Gene GL50803_24321 (G.lamblia)
GL50803_24321
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
---|---|---|---|---|---|
GL50803_24321.AA | Protein | None | 288 | None | Fasta, JSON |
GL50803_24321.kin_dom | Protein Kinase Domain | None | 269 | None | Fasta, JSON |
Protein domains of GL50803_24321.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | GL50803_24321.AA | Ciliate-E2b | 142-222 | 31 | 1.8e-18 | 52.86 | In-house | 120-208 (272) | Show / Hide |
Range on Protein: 142-222 Range on HMM: 120-208/272 Sequence Identity: 31% (28 aa) TRAIIHRYIMPRRIFMVSETRCKLADIGWSRDLLSMEG---KMGYIQGTLQYYAPELIV-----NEGYGREVDIFALGCTMYEIMMKRV .. ||.| | | | .. .||.| | . . . .. . | ||. | |||.| . ||. .|||...| . ||.|...| NQNIIYRDIKPENIMVDHKGYMKLIDMGTAKHMYKKNEQMTRTFTIIGTPHYMAPEIIQSLQPGGKGYTYKVDIWSVGICLYEFMCGYV |
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Kinase | GL50803_24321.AA | AGC | 186-269 | 22 | 1.9e-18 | 42.85 | In-house | 267-376 (395) | Show / Hide |
Range on Protein: 186-269 Range on HMM: 267-376/395 Sequence Identity: 22% (26 aa) G--TLQYYAPELIVNEGYGREVDIFA--LGCTMYEIMMKRVLVEDNPEE--------PLEALKKIR-------LPLII-----------TTYSKKLVNLV | | .| ||| . ||...|. . ||| ||| . . ... . | | .||. .. . |. ...|. GPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLI SSMLNPDPKKRPTA . .|..||.||... KKLLCKDPEKRLGC |
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Kinase | GL50803_24321.AA | Pkinase | 155-271 | 21 | 2.6e-18 | 65.83 | Pfam | 139-286 (293) | Show / Hide |
Range on Protein: 155-271 Range on HMM: 139-286/293 Sequence Identity: 21% (33 aa) IFMVSETRC----KLADIGWSRDL-LSMEGKMGYIQGTLQYYAPELIV-NEGYGREVDIFALGCTMYEIMMKRVLVE-D----NPEEPLEALKKIRLPLI |..... . |..| | .. . . . | . ||. | |||.| ...||..||....||..|| . .| . . | .... ...|. | . ILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPL ITTYS-----------------------KKLVNLVSSMLNPDPKKRPTAFE .. . . .....|..|||||||| . HFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQ |
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Kinase | GL50803_24321.AA | TKL | 139-269 | 16 | 3.2e-18 | 62.24 | In-house | 149-357 (364) | Show / Hide |
Range on Protein: 139-269 Range on HMM: 149-357/364 Sequence Identity: 16% (34 aa) HRFT------RAIIHRYIMPRRIFMVSETR--------------CKLADIGWSRDLLSMEG-------------------KMGYIQGTLQYYAPELIVNE | . ..|||| . .. |. . . ||..| | ||.. ... . . . ||... |||.. .. HSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQ ----------------GYGREVDIFALGCTMYEIMMKRVLVEDNPEEP-----------LEALKKIRLPLII------------TTYSKKLVNLVSSMLN | .|... | ..||. .. .|.|..| . .| . |.| .. . . .| . MNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWD PDPKKRPTA .||.|||.. HDPEKRPSF |
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Kinase | GL50803_24321.AA | Ciliate-E2 | 155-271 | 16 | 3.6e-17 | 55.49 | In-house | 192-358 (365) | Show / Hide |
Range on Protein: 155-271 Range on HMM: 192-358/365 Sequence Identity: 16% (30 aa) IFMVSETRCKLADIGWSRDLL-------------------SMEGKMGYI------------QGTLQYYAPELIVNEG---------YGREVDIFALGCTM |.. .|..| | |... ... ||. ||. | ||| . ... |. ..||..||... ILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL YEIMMKRVLVEDNPEEPLEALKKIRL-PLIIT-------------------TYSKKLVNLVSS----MLNPDPKKRPT-AFE || .... ...| .. . |.. .| . ||. ||.||.| . . YEMLFGKPPF----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQ |
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S_TKc | GL50803_24321.AA | S_TKc | 10-278 | 20 | 1.3e-16 | 62.38 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 10-278 Range on HMM: 1-231/231 Sequence Identity: 20% (57 aa) YTEVGVIEEAEYQRLVEVQDKETGERYLCRQISLEEYTTKVCDLCKTDITLSTQVASPFFATVHEATYEAKSKKVFVLMEDFPM--GTLNDYLYGLPEDE |. . .| . . . ...|.||... . .|. . . | . . |. . ... .. ..... || . |.| ||. . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG F---LPEQTCWCLLACLVEAICQLHEPSRMKDIEHRFTRAIIHRYIMPRRIFMVSETRCKLADIGWSRDLLSMEGKMGYIQGTLQYYAPELIVNEGYGR- .|| ....... ...|. .|. . |||| . | |.. . . |..| | .| | . ||. | |||.. |||. LRFPFPE-HARFYMYQICCALEYCHS------------HGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKC EVDIFALGCTMYEIMMKRVLVEDNPEEPLEALKKIRLPLIITTYSKKLVNLVSSMLNPDPKKRPTAFEMRT-------IPEI ..|. ..||..|| . . . . .. . .|||. |. . .... .|. ||.||||| | . | . KCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | GL50803_24321.AA | Ciliate-E2-Unclassified | 145-278 | 21 | 3.5e-14 | 45.6 | In-house | 165-352 (352) | Show / Hide |
Range on Protein: 145-278 Range on HMM: 165-352/352 Sequence Identity: 21% (41 aa) IIHRYIMPRRIFMVSET---RCKLADIGWSRDLLSMEGKMGYIQ----------------GTLQYY----APELIVNEGYGRE----VDIFALGCTMYEI |||| | | |.. .. ..|..| | |. . ..... . | ||..| |||.. ...|. . .||..||. .||. IIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEM MMKRVLVEDNPEEP----------------LEALKKIR-----------LPLIITTYSKKLVN-LVSSMLNPDPKKRPTAFEMRTIPEI .. . .|| .| |. .| . | .. | ..| | ..||. .|.||.|. . | . LFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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Kinase | GL50803_24321.AA | PKR | 134-275 | 31 | 1.2e-13 | 45.08 | In-house | 133-272 (272) | Show / Hide |
Range on Protein: 134-275 Range on HMM: 133-272/272 Sequence Identity: 31% (46 aa) MKDIEHRFTRAIIHRYIMPRRIFMVSETRCKLADIGWSRDLLSMEGK-MGYIQGTLQYYAPELIVNEGYGREVDIFALGCTMYEIMMKRVLVEDNPEEPL .| .. . .||| . | ||.| | . |. | | | .|| .||||| .|| | . ||.||||.||| . |.. | . | VKGVDYIHSKKLIHRDLKPSNIFLVDERHIKIGDFGLVT-ALKNDGKSRTRRKGTLQYMSPEQIFSQHYGKEVDIYALGLILAELLH----VCFTEFEKI EALKKIRLPLII-TTYSKKLVNLVSSMLNPDPKKRPTAFE-MRTI . .| . . .| |. .| || || | .||. KFFEDLRDGDFSNDIFDNKEKTLLQKLLSKKPKDRPNTSEILRTL |
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Kinase | GL50803_24321.AA | STE | 155-278 | 20 | 1.6e-13 | 44.18 | In-house | 183-359 (359) | Show / Hide |
Range on Protein: 155-278 Range on HMM: 183-359/359 Sequence Identity: 20% (37 aa) IFMVSETRCKLADIGWSRDLLS----------------MEGKMGYIQGTLQYYAPELIVN------EGYGREVDIFALGCTMYEIMMKRVLVED-NPE-E |.. .||.| | . | . | .| . || . ||| | . ||.. .|| ||||. | .. | .| ILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRA PLEALKKI--------------RLPLIIT-------------------TYSKKLVNLVSSMLNPDPKKRPTAFEMRT--IPEI ....... | . . .|... . .. |. ||.||||| .. | | MFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI |
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Kinase | GL50803_24321.AA | CAMK | 164-271 | 16 | 2.1e-13 | 38.82 | In-house | 236-418 (425) | Show / Hide |
Range on Protein: 164-271 Range on HMM: 236-418/425 Sequence Identity: 16% (30 aa) KLADIGWSRDLLSMEG-----------------------KMGYIQGTLQYYA-PELIVN--------------EGYGREVDIFALGCTMYEIMMKRVLVE |..| | .. . . |. || ||. | | ||.. ..||...|. ..|. .| . . KIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFY D--------------NPEEPLEALKKIRLPLIITTYSK-----------------------KLVNLVSSMLNPDPKKRPTAFE . |..| .| .| . . |. .|...||..||.||.|. . GDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQ |
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Kinase | GL50803_24321.AA | NEK6 | 137-217 | 34 | 4.3e-11 | 32.51 | In-house | 116-196 (252) | Show / Hide |
Range on Protein: 137-217 Range on HMM: 116-196/252 Sequence Identity: 34% (28 aa) IEHRFTRAIIHRYIMPRRIFMVSETRCKLADIGWSRDLLSMEGKMGYIQGTLQYYAPELIVNEGYGREVDIFALGCTMYEI .|| . ..|| | | .|. .. || |.| | | . || | .|| | .|| ||..||| .||. LEHMHSKRVMHRDIKPANVFITANGIVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEM |
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Kinase | GL50803_24321.AA | WEE | 237-278 | 30 | 3.1e-08 | 23.79 | In-house | 256-297 (297) | Show / Hide |
Range on Protein: 237-278 Range on HMM: 256-297/297 Sequence Identity: 30% (13 aa) KIRLPLIITTYSKKLVNLVSSMLNPDPKKRPTAFEMRTIPEI .|. | .. .|. | .|. .|..|||..|||. . . |.. QIPFPEFDNIISQELKQLIKWMMHPDPEQRPTCQQLLQHPVL |
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Kinase | GL50803_24321.AA | WEE | 155-218 | 25 | 1.9e-07 | 21.09 | In-house | 143-230 (297) | Show / Hide |
Range on Protein: 155-218 Range on HMM: 143-230/297 Sequence Identity: 25% (22 aa) IFMVSET--------------------RCKLADIGWSRDLLSMEGKMGYI-QGTLQYYAPELIV-NEGYGRE--VDIFALGCTMYEIM ||. .. .||..| | . |. | . . ... | | |||.. . |.. |||.||.|.||.. IFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDFGHVTDMNSNNNNPHQEQEGDSRYMAPEILQGYYHYTHLYKADIFSLGITIYELA |
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TyrKc | GL50803_24321.AA | TyrKc | 58-279 | 16 | 1.6e-05 | -133.26 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 58-279 Range on HMM: 1-280/280 Sequence Identity: 16% (50 aa) ITLSTQVASPFFATVHEATYEAKSKKVFV--LMEDFPMGTLNDYLYGLPEDEFLPEQTCWCLL------------ACLV--------EAICQLHE----- ||| . . .| .|...|. .| | | || . .|. | | | .|. | .. . | ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHG --PSRMKDIEHRFTRA--------------------IIHRYIMPRRIFMVSETRCKLADIGWSRDLLSM--------EGKM----GYIQ-GTLQYYAPEL .. .. ..... . .||| . | . .. ..| .| | |||. . .. | . .||| DLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC IVNEG-YGREVDIFALGCTMYEIMMK-RVLVED------NPEEPLEALKKIRLPLIITT--------YSKKLVNLVSSMLNPDPKKRPTAFEMRTIPEIA | |.| . . |... | .|.||. .. ...| .| .|. . . . .... .. .. . ||..||| ...| |. I-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPT---FSEIHECF |
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Kinase | GL50803_24321.AA | NEK6 | 241-269 | 41 | 0.000695 | 8.39 | In-house | 224-252 (252) | Show / Hide |
Range on Protein: 241-269 Range on HMM: 224-252/252 Sequence Identity: 41% (12 aa) PLIITTYSKKLVNLVSSMLNPDPKKRPTA || ||..| .||. ...|||..|| PLPADHYSEQLRQLVCMCIHPDPEWRPDI |