Gene GL50803_17563 (G.lamblia)

GL50803_17563

Species: G.lamblia
Alias: GL50803_17563, GK037
External Links: GiardiaDB ,
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK1

Sequence

Name Sequence Type Origin Length Description Download
GL50803_17563.AA Protein None 385 None Fasta, JSON
GL50803_17563.kin_dom Protein Kinase Domain None 301 None Fasta, JSON

Protein domain

Protein domains of GL50803_17563.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_17563.AA MAPK 19-319 49 2.7e-171 575.38 In-house 1-328 (328) Show / Hide 
Range on Protein: 19-319
Range on HMM: 1-328/328
Sequence Identity: 49% (164 aa)

YKVTKALGAGAYGVVAEAVDTR------TNTTVAIKKISNLFVHLVDSKRTLREITILRML-DHENIVKLLDVLVP------EDPSNFDDLYVVFDFMQT
|.  | .| ||||||. |.|.|      ....|||||||. | .... |||.||| .||.. .||||.||||.. |      .....|.|.|.|...|.|
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DMHKIISSKQDLSPDHMQYFVYQLLRG--LKYLHSANCVHRDLKPSNLLLNSDCALEICDLGLARLVDDHAAKTKELKDAEKHDT---QMTEYVATRWYR
|.|.|| | | || ||.|||.||.|||  |||.|||| .||||||||.|.|..| | ||| |||| .|..  . .. .|.        .|||||||||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDP-HC-FQKMHMTEYVATRWYR

APEIILG--WPQYGKPVDIFSVGCIFAELIA-RKPLFPGRDYIHQLHLILEVLGTPEKELLDRIA-SDSAKSYVLAL---KPSAPQDLSQKFPM----LD
||||.|.  |  | | ||. ||||||||..  |||||||.|||.|. ||.||||||..|.. .|  |..|..|.  |   ..  ...... ||      .
APEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNAN

EAGIDLLTRMLTLDPLKRITVNECLSHPYF
   |||| .||..|| ||||| |.|.||||
PQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase GL50803_17563.AA ERK 19-319 51 4.7e-168 564.59 In-house 1-307 (307) Show / Hide 
Range on Protein: 19-319
Range on HMM: 1-307/307
Sequence Identity: 51% (162 aa)

YKVTKALGAGAYGVVAEAVDTR-----TNTTVAIKKISNLFVHLVDSKRTLREITILRMLD-HENIVKLLDVLVPEDPSNFDDLYVVFDFMQTDMHKIIS
|. .| .| ||||||. |.|.      |...||||||.| | |... ||||||| .||... ||||..|.|...|. | ...|.|.|...|.||.|.|| 
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIIN

SKQDLSPDHMQYFVYQLLRGLKYLHSANCVHRDLKPSNLLLNSDCALEICDLGLARLVDDHAAKTKELKDAEKHDTQMTEYVATRWYRAPEIILGWPQYG
|.| ||.|| |||.||.|.||||.|||| .||||||||.|.||.| | |||.|||| .| ....  |       . .|||||||||||||||.| |. | 
SQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHE-----CNQNFMTEYVATRWYRAPEIMLSWQKYT

KPVDIFSVGCIFAELIARKPLFPGRDYIHQLHLILEVLGTP-EKELLDRIASDSAKSYVLALKP--SAPQDLSQKFPM--LDEAGIDLLTRMLTLDPLKR
|..|| |.||||||...|||||||.||.||. .|....|||  .| | .|.|. |. |.  |     .|....  ||   .   .|||| .||. || ||
KAMDIWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKR

ITVNECLSHPYF
||| |||.||||
ITVEECLEHPYF
Kinase GL50803_17563.AA CMGC 19-319 28 6.9e-141 466.2 In-house 1-513 (513) Show / Hide 
Range on Protein: 19-319
Range on HMM: 1-513/513
Sequence Identity: 28% (149 aa)

YKVTKALGAGAYGVVAEAVDTRTN--------------TTVAIKKISNLFVHLVDSK----------RTLREITILRML-----------------DHEN
|.. | .| |.|||| ...|.|||                ||||||.| | .  . |          |.|||| ||..|                 .|.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVKLLDVLVPED-------------PSNFDDLYVVFDFMQTDMHKIISSKQ---------DLSPDH------------MQYFV------YQLLRGLK--Y
||||.|......             . .|..|| ||..|..| ...| ..|          ||. |             .||.      ||.|||||  |
IVKLYDIFYHKNSDGNEYEDKHIISQ-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

LHSAN--CVHRDLKPSNLLLNSDCAL--------------------EICDLGLARLVDDH----------------AAKTKELKDAEKHDTQMTEYVATR
.||..   .||||||.|.|.|..| |                     ||| |||| ...|                .       |. |.  ..|.||.||
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNK-------DD-KPNRPYTHYVVTR

WYRAPEIILGWPQY---------GKPVDIFSVGCIFAELIAR--------KPLFP-----------GRDYIHQLHLILEVLGTP----------------
|||||||.|||..|         ..|.|. ||||||||.. .        |||||           |...|.||..| .|||||                
WYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKH

EKELLDRIA--------------------SDSAKSYVLA---LKPSAPQDLSQKFPM-----------------------------------LDEAGIDL
|.|  ..|                     |..|. |.     ...  |......||                                    .|. .|||
EEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDL

LTRMLTLDPLKRITVNECLSHPYF
| .||..|| ||||. ..|.||||
LKKMLQYDPDKRITAEQALQHPYF
Kinase GL50803_17563.AA p38 19-319 46 4.3e-136 458.43 In-house 1-289 (289) Show / Hide 
Range on Protein: 19-319
Range on HMM: 1-289/289
Sequence Identity: 46% (142 aa)

YKVTKALGAGAYGVVAEAVDTRTNTT---VAIKKISNLFVHLVDSKRTLREITILRMLDHENIVKLLDVLVP--EDPSNFDDLYVVFDFMQTDMHKIISS
|.  . .| |||| |. |.|.||..    |||||..  |   .. ||| ||.  |....|||...||||  |  .. ..| | |.|  ||..| ..|. .
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

KQDLSPDHMQYFVYQLLRGLKYLHSANCVHRDLKPSNLLLNSDCALEICDLGLARLVDDHAAKTKELKDAEKHDTQMTEYVATRWYRAPEIILGWPQYGK
.. || || |. |||.|||||| |||. .||||||||. .| || | | | ||||                . |. ||.||||||||||||.| | .| .
QR-LSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR----------------HCDDEMTGYVATRWYRAPEIMLNWMHYTQ

PVDIFSVGCIFAELIARKPLFPGRDYIHQLHLILEVLGTPEKELLDRIASDSAKSYVLALKPSAPQDLSQKFPMLDEAGIDLLTRMLTLDPLKRITVNEC
 ||| ||||| |||| ...|||| |.|.||  |..|.|||..|.. .|.|..|..|.  . .   .|... |.. .   |||| .|| ||| ||||. | 
TVDIWSVGCIMAELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEA

LSHPYF
..||||
MQHPYF
Kinase GL50803_17563.AA ERK5 19-319 46 9.79999999999e-120 404.09 In-house 1-295 (295) Show / Hide 
Range on Protein: 19-319
Range on HMM: 1-295/295
Sequence Identity: 46% (142 aa)

YKVTKALGAGAYGVVAEAVDTRTNTTVAIKKISNLFVHLVDSKRTLREITILRMLDHENIVKLLDVLVPEDP-SNFDDLYVVFDFMQTDMHKIISSKQDL
||.   .| ||||||. |.  ..   |||||| | |  .   |||.||. |||   |.||. . |.| |. | | . | ||||| |  |.|.|| | | .
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPF

SPDHMQYFVYQLLRGLKYLHSANCVHRDLKPSNLLLNSDCALEICDLGLARLVDDHAAKTKELKDAEKHDTQMTEYVATRWYRAPEIILGWPQYGKPVDI
. .|. ||.||.||||||.|||. .|||||||||| |  | | | | |.|| .   .        ..||   ||||||||||||||...   .| . .|.
TLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFS--------PDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDV

FSVGCIFAELIARKPLFPGRDYIHQLHLILEVLGTPEKELLDRIASDSAKSYVLA-LKPSAPQDLSQKFPMLDEAGIDLLTRMLTLDPLKRITVNECLSH
.|||||| |.|||. .|||. ||||| ||..|||.|   ..  ...|  . |.   . .  |.|... .|  |  ..|||.|||  .| .|||||. | |
WSVGCIFGEMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQH

PYF
|. 
PFL
Kinase GL50803_17563.AA ERK7 19-319 43 9.60000000001e-116 390.83 In-house 1-292 (292) Show / Hide 
Range on Protein: 19-319
Range on HMM: 1-292/292
Sequence Identity: 43% (132 aa)

YKVTKALGAGAYGVVAEAVDTRTNTTVAIKKISNLFVHLVDSKRTLREITILRMLD-HENIVKLLDVLVPEDPSNFDDLYVVFDFMQTDMHKIISSKQDL
|.. | || ||||.|  |.| ||  .||.|||   |   .|. || |||..|. .. |.||..|..|.  .   |  |.|.||.|| ||.| .|   . |
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRAD---NDRDIYLVFEFMETDLHAVIRKGNIL

SPDHMQYFVYQLLRGLKYLHSANCVHRDLKPSNLLLNSDCALEICDLGLARLVDDHAAKTKELKDAEKHDTQMTEYVATRWYRAPEIILGWPQYGKPVDI
   | || .||||| .||.||.| .||||||||.||.|.| . .|| |||| .    |...|.   ....  .|||||||||||||| ||  .| | || 
KDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSI----AQQEEY---DEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDM

FSVGCIFAELIARKPLFPGRDYIHQLHLILEVLGTPEKELLDRIASDSAKSYVLALKPSAPQDLSQKFPMLDEAGIDLLTRMLTLDPLKRITVNECLSHP
 |.||| .|..  ||.|||   ..|. .|||... | .| .  | |. | . . ... . .. |.| .|.  ...|||| |.| . | ||.|....|.||
WSIGCILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHP

YF
| 
YV
Kinase GL50803_17563.AA ERK1 19-319 48 1.8e-111 376.64 In-house 1-289 (289) Show / Hide 
Range on Protein: 19-319
Range on HMM: 1-289/289
Sequence Identity: 48% (145 aa)

YKVTKALGAGAYGVVAEAVDTRTNTTVAIKKISNLFVHLVDSKRTLREITILRMLDHENIVKLLDVLVPEDPSNFDDLYVVFDFMQTDMHKIISSKQDLS
|   ...| ||||.|. |.||.... |||||||  | |    .||||||.||    ||||... |..  .   .. |.|.| . | ||. |.. . | ||
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKISP-FEHQTYCQRTLREIKILTRFKHENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKLLKT-QHLS

PDHMQYFVYQLLRGLKYLHSANCVHRDLKPSNLLLNSDCALEICDLGLARLVDDHAAKTKELKDAEKHDTQMTEYVATRWYRAPEIILGWPQYGKPVDIF
 ||. ||.||.||||||.|||| .||||||||||||  | | ||| ||||. | .            |   .||||||||||||||.|    | | .||.
NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHD----------HTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIW

SVGCIFAELIARKPLFPGRDYIHQLHLILEVLGTPEKELLDRIASDSAKSYVLALKPSAPQDLSQKFPMLDEAGIDLLTRMLTLDPLKRITVNECLSHPY
||||| ||... .|.|||. |. || .|| ||| | .. |. |  . |..|. .|   . . . . ||  |.  .||| .|||  | ||||| | | |||
SVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPY

F
 
L
Kinase GL50803_17563.AA nmo 20-319 44 8.10000000001e-110 338.99 In-house 2-292 (292) Show / Hide 
Range on Protein: 20-319
Range on HMM: 2-292/292
Sequence Identity: 44% (136 aa)

KVTKALGAGAYGVVAEAVDTRTNTTVAIKKISNLFVHLVDSKRTLREITILRMLDHENIVKLLDVLVPEDPSNFDDLYVVFDFMQTDMHKIISSKQDLSP
.  . .| ||.|||    | |    ||.||. | |  || .||  ||. .| .  |.|.. .||.| | ... |...||| . || |.|||| | | ||.
QPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHKDFFQEIYVVTELMQSDLHKIIVSPQHLSS

DHMQYFVYQLLRGLKYLHSANCVHRDLKPSNLLLNSDCALEICDLGLARLVDDHAAKTKELKDAEKHDTQMTEYVATRWYRAPEIILGWPQYGKPVDIFS
||.. |.||.||||||||||| .|||.|| |||.||.| | ||| ||||  .   .|            .||. | | .||||||..|  .|   |||.|
DHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWEQDQSK------------HMTQEVVTQYYRAPEILMGARHYTSAVDIWS

VGCIFAELIARKPLFPGRDYIHQLHLILEVLGTPEKELLDRIASDSAKSYVLALKPSAPQDLSQKFPMLD------EAGIDLLTRMLTLDPLKRITVNEC
||||||||. |. ||  .  |.||..| ..||||  | . . | . ||. .|   . .| .|.. . .        || ..|| |||  || ||| ... 
VGCIFAELLGRRILFQAQSPIQQLQMITDLLGTPSMEDM-KYACEGAKAHMLRMPHKPP-CLQVLYTLSSPDHATHEA-VHLLCRMLHFDPDKRISCKDA

LSHPYF
| ||| 
LAHPYL
Kinase GL50803_17563.AA S_TKc 19-319 27 7.1e-97 329.06 SMART 1-231 (231) Show / Hide 
Range on Protein: 19-319
Range on HMM: 1-231/231
Sequence Identity: 27% (87 aa)

YKVTKALGAGAYGVVAEAVDTRTNTTVAIKKISNLFVHLVDSKRTLREITILRMLDHENIVKLLDVLVPEDPSNFDDLYVVFDFMQT---DMHKIISSKQ
|.. . .| ||.|.|  .....|.  ||||.|.         ....||| ||.. .|.|||||.|| .       |.||.|.... .   |....| ...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRG

D------LSPDHMQYFVYQLLRGLKYLHSANCVHRDLKPSNLLLNSDCALEICDLGLARLVDDHAAKTKELKDAEKHDTQMTEYVATRWYRAPEIILGWP
       ... | ....||....|.|.|| . .||||||.|.||..   . ||| ||||..                    | .. |.||.|||..    
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------------------TTFCGTPWYMAPEVL----

QYGK-PVDIFSVGCIFAELIARKPLFPGRDYIHQLHLILEVLGTPEKELLDRIASDSAKSYVLALKPSAPQDLSQKFPMLDEAGIDLLTRMLTLDPLKRI
.||| ..|. |.|||..|.....|.||      |........|                                     .. ..|.. ..|. || ||.
GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRP

TVNECLS-------HPYF
|. |.|        ||.|
TA-EALQDEWDIKCHPWF
Kinase GL50803_17563.AA Pkinase 19-319 28 7.6e-93 319.56 Pfam 1-293 (293) Show / Hide 
Range on Protein: 19-319
Range on HMM: 1-293/293
Sequence Identity: 28% (91 aa)

YKVTKALGAGAYGVVAEAVDTRTNTTVAIKKISNLFVHLVDSKRTLR--EITILRMLDHENIVKLLDVLVPEDPSNFDDLYVVFDFMQT-----DMHKII
|.. . .|.|..|.| ....  |. .||.|.|.    .    .. .|  || |...|.|.|||.|.|.         |..|.|.....      | . .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYI

S--SKQDL--SPDHMQYFVYQLLRGLKYLHSANCVHRDLKPSNLLLNSDCAL----EICDLGLARLVDDHAAKTKELKDAEKHDTQMTEYVATRWYRAPE
|  ..  .  |... . ..||.||||.|.|| ...||||||.|.|..... .     ||| |||...|            . ... || .. |.||.|||
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------------Y-NNS-MTTFCGTPWYMAPE

IILGWPQYGKPVDIFSVGCIFAELIARKPLFPGR----DYIHQLHLILEVLG--TPEKELLDRIASDSAKSYVLALKPSAPQDLSQKFPMLDEAGIDLLT
.|.| . ||..||..|.|||..|.. ..|.|||.    . . |...| ...|  ... .  ..  |..   .    .    . .. . . ..|...|...
VIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H----F-HWTF-HNWSEECKDFIK

RMLTLDPLKRITVNECLSHPYF
..|..|| ||.|  ..| ||.|
WCLCKDPKKRPTAEQILQHPWF
Kinase GL50803_17563.AA CDK 19-319 33 2e-91 292.78 In-house 1-284 (284) Show / Hide 
Range on Protein: 19-319
Range on HMM: 1-284/284
Sequence Identity: 33% (111 aa)

YKVTKALGAGAYGVVAEAVDTRTN-----TTVAIKKISNLFV----H--LVDSKRTLREITILRMLDHENIVKLLDVLVPEDPSNF------DDLYVVFD
|.  . .| |.||||  | |..|.       ||.|||         .   . .  ..|||..|. | |.|||||.|| . .....         || ||.
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPIT-AIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFE

FMQTDMHKIISSKQDLSPDHMQYFVYQLLRGLKYLHSANCVHRDLKPSNLLLNSDCA-----LEICDLGLARLVD---DHAAKTKELKDAEKHD--TQMT
.| .|  |...          . . .|||||| |.|| . .||||||.|.|.|..       | | | ||||.     .           .. .    .|
YMDHDLKKYMD---------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQ-----------MS-EPNRTYT

EYVATRWYRAPEIILGWPQYG--KPVDIFSVGCIFAELIA---RKPLFPGRDYIHQLHLILEVLGTPEKELLDRIASDSAKSYVLALKPSAPQDLSQKFP
  | |.||||||. ||  .|.   |.|. ||||||||..    |||||||.  |.||..| ...|||  .    . .                       
HEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-------------------

MLDEAGIDLLTRMLTLDPLKRITVNECLSHPYF
       ||| .||..|| |||.  ..|.||||
-------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase GL50803_17563.AA MAPK-Unclassified 19-172 51 5.7e-84 285.28 In-house 1-161 (575) Show / Hide 
Range on Protein: 19-172
Range on HMM: 1-161/575
Sequence Identity: 51% (83 aa)

YKVTKALGAGAYGVVAEAVDTRT-NTTVAIKKISNLFVHLVDSKRTLREITILRMLDHENIVKLLDVLVPEDPSN--FDDLYVVFDFMQT---DMHKIIS
| ..| .|.||||.|..|.|... |  |||||.  .|   .| ||.|||| ||| | |.||... |.. .....|  |||.|.| |.|||   |.|.|| 
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK

SKQ-DLSPDHMQYFVYQLLRGLKYLHSANCVHRDLKPSNLLLNSDCALEICDLGLARLVDD
| |  ..  | ||| ||.||||||||||. .||||||||||.| ||.. ||| |..| . |
SNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSRSIED
Kinase GL50803_17563.AA MAPK-Unclassified 182-319 32 1.3e-51 177.83 In-house 397-575 (575) Show / Hide 
Range on Protein: 182-319
Range on HMM: 397-575/575
Sequence Identity: 32% (59 aa)

DAEKHDTQMTEYVATRWYRAPEIILGWPQYGKPVDIFSVGCIFAELIAR-----------KPLFPGRD--------------------YIHQLHLILEVL
. ..|  .||.||.|||||||||.|  . |.. ||| |.||||||.. .           .|||||.|                    .. |. .|...|
NDCHHCYHMTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYL

GTPEKELLDRIASDSAKSYVLALKPSAPQDLSQKFPMLDE----------AGIDLLTRMLTLDPLKRITVNECLSHPYF
|.|..| ...| .|||. |. ..|. .| . .. ..                ||..  ||  .| ||||  . |.||||
GMPPEEDCNFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase GL50803_17563.AA Pkinase_Tyr 19-172 30 3.7e-19 65.51 Pfam 1-165 (270) Show / Hide 
Range on Protein: 19-172
Range on HMM: 1-165/270
Sequence Identity: 30% (51 aa)

YKVTKALGAGAYGVVAEAVDT----RTNTTVAIKKISNLFVHLVD--SKRTLREITILRML-DHENIVKLLDVLV-PEDPSNFDDLYVVFDFMQT-DMHK
 .  | ||.||.|.| ... .     |...||.|.. .   .  .  ..  .||. |.. | .|.|||.|. | .  ..|.    .|.|. .|.  |...
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN---QIYIVMEYMPHGDLLD

IISS----KQDLSPDHMQYFVYQLLRGLKYLHSANCVHRDLKPSNLLLNSDCALEICDLGLARLV--DD
   .    || |.. ..  . .|  .|. ||.| ||.||||   | |....    ||| ||||..  ||
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDD
Kinase GL50803_17563.AA TyrKc 19-319 21 2.9e-14 8.03 SMART 1-280 (280) Show / Hide 
Range on Protein: 19-319
Range on HMM: 1-280/280
Sequence Identity: 21% (69 aa)

YKVTKALGAGAYGVVAEAVDTRTNTTVAIKKIS-NLFVHLVDSKRTLREITILRML--DHENIVKLLDVLVPE--DPSNF---DDLYVVFDFMQT-DMHK
 .  | || ||.|.| ... .   ..||.|..  .        .  .||. |...|  .|.|||.|. | . .      |   . |..|. .|   | ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN---FMYIEPLMIVMEYMPHGDLKD

IISSKQD-LSPDHMQYFVYQLLRGLKYLHSANCVHRDLKPSNLLLNSDCALEICDLGLARLVDDH-AAKTKELKDAEKHDTQ----MTEY-VATRWYRAP
 . .... |..... .| .|  .|  |||| ||.||||   | |....    |.| ||.| ..|. ..       ...  ..     . . .  ||. ||
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-----ESKDYYRKKEHKGGKTMLPIRWM-AP

EIILGWPQYG---KPVDIFSVGCIFAELIAR-KPLFPGR----DYIHQLHLILEVLGTPEKELL--DRIASDSAKSYVLALKPSAPQDLSQKFPMLDEAG
| |    .||      |..| |    |.  . ..  ||         ...  ..  . ...       ..                      |.   .. 
ECI----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MS----------------------FVCCPDEM

IDLLTRMLTLDPLKRITVNECLSHPYF
 .. ..    || .| | .|.  | .|
YQIMKQCWHEDPEDRPTFSEI--HECF