSKTYSTDLQQVIRFML
TyrKc GL50803_5553.AA TyrKc 9-273 13 2.3e-05 -135.78 SMART 1-280 (280) Show / Hide 
Range on Protein: 9-273
Range on HMM: 1-280/280
Sequence Identity: 13% (43 aa)

YEILGQIARSRCSVIMLAVDSTQEEAGPVVVKKFVLPLPTEELARAFQAELLMARSL--RNKYLVPYLDTFFEK-----QWAGYFAVMPYYKSQSLYEQI
 . . .. .    ...... .      .| ||.           ..|  |. . ..|  ... .|  .    ..         .. || | .  .| . .
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

-RHRKTIQKPFEEASIWIFLASMLDLFVLLHGSSN----IESLSCPHNYV---IRPDNIFVSKYGIFQLHRFHLGKYEHFR--------TNKPKLTPCYH
 .||..               .| ||    .  ..    ..|     |..   .   |. |.. ..     | | .. .          . ..| . . .
RKHRPK--------------LCMKDLLSFCWQIACGMEYLHSK----NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGK

--------APEVIGGKNWSIKSDVWSVACIAYEMCTL-RPLYEL-----LDVSELFGLIKDA-RPTFNLRGY-------SREMQDLLSTMLDPIASSRAS
        |||.|  .  ..||||||     .|..|.  . |.      .. .|.. ..|.  |.     .|       . || .. ..  .  ...| .
TMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPT

PEYLLKNSTL
 . .   . .
FSEI--HECF
Kinase GL50803_5553.AA NEK2 242-273 25 0.015285 4.24 In-house 288-319 (319) Show / Hide 
Range on Protein: 242-273
Range on HMM: 288-319/319
Sequence Identity: 25% (8 aa)

YSREMQDLLSTMLDPIASSRASPEYLLKNSTL
|||. ... . |..   ..| | | .|... .
YSRHLNEIIHFMINVDHYHRPSIEEILQHPQI
Kinase GL50803_5553.AA NEK 242-273 31 0.025912 4.42 In-house 255-286 (286) Show / Hide 
Range on Protein: 242-273
Range on HMM: 255-286/286
Sequence Identity: 31% (10 aa)

YSREMQDLLSTMLDPIASSRASPEYLLKNSTL
||...|.|.| || .  ..| | . .|... .
YSQDLQNLISQMLQKDPEQRPSCNQILEMPFI