Gene GL50803_17449 (G.lamblia)

GL50803_17449

Species: G.lamblia
Alias: GL50803_17449, GK010
External Links: GiardiaDB ,
Annotation:

Classification

Group: PKL
Family: RIO
Subfamily: RIO1

Sequence

Name Sequence Type Origin Length Description Download
GL50803_17449.AA Protein None 434 None Fasta, JSON
GL50803_17449.kin_dom Protein Kinase Domain None 246 None Fasta, JSON

Protein domain

Protein domains of GL50803_17449.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_17449.AA RIO1 29-253 40 1e-76 261.15 In-house 2-225 (225) Show / Hide 
Range on Protein: 29-253
Range on HMM: 2-225/225
Sequence Identity: 40% (93 aa)

VLDDRVRKLIFRLIEKGALLSVDSVINTGKEANVFLCNSEAGN---VALKIYSTSILSFRNRIEYVEGEHRFETVTRSQKSNSRRMVKLWAEKEFRNLIR
|.| | | ..|... .| .  ..  | ||||.||.   .  |     | ||| |||| |  |  || || ||    .. |.| | |.|.|||||.|||.|
VIDPRTRMILFKMLTRGIITEINGCISTGKETNVYHASETNGKRAEYAIKIYKTSILVFKDREKYVDGEFRFRH-GHC-KHNPRKMIKIWAEKEMRNLKR

TQQLGSICIPKPLFITTTMIGLEFIGYDRAPAPRLKDVISDLSQARII-KLYWSIMRVLRTLYIGAGLVHGDLSEYNLLYLNKKLYLIDMGQSVHVTHPN
  |  .|  |.|. .       |||| |  .||||||.  ...    . ..|  ...  |..|  . |||.||||||.|| | |||.||  |||   || 
IYQS-EIPCPEPIMVKSNVLMMEFIGKDGMAAPRLKDY--QYKERDQYFHYYHQMIQYMRRMYQDCRLVHADLSEYNMLYHNDKLYMIDVSQSVEHDHPH

ALQFLRIDIININFFFARQGIPVLSAREV
.| ||| |. |.| .| .... ... |..
SLEFLRMDCKNVNMYFMKHNVIIFPVRDI
RIO GL50803_17449.AA RIO 19-259 38 6.5e-74 252.78 SMART 1-253 (253) Show / Hide 
Range on Protein: 19-259
Range on HMM: 1-253/253
Sequence Identity: 38% (99 aa)

DKSDRATTNLVLDDRVRKLIFRLIEKGALLSVD--SVINTGKEANVF---L--CNSEAGNVALKIYSTSILSFRNRIEYVEGEHRFETVTRSQKSNSRRM
|| |.|| ..|.| | |....... .| . ...   .|.|||||||.   .    ..   .| ||| ||...|... .|..|. ||  .  ....| | |
DKEDYATYEEVFDPRTRMTLYKMVNRGYIEEINNHGCISTGKEANVYHAMGGDFDKNGNECAVKIYRTSTTEFKRMWRYIQGDFRFKHG--YHHINWRKM

VKLWAEKEFRNLIRTQQLGSICIPKPLFITTTMIGLEFIGYDRAPAPRLKDVISDLSQARII-KLYWSIMRVLRTLYIGAGLVHGDLSEYNLLYL-----
|.|||||||||| | ..   .  |||       .  ||||.|  |||||||| ...  .    ..|| ||.  | .|  . |||.||||||.||      
VRLWAEKEFRNLQRMYEA-GVPCPKPIAWRRHVLVMEFIGDDGWPAPRLKDVEWEEWEMDFKWEYYWQIMEYMRKMYHECHLVHADLSEYNMLYHDLEDE

-NKKLYLIDMGQSVHVTHPNALQFLRIDIININFFFARQGIPVLS-AREVLAFICS
 . |...||..||| ..|| .|.||. || ||. || | |..... .||   .| .
NDCKVWIIDWSQSVECDHPMWLEFLERDIWNIINFFRRKGVDCDDIYREIFERITG
Kinase GL50803_17449.AA RIO1 61-253 42 3.7e-65 203.67 Pfam 1-200 (200) Show / Hide 
Range on Protein: 61-253
Range on HMM: 1-200/200
Sequence Identity: 42% (86 aa)

NVFLCNS-EAGN--VALKIYSTSILSFRNRIEYVEGEHRFETVTRSQKSNSRRMVKLWAEKEFRNLIRTQQLGSICIPKPLFITTTMIGLEFIG-YDRAP
||. . | | |.  .|.||| |....|... .|.... ||.   |  ..| | ||..||||||||| | .. | . .|||       .  |||| .|  |
NVYHAYSMEDGKDECAVKIYRTGTTCFKKMKRYRDYDFRFR--HRYHHHNWRYMVRMWAEKEFRNLKRMYEAG-VPCPKPIDWNRHVLVMEFIGDKDGWP

APRLKDVI--SDLSQARIIKLYWSIMR-VLRTLYIGAGLVHGDLSEYNLLYLNK-KLYLIDMGQSVHVTHPNALQFLRIDIININFFFARQGIP--VLSA
|||||||   ..||.  .  .|. |.|  .| .|  .|||||||||||.|.    |...||..|.| . ||.||.||. |. ||. ||.|.|..  |.. 
APRLKDVEMELELSEEEAEEIYDEIIREYMRRMYQECGLVHGDLSEYNILVHDDGKPWIIDWPQAVEHDHPHALEFLERDCRNIINFFRRKGVDERVMDF

REV
|| 
REI
Kinase GL50803_17449.AA RIO 26-267 27 4.8e-62 211.55 In-house 1-276 (276) Show / Hide 
Range on Protein: 26-267
Range on HMM: 1-276/276
Sequence Identity: 27% (76 aa)

TNLVLDDRVRKLIFRLIEKGALLSVDSVINTGKEANVFLCNSEAGN------------VALKIYSTSILSFRNRIEYVEGEHRFETVTRSQKSNSRRMVK
  ...| . | ...... .| . ||   | .|||.... | .| |.            .|.||. |...||..|  |. || .|    | .|.| | |..
YEQTNDPYTRMIMYKMVNRGMVESVGNCIGVGKESDIYHCSNENGEDEKEDSKVIPTECAIKIHRTGRTSFKDRKKYRDGEFYFK--HRHCKHNWRYMHR

LWAEKEFRNLIRTQQLGSICIPKPLFITTTMIGLEFIGYDRAPAPRLKDVISDLS-QARIIKLYWSIMRVLRTLYIGAGLVHGDLSEYNLLYLNKKL---
||||||.||..| .|  ..  |.|.      .  |||. |  |||.....   ..    . ..|   |.  |.||  . |||.|..|.|... ..|.   
LWAEKEMRNMKRLYQS-GFPCPEPIDYKRHVLVMEFINHDQMPAPKYPMC--QIHEHENMKHVYHQCMCYMRRLYQHCRLVHCDFNEFNMMWHDGKHDEN

----YLIDMGQSVHVTHPNALQFLRIDIININFFFARQGI-PVLSAREVLAFI------------------CSPNIPKTDD
    |.||  |.|  .||.|| ..| |. ..| || . ..  ... || . |                    .... .   
DCGFYMIDFPQMVEHDHPHALWYFRRDCKCVNMFFMKRFVYEPFPEREMFDFVGFGDGYKYAYPDFKRDVKRTDTLDHENM
Kinase GL50803_17449.AA RIO3 23-268 33 8.4e-45 148.66 In-house 1-254 (254) Show / Hide 
Range on Protein: 23-268
Range on HMM: 1-254/254
Sequence Identity: 33% (88 aa)

RATTNLVLDDRVRKLIFRLIEKGALLSVDSVINTGKEANVFLCN----------SEAGN--VALKIYSTSILSFRNRIEYVEGEHRFETVTRSQKSNSRR
 .|..  .| . | |...... | | ..  .| ||||. ||             |       |.|.. |..  |.||  |.  . ||    |  | | |.
HSTAEKAVDPKTRLLMYKMVNSGMLETITGCIATGKESVVFHAYGGSMEDEKEDSKVIPTICAIKVFKTTLNEFKNRDKYIKDDFRFK--DRFSKLNPRK

MVKLWAEKEFRNLIRTQQLGSICIPKPLFITTTMIGLEFIGYDRAPAPRLKDVISDLSQARIIKLYWSIMRVLRTLYIGAGLVHGDLSEYNLLYLNKKLY
. ..|||||  || | |. | |  |  ...   .. . |||.|. |||.||.|   |    . . |.  . ..| ||    ||| ||||||.|.   |..
IHRMWAEKEMHNLARMQRAG-IPCPTVVLLKKHILVMSFIGHDQVPAPKLKEV--KLNSEEMKEAYYQTLHLMRQLYHECTLVHADLSEYNMLWHAGKVW

LIDMGQSVHVTHPNALQFLRIDIININFFFARQGI-PVLSAREVLAFICSPNIPKTDDM
|||. |||  |||  |.||  |  |.  || . |.   || ||..  .   ||   .. 
LIDVSQSVEPTHPHGLEFLFRDCRNVSQFFQKGGVKEALSERELFNAVSGLNITADNEA
Kinase GL50803_17449.AA Ciliate-C1 56-76 26 0.000407 5.97 In-house 9-31 (328) Show / Hide 
Range on Protein: 56-76
Range on HMM: 9-31/328
Sequence Identity: 26% (6 aa)

TGKEANVFLCNSEAGN--VALKI
.|. . ||.|. . ..  .|.|.
HGYTCKVFYCKMPNNQKVYAVKQ