Gene GL50803_5489 (G.lamblia)

GL50803_5489

Species: G.lamblia
Alias: GK293, GL50803_5489
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_5489.AA Protein None 536 None Fasta, JSON
GL50803_5489.kin_dom Protein Kinase Domain None 274 None Fasta, JSON

Protein domain

Protein domains of GL50803_5489.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_5489.AA NEK4 268-303 30 2.8e-07 22.38 In-house 222-257 (257) Show / Hide 
Range on Protein: 268-303
Range on HMM: 222-257/257
Sequence Identity: 30% (11 aa)

LSRYYSRQLREIIKTMLSAYYGERPTILNIYARPFI
... || .| .....||.    .|| | .|.  |.|
MPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase GL50803_5489.AA NEK 268-303 31 3e-06 18.59 In-house 249-286 (286) Show / Hide 
Range on Protein: 268-303
Range on HMM: 249-286/286
Sequence Identity: 31% (12 aa)

LSRY--YSRQLREIIKTMLSAYYGERPTILNIYARPFI
.. .  ||..|...|  ||     .||..  | ..|||
IPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase GL50803_5489.AA CAMKL 203-303 23 4e-06 15.53 In-house 219-297 (297) Show / Hide 
Range on Protein: 203-303
Range on HMM: 219-297/297
Sequence Identity: 23% (25 aa)

IWTIGFILFNMMCSGYSYGEINFRDVTHKPDYEGDTDDEGNEKSEKERIEGMDMYLYVSKRLNTELSRYY-----SRQLREIIKTMLSAYYGERPTILNI
|| .| ||..|.|     |.  |.| |..                     |.| . |  .. ..   ..      | ..| .|. ||     .|||| .|
IWSCGVILYAMVC-----GYLPFDDDTYN-K------------------QGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQI

YARPFI
   |. 
MNHPWM
S_TKc GL50803_5489.AA S_TKc 8-303 10 9e-06 -92.55 SMART 1-231 (231) Show / Hide 
Range on Protein: 8-303
Range on HMM: 1-231/231
Sequence Identity: 10% (36 aa)

LTVSRML------TPHSAIVTPQSSLDKYILRCLPASSLDPEVLKNVMSDVGFVIREKCHWMVQCFVEKLVDDDTRMDLSTDSRNYYVLTECYAS--DSL
 .. | .      . . .. .   .  .. . ...         ..... .    .   |  .  . .  .|            ..|. .|.      .|
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD-----------DHLYMVMEYCDGDLGDL

QALVVTRDRVKKP--FTEDEIIQTLLQLIMPVEFL--MKIGWRD--------------------KSFFKHVLHPNRLRVSNNGLISLDICHAIVSSKIVL
  . . | | ...  |.| ..   . |..  .|..  ..|  ||                    . .                                 
FDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQL---------------------------------

EQFRDEQ----SYMPPEAIFSNASTYDE-RSFIWTIGFILFNMMCSGYS-YGEINFRDVTHKPDYEGDTDDEGNEKSEKERIEGMDMYLYVSKRLNTELS
    . .     ||.|| .      |.  .. .| .| ||. |.| ||  .   .   . .|                                      
----TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG------------------------------------

RYYSRQLREIIKTMLSAYYGERPTILNIYA-------RPFI
   |......|. .|     .|||.  . .        |..
---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_5489.AA NEK2 271-303 42 2.3e-05 13.92 In-house 287-319 (319) Show / Hide 
Range on Protein: 271-303
Range on HMM: 287-319/319
Sequence Identity: 42% (14 aa)

YYSRQLREIIKTMLSAYYGERPTILNIYARPFI
.||| | |||  |.      || |  | . |.|
QYSRHLNEIIHFMINVDHYHRPSIEEILQHPQI
Kinase GL50803_5489.AA IKS 195-303 25 3.5e-05 11.49 In-house 265-360 (360) Show / Hide 
Range on Protein: 195-303
Range on HMM: 265-360/360
Sequence Identity: 25% (29 aa)

STYDERSFIWTIGFILFNMMCSGYSYGEINFRDVTHKPDYEGD----TDDEGNEKSEKERIEGMDMYLYVSKRLNTELSRYYSRQLREIIKTMLSAYYGE
. ||... .|  | |.. |      |||  .|       | ||     |   . |.    ||||     . ...   .    .| . ...  .| .   |
NDYDFKCDMWSLGMICYFMV-----YGELPYR-------YQGDPFIDVDPNRRIKNFRFDIEGM-----INNHQIMKQKPQDRRDIFHMMDILLQPNNHE

RPTILNIYARPFI
||||  |    ||
RPTIKQIEETHFI
Kinase GL50803_5489.AA NEK1 268-303 30 0.000161 11.79 In-house 241-276 (276) Show / Hide 
Range on Protein: 268-303
Range on HMM: 241-276/276
Sequence Identity: 30% (11 aa)

LSRYYSRQLREIIKTMLSAYYGERPTILNIYARPFI
... ||. |.. .. |..   . || .  |  ||||
IPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase GL50803_5489.AA MARK 273-303 35 0.000405 9.55 In-house 232-262 (262) Show / Hide 
Range on Protein: 273-303
Range on HMM: 232-262/262
Sequence Identity: 35% (11 aa)

SRQLREIIKTMLSAYYGERPTILNIYARPFI
|...| .|. .| .   ||||| .|  .|..
SKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase GL50803_5489.AA NEK2 184-213 36 0.108479 1.33 In-house 230-257 (319) Show / Hide 
Range on Protein: 184-213
Range on HMM: 230-257/319
Sequence Identity: 36% (11 aa)

YMPPEAIFSNASTYDERSFIWTIGFILFNM
|| || .  .   |.|.| || .| ... |
YMSPEQM--HGQKYNEKSDIWSVGCLIYEM
Ank GL50803_5489.AA Ank 320-338 36 2.275763 5.59 Pfam 1-19 (33) Show / Hide 
Range on Protein: 320-338
Range on HMM: 1-19/33
Sequence Identity: 36% (7 aa)

EGGTPLMVAARIGDMHYIT
.| |||..|.| |..  ..
DGFTPLHLACRCGHTEVVK
Ank GL50803_5489.AA Ank 350-371 27 0.006241 14.83 Pfam 1-22 (33) Show / Hide 
Range on Protein: 350-371
Range on HMM: 1-22/33
Sequence Identity: 27% (6 aa)

KGRTALMFAAANGCAQACDYLI
 |.|.|. |. .|... . .|.
DGFTPLHLACRCGHTEVVKMLL
Ank GL50803_5489.AA Ank 381-401 33 0.000846 17.96 Pfam 1-21 (33) Show / Hide 
Range on Protein: 381-401
Range on HMM: 1-21/33
Sequence Identity: 33% (7 aa)

KKWTALMYAAANGHVNCAKLL
  .|.|..|. .||....|.|
DGFTPLHLACRCGHTEVVKML
Ank GL50803_5489.AA Ank 412-432 38 0.024312 12.7 Pfam 1-21 (33) Show / Hide 
Range on Protein: 412-432
Range on HMM: 1-21/33
Sequence Identity: 38% (8 aa)

DNDTALIIATERNHVEIVDFL
| .|.| .| ...|.|.| .|
DGFTPLHLACRCGHTEVVKML
Ank GL50803_5489.AA Ank 443-464 22 2.246892 5.61 Pfam 1-22 (33) Show / Hide 
Range on Protein: 443-464
Range on HMM: 1-22/33
Sequence Identity: 22% (5 aa)

NGESALVVAAWHCYPRCVALLM
.|...| .|. . ....| .|.
DGFTPLHLACRCGHTEVVKMLL