Gene GL50803_4912 (G.lamblia)

GL50803_4912

Species: G.lamblia
Alias: GK265, GL50803_4912
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_4912.AA Protein None 296 None Fasta, JSON
GL50803_4912.kin_dom Protein Kinase Domain None 268 None Fasta, JSON

Protein domain

Protein domains of GL50803_4912.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_4912.AA NEK10 94-215 29 1.7e-14 43.96 In-house 100-215 (279) Show / Hide 
Range on Protein: 94-215
Range on HMM: 100-215/279
Sequence Identity: 29% (36 aa)

CTLEDYLREQQAKGETISESMLWAILVRIVKALRYLHDPAKHGGRVIVHRDVRPSNMYMADDSTVYLGDSIFCSSYTYPGSHVVGSALTNMAYAPPEMMT
| | ...     | .  .|  .|.... .. ||||||   .     ||||| .| |  | |.  |   |         | .    |.     |  || . 
CPLYEHFNSMKEKHHHFEEERIWHMFIQMCLALRYLHKEKQ-----IVHRDLTPNNIMMGDKDRVTITDFGLAKQKQ-PDPSKMTSVVGTILYSCPEIVQ

SDVYTTAYDIWSLGCSLYELAT
|  |    |.|. || ||...|
SEPYGEKADVWAFGCCLYQMCT
S_TKc GL50803_4912.AA S_TKc 17-277 18 9.3e-13 10.19 SMART 1-231 (231) Show / Hide 
Range on Protein: 17-277
Range on HMM: 1-231/231
Sequence Identity: 18% (53 aa)

SSDLRL-------KTHLVRSKETQETRMCRGIEYLYHTKSARADLEDALYDMLRVRCPYIIHYTDVYNEEGSKRYMALLSYNYK-CTLEDYLREQQAKG-
   ||.       | ...| |.|..   .  |         ..  | ..  .   ..|.|... ||. .  .. || .   .    .| ||..... .| 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK---HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

-ETISESMLWAILVRIVKALRYLHDPAKHGGRVIVHRDVRPSNMYMADDSTVYLGDSIFCSSYTYPGSHVVGSALTNMAYAPPEMMTSDVYTT-AYDIWS
   ..| . . ..  |..|| |.|.      . |.|||. |.|  . .  .. ..|  ..  .         .      | .||..    |.. . |.||
RFPFPE-HARFYMYQICCALEYCHS------HGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWS

LGCSLYELATGAK-YSEIVKTAFPGLSYLQALERLQMQALVIPGYSESFCVNLQRMLHVDPTERPTAAGLLS----------L
.|| |||...|   ..           . . ....          |....  ....|..||..||||  .|           .
CGCILYEMLCGYPPFP----------QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_4912.AA NEK6 110-271 30 1e-12 37.91 In-house 100-252 (252) Show / Hide 
Range on Protein: 110-271
Range on HMM: 100-252/252
Sequence Identity: 30% (50 aa)

ISESMLWAILVRIVKALRYLHDPAKHGGRVIVHRDVRPSNMYMADDSTVYLGD---SIFCSSYTYPGSHVVGSALTNMAYAPPEMMTSDVYTTAYDIWSL
| |  .|   | . .||  .|       . ..|||..| |...  .  | |||     | || |     .||       |  || .    |    |||||
IPERTIWKYFVQLCSALEHMHS------KRVMHRDIKPANVFITANGIVKLGDLGLGRFFSSKTTAAHSLVGTPY----YMSPERIHENGYNFKSDIWSL

GCSLYELATGAKYSEIVKTAFPGLSYLQALERLQMQALVIPGYSESFCVNLQRMLHVDPTERPTA
|| |||.|  |  |          |  . .|. .   |    |||    ..  ..| ||..||  
GCLLYEMA--ALQSPFYGDKMNLYSLCKKIEQCDYPPLPADHYSEQLRQLVCMCIHPDPEWRPDI
Kinase GL50803_4912.AA CDK10 111-213 29 1.2e-11 36.57 In-house 98-194 (285) Show / Hide 
Range on Protein: 111-213
Range on HMM: 98-194/285
Sequence Identity: 29% (30 aa)

SESMLWAILVRIVKALRYLHDPAKHGGRVIVHRDVRPSNMYMADDSTVYLGDSIFCSSYTYPGSHVVGSALTNMAYAPPEMMTSDVYTTAYDIWSLGCSL
.|.    | . ....|.||||      . ..|||.. ||. |.|.  . . |      |  |   .     |    ||  .. .   ||| |.| .|| |
TETQVKCIMLQMLRGLKYLHD------NFMIHRDLKVSNLLMTDKGCIKVADFGLARMYGVPVKPMTPKMVTLWYRAPELLLGCRTQTTAIDMWAVGCIL

YEL
 ||
GEL
Kinase GL50803_4912.AA NEK-Unclassified 96-215 30 1.3e-11 34.44 In-house 80-192 (258) Show / Hide 
Range on Protein: 96-215
Range on HMM: 80-192/258
Sequence Identity: 30% (38 aa)

LEDYLREQQAKGETISESMLWAILVRIVKALRYLHDPAKHGGRVIVHRDVRPSNMYMADDSTVYLGDSIFCSSYTYPGSHVVGSALT---NMAYAPPEMM
|   .. .  | | . |  .    . .. |. | |       | |.||| .|.| .. || || .||  |  | .    | .  | |    | .  || .
LDRRIQKHRKKNEPFDEGRIMQWCIQMIMAVQYIHQ------RKIIHRDLKPQNIFLTDDDTVSMGD--FGISRIM--DHTRDKARTCVGTMCWMSPEVC

TSDVYTTAYDIWSLGCSLYELAT
    |    |.||||| .||..|
QDQPYNNRSDVWSLGCIIYEMCT
Kinase GL50803_4912.AA TKL 122-278 13 1.8e-11 37.54 In-house 141-364 (364) Show / Hide 
Range on Protein: 122-278
Range on HMM: 141-364/364
Sequence Identity: 13% (32 aa)

IVKALRYLHD--P--AKHGGRVIVHRDVRPSNMYMADDST--------------VYLGDSIFCSSYTYPGS------------------HVVGSALTNMA
| ... |||   |   .   . |.|||  ..|    .. |              . ..|  .. . .  |.                     ..   . .
IARGMNYLHSMNPKWCT--KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPR

YAPPEMMTSD----------------VYTTAYDIWSLGCSLYELATGAKYSEIVKTAFPGLSYLQ-----------ALERLQMQALVIP-----------
. .||..  .                 |... |..| |  |.|..|. .        . .. | .           ..  .  . . ||           
WMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCP

--GYSESFCVNLQRMLHVDPTERPTAAGLLSLS
     .|..  .|.  . ||..||..  .|.  
CPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase GL50803_4912.AA MEK5 110-280 30 3.9e-11 36.93 In-house 90-254 (254) Show / Hide 
Range on Protein: 110-280
Range on HMM: 90-254/254
Sequence Identity: 30% (53 aa)

ISESMLWAILVRIVKALRYLHDPAKHGGRVIVHRDVRPSNMYMADDSTVYLGDSIFCSSYTYPGSHVVGSALTNMAYAPPEMMTSDVYTTAYDIWSLGCS
| |..|  . | ||| | || .        |.||||.|||| .     . | |  |  |     |       || ||  || .  | |    |.|||| .
IPEHILGRMTVAIVKGLNYLWN------LKIMHRDVKPSNMLVNTQGQIKLCD--FGVSTQLVNSITRTYIGTN-AYMAPERISGDQYGIHSDVWSLGIF

LYELATGA-KYSEIVKTA--FPGLSYLQALERLQMQALVIPGYSESFCVNLQRMLHVDPTERPTAAGLLSLSGS
. |.|||   | .| .       .  || .   .   | .  .|| |   ... ..  | .||    |.     
FMEMATGRFPYPQIQRDQGELMPIQLLQCIVDEHPPRLPVDKFSEPFVHFINQCMQKQPKDRPKPQDLMQHPFI
Kinase GL50803_4912.AA MEK1 110-216 35 7.4e-11 32.8 In-house 94-192 (297) Show / Hide 
Range on Protein: 110-216
Range on HMM: 94-192/297
Sequence Identity: 35% (38 aa)

ISESMLWAILVRIVKALRYLHDPAKHGGRVIVHRDVRPSNMYMADDSTVYLGDSIFCSSYTYPGSHVVGSALTNMAYAPPEMMTSDVYTTAYDIWSLGCS
| |..|  . | ... | ||.|  |     |.||||.|||. .     . | |  |  |     | .  |     .|  || ..   ||   ||||.| |
IPEKILGKVSVAVLRGLTYLRDKHK-----IMHRDVKPSNILVNSRGEIKLCD--FGVSGQLIDS-MANSFVGTRSYMSPERLQGTHYTVQSDIWSMGLS

LYELATG
| |.| |
LVEMAIG
Kinase GL50803_4912.AA STE 103-216 27 8.6e-10 30.88 In-house 142-264 (359) Show / Hide 
Range on Protein: 103-216
Range on HMM: 142-264/359
Sequence Identity: 27% (38 aa)

QQAKGETISESMLWAILVRIVKA-LRYLHDPAKHGGRVIVHRDVRPSNMYMADDSTVYLGD----SIFCSSYT-----------YPGS----HVVGSALT
.|. . ...|| . .|.. |.|. | |||   .|.   |.|||. |.|  .     | | |    ... .|..           . ..    ..||.   
RQH-QHRFPESQIAYICRQILKGLLYYLH---SHH---IIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP--

NMAYAPPEMMTS------DVYTTAYDIWSLGCSLYELATG
   .  ||...       . |.|  ||||||| . |.|||
---WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATG
Kinase GL50803_4912.AA NEK 65-162 26 1.2e-09 30.52 In-house 62-166 (286) Show / Hide 
Range on Protein: 65-162
Range on HMM: 62-166/286
Sequence Identity: 26% (28 aa)

RCPYIIHYTDVYNEEGSKRYMALLSYNY-KCTLEDY---LREQQAKGETISESMLWAILVRIVKALRYLHDPAKHGGRVIVHRDVRPSNMYMADDST---
..|.|. | | . ||.. . .    |   . .|..    . .|. ||. ..|.. | ... ...||.|.||    . | |.|||  |.|  . .. .   
KHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRK-GPQRKILHRDIKPQNIFLTKNNNDYH

-VYLGD
 | .||
NVKIGD
Kinase GL50803_4912.AA SgK071 90-162 27 3.9e-09 27.86 In-house 81-147 (283) Show / Hide 
Range on Protein: 90-162
Range on HMM: 81-147/283
Sequence Identity: 27% (20 aa)

YNYKCTLEDYLREQQAKGETISESMLWAILVRIVKALRYLHDPAKHGGRVIVHRDVRPSNMYMADDSTVYLGD
|. . ...  . |   |.. . |. .  ..  .. |. |||.      | |.|||  ||| |  |. .  |.|
YYKMGDFDRFMKEKRKKKKIMCEEWMQRWCGQMLHAIEYLHH------RNIIHRDLKPSNIYLTDQMHCKLQD
Kinase GL50803_4912.AA Pkinase 186-272 20 2.6e-08 30.45 Pfam 177-285 (293) Show / Hide 
Range on Protein: 186-272
Range on HMM: 177-285/293
Sequence Identity: 20% (24 aa)

YAPPEMMT-SDVYTTAYDIWSLGCSLYELATGAKYSEIVKTAFPGL----SYLQALERLQMQALVIPGYS-------------------------ESFCV
|..||    .  |... |.||.|| |||...|        . |||     . .  ......    .. ..                         |... 
YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGR-------PPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKD

NLQRMLHVDPTERPTAA
 . ..|..||..||||.
FIKWCLCKDPKKRPTAE
TyrKc GL50803_4912.AA TyrKc 35-278 16 1e-06 -115.59 SMART 1-280 (280) Show / Hide 
Range on Protein: 35-278
Range on HMM: 1-280/280
Sequence Identity: 16% (48 aa)

TRMCRGIE-------------------YLYHTKSARADLEDALYDMLRV--RCPYIIHYTDVYNEEG------SKRYMALLSYNYKCTLEDYLREQQAKG
 .. . .                     | . .  |.|. . .  | ..  . | |.    |  ..|         .. .    .   | ||||. . | 
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLRKHRPK-

ETISESMLWAILVRIVKALRYLHDPAKHGGRVIVHRDVRPSNMYMADDSTVYLGD-----SIFCS-------SYTYPGSHVVGSALTNMAYAPPEMMTSD
  .. . |  . . | .  .|||.        ..|||    |   ... ||  .|      |          .|  . .|  | ..      .|| .   
--LCMKDLLSFCWQIACGMEYLHSK------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

VYTTAYDIWSLGCSLYELATGAKYSEIV-----KTAFPGLSYLQALERLQMQAL-----VIPGYSESFCVNLQRMLHVDPTERPTAAGLLSLS
..||. |.|| |  ..|. |  .          ....  . |... .|.   .        .. ..      ..  | || .||| . . .. 
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF-VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase GL50803_4912.AA NEK 202-215 78 0.000136 12.54 In-house 206-219 (286) Show / Hide 
Range on Protein: 202-215
Range on HMM: 206-219/286
Sequence Identity: 78% (11 aa)

DIWSLGCSLYELAT
||||||| |||..|
DIWSLGCVLYEMCT
Kinase GL50803_4912.AA SgK071 202-215 57 0.004599 6.5 In-house 203-216 (283) Show / Hide 
Range on Protein: 202-215
Range on HMM: 203-216/283
Sequence Identity: 57% (8 aa)

DIWSLGCSLYELAT
||||||| . . .|
DIWSLGCIILDMTT
Kinase GL50803_4912.AA STE 249-280 32 0.051689 3.05 In-house 326-359 (359) Show / Hide 
Range on Protein: 249-280
Range on HMM: 326-359/359
Sequence Identity: 32% (11 aa)

YSESFCVNLQRMLHVDPTERPTAAGLLS--LSGS
.|..|.  ... |  || .||||  ||.   .  
WSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase GL50803_4912.AA NEK 257-280 29 0.08082 2.66 In-house 263-286 (286) Show / Hide 
Range on Protein: 257-280
Range on HMM: 263-286/286
Sequence Identity: 29% (7 aa)

LQRMLHVDPTERPTAAGLLSLSGS
...||..||..||..  .|...  
ISQMLQKDPEQRPSCNQILEMPFI
Kinase GL50803_4912.AA SgK071 257-279 26 0.12062 1.51 In-house 261-283 (283) Show / Hide 
Range on Protein: 257-279
Range on HMM: 261-283/283
Sequence Identity: 26% (6 aa)

LQRMLHVDPTERPTAAGLLSLSG
|  |||..| .|...  .. .  
LPFMLHINPQDRISIKDVMHITF
Pkinase GL50803_4912.AA Pkinase 61-149 21 4.413976 1.37 Pfam 54-138 (293) Show / Hide 
Range on Protein: 61-149
Range on HMM: 54-138/293
Sequence Identity: 21% (21 aa)

MLRVRCPYIIHYTDVYNEEGSKRYMALLSYNYKC-----TLEDYLREQQAKGETI--SESMLWAILVRIVKALRYLHDPAKHGGRVIVHRDVRPSN
|.|...|.|. . |.. .   |... .      .      | ||..    .. ..  ||  .  ..  |...| |.|.        |.|||. |.|
MKRLNHPNIVRLYDWFED---KDHIYMVMEYCEGGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHS-M-----GIIHRDLKPEN