Gene GL50803_22165 (G.lamblia)

GL50803_22165

Species: G.lamblia
Alias: GL50803_22165, GK083
External Links: GiardiaDB ,
Annotation:

Classification

Group: STE
Family: STE7
Subfamily: MEK1

Sequence

Name Sequence Type Origin Length Description Download
GL50803_22165.AA Protein None 357 None Fasta, JSON
GL50803_22165.kin_dom Protein Kinase Domain None 262 None Fasta, JSON

Protein domain

Protein domains of GL50803_22165.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_22165.AA STE 73-334 27 1.2e-83 284.24 In-house 1-359 (359) Show / Hide 
Range on Protein: 73-334
Range on HMM: 1-359/359
Sequence Identity: 27% (102 aa)

LEVVKPLGAGAFGTVNLVKVKT---------------TGQLCAMKEIRISDEE----------------QTQKNIYREIKASISLSC-NPYMVKTYNIYS
.| .. .| |||||| . . .                ||...|.|........                . ...| .|||    ...  |. || |  | 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

HPG------SILHILLEFCKYGSSQDMLK-KLKTGK-LT----------ENALAVFIIDTLRG-LAYLHDNCKIIHRDIKSANILIDEHGYCKLADFGVA
. |      . |.| .|.. .||  |..| | ..|| |.          |. .|... ..|.| |.|||..  |||||||.||||.     .||.||||.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH-IIHRDIKPANILL-----VKLCDFGVC

SSVLPN-------------DDEA-AMKTFVGSLSYMSPERIQN------QPYSYVSDVWSMGLTYVELLTGSYPYDNVNSF---------------WDAM
... ..             .. .   .||||.  .|.||.||.      ..|.. .|.|| |.| .|..|| .|. . . .               .. .
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

NVIVNGAPPLLKED-----------------AGYSPGLCDLVNAMLEKDPSKRMTAAQLLK--LPFC
  |||| || |...                   .|| ..| .|  |.|||.|| || ||||   || 
-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase GL50803_22165.AA S_TKc 73-334 28 1.1e-79 271.98 SMART 1-231 (231) Show / Hide 
Range on Protein: 73-334
Range on HMM: 1-231/231
Sequence Identity: 28% (78 aa)

LEVVKPLGAGAFGTVNLVKVKTTGQLCAMKEIRISDEEQTQKNIYREIKASISLSCNPYMVKTYNIYSHPGSILHILLEFCKY--GSSQDMLKKLKTGK-
 |.....| ||||.| ... | ||...|.|.|.        ..|.|||.   .    |. || | .. .  . |.. .|.|    |.  |..|| .... 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LTENALAVFIIDTLRGLAYLHDNCKIIHRDIKSANILIDEHGYCKLADFGVASSVLPNDDEAAMKTFVGSLSYMSPERIQNQPYSY-VSDVWSMGLT
   ..|   . ..  ....|.|.|.. .|||||.| .|||.||    |..|||.|  .         .||.|.. ||.|| .   .|..  .|.|| | .
RFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

YVELLTGSYPYDNVNSFWDAMNVIVNGAPPLLKEDAGYSPGLCDLVNAMLEKDPSKRMTAAQLLK-------LPFC
  |.|.|  |..        ...|.             || ..|... .|.|||.||.|| ..|.        |. 
LYEMLCGYPPFP---QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_22165.AA STE7-Unclassified 73-334 34 4.2e-71 242.52 In-house 1-301 (301) Show / Hide 
Range on Protein: 73-334
Range on HMM: 1-301/301
Sequence Identity: 34% (107 aa)

LEVVKPLGAGAFGTVNLVKVKT------TGQLCAMKEIRISDE-EQTQKNIYREIKASISLSCNPYMVKTYNIYSHPGS--ILHILLEFCKYGSSQ---D
||..| ||.|..||| ... |.      .|   |.|.|.  |  .  .| | ||.|. .. .  || |. |  | | ..   .||..|.   ||.    |
LERLKYLGHGMHGTVVKCLHKNGMVIARDGKIMAWKVIPTMDNDNEFMKQILRELKTLHKCQPHPYIVHYYGAYYHECMDCKIHICMEYMDCGSLDNKID

MLKKL------KTGKLTENALAVFIIDTLRGLAYLHDNCKIIHRDIKSANILIDEHGYCKLADFGVASSVLPNDDEAAM---KTFVGSLSYMSPERIQNQ
..||.      . |.. |  |.   .  ..|| |||.  .|||||||  |||... |. |..||||.  .     |...   ||.||  .|||||||| |
IYKKMYERGPIRGGWIPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNILVNSKGQVKICDFGVCGQL-----ENTLDEAKTWVGCQMYMSPERIQGQ

-----PYSYVSDVWSMGLTYVELLTGSYPYD--------NVN------SFWDAMNVIVNGAPPLLKEDA---GYSPGLCDLVNAMLEKDPSKRMTAAQLL
     .||  ||.|| |||  |. || |||.        | |      |||.  . |||   | |..|     .|. . |...  . |.|  | ...|||
MPHRPSYSVKSDIWSLGLTIWECATGKYPYEYNFQSEQYNQNFQPENMSFWELLSCIVNFPVPRLPDDPEDIIWSKEFMDFISKCCKKHPRERPDIHQLL

K-LPFC
. .|. 
NEHPWI
Kinase GL50803_22165.AA Pkinase 73-334 28 1.1e-66 232.65 Pfam 1-293 (293) Show / Hide 
Range on Protein: 73-334
Range on HMM: 1-293/293
Sequence Identity: 28% (86 aa)

LEVVKPLGAGAFGTVNLVKVKTTGQLCAMKEIRISDEEQTQKNIYR---EIKASISLSCNPYMVKTYNIYSHPGSILHILLEFCKYG----SSQDMLKKL
.......|.|.||.| . . | ||.. |.|.|. ..|.  .. . |   ||.   .| . |. |..| ..  ...|  . .|.|  |    .  |...  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIY-MVMEYCEGGLYVMDLFDYISTW

KTGKL--TENALAVFIIDTLRGLAYLHDNCKIIHRDIKSANILIDEHGYC----KLADFGVASSVLPNDDEAAMKTFVGSLSYMSPERIQ-NQPYSYVSD
. |..  .|. .  ..  .||||.|.|. ..|||||.|..|||||..|..    |..|||.|  .  .     |.||.|.. ||.|| |. .|.|.. .|
RHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

VWSMGLTYVELLTGSYPYDNV---NSFWDAMNVIVNGAPPLLKEDAGYS---------------------PGLCDLVNAMLEKDPSKRMTAAQLLKLPFC
.||.|..  |.|.|  |...     .  | | .|..  .| |..|  ..                     . ..|... .|.|||.|| ||.|.|. |. 
MWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase GL50803_22165.AA STE7 73-334 34 1.2e-66 227.73 In-house 1-288 (288) Show / Hide 
Range on Protein: 73-334
Range on HMM: 1-288/288
Sequence Identity: 34% (101 aa)

LEVVKPLGAGAFGTVNLVKVKTTGQLCAMKEIRISDEE-QTQKNIYREIKASISLSCNPYMVKTYNIYSHPGS-ILHILLEFCKYGSSQ---DMLKKL--
||... ||.|..|.|. .  | .|.. |.|.|| .. . . || | .|...  . .. ||.|. |  . . |.   .| .|.   |.     ...||   
LEHIGELGHGNYGVVYKMRHKPSGKIMAVKRIRLTNNDPEEQKQILMELDVLHKCNDCPYIVQFYGAFYTEGDDCIWICMEYMDGGCLDKFYKRVKKVYR

--KTGKLTENALAVFIIDTLRGLAYLHDNCKIIHRDIKSANILIDEHGYCKLADFGVASSVLPNDDEAAM---KTFVGSLSYMSPERIQN--QPYSYVSD
  | |.. |. |.   . ...|| |||.. ||||||.|  |||....|. ||.|||..        .  |   .||||  .||.||||.   | |.  ||
GIKKGRIPEQILGKIAVAVIKGLHYLHEKHKIIHRDVKPSNILVNSRGQVKLCDFGICGQL-----VDSMDAATTFVGCQPYMAPERIDGNKQHYDVRSD

VWSMGLTY-VELLTGSYPYDNVNS-----------------FWDAMNVIVNG-APPLLKEDAGYSPGLCDLVNAMLEKDPSKRMTAAQLLK-LPFC
|||.|.|  .|. || |||.| |.                 ... .. |||.  || |.   ..|| ..|.||  | |||..| .  ||.|  || 
VWSLGITMGIEMATGRYPYPNWNTHPPDQKQYNNMFQPEMAIFEQLTCIVNENPPPRLP---KFSPEFQDFVNKCLQKDPNERPKYHQLMKEHPFI
Kinase GL50803_22165.AA AGC 73-334 20 9.6e-66 167.99 In-house 1-395 (395) Show / Hide 
Range on Protein: 73-334
Range on HMM: 1-395/395
Sequence Identity: 20% (81 aa)

LEVVKPLGAGAFGTVNLVKVK------TTGQLCAMKEIRISD-----EEQTQKNIYRE------------IKASISLSC---------NPYMVK-TYNIY
 |..|..| |.||.| ||. |      .||...||| .. ..     ..........|             .    ..          .|. ||  .  .
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

SHPGS-ILHILLEFCK----------YGSSQDMLKKL-KTGKLTENALAVFIID-------TLRGLAYLHDNCKIIHRD-IKSANILIDEHGYCKLADFG
  .    |....|...           . .  .|..  | |...|..   ..         .. .| |||.. .||||| .|  |||.||.|..||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

VASSVLPND------------------------------------------------DEAAMKTFVG--SLSYMSPERIQNQPYSYVSDVWS--MGLTYV
 .  .  ..                                                ...  .||.|  .  ||.|| .    |..  | ||  .|    
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

ELLTGSYPYDNVN---------SFWDAMNVIVNG-----APPLLK--------EDAGYSPGLCDLVNAMLEKDPSKRMT----------AAQLLKLPFC
|.|||  |. . |         .  . .. | ||      .. .         ||   || . ||.. .|.|||.|| .          | .. . |. 
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase GL50803_22165.AA STE20 73-334 35 2.2e-63 216.92 In-house 1-288 (288) Show / Hide 
Range on Protein: 73-334
Range on HMM: 1-288/288
Sequence Identity: 35% (103 aa)

LEVVKPLGAGAFGTVNLVKVKTTGQL----CAMKEIRISDEE---QTQKNIYREIKASISLSCNPYMVKTYNIYSHP---GSILHILLEFCKYGSSQDML
 | .. .| |..|.| ..  | ||..    .| | . .....   . ...|  ||     .  .|. || |. |      .. | |. |.| .|| .|..
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCK-HPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIM

KKL-KTGK------LTENALAVFIIDTLRGLAYLHDNCKIIHRDIKSANILIDEHGYCKLADFGVASSVLP--NDDEAAM---KTFVGSLSYMSPERIQN
|.  |.||      ..|   |.   ..|.||.||| | .|||||||..|||..|.| .|||||||.... .    | .     .||||.  .|.|| || 
KHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSN-HIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGR-D-TMQFKRNTFVGTPYWMAPEVIQC

-----QPYSYVSDVWSMGLTYVELLTGSYPYDNVNSFWDAMNVIVNG--APPLLKE--DAGYSPGLCDLVNAMLEKDPSKRMTAAQLLKLPFC
     ..| | .|.|| | |  |...|  || ... .  ||  | ..   || ||.     .|| ..|.|. .|.|||.|| || |||| || 
MEGPDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPM-RAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase GL50803_22165.AA CAMK 78-334 19 1.4e-54 173.95 In-house 1-425 (425) Show / Hide 
Range on Protein: 78-334
Range on HMM: 1-425/425
Sequence Identity: 19% (84 aa)

PLGAGAFGTVNLVKVK-TTG-----------QLCAMKEIRISD---------------------------EEQTQKNIYREIKASISLS------CNPYM
 || |.||.| |.. | |||           | .|.| |  .                            .....||..|||.   .|.        |  
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKTYNIYSHPGSI------------------LHILL---EFCKYG----SSQDMLKKLKT-------------GKLTENALAVFIIDTLRGLAYLHDNCK
.| | .|  |  .                  ... .   |.|  |       |.... .              |..||   . ..   . ...|.|..  
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN-

IIHRDIKSANILIDEHG----------------Y-CKLADFGVASSVLPNDDEA---------------------AMKTFVGSLSYMS-PERIQN-----
|.|||.|  |||.|...                .  |..||| |  . |....                       ||||.|...||. || ..      
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------QPYSYVSDVWSMGLTYVELLTGSYPYD---------------NVNSFWDAMNVIVNG-APPLLKE---------DAGYSPG--------LC
         ..|.. .|.||.|     .|.| .|..               | .  .           || ...         . . |            
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DLVNAMLEKDPSKRMTAAQLLKLPFC
||.. ||..||.||||..| |. |. 
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase GL50803_22165.AA Ciliate-E2 73-334 20 1.9e-49 167.92 In-house 1-365 (365) Show / Hide 
Range on Protein: 73-334
Range on HMM: 1-365/365
Sequence Identity: 20% (77 aa)

LEVVKPLGAGAFG-----TVNLVKV------------------KTTGQLCAMKEIRISDEEQTQ--KNIYR---------EIKASISLSCNPYMVKTYNI
 ...| .| |.||     .| .|.                   |..... ||| .. .. ||.   ..|.|         . |   ..  .|. .| |  
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YS--HPGSILHILLEFCKYGSSQDMLKKL----------KTGKLTENALAVFIIDTLR---------------GLAYLHDNCKIIHRDIKSANILIDEHG
.      .|  . .|.|..|. .| .|.           . ...||.  . ..   |.               .| ||| . .|||||||  |||.    
FQEKDDNNIY-LVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

YCKLADFGVASSVLPNDDEAAM-----------------------------KTFVGSLSYMSPERIQNQP---------YSYVSDVWSMGLTYVELLTGS
 .|..||| .  . .. ..  .                             .|..|.. ||.|| .....         |.| .|.||.| .  |.|.| 
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

YPYDNVNSFWDAMNVIVNGAPPLLKED---------------AGYSPGLCDLVNA----MLEKDPSKRMT-AAQLLKLPFC
.|.         .. | ..   . ...                  |.   || .     ||.|||.||.| . |.|. |. 
PPF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase GL50803_22165.AA Ciliate-E2-Unclassified 74-334 24 2.3e-48 165.87 In-house 2-352 (352) Show / Hide 
Range on Protein: 74-334
Range on HMM: 2-352/352
Sequence Identity: 24% (88 aa)

EVVKPLGAGAFGTVNLVKVKTTGQLCAMKEIR---ISDEEQTQKNIYREIKASISLSC---------------------NPYMVKTYNIYSHPGSILHIL
...| .| |.||.| ... | ..|. |||..    | .  | .... ...   . . .                     .|. || . .      |  | 
KIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIY-IV

LEFCKYGSSQDMLKKLKT---------------GKLTENALA-----VFIIDTLRGLAYLHDNCKIIHRDIKSANILIDEHG---YCKLADFGVASSVLP
.|.|..|. ....|| |.                ..||.. .      ..   | || ||| . .|||||||  |||.|. |   |.|..||| ..    
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

NDD-------------EAAMKTFVGSLSYM----SPERIQNQPYS----YVSDVWSMGLTYVELLTGSYPYDNVNSFW---------------DAMNVIV
|..             .  |.||.|...||    .|| .|.| |.    | .|.||.|    |.|.| ||..  |.                    . | 
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

NGAPPLLKED-----AGYSPGLCDLVN----AMLEKDPSKRMTAAQLLKLPFC
.. .   |..      . ||   |..|     ||.|.|.||.|. |.|. |. 
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase GL50803_22165.AA TKL 79-332 20 3.4e-46 159.8 In-house 1-364 (364) Show / Hide 
Range on Protein: 79-332
Range on HMM: 1-364/364
Sequence Identity: 20% (75 aa)

LGAGAFGTVNLVKVKT--------TGQLCAMKEIRIS------------------------DEEQTQKNIYREIKASISLSC-NPYMVKTYNIYSHPGS-
.| |.||.|   | .         ||.  |.| ...                         |.|. . .  .|  . . ...  |  |. . .   |.. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-----------ILHILLEFCKYGS-SQDMLKKLKTGKLTENALAVFIIDTLRGLAYLHD-------NCKIIHRDIKSANILIDEHGY-------------
            |.|  |.|. ||   ...          . .  ...|. ||..|||         ..|||||.||.|||.||..              
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-CKLADFGVASSVLPN-DDEAAMKT----------------FVGSLSYMSPERIQNQ----------------PYSYVSDVWSMGLTYVELLTGSYPYDN
 ||..||| . .. .. .... |.|                 .|.. .|.|| ...|                .||  .||.|.|.   |.||.  ||..
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYD

VNSF---------WDAMNVIVNGAPPLLKE----------DAGYSPGLCDLVNAMLEKDPSKRMTAAQLLKLP
 ...         ...| |...| .|....               |....|     . ||.|| .. ..||  
YPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase GL50803_22165.AA STE11 144-334 33 1.3e-39 137.91 In-house 86-303 (303) Show / Hide 
Range on Protein: 144-334
Range on HMM: 86-303/303
Sequence Identity: 33% (74 aa)

SILHILLEFCKYGSSQDMLK-KLKTGKLTENALAVFIIDTLRGLAYLHDNCKIIHRDIKSANILIDEHGY-CKLADFGVASSVL-PNDDEAA-------M
. . | .|.|  ||  .||. |  ..|..|.   ... . |.||.|||... ||||||| ||||.|  |  ||||||| | ..   .   .        .
DHVNIFMEYCPGGSLSSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHG-IIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHC

KTFVGSLS--------YMSPERIQNQP---YSYVSDVWSMGLTYVELLTGSYPYDNVNS-FWDAMNVIVNG--APPLLKEDAG----YSPGLCDLVNAML
|.. |..         .|.|| | ...   |.  .|.|| | | .| .||  |. | ..  . ||  |. |   .| . |.       |. . | ..  .
KSMTGTPYNSMMGTPMWMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCF

EKDPSKRMTAAQLLKLPFC
|.||.|| ||.|||. ||.
EHDPKKRPTANQLLQHPFI
Kinase GL50803_22165.AA TyrKc 73-332 22 1.1e-14 14.98 SMART 1-280 (280) Show / Hide 
Range on Protein: 73-332
Range on HMM: 1-280/280
Sequence Identity: 22% (65 aa)

LEVVKPLGAGAFGTVNLVKVKTTGQLCAMKEIRISDEEQTQKNIYREIKASISL-SCNPYMVKTYNIYSHPG------SILHILLEFCKYGSSQDMLKKL
..  | || ||||.| . . |   . .| | .. .     .. ..||..   .|   .|  |. | . ...|        | |..|....|. .| |.| 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

KTGKLTENALAVFIIDTLRGLAYLHDNCKIIHRDIKSANILIDEHGYCKLADFGVASSVLPN-------DDEAA----MKTFVGSLSYMSPERIQNQPYS
.   |.   |  | ..  .| .|||.. ..||||.   |.|..| . .| .||| .  .          |   .     . ..  .  |.|| |.   ..
RPK-LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

YVSDVWSMGLTYVELLT-GSYPYDNV----NSFWDAMNVIVNGAPPLLKED------AGYSPGLCDLVNAMLEKDPSKRMTAAQLLKLP
  ||||| | .  |..| |  || ..     |  .... . .|  .   ..       . .. . ..     . ||..| | ... .. 
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase GL50803_22165.AA Pkinase_Tyr 148-261 29 1.5e-12 43.1 Pfam 84-199 (270) Show / Hide 
Range on Protein: 148-261
Range on HMM: 84-199/270
Sequence Identity: 29% (34 aa)

ILLEFCKYGSSQDMLKKL--KTGKLTENALAVFIIDTLRGLAYLHDNCKIIHRDIKSANILIDEHGYCKLADFGVASSVLPNDDE-AAMKTFVGSLSYMS
| .|....|.  | |.|     ..||   |  . ..  .|..||...  .||||.   |.|..| . .| .||| |  . . |    . .        |.
IVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN-CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMA

PERIQNQPYSYVSDVWS
|| |..  ..  |||||
PECINYGKFTTKSDVWS
Kinase GL50803_22165.AA STE11 79-121 34 3e-06 18.85 In-house 7-58 (303) Show / Hide 
Range on Protein: 79-121
Range on HMM: 7-58/303
Sequence Identity: 34% (18 aa)

LGAGAFGTVNLVKVKTTGQLCAMKEIRISDEEQ---TQKNIYRE------IK
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IGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQ
Kinase GL50803_22165.AA Pkinase_Tyr 73-121 27 0.004445 11.05 Pfam 1-55 (270) Show / Hide 
Range on Protein: 73-121
Range on HMM: 1-55/270
Sequence Identity: 27% (15 aa)

LEVVKPLGAGAFGTVNLVKVK----TTGQLCAMKEIRISDEEQT--QKNIYREIK
..  | ||.||||.| . . |     |.. .| | .. .  ..   ..   ||.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAK