Gene GL50803_17216 (G.lamblia)
GL50803_17216
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| GL50803_17216.AA | Protein | None | 844 | None | Fasta, JSON |
| GL50803_17216.kin_dom | Protein Kinase Domain | None | 260 | None | Fasta, JSON |
Protein domains of GL50803_17216.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| S_TKc | GL50803_17216.AA | S_TKc | 26-285 | 24 | 1e-15 | 53.59 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 26-285 Range on HMM: 1-231/231 Sequence Identity: 24% (67 aa) FASIQCVGSSTAGKTYLAIKVDQGCPVILKEVDLSNLSSDQIDLLEGYVTAIKELTCPNIVRYKAIHKGSMGDKVYLESEYCSL--GSVQDMVINHKA-- . .. .|. . || |...... | | .|... . .. . |. .||||... . |..|. |||. |.. |. ... YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG SRRIIREDFIWRVAAVIVFVLEYLHTHLTPQYCSIKSYRCLRPSNILLTEDDIIKIDNFSATRLLGDYSSESLRIYIAPELLAGAAYGP-AADAWSLGCI |. . | ...... |. |||.| | .| | |.||||.| ||| | |.| .. . |.|||.| ||. ..| ||.||| LRFPFPE-HARFYMYQICCALEYCHSHG-------IIHRDLKPENILLDE--HIKICDFGLARQL--TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI LLTMCTLLEPLSVIDPRASNEPLDLSTLHGLEHYSNELLELIKNCLYISVNMRSTISQLRS-------HPRI | |.. | . .. . . | | |....|..|| . | |. .. || . LYEMLCGYPPFP--------QMQMMFKKIG----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | GL50803_17216.AA | STE | 197-285 | 22 | 2e-12 | 40.27 | In-house | 228-359 (359) | Show / Hide |
Range on Protein: 197-285 Range on HMM: 228-359/359 Sequence Identity: 22% (30 aa) YIAPELLAG------AAYGPAADAWSLGCILLTMCTLLEPLSV-IDPRASNEPL-----------------DLSTLHG-----------------LEHYS . ||| . . |. .| ||||| .. |.| |.. ..|| . . . .| ...| WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWS NELLELIKNCLYISVNMRSTISQLRS--HPRI |. . |..|| . | | | ||| . || | PEFKDFINKCLQKDPNKRPTASQLLKSEHPFI |
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| Kinase | GL50803_17216.AA | Pkinase | 197-285 | 23 | 6.2e-12 | 43.27 | Pfam | 177-293 (293) | Show / Hide |
Range on Protein: 197-285
Range on HMM: 177-293/293
Sequence Identity: 23% (28 aa)
YIAPELLA-GAAYGPAADAWSLGCILLTMCTLLEPLSVID----PRASNEPLDLSTLHGLEHYS-------------------------NELLELIKNCL
|.|||.. | |||..| ||.|||| |.. | . . . .. . .... |.. |....||.||
YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL
YISVNMRSTISQLRSHPRI
. | |. |. || .
CKDPKKRPTAEQILQHPWF
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| Kinase | GL50803_17216.AA | STE | 26-148 | 16 | 2e-11 | 36.76 | In-house | 1-171 (359) | Show / Hide |
Range on Protein: 26-148
Range on HMM: 1-171/359
Sequence Identity: 16% (29 aa)
FASIQCVGSSTAGKTYLAIKVD---------------QGCPVILKEVDLSNLSS---------------DQIDLLEGYVTAIKELT--CPNIVRYKAIHK
. |...|. . |..|.|.... .|. . |...|.| .. .... .. . |.. .||||.| .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF
GS-----MGDKVYLESEYCSLGSVQDMVI-NHKASR---------RIIREDFIWRVAAVIVFV-LEYLHTH
.|.... ||.. ||. |.. ... . . |. | ... |. |.||| |
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSH
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| Kinase | GL50803_17216.AA | Ciliate-E2 | 162-285 | 19 | 8.7e-10 | 29.76 | In-house | 187-365 (365) | Show / Hide |
Range on Protein: 162-285 Range on HMM: 187-365/365 Sequence Identity: 19% (37 aa) LRPSNILLTEDDIIKIDNFS-ATRLLGDYSSES-----------------------------------LRIYIAPELLAGAA---------YGPAADAWS . |.|||. ||| | .... |. .. | ||| | | |. ..| || IKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWS LGCILLTMCTLLEPLSVIDPRASNE--PLDLSTLH-------------GLEHYSNELLELIKN----CLYISVNMRST-ISQLRSHPRI ||.|| |.. | .. ..|.. . .. |.| |||. .| . | | ..|. || . LGVILYEMLFGKPPF-----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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| Kinase | GL50803_17216.AA | NEK10 | 74-227 | 27 | 2.1e-09 | 26.94 | In-house | 63-216 (279) | Show / Hide |
Range on Protein: 74-227 Range on HMM: 63-216/279 Sequence Identity: 27% (44 aa) VTAIKE-LTCPNIVRYKAIHKGSMGDKVYLESEYCSLGSVQDMVINHKASRRIIREDFIWRVAAVIVFVLEYLHTHLTPQYCSIKSYRCLRPSNILLTED .. ||| . |||||| . .. | | . .. .. | . |. ||.. .. | ||| | | |.| ||..... LKIIKEQMRHPNIVRYYRTFVEPQNHRMYIVMELIEGCPLYEHFNSMKEKHHHFEEERIWHMFIQMCLALRYLH-----KEKQI-VHRDLTPNNIMMGDK DIIKIDNFSATRLLG-DYSSESLR------IYIAPELLAGAAYGPAADAWSLGCILLTMCTL | . | | . . | .. .. .| || . || || |. ||.| |||| DRVTITDFGLAKQKQPD--PSKMTSVVGTILYSCPEIVQSEPYGEKADVWAFGCCLYQMCTL |
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| Kinase | GL50803_17216.AA | MELK | 26-224 | 25 | 4.4e-09 | 26.87 | In-house | 1-193 (254) | Show / Hide |
Range on Protein: 26-224 Range on HMM: 1-193/254 Sequence Identity: 25% (53 aa) FASIQCVGSSTAGKTYLAIKVDQGCPVILKEVDLSNLSSDQIDLLEGYVTAIKELTCPNIVRYKAIHKGSMGDKVYLESEYCSLGSVQDMVINHKASRRI .. . .|. .| || . . | .| .| .| .| . .. . |.|.| .| . | ||... |||. | . | .| .. YEVHDEIGTGGFAKVKLACHILTNQMVAIKIMDKNQLGHD-LPRVKTEMDALKNLRHQHICQL--YHYIETEDKIFMVMEYCPGGEMFDYII----RQDR IREDFIWRVAAVIVFVLEYLHTHLTPQYCSIKSYRCLRPSNILLTEDDIIKIDNFS-ATRLLGDYSSESLRI------YIAPELLAGAAY-GPAADAWSL . |. . || . |.| | .| |.| |.|..|| .|. .| . | | | ||||. | | | || ||. LEEEETRHFFRQIVSAIAYVHSQ---GYA----HRDLKPENLLFDEDHHLKLIDFGLCAKTKGRKDYHNLQTCCGSPAYAAPELIQGKQYIGSEADVWSM GCILLTM | .| .. GILLYVL |
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| Kinase | GL50803_17216.AA | NEK | 38-146 | 21 | 1.6e-08 | 26.56 | In-house | 13-131 (286) | Show / Hide |
Range on Protein: 38-146 Range on HMM: 13-131/286 Sequence Identity: 21% (26 aa) GKTYLAIKVDQGCP-----VILKEVDLSNLSSDQIDLLE-GYVTAIKELTCPNIVRYKAIHKGSMGDKVYLESEYCS-LGSVQDM---VINHKASRRIIR || |.. . | ...|.....|.|. . . . | |.| .||||.|. ... . . ||| | ... ..| .. . GKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKSIKKQKQKGKYFE EDFIWRVAAVIVFVLEYLH |. ||.. . .. | |.| EEQIWDWFIQMCLALKYMH |
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| Kinase | GL50803_17216.AA | STE-Unique | 196-285 | 21 | 2.4e-08 | 25.16 | In-house | 513-616 (616) | Show / Hide |
Range on Protein: 196-285 Range on HMM: 513-616/616 Sequence Identity: 21% (22 aa) IYIAPELLAGA-----AYGPAADAWSLGCILLTMCTLLEPLSVIDPRAS-NEPLDLSTLHGL--------EHYSNELLELIKNCLYISVNMRSTISQLRS .|..|| . .. |. .| |||||... ||... | . .. . | ..... . . .. |. ..| || . |....||. CYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPWHQRYHMQAYIEMCIHIHCQPPQCPIENIPPKCQPEQQQFIEKCLERNPHHRPSAHQLLH HPRI |. HFWL |
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| Kinase | GL50803_17216.AA | AGC | 197-221 | 51 | 2.5e-08 | 16.12 | In-house | 273-295 (395) | Show / Hide |
Range on Protein: 197-221 Range on HMM: 273-295/395 Sequence Identity: 51% (14 aa) YIAPELLAGAAYGPAADAWS--LGCIL |.||| | ||.|.| || |||.. YMAPEIL----YGKACDWWSFGLGCLM |
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| Kinase | GL50803_17216.AA | RAD53 | 197-221 | 30 | 4.2e-08 | 19.69 | In-house | 192-231 (305) | Show / Hide |
Range on Protein: 197-221 Range on HMM: 192-231/305 Sequence Identity: 30% (12 aa) YIAPELLAG---------------AAYGPAADAWSLGCIL | ||| ... ..|... |.||.|||| YVAPEVITSKGHNCYHENEERQVQVGYTKKVDCWSMGCIL |
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| Kinase | GL50803_17216.AA | Ciliate-E2-Unclassified | 162-226 | 22 | 1e-07 | 22.87 | In-house | 170-265 (352) | Show / Hide |
Range on Protein: 162-226 Range on HMM: 170-265/352 Sequence Identity: 22% (22 aa) LRPSNILLTED----DIIKIDNFSATRLLGDYSSESLR--------------------IYI----APELLAGAAYG----PAADAWSLGCILLTMCT . |.|||.... | || ... .. .. .. . .|. |||.| | |. ..| ||||.|| |.. IKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLF |
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| Kinase | GL50803_17216.AA | TyrKc | 26-285 | 15 | 1e-06 | -115.68 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 26-285
Range on HMM: 1-280/280
Sequence Identity: 15% (49 aa)
FASIQCVGSSTAGKTYLAIKVDQGCPVILKEVDLSNLSSDQIDLLEGYVTAIKEL--TCPNIVRYKAIHKGSMG-----DKVYLESEYCSLGSVQDMVIN
.. |. |. |... .| | . . . . ..| ||||| .. . . . ... ||...|. .| .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK
HKASRRIIREDFIWRVAAVIVFVL------EYLHTHLTPQYCSIKSYRC----LRPSNILLTEDDIIKIDNFSATRLLGDY-----SSESLRI-------
|. .. . | . |||| . .| | |.|..|. ..|| | .| ..|. |.. |
HRPK---------LCMKDLLSFCWQIACGMEYLHSK-----------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGK
------YIAPELLAGAAYGPAADAWSLGCIL---LTMCTLLEPLS----VIDPRASNEPLDLSTLHGLEH--------YSNELLELIKNCLYISVNMRST
||| . . .. | || | . .| . | . . .. . . . .. . |. ...| | ..| |
TMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPT
ISQLRSHPRI
|.. | ..
FSEI--HECF
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| Kinase | GL50803_17216.AA | NEK | 197-227 | 48 | 1.8e-05 | 15.63 | In-house | 190-220 (286) | Show / Hide |
Range on Protein: 197-227 Range on HMM: 190-220/286 Sequence Identity: 48% (15 aa) YIAPELLAGAAYGPAADAWSLGCILLTMCTL |..||.. . |. .| |||||.| |||| YMSPEVCQNKPYNNKSDIWSLGCVLYEMCTL |
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| Kinase | GL50803_17216.AA | STE20 | 26-116 | 23 | 2.5e-05 | 15.74 | In-house | 1-99 (288) | Show / Hide |
Range on Protein: 26-116 Range on HMM: 1-99/288 Sequence Identity: 23% (23 aa) FASIQCVGSSTAGKTYLAIKVDQGCP----VILKEVDLSNLSS--DQIDLLEGYVTAIKELTCPNIVRYKAIHKGSMG--DKVYLESEYCSLGSVQDMV . ....|. . || |.|.... | | | ..|.. . |...... . |.. .||||.| . . |. .. |||. ||..|.. YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIM |
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| Kinase | GL50803_17216.AA | NEK | 252-285 | 30 | 9.6e-05 | 13.08 | In-house | 251-286 (286) | Show / Hide |
Range on Protein: 252-285 Range on HMM: 251-286/286 Sequence Identity: 30% (11 aa) EH--YSNELLELIKNCLYISVNMRSTISQLRSHPRI .| ||..| .|| ..| . .| ...|. ..| | SHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI |
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| Kinase | GL50803_17216.AA | Pkinase | 26-121 | 24 | 0.000531 | 15.23 | Pfam | 1-102 (293) | Show / Hide |
Range on Protein: 26-121 Range on HMM: 1-102/293 Sequence Identity: 24% (26 aa) FASIQCVGSSTAGKTYLAIKVDQGCPVILKEVDLSNLSS--DQIDLL--EGYVTAIKELTCPNIVRYKAIHKGSMGDKVYLESEYCSLG----SVQDMVI . ....|| . |. |...... |. | .|...... .| ||.... | .. |.| .|||||.. . .|..|. ||| | . |.. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQI--MKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIS --NHKA .|.. TWRHGC |
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| Kinase | GL50803_17216.AA | STE20 | 197-218 | 33 | 0.003267 | 7.94 | In-house | 188-214 (288) | Show / Hide |
Range on Protein: 197-218 Range on HMM: 188-214/288 Sequence Identity: 33% (9 aa) YIAPELLAG-----AAYGPAADAWSLG . |||.... |. .| |||| WMAPEVIQCMEGPDKGYDYKCDIWSLG |
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| Kinase | GL50803_17216.AA | Ciliate-E2-Unclassified | 255-285 | 28 | 0.028504 | 3.71 | In-house | 318-352 (352) | Show / Hide |
Range on Protein: 255-285 Range on HMM: 318-352/352 Sequence Identity: 28% (10 aa) SNELLELIK----NCLYISVNMRSTISQLRSHPRI |.| ..|. .| | | |..|. || . SPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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| Kinase | GL50803_17216.AA | RAD53 | 255-285 | 35 | 0.029026 | 1.96 | In-house | 275-305 (305) | Show / Hide |
Range on Protein: 255-285 Range on HMM: 275-305/305 Sequence Identity: 35% (11 aa) SNELLELIKNCLYISVNMRSTISQLRSHPRI |.| . |||. | . .. |.|| .. .|| . SEEAKDLIKWMLCVDPEKRYTIDEALNHPWM |
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| Kinase | GL50803_17216.AA | STE20 | 247-285 | 34 | 0.043038 | 3.8 | In-house | 248-288 (288) | Show / Hide |
Range on Protein: 247-285 Range on HMM: 248-288/288 Sequence Identity: 34% (14 aa) TLHG--LEHYSNELLELIKNCLYISVNMRSTISQLRSHPRI || . ...| |. .....|| . .. | | ||| .|| | TLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI |
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| Ank | GL50803_17216.AA | Ank | 471-485 | 26 | 8.157292 | 3.59 | Pfam | 1-15 (33) | Show / Hide |
Range on Protein: 471-485 Range on HMM: 1-15/33 Sequence Identity: 26% (4 aa) SDDTALMIAVRNRNM .|.|..|.|. .. DGFTPLHLACRCGHT |
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| Ank | GL50803_17216.AA | Ank | 501-523 | 34 | 0.007955 | 14.45 | Pfam | 1-23 (33) | Show / Hide |
Range on Protein: 501-523 Range on HMM: 1-23/33 Sequence Identity: 34% (8 aa) DNTTALMIAAETGNSEALSYLLG | |.|..|.. |. | ...||. DGFTPLHLACRCGHTEVVKMLLQ |
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| Ank | GL50803_17216.AA | Ank | 531-551 | 47 | 8.2e-05 | 21.62 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 531-551 Range on HMM: 1-21/33 Sequence Identity: 47% (10 aa) DGKTALMLAILNGHVDVARVL || |.|.||...||..|.. | DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_17216.AA | Ank | 562-592 | 36 | 3.1e-05 | 23.14 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 562-592 Range on HMM: 1-33/33 Sequence Identity: 36% (12 aa) DGRTALMYACERGMSELINVLLD--AESGMTDV ||.|.|..||..| | . ||. |. ..| DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_17216.AA | Ank | 593-625 | 24 | 0.00982 | 14.12 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 593-625 Range on HMM: 1-33/33 Sequence Identity: 24% (8 aa) NGYSALMLALQRNNIDGVRALAKREAMITLSDG .|...|.|| ...... |. | .. | . . | DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_17216.AA | Ank | 726-746 | 33 | 0.039748 | 11.93 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 726-746 Range on HMM: 1-21/33 Sequence Identity: 33% (7 aa) KGWTALMKAAFYGKSECIPLL |.|.|. |...| |.. .| DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_17216.AA | Ank | 756-777 | 36 | 0.020594 | 12.96 | Pfam | 1-22 (33) | Show / Hide |
Range on Protein: 756-777 Range on HMM: 1-22/33 Sequence Identity: 36% (8 aa) AKYTALMSAAGNGHSACVRLLL .|.|. |. .|| .|..|| DGFTPLHLACRCGHTEVVKMLL |
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| Ank | GL50803_17216.AA | Ank | 786-818 | 24 | 0.001128 | 17.51 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 786-818 Range on HMM: 1-33/33 Sequence Identity: 24% (8 aa) KNETALMLAIMNEQEECIKLLMDKEGSLRTHDG .|.|.||... ..|..|.|... .. .| DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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