Gene GL50803_17406 (G.lamblia)
GL50803_17406
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| GL50803_17406.AA | Protein | None | 1638 | None | Fasta, JSON |
| GL50803_17406.kin_dom | Protein Kinase Domain | None | 518 | None | Fasta, JSON |
Protein domains of GL50803_17406.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| PI3K_C2 | GL50803_17406.AA | PI3K_C2 | 77-132 | 23 | 1e-05 | 22.81 | Pfam | 30-105 (168) | Show / Hide |
Range on Protein: 77-132 Range on HMM: 30-105/168 Sequence Identity: 23% (18 aa) KKTQ----LTYVWNSQQLTFP-ISISNLPQAAHFHISIYVH----G-----------VLLGSTEFPLYNE-HFALRC |... ...|| ...||| | ...|| .|...|.|. . . ...| . .||... ||| KPFNNHFFPRWNWN-EWITFPQIQYCDLPRDARLCITIWEIYCKKKSESNMNEQNKKCPIGWCNLPLFDHEKCMLRC |
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| PI3Ka | GL50803_17406.AA | PI3Ka | 442-634 | 16 | 0.000512 | -52.6 | SMART | 1-232 (232) | Show / Hide |
Range on Protein: 442-634 Range on HMM: 1-232/232 Sequence Identity: 16% (42 aa) VPDNAS--AGKLAKLCDVLF----THQLRSQDKDLIWKYR-YYMRKYPRGLIKVISSIPQSYRNVLIRQRSVKDKGQDSGQNFGDSIDESTNQDLRHIVG | .. .. .. .. | .| ...||||||.| || ...|. | | | . ..| . .. | DYDLKPRWNEEERDQLEDIMKYPPTYELTEEEKDLIWKFRHYYLTNHPKALP--------------------------SMC-F-PKFLRCVNWSWADEVK ELKTLLYTW--NDPAIDQLLLLLSQEYSLYNLNTNVIREYAINKLNQFADSVLLQFLLELT----FK--------------------------IDLDESL .. |.. | . ... | ||. .. | |. ..|.||. .|.|. | ||..|| | . .| | QAYQLMHQWWWPPIDPEDALELLDPKFPDY--NCPHVRQYAVQCLEQMSDDELLHYLLQLVQALKYENFDHIKHHFCEFDQDQSMSMTKEEDGPYHDSPL C---------------------IVDL--------FNYKELYQSIEDQMIDQQ-ETLAREKKK | ... .|.. .... ....... .. |. .| CRFLLQRALCNPRIGHFFYWYLKSEMYDHCQLHDPHYCQRFGMLLEMYCRGCCGHHMRHLFK |
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| PI3Kc | GL50803_17406.AA | PI3Kc | 1135-1635 | 11 | 1.8e-34 | 121.72 | SMART | 1-336 (336) | Show / Hide |
Range on Protein: 1135-1635
Range on HMM: 1-336/336
Sequence Identity: 11% (64 aa)
PVLLKINDDVRLDMLYVHLFSLMDSYMQTH----NLDMKFTIYSCFALSPSIGFIECILPSESQDDIYK-------------------------------
.|..| .|| | ||. .|.||. |. ..|.....|.| ...| .|.||.. .|. | |
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM
---------------------------KKELGTITDYFNAMLCKYRSQVSPSVLSQALVKLPSLLSEISAKLLADESLCLSSLISESILDGKLPPQSPYA
.. . .. .. . .. . .
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPN--------------------------------------------------
FSEFSDKTIPSVAGKGSLPFGEESYQMVKKRTRPSNLSSTSVHIPNMSTSMDDLMGGIRSTKGAHKSVFSDDGVEKRQENSRGHSRHVSTSDCSYGGSEA
----------------------------------------------------------------------------------------------------
KGSGDKGSETIESDKVMSAGATPSIQSRHTRGVPSNLSLQIGNRPLTQDIVQKWLVEQLTVKGIESLPQKVYAIIGSVIDKVYRFNGPLNCMNDITAEAQ
. .
----------------------------------------------------------------------------------------------EDWWEA
MSNFVKSTAAYSVATYLLRAGDRHGENLLIR-PDGRMFHIDFGWCFGKDPKLMAPK--------MKVSKDLVKAMG--GEGSADFESYLNYVAEIFCMLR
..||..|.|.|...||.| ||||..|... .| .|||||| .||..||.. .| .. .|.| .|| | | .| . .. ......|
RDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGHIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMR
QDVYIIISLLYILQGGGM-AYLDEAAQSHFYVIEDNYQLS-LERDAAIYYILD-----VVKASMKAIMGQFIDAFHRFTQG
.. |..|. ....... .. . ..... .|. | . |. |. . . ..| . .... ||...|.
KHSNLIMNLFEMMVYDPIMPCWRMM-EKDIKYLRQRFRLDHLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
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| PI3_PI4_kinase | GL50803_17406.AA | PI3_PI4_kinase | 1473-1571 | 29 | 7.2e-23 | 86.26 | Pfam | 164-280 (300) | Show / Hide |
Range on Protein: 1473-1571 Range on HMM: 164-280/300 Sequence Identity: 29% (35 aa) MSNFVKSTAAYSVATYLLRAGDRHGENLLI---RPDGRMFHIDFGWCFG-----KDPKLMAPKMKVSK------DLVKAMGG----EGSADFESYLNYVA ..|||.| | ..|..|.|. ||||..|... ...| .|||||| ||. ..|. .. .. . ..|.|||| . | |.. . | RDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCW EIFCMLRQDVYIIISLL ... ||.. ....|| HAYRALRRHMNLCMNLL |
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| PI3_PI4_kinase | GL50803_17406.AA | PI3_PI4_kinase | 1133-1201 | 17 | 1.6e-11 | 44.32 | Pfam | 1-98 (300) | Show / Hide |
Range on Protein: 1133-1201 Range on HMM: 1-98/300 Sequence Identity: 17% (17 aa) EIPVLLKINDDVR--LDMLYVHLF-----------------------SLMDSYMQTHNLDMK----FTIYSCFALSPSIGFIECILPSESQDDIYKKK ..|...| .|| | ||. .... .||. . ...| . ...|.| ...| |.||.. ... . | ... WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTY |
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| Kinase | GL50803_17406.AA | ATR | 1474-1574 | 21 | 7.3e-10 | 29.34 | In-house | 165-267 (267) | Show / Hide |
Range on Protein: 1474-1574 Range on HMM: 165-267/267 Sequence Identity: 21% (23 aa) SNFVKSTAAYSVATYLLRAGDRHGENLLIRP-DGRMFHIDFGWCFGKDPKLMAPKM---KVSKDLVKAMGGEGSADFESYLNYVAEIFCMLRQDVYIIIS .|...|.|.... |.. ||||..|.|| | . |.|. |.. .. | . .. . .| .|| .. . . .| ..|. |.| ENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGL--FRRACEVIMMCMRDHRDDIMS LLYIL .. VWDCF |
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| Kinase | GL50803_17406.AA | FRAP | 1475-1517 | 47 | 1.6e-08 | 27.6 | In-house | 139-182 (251) | Show / Hide |
Range on Protein: 1475-1517 Range on HMM: 139-182/251 Sequence Identity: 47% (21 aa) NFVKSTAAYSVATYLLRAGDRHGENLLI-RPDGRMFHIDFGWCF |. .| | |.| |.| |||| |... | |.. ||||| || NYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCF |
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| Kinase | GL50803_17406.AA | PIKK | 1474-1519 | 42 | 2.4e-08 | 26.89 | In-house | 187-233 (290) | Show / Hide |
Range on Protein: 1474-1519 Range on HMM: 187-233/290 Sequence Identity: 42% (20 aa) SNFVKSTAAYSVATYLLRAGDRHGENLLIRPD-GRMFHIDFGWCFGK .|. |.| ... | | ||||.||..| . | ||||| ||.. ENYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFES |
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| Kinase | GL50803_17406.AA | SMG1 | 1476-1527 | 41 | 6.2e-07 | 18.85 | In-house | 190-242 (242) | Show / Hide |
Range on Protein: 1476-1527 Range on HMM: 190-242/242 Sequence Identity: 41% (22 aa) FVKSTAAYSVATYLLRAGDRHGENLLI-RPDGRMFHIDFGWCFGKDPKLMAPK . .||| |. |.. |||| .| || | . |||. || | || .| YARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLNVPE |
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