Gene GL50803_17368 (G.lamblia)

GL50803_17368

Species: G.lamblia
Alias: GK069, GL50803_17368
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: Fused

Sequence

Name Sequence Type Origin Length Description Download
GL50803_17368.AA Protein None 2294 None Fasta, JSON
GL50803_17368.kin_dom Protein Kinase Domain None 256 None Fasta, JSON

Protein domain

Protein domains of GL50803_17368.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc GL50803_17368.AA S_TKc 4-259 29 6e-90 306.06 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-259
Range on HMM: 1-231/231
Sequence Identity: 29% (80 aa)

YEQIAQIGKGSFGVVYKCRLKQTGQFVAVKQISTYGKSSSELAALNSEISLLKEINHPNTIRFFESFEEDGSVVIVTELAQS---DLHSIFASDGP----
|| . .||||.||.||||| | ||. ||.|.|.           . .||..||. .||| ......|.. ... .|.|..     ||...  . |.    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LNIETIQKVCFQLLNVLTYLHSRRIAHRDIKSQNVLISQGVCKLCDFGFARQMSQQTLALQSIKGTPLYLAPEIAKGKKYNT-ISDMWAFGVMIFELA
  ..  ...... |... | |.||..| |||.| .|.|... . |.||||.|||.        .. ||| |.|||.    .|..  .|.|..|....|..
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

TGRTPFTATDFLTLMSILQDDSNKVPYDKYPIFAREPLFKSFCECMLQRNPDKRWASKQMLD-------HPFL
.|..||  ......  |.                  | .|.| . .||..|.||.   . |        ||..
CGYPPFP-QMQMMFKKIG-----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Pkinase GL50803_17368.AA Pkinase 4-259 29 6.2e-81 279.98 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-259
Range on HMM: 1-293/293
Sequence Identity: 29% (88 aa)

YEQIAQIGKGSFGVVYKCRLKQTGQFVAVKQISTYGKSSSEL-AALN-SEISLLKEINHPNTIRFFESFEEDGSVVIVTELAQS-----DLHSIFA--SD
|. . .||.||||.||||. | ||. ||||.|.  ...|... .... |||...|..|||| .|....||..... .|.|...      ||...    ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GPL--NIETIQKVCFQLLNVLTYLHSRRIAHRDIKSQNVLIS-QGVC----KLCDFGFARQM-SQQTLALQSIKGTPLYLAPEIAK-GKKYNTISDMWAF
|..    ....... |.|  | |.||..| |||.|..|.||. .|..    |.||||.|.|.       .... ||| |.|||. . |..| . .|||..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVMIFELATGRTPFTAT----DFLTLMSILQDDSN-KVPYDKYPIFARE-----------------PLFKSFCECMLQRNPDKRWASKQMLDHPFL
|....|...||.||       . .. | ... .   ....| .    .                  . .|.|....|...| ||.  .| | ||..
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase GL50803_17368.AA Fused 4-259 39 5.8e-78 265.31 In-house 1-251 (251) Show / Hide 
Range on Protein: 4-259
Range on HMM: 1-251/251
Sequence Identity: 39% (102 aa)

YEQIAQIGKGSFGVVYKCRLKQTGQFVAVKQISTYGKSSSELAALNSEISLLKEINHPNTIRFFESFEEDGSVVIVTELAQSDLHSIFASDGPLNIETIQ
|     .|.|||| ||| | |   . ||.| |.  | |  ||  |  |.   ... ||. |   .||| |  ||.||. |  .|| .   || .  | ..
YHVSEMVGQGSFGCVYKARRKYDSKVVAIKFIPKRGRSDKELKNLRRECEIMRRMHHPHIIHMIDSFETDKEVVVVTDYAEMELHQYLEYDGKMPEEQVR

KVCFQLLNVLTYLHSRRIAHRDIKSQNVLISQG-VCKLCDFGFARQMSQQTLALQSIKGTPLYLAPEIAKGKKYNTISDMWAFGVMIFELATGRTPFTAT
..  .|.  | |||| || |||.| ||.|   . . ||||||||| ||  |. | ||||||||.|||    . |    |||  |  ..||. |  || |.
RIACHLVSALYYLHSHRILHRDMKPQNILLDKNMHIKLCDFGFARNMSINTHVLTSIKGTPLYMAPELVEEQPYDHHADMWSLGCILYELMVGQPPFCAN

DFLTLMSILQDDSNKVPYDKYPIFAREPLFKSFCECMLQRNPDKRWASKQMLDHPFL
  . | |.   |  | |          . ...|   .| . | .|    |.| ||| 
SIFHLVSMIKHDDVKWPS------TITSCCRNFLQGLLTKDPRHRISWPQLLCHPFV
Kinase GL50803_17368.AA ULK 4-259 25 1.1e-73 251.1 In-house 1-329 (329) Show / Hide 
Range on Protein: 4-259
Range on HMM: 1-329/329
Sequence Identity: 25% (85 aa)

YEQIAQIGKGSFGVVYKCRLKQT----GQFVAVKQISTYGKSSSELA--------ALNSEISLLKEIN--------HPNTIRFFESFEEDGS--VVIVTE
|. . ..||||||.||| | |.|    .. ||.|.|.   .. ..           |..|| ..|...        |||...... ||.. .  . |..|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

LAQS-DLHSIFASDGPLNIET----------IQKVCFQLLNVLTYLHSRRIAHRDIKSQNVLISQG-------------VCKLCDFGFARQMS-----QQ
. .  || ..   ...|. .|          ..... |.|| . .||...| ||||| ||.||. |             |.|..|||||....     ||
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

TLALQS----IKGTPLYLAPEIAK----GKKYNTI-SDMWAFGVMIFELATGRTPFTATDFLTLM-----SILQD--------DSNKVPYDKY-PIFARE
 .  ..    ..||||| ||.| .    .|.|..  .|.| .|....|. .|..|| |  | ..      . ...        ....  ..|. ..  . 
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

PLFKSFCECMLQRNPDKRWASKQMLDHPFL
| .|..  .|||.....|    ....||..
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase GL50803_17368.AA ULK 4-259 25 2e-71 243.58 In-house 1-324 (324) Show / Hide 
Range on Protein: 4-259
Range on HMM: 1-324/324
Sequence Identity: 25% (83 aa)

YEQIAQIGKGSFG-VVYKCRLKQT---GQFVAVKQIS-TYGKSSSELA-------ALNSEISLLKEIN---HPN--TIRFFESFEEDGS--VVIVTELAQ
|. . ..|||||| .||| | |.|   .|.||.|.|.  . . .. ..        |..||...|...   |||  ...... ||.. .  . |..|. .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

S-DLHSIFASDGPLNIET----------IQKVCFQLLNVLTYLHSRRIAHRDIKSQNVLISQG-------------VCKLCDFGFARQMS---QQTLALQ
  || ..   ...|.  |          ..... |..| . .||.. | ||||| || ||. |             |.|..|||||..     ..   .|
GGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQ

SIK------GTPLYLAPEIAK----GKKYNTI-SDMWAFGVMIFELATGRTPFTATDFLTLM----SILQ--------DDSNKVPYDKY-PIFAREPLFK
...      ||||| ||.| .    .|.|... .|.| .|....|. .|..|| .  | ..     . ..           ......|. ..  . | .|
TCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECK

SFCECMLQRNPDKRWASKQMLDHPFL
..  .|||.....|    ....||..
DLIRRMLQYDEKDRISWEEIFNHPWF
Kinase GL50803_17368.AA STE 4-259 24 1.1e-69 237.86 In-house 1-359 (359) Show / Hide 
Range on Protein: 4-259
Range on HMM: 1-359/359
Sequence Identity: 24% (90 aa)

YEQIAQIGKGSFGVVYKCRLKQ---------------TGQFVAVKQISTYGKSS---------------SELAALNSEISLLKEIN--HPNTIRFFESFE
.| | .||||.||.|||.. .                ||...|.||..   ...               .|.  .  ||...|. |  ||| .... ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EDG-------SVVIVTELAQ-----SDLHSIFASDGPLN----------IETIQKVCFQLLNV-LTYLHSRRIAHRDIKSQNVLISQGVCKLCDFGFARQ
 .|       .. |. |.       . ... .   .|||           . | ..|.|.|   | |||| .| |||||..|.|.    .||||||.. |
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCGQ

MSQQ--------------TLALQ--SIKGTPLYLAPEIAKG------KKYNTISDMWAFGVMIFELATGRTPFTATDFLTLMSILQDDS-----------
...               | . .  .. ||| . |||. ..      |.|.| .|.| .| .| |.|||. |.     .  |   .. .           
LTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCI

--NKVPYDKYPIFARE----------------PLFKSFCECMLQRNPDKRWASKQMLD--HPFL
  .. |  . ..   |                | || | .  ||..|.||. ..|.|   |||.
VNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase GL50803_17368.AA Ciliate-E2 4-259 22 1e-65 224.54 In-house 1-365 (365) Show / Hide 
Range on Protein: 4-259
Range on HMM: 1-365/365
Sequence Identity: 22% (86 aa)

YEQIAQIGKGSFGVVYKCRLKQTGQFVA----------------VKQISTYGKSS--SELAALNSEISLLKEIN----------------HPNTIRFFES
|. | .||.|.||.||||. ..... .|                ||.   . |.   ... ....||....|||                ||| |...|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FE--EDGSVVIVTELAQS-DLHS------IFA------SDGPLNIETIQKVCFQLLN---------------VLTYLHSRR-IAHRDIKSQNVLISQGVC
|.   | .. .|.|..|  || .      ..         ...... |...  |.|.                | ||||.  | ||||| .|.|.    .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----I

KLCDFGFARQ----------MSQQTLALQSI----------------------KGTPLYLAPEIAKGKK---------YNTISDMWAFGVMIFELATGRT
|..|||....          ..|. . ..                         ||| |.|||| .|||         |.. .|.|..||...|. .|..
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFTATDFLTLMSILQDDSN-KVPYDKYP-------------IFAREPLF-KSFCEC----MLQRNPDKRWA-SKQMLDHPFL
||           .|   . |. ....              ..   ..  | ..      |||..|.||    .| |.||..
PF-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase GL50803_17368.AA CAMK 9-259 18 5.8e-62 198.14 In-house 1-425 (425) Show / Hide 
Range on Protein: 9-259
Range on HMM: 1-425/425
Sequence Identity: 18% (78 aa)

QIGKGSFGVVYKCRLKQTG------------QFVAVKQISTYGKSSSE--------------------------LAALNSEISLLKE-------INHPNT
..|.||||.|..|. |.|.            | ||.| |..   ....                          .. . .||...|        ..||| 
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IRFFESFEEDGS-------------------VVIVT---ELAQSD------------LHS---------IFASDGPLNIETIQKVCFQLLNVLTYLHSRR
|...| .| .                     ...|.   |...                .         |  ..| .. .  ...  |..  . |.||. 
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSHN

IAHRDIKSQNVLISQ------------------GVCKLCDFGFARQMSQ-----------------------QTLALQSIKGTPLYLA-PEIAKGKK---
|.|||.|  |.|...                  .  |..|||||... .                       ..  ..   ||| | | ||. .||.   
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

-----------YNTISDMWAFGVMIFELATGRTPFTA--------------TDFLTLMSILQDDSNKVPYDKYPIFAREPL-------------------
           |.  .|||. ||. . . .|. || .              .|  ..  |.. . .  |.   || .                       
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCN--YGPEWWDDISDEFHHFVSQE

FKSFCECMLQRNPDKRWASKQMLDHPFL
 |..  .|||..|.||.  .| |.||..
CKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase GL50803_17368.AA Ciliate-E2-Unclassified 4-259 21 2.7e-59 203.33 In-house 1-352 (352) Show / Hide 
Range on Protein: 4-259
Range on HMM: 1-352/352
Sequence Identity: 21% (76 aa)

YEQIAQIGKGSFGVVYKCRLKQTGQFVAVKQISTYGKSS-----SELAALNSEISLLKEIN-------------------HPNTIRFFESFEEDGSVVIV
|. | |||.|.||.||||. |...|. | |... . . .     ..   .. |.  .....                   ||. ...|. |. .  . ||
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

TELAQSDLHSIFASD------------------GPLNIETIQ-----KVCFQLLNVLTYLHSR-RIAHRDIKSQNVLISQG----VCKLCDFGFAR---Q
.|...   .. . ..                    .  . ..     . . |.|. | |||.   | ||||| .|.|....     .|..|||...   |
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

MSQQTLA-------------LQSIKGTPLYL----APEIAKGKKYNTI----SDMWAFGVMIFELATGRTPFTATDFLT-------------LMSILQDD
.....               .... ||| |.    |||. .|..|..     .|.|..|| ..|. .|. || ...                 . ..|. 
NNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

-SNKVPYDKYPI----FAREPLFKSFCE----CMLQRNPDKRWASKQMLDHPFL
  ... ..|.|         |  | |..    .||. ||.||   .| | ||..
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase GL50803_17368.AA NEK 4-219 30 6.2e-59 202.1 In-house 1-250 (286) Show / Hide 
Range on Protein: 4-219
Range on HMM: 1-250/286
Sequence Identity: 30% (75 aa)

YEQIAQIGKGSFGVVYKCRLKQTGQF-----VAVKQISTYGKSSSELAALN-SEISLLKEINHPNTIRFFESFEEDG--SVVIVTELAQS--DLHSIFAS
|| | .||.||||.|||.| |..|.      .. |.|.. . |. |  ..  .|. .||...||| .....||.|..  .  || | .    ||.  . |
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

--DG-----PLNIETIQKVCFQLLNVLTYLHSR-----RIAHRDIKSQNVLISQ-GV----CKLCDFGFARQMSQQTLALQS-IKGTPLYLAPEIAKGKK
   .     ..  |.| ....|..  | |.|.|     .| |||||.||. ..  .      |. ||| ...... | ....   ||| |..||. ..|.
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YNTISDMWAFGVMIFELATGRT--PFTAT--DFLTLM-SILQD-DSNKVP
||  ||.|..|. ..|..| .   || |.  ... |.  | .  . ...|
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIP
Kinase GL50803_17368.AA CMGC 4-199 21 5.5e-51 165.28 In-house 1-342 (513) Show / Hide 
Range on Protein: 4-199
Range on HMM: 1-342/513
Sequence Identity: 21% (75 aa)

YEQIAQIGKGSFGVVYKCRLKQTG--------------QFVAVKQISTYGKSSSELAAL------------NSEISLLKEIN-----------------H
|| | .||.|..||||||| |.|.              ..||.| |.   .   |  |.            . ||..||..|                 |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKN--PF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHH

PNTIRFFESFEEDG-----------------SVVIVTELAQSDLHSIFASDG---------PLNIET------------IQKVC------FQLLNVLT--
.| .. ...|  ..                 .. .|.|. . ||. .  .           ||.               |..        .|.|. |   
NNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLK

YLHSRR--IAHRDIKSQNVLISQ---------------------GVCKLCDFGFARQMSQQ---------------------TLALQSIKGTPLYLAPEI
|.||..  | |||.| .|.||..                     |. |.||||.||. ..                      . .. .   |  | ||||
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI

AKG----------KKYNTISDMWAFGVMIFELATG-------RTPF
  |          ..|.|  |||..| ...|. ||       . |.
LLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPL
Kinase GL50803_17368.AA STE20 4-199 30 3.3e-50 173.1 In-house 1-227 (288) Show / Hide 
Range on Protein: 4-199
Range on HMM: 1-227/288
Sequence Identity: 30% (70 aa)

YEQIAQIGKGSFGVVYKCRLKQTGQF----VAVKQISTYGKSS--SELAALNSEISLLKEINHPNTIRFFESFEED----GSVVIVTEL-----AQSDLH
|| . .||.||.|.|||.. |.||.     ||.|...   ..    |.  .  ||| .|. .||| .....|.  |     .  || |.     ..  ..
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

SIFASDG-----PLNIETIQKVCFQLLNVLTYLHSRRIAHRDIKSQNVLISQG-VCKLCDFGFARQMSQQ---TLA--LQSIKGTPLYLAPEIAKG----
  .  ..     |.| | |  .| ..|  | ||||..| |||||..|.|...   .||.|||.. |....   | .   ... ||| ..|||. ..    
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

-KKYNTISDMWAFGVMIFELATGRTPF
 |.|.. .| |..| .. |.|.|. |.
DKGYDYKCDIWSLGITAIEMAEGEPPY
Kinase GL50803_17368.AA Pkinase_Tyr 4-199 28 1.3e-30 104.28 Pfam 1-216 (270) Show / Hide 
Range on Protein: 4-199
Range on HMM: 1-216/270
Sequence Identity: 28% (62 aa)

YEQIAQIGKGSFGVVYKCRLK----QTGQFVAVKQISTYGKSSSE--LAALNSEISLLKEI-NHPNTIRFFESFE-EDGS--VVIVTELAQS-DLHSIFA
 . . ..|.|.||.|||...|    .|.. |||| .   | ....  .... .|....|.. .||| .|.      ....  . ||.|...  ||..   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

S----DGPLNIETIQKVCFQLLNVLTYLHSRRIAHRDIKSQNVLIS-QGVCKLCDFGFARQM-------SQQTLALQSIKGTPLYLAPEIAKGKKYNTIS
.    ..||..... . |.|  . . ||.|... |||.   |.|.. ..|.| |||| || .        ... .   || .    |||  . .|..| |
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM----APECINYGKFTTKS

DMWAFGVMIFELAT-GRTP-F
| |.||| ..|. | |..| .
DVWSFGVLMWEIFTYGEQPTY
Kinase GL50803_17368.AA TyrKc 4-259 21 2.8e-17 56.64 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-259
Range on HMM: 1-280/280
Sequence Identity: 21% (64 aa)

YEQIAQIGKGSFGVVYKCRLKQTGQFVAVKQISTYGKSSSELAALNSEISLLKEI--NHPNTIRFFESFEED-------GSVVIVTELAQS-DLHSIFAS
 . . ..| | ||.|||...|   . |||| .  .      .... .|.......  .||| .|..    ..       . . ||.|..   ||..   .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

DGP-LNIETIQKVCFQLLNVLTYLHSRRIAHRDIKSQNVLISQGV-CKLCDFGFARQMSQQ--------TLALQSIKGTP--L---YLAPEIAKGKKYNT
 .| |. ..  . |.|  .   ||||... |||.   |.|.. .  .| .||| .|             .   .. ||.   |    .|||  . .|..|
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

ISDMWAFGVMIFELAT-GRTPFTA-----TDFLTLMSILQDD--SNKVPYDKYPIF----AREPLFKSFCECMLQRNPDKRWASKQMLDHPFL
 || |.|||...|. | | .|         .   ..  ...     . |.|  |      . . ...   ..  ...|..|   ..   | ..
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--HECF
Kinase GL50803_17368.AA STE20 230-259 43 5.9e-10 32.86 In-house 259-288 (288) Show / Hide 
Range on Protein: 230-259
Range on HMM: 259-288/288
Sequence Identity: 43% (13 aa)

PLFKSFCECMLQRNPDKRWASKQMLDHPFL
| |. | . .||..|.||. ..|.| |||.
PEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase GL50803_17368.AA CMGC 212-259 23 4.2e-08 21.76 In-house 450-513 (513) Show / Hide 
Range on Protein: 212-259
Range on HMM: 450-513/513
Sequence Identity: 23% (16 aa)

QDDSNKVPYDKYPIFARE---------------------PLFKSFCECMLQRNPDKRWASKQMLDHPFL
.|| |  ..  . .| ..                     |..  . . ||| .||||.  .| |.||..
WDD-N-NKK--AMVF-NWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase GL50803_17368.AA NEK 239-259 42 0.135536 1.86 In-house 266-286 (286) Show / Hide 
Range on Protein: 239-259
Range on HMM: 266-286/286
Sequence Identity: 42% (9 aa)

MLQRNPDKRWASKQMLDHPFL
|||..|..|   .| | .||.
MLQKDPEQRPSCNQILEMPFI