Gene GL50803_16436 (G.lamblia)

GL50803_16436

Species: G.lamblia
Alias: GL50803_16436, GK071
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Uni1

Sequence

Name Sequence Type Origin Length Description Download
GL50803_16436.AA Protein None 3180 None Fasta, JSON
GL50803_16436.kin_dom Protein Kinase Domain None 405 None Fasta, JSON

Protein domain

Protein domains of GL50803_16436.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc GL50803_16436.AA S_TKc 2291-2695 14 1.4e-11 -7.31 SMART 1-231 (231) Show / Hide 
Range on Protein: 2291-2695
Range on HMM: 1-231/231
Sequence Identity: 14% (61 aa)

ATKFSLMAQGAYGSVYSGNVSLVTEDNQTNQSFLTPVAVKIQDRSKSIYDRCVLHDIFNEITVMERLANYSGVSRMYDYGVTKDGYYIIMHKYVTSLRDL
 ..  .  .||.|.|| .                  ||.|| .            .| .|| ....  .   . ..||. .. | .|..|    ..| ||
YEILRKIGKGAFGKVYKCRHKK----------TGRIVAIKIIK-----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDL

RLKLFDDPA-----TLQSNQLLYHPEPKYKHLPIYGHELSYMKYIRIYLLIFIKFLRHLEYLHTAGVNHYDIKADNVFFDPRTVQWYSKLARLDENSRPA
.  . . .       .   .  .                           ..   .. |||.|  |. | |.| .|...|                    
FDYIKKRGRHGLRFPFPE-HARF---------------------------YMYQICCALEYCHSHGIIHRDLKPENILLDE-------------------

GTVDTGTPITKIFLDKIFTDYQAVPSYELLPFRIAIADFGESMVFSDEESSYTLINKGTEYNKSPEMLLSANMVAQTRSNFDRRRPKGAGS-SSDIWSAA
                                .| |.||| . ..            || .  .||.|                   | |  ..|.||  
--------------------------------HIKICDFGLARQL--------TTFCGTPWYMAPEVL-------------------GYGKCKCDWWSCG

CFLYELLTGDILFFDSDWIRFFIRVTKDSYQSNVRARARDKSAAQSFTFDHSGKFAQLYRGVSLSPEKKAMLGNCQPIIDLLEFCLVPNPTLRPQIRDVI
| |||.|.|  .|   .  . | ..                                                  .. .|... ||. .|. || . .. 
CILYEMLCGYPPFP--QMQMMFKKIG------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EAL

AMTEHIL-KVYF
.. ..|    .|
QDEWDIKCHPWF
Kinase GL50803_16436.AA SRPK 2579-2597 68 1.4e-09 19.3 In-house 434-452 (554) Show / Hide 
Range on Protein: 2579-2597
Range on HMM: 434-452/554
Sequence Identity: 68% (13 aa)

DIWSAACFLYELLTGDILF
||||.|| ..||.||| ||
DIWSTACMAFELATGDYLF
Kinase GL50803_16436.AA Pkinase 2444-2604 18 1e-08 31.93 Pfam 121-222 (293) Show / Hide 
Range on Protein: 2444-2604
Range on HMM: 121-222/293
Sequence Identity: 18% (31 aa)

LEYLHTAGVNHYDIKADNVFFDPRTVQWYSKLARLDENSRPAGTVDTGTPITKIFLDKIFTDYQAVPSYELLPFRIAIADFGESMVFSDEESSYTLINKG
|||.|  |. | |.| .|...| .. .  .                                            .. |.||| . .|.   .| .    |
LEYCHSMGIIHRDLKPENILID-NNGHIDA--------------------------------------------CVKICDFGLAKQFDY-NNS-MTTFCG

TEYNKSPEMLLSANMVAQTRSNFDRRRPKGAGSSSDIWSAACFLYELLTGDILFFDS----DWIR
| .  .|| ..                 .. |...|.||. | |||.|.|  .| ..    . ..
TPWYMAPEVIR---------------GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HD
Kinase GL50803_16436.AA Ciliate-E2 2444-2684 13 1.5e-07 21.98 In-house 173-360 (365) Show / Hide 
Range on Protein: 2444-2684
Range on HMM: 173-360/365
Sequence Identity: 13% (40 aa)

LEYLHTAG-VNHYDIKADNVFFDPRTVQWYSKLARLDENSRPAGTVDTGTPITKIFLDKIFTDYQAVPSYELLPFRIAIADFGESMVFSDEES-------
|||||  . . | ||| .|..|                                                      | |.||| |  ..|..        
LEYLHSKNNIIHRDIKPENILF------------------------------------------------------IKIIDFGLSKKYDDDNQNRTHKQQ

SYTLINKG------------------------TEYNKSPEMLLSANMVAQTRSNFDRRRPKGAGSSSDIWSAACFLYELLTGDILFFDSDWIRFFIRVTK
.. ... .                        | . ..||.| . .   |          || . ..||||. . |||.|.|   |              
CKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQ-------QKQKGYDYKCDIWSLGVILYEMLFGKPPF--------------

DSYQSNVRARARDKSAAQSFTFDHSGKFAQLYRGVSLSPEKKAMLGNCQ-------------------------PIIDLLEF----CLVPNPTLRPQ-IR
                                       ... . ....                           .||.      .|. .|  |.. . 
---------------------------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWE

DVI
...
QIL
Kinase GL50803_16436.AA CLK 2578-2597 55 2.8e-05 11.01 In-house 228-247 (350) Show / Hide 
Range on Protein: 2578-2597
Range on HMM: 228-247/350
Sequence Identity: 55% (11 aa)

SDIWSAACFLYELLTGDILF
.|.|| .| |.|| ||. ||
CDVWSIGCILFELYTGFTLF
Kinase GL50803_16436.AA Worm8 2357-2380 50 4.5e-05 10.53 In-house 54-77 (261) Show / Hide 
Range on Protein: 2357-2380
Range on HMM: 54-77/261
Sequence Identity: 50% (12 aa)

LANYSGVSRMYDYGVTKDGYYIIM
||. .||.||.||| |    .|.|
LADVNGVPRMFDYGSTDYHNWIVM
Kinase GL50803_16436.AA AGC 2549-2601 25 5.1e-05 7.35 In-house 275-309 (395) Show / Hide 
Range on Protein: 2549-2601
Range on HMM: 275-309/395
Sequence Identity: 25% (14 aa)

SPEMLLSANMVAQTRSNFDRRRPKGAGSSSDIWS--AACFLYELLTGDILFFDSD
.||.|                     | . |.||    |..||.|||   |.. .
APEIL--------------------YGKACDWWSFGLGCLMYEMLTGYPPFYGDN
Kinase GL50803_16436.AA PRP4 2579-2597 63 5.2e-05 14.36 In-house 187-205 (320) Show / Hide 
Range on Protein: 2579-2597
Range on HMM: 187-205/320
Sequence Identity: 63% (12 aa)

DIWSAACFLYELLTGDILF
|.||..| |||| || |.|
DMWSVGCTLYELYTGKIMF
Kinase GL50803_16436.AA Ciliate-D1 2579-2597 57 6.6e-05 17.15 In-house 1-19 (19) Show / Hide 
Range on Protein: 2579-2597
Range on HMM: 1-19/19
Sequence Identity: 57% (11 aa)

DIWSAACFLYELLTGDILF
||||  | |||.|.|   |
DIWSFGCILYEMLFGQPPF
Kinase GL50803_16436.AA Dicty2 2444-2461 66 0.000141 12.04 In-house 116-133 (264) Show / Hide 
Range on Protein: 2444-2461
Range on HMM: 116-133/264
Sequence Identity: 66% (12 aa)

LEYLHTAGVNHYDIKADN
|.|||  || | ||||.|
LVYLHRQGVIHRDIKAAN
Kinase GL50803_16436.AA NEK 2575-2592 55 0.000225 11.76 In-house 202-219 (286) Show / Hide 
Range on Protein: 2575-2592
Range on HMM: 202-219/286
Sequence Identity: 55% (10 aa)

GSSSDIWSAACFLYELLT
.. |||||  | |||. |
NNKSDIWSLGCVLYEMCT
Kinase GL50803_16436.AA ERK3 2579-2597 57 0.000871 7.63 In-house 197-215 (300) Show / Hide 
Range on Protein: 2579-2597
Range on HMM: 197-215/300
Sequence Identity: 57% (11 aa)

DIWSAACFLYELLTGDILF
|.|.| | | |.|||  ||
DMWAAGCILAEMLTGKMLF
Kinase GL50803_16436.AA ERK3 2441-2463 52 0.001563 6.8 In-house 120-142 (300) Show / Hide 
Range on Protein: 2441-2463
Range on HMM: 120-142/300
Sequence Identity: 52% (12 aa)

LRHLEYLHTAGVNHYDIKADNVF
|| | |.| | | | | | .|.|
LRGLKYIHSANVLHRDLKPANIF
Kinase GL50803_16436.AA NEK 2664-2689 23 0.013145 5.47 In-house 261-286 (286) Show / Hide 
Range on Protein: 2664-2689
Range on HMM: 261-286/286
Sequence Identity: 23% (6 aa)

DLLEFCLVPNPTLRPQIRDVIAMTEH
.|....| ..|..|| ......|   
NLISQMLQKDPEQRPSCNQILEMPFI
Kinase GL50803_16436.AA Dicty2 2573-2593 47 0.023004 4.24 In-house 183-205 (264) Show / Hide 
Range on Protein: 2573-2593
Range on HMM: 183-205/264
Sequence Identity: 47% (11 aa)

G--AGSSSDIWSAACFLYELLTG
|  . ...||||  | . |||||
GNHCCTACDIWSLGCTIIELLTG
Kinase GL50803_16436.AA Worm8 2448-2461 64 0.070727 1.13 In-house 116-129 (261) Show / Hide 
Range on Protein: 2448-2461
Range on HMM: 116-129/261
Sequence Identity: 64% (9 aa)

HTAGVNHYDIKADN
|  |. | ||||||
HSFGIVHGDIKADN
DSPc GL50803_16436.AA DSPc 2797-2970 18 0.000185 -12.38 SMART 1-172 (172) Show / Hide 
Range on Protein: 2797-2970
Range on HMM: 1-172/172
Sequence Identity: 18% (36 aa)

PATNIIDGFLWIGSVSVLR--HAEHLLAYNVTSVIDCLTT----------SLEQSMETKRVIEMTTIHYYKLPLVLT---QIINPTSNKTLFLGSPREST
. ..|  . |..|| ..    ... | ..|.| ||..             . ..   ..  ...  ..|  .|..      | . .. .           
GPSEITPH-LYLGSYPHHMEPNPCFLKKHNITHVINVTMECPWNFHHCQKN-DMHYTNEWIYHNSHFQYMHIPMIDDIYYHIRWNHCTNI----------

PGLPKAEFLRYSAALDSVLDFLRRTVTHGGRCLLYDENGTGLSAAVAIAMLVEFRSLSLFAAYLHV-----RNLR-PHIAPPLPFLDFLHYWFLF
           |. ...| ||. .  . ||..| .   |   ||...|| |   ...|. .|| .|     .  | |.| | . |.  |. |  .
-----------SQYFPEVYDFIHDCRQKGGKVLVHCQAGISRSATLCIAYLMKYMNMSYNDAYHFVYIYHIKQRRCPIICPNFNFWHQLCEWERK