Gene GL50803_16805 (G.lamblia)
GL50803_16805
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| GL50803_16805.AA | Protein | None | 2633 | None | Fasta, JSON |
| GL50803_16805.kin_dom | Protein Kinase Domain | None | 229 | None | Fasta, JSON |
Protein domains of GL50803_16805.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | GL50803_16805.AA | ATR | 2486-2583 | 30 | 8e-17 | 53.45 | In-house | 170-267 (267) | Show / Hide |
Range on Protein: 2486-2583 Range on HMM: 170-267/267 Sequence Identity: 30% (30 aa) TLAHWCAVCIVTGLGDRHSCNILIDTDDGSVHFIDFEAVFEYPKLLSYAELVPFRLTALIAQLLGPTGIHGCFYWELVKMVSLIQENAPAFINVFYPL . | || | . ||||||. ||||| | . .|. .| . . |.|||||| . .|| . .| | .. .. ..... . |. SYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF |
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| Kinase | GL50803_16805.AA | PIKK | 2482-2559 | 40 | 1.5e-16 | 57.02 | In-house | 188-266 (290) | Show / Hide |
Range on Protein: 2482-2559 Range on HMM: 188-266/290 Sequence Identity: 40% (32 aa) MFATTLAHWCAVCIVTGLGDRHSCNILIDTDDGSVHFIDFEAVFEYPKL-LSYAELVPFRLTALIAQLLGPTGIHGCFY ... ..| .| | ..|||||| ||.|| . | . ||| || . |. |.|||||| . ..||.|. | |. NYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFR |
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| Kinase | GL50803_16805.AA | ATM | 2493-2558 | 45 | 1.9e-12 | 35.67 | In-house | 150-215 (304) | Show / Hide |
Range on Protein: 2493-2558 Range on HMM: 150-215/304 Sequence Identity: 45% (30 aa) VCIVTGLGDRHSCNILIDTDDGSVHFIDFEAVFEYPKLLSYAELVPFRLTALIAQLLGPTGIHGCF | . |||||| |||| . || || |.| | |||||| | .| ||. | | VGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVF |
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| PI3Kc | GL50803_16805.AA | PI3Kc | 2354-2632 | 15 | 2.4e-07 | -48.29 | SMART | 1-336 (336) | Show / Hide |
Range on Protein: 2354-2632
Range on HMM: 1-336/336
Sequence Identity: 15% (56 aa)
RLILKCGEDTVADYAVMQFTEELAKCSVNT--------FFKPYFVAVLINIPKNQVSIIEHIDGNVVPIDELLT--------------------------
..|.|||.| |. .||. . |. . ..|| . .. . .|| . |.... ...
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTG----PKCGMIEWVP-NCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQ
---------------------------------PVFMGAKTKAAEFINEQEPNEDGCFPTFDLFMASVTALSHMEMALSKTHPCRFIALSQKNQRMFATT
... . ... |. |... .. .. |.
KNMYMMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPN--------------------------------EDWWEARDNFTRS
LAHWCAVCIVTGLGDRHSCNILIDTDDGSVHFIDFEAVFE-YPKLLSYA----ELVPFRLTALIAQLLG----PTGIHGCFYWELVKMVSLIQENAPAFI
.| .| |. . |.||||. ||..| ..| . ||| |. .||.. . |.|||||| . . | |.| | |. .. .. ... ...
CAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGHIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIM
NVFYPLAIVRASLGYVRQ--VKEMLETQRAEE--IVNAALAQA--------ADSS------RLSCMFGGWMAF
|.| .. . ...|. . .. .. |. .. .| |. || |. .
NLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDHLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
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| Kinase | GL50803_16805.AA | DNAPK | 2492-2559 | 36 | 2.4e-07 | 22.6 | In-house | 195-267 (301) | Show / Hide |
Range on Protein: 2492-2559 Range on HMM: 195-267/301 Sequence Identity: 36% (27 aa) A-VCI---VTGLGDRHSCNILIDTDDGSVHFIDFEAVFE-YPKLLSYAELVPFRLTALIAQLLGPTGIHGCFY | .|| . | |||| | .. . | . ||| | | || ||||| |. | .| | .| AVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMY |
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| Kinase | GL50803_16805.AA | FRAP | 2498-2556 | 38 | 1e-06 | 20.69 | In-house | 155-214 (251) | Show / Hide |
Range on Protein: 2498-2556 Range on HMM: 155-214/251 Sequence Identity: 38% (23 aa) GLGDRHSCNILIDTDDGSVHFIDFEAVFEYP-KLLSYAELVPFRLTALIAQLLGPTGIHG |||||| ||... | . ||| || . .. |..||||| .. . .|| | GLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTRMLVNAMEACGIEG |
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| Kinase | GL50803_16805.AA | SMG1 | 2493-2535 | 46 | 3e-06 | 16.7 | In-house | 200-242 (242) | Show / Hide |
Range on Protein: 2493-2535 Range on HMM: 200-242/242 Sequence Identity: 46% (20 aa) VCIVTGLGDRHSCNILIDTDDGSVHFIDFEAVFEYPKLLSYAE | . |||||| |.||| | | ||. || | | | VGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLNVPE |
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| Kinase | GL50803_16805.AA | PI3_PI4_kinase | 2483-2580 | 26 | 6e-06 | 23.58 | Pfam | 167-280 (300) | Show / Hide |
Range on Protein: 2483-2580 Range on HMM: 167-280/300 Sequence Identity: 26% (30 aa) FATTLAHWCAVCIVTGLGDRHSCNILI--DTDDGSVHFIDFEAVFE--YPKLLSYAELVPFRLTA-------LIAQL-----LGPTGIHGCFYWELVKMV |.. .| .| | .. |.||||. ||.. |...| . ||| |. | . |.||||.| .. .. |.|.| | | ..... FVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAY SLIQENAPAFINVF .. ... ...|.. RALRRHMNLCMNLL |
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| Kinase | GL50803_16805.AA | FATC | 2601-2633 | 27 | 1.1e-05 | 21.25 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 2601-2633 Range on HMM: 1-33/33 Sequence Identity: 27% (9 aa) ETQRAEEIVNAALAQAADSSRLSCMFGGWMAFL | |. |. ..| | ..|. |. ||.... EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW |
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| PI3_PI4_kinase | GL50803_16805.AA | PI3_PI4_kinase | 2352-2372 | 30 | 0.2779 | 6.44 | Pfam | 1-23 (300) | Show / Hide |
Range on Protein: 2352-2372 Range on HMM: 1-23/300 Sequence Identity: 30% (7 aa) GTRLILKCGEDTV--ADYAVMQF ....|.|.|.| . | .||. WYPFIFKGGDDLRCRQDMRMMQM |
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