Gene GL50803_16251 (G.lamblia)

GL50803_16251

Species: G.lamblia
Alias: GL50803_16251, GK198
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_16251.AA Protein None 706 None Fasta, JSON
GL50803_16251.kin_dom Protein Kinase Domain None 268 None Fasta, JSON

Protein domain

Protein domains of GL50803_16251.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc GL50803_16251.AA S_TKc 10-277 18 3.8e-20 74.18 SMART 1-231 (231) Show / Hide 
Range on Protein: 10-277
Range on HMM: 1-231/231
Sequence Identity: 18% (56 aa)

LQLEQVLATGEHSVIYQCADLRTGSTYACKKICYSRFDQLKEDALNHELAVVHRANHGNVVAYLDVIHDKPCQTYYIIMPFYRF--YDLGTQICKKIEEG
 .. ...  |  .. |.| . .||  .|.|.|          . .  |... .. .| |.| ..||..|   . .|..| .      || . |.|.  .|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

GR--FEEACVWLILVQCLLALDYL----------------------------DTELSDVDADARPTNKLVFGNIRPTSIYVDLQGNTYINTFRLSKYPSL
.|  | |  .. .. | ..||.|.                             ..|                                            
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQL--------------------------------------------

LNGTAAPKLAPYW-APEQLMNYSHSS-KIEIWSLGCIVYEMCLLHSLFRGTCEDVLEQIQKLRRPVKLPNYSAQLEEVVNSLLEPSPDKRLSAAELLK--
          |.. ||| |   ...  |. .||.|||.|||.    .|.    .. . ..|..        | .. . .. .|.  |.||..| |.|.  
----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDE

-----HPTI
     || .
WDIKCHPWF
Kinase GL50803_16251.AA Ciliate-E2 187-277 21 3.6e-18 58.97 In-house 251-365 (365) Show / Hide 
Range on Protein: 187-277
Range on HMM: 251-365/365
Sequence Identity: 21% (27 aa)

APYWAPEQLMNYS---------HSSKIEIWSLGCIVYEMCLLHSLFRGTCEDVLEQIQKLRRPVKLP-------------------NYSAQLEEVVNS--
..| ||| |.. .         .. |. |||||.| |||.     |         |.|..  ....|                   . | .     .   
PGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFG

--LLEPSPDKRLS-AAELLKHPTI
  .|.  |.||.. . ..|.|| .
KRMLQKDPEKRITGWEQILNHPWF
Kinase GL50803_16251.AA NEK 206-277 32 3.8e-18 60.83 In-house 207-286 (286) Show / Hide 
Range on Protein: 206-277
Range on HMM: 207-286/286
Sequence Identity: 32% (26 aa)

IWSLGCIVYEMCLLHS--LFRGT--CEDVLE-QIQKLRRPVKLP-N--YSAQLEEVVNSLLEPSPDKRLSAAELLKHPTI
||||||..|||| |..   |...      |  .|.| . . ..| .  || .| ......| ..|..| |. ..|..| |
IWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase GL50803_16251.AA Ciliate-E2-Unclassified 189-277 25 2.6e-17 56.63 In-house 232-352 (352) Show / Hide 
Range on Protein: 189-277
Range on HMM: 232-352/352
Sequence Identity: 25% (31 aa)

YWAPEQLMN--YSHS--SKIEIWSLGCIVYEMCLLHSLFRGTCEDV----------------LEQIQKLRRPVKLP--------NYSAQLEEVVN----S
| ||| |..  |.||   |. |||||.| |||.     | .....                 |.|..| . . . .        . | . .. .|    .
YTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQK

LLEPSPDKRLSAAELLKHPTI
.|.  |.||... ..|.|| .
MLKKNPNKRITFEQILNHPWF
Kinase GL50803_16251.AA AGC 189-277 24 1e-14 33.0 In-house 273-395 (395) Show / Hide 
Range on Protein: 189-277
Range on HMM: 273-395/395
Sequence Identity: 24% (31 aa)

YWAPEQLMNYSHSSKIEIWS--LGCIVYEMCLLHSLFRGT-----------CEDVLEQIQKLR----RPVKLP-----------NYSAQLEEVVNSLLEP
| ||| |    ..    .||  |||. |||   .. |.|             ... ..|.. |     .||.|           . | ..   .. ||..
YMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCK

SPDKRLS----------AAELLKHPTI
 |.|||           | |. .||  
DPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase GL50803_16251.AA Pkinase 188-277 21 2e-14 52.07 Pfam 176-293 (293) Show / Hide 
Range on Protein: 188-277
Range on HMM: 176-293/293
Sequence Identity: 21% (25 aa)

PYWAPEQLM-NYSHSSKIEIWSLGCIVYEMCLLHSLFR-G----TCEDVLEQIQKLRRPVKLPNYS-----------------------AQLEEVVNSLL
.| ||| .. .  ...|. .||.|||.|||.. . .|.      .  | .. |.. ..|    ...                         . ......|
WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL

EPSPDKRLSAAELLKHPTI
.. | ||..|...|.|| .
CKDPKKRPTAEQILQHPWF
Kinase GL50803_16251.AA NEK2 189-277 35 1.1e-13 42.37 In-house 230-319 (319) Show / Hide 
Range on Protein: 189-277
Range on HMM: 230-319/319
Sequence Identity: 35% (32 aa)

YWAPEQLMNYSHSSKIEIWSLGCIVYEMCLLHSLFRGTCEDVLEQIQKLRRPVKLPN-YSAQLEEVVNSLLEPSPDKRLSAAELLKHPTI
|  |||..  . . |  |||.||..|||| ||  |..|  . |    |  .   .|  ||  | |.. . ..  . .| |  |.|.|| |
YMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFMINVDHYHRPSIEEILQHPQI
Kinase GL50803_16251.AA STE 191-277 22 3.3e-13 43.09 In-house 230-359 (359) Show / Hide 
Range on Protein: 191-277
Range on HMM: 230-359/359
Sequence Identity: 22% (29 aa)

APEQLMNYS------HSSKIEIWSLGCIVYEMCLLHSLFRG-TCEDVLEQIQKL--------------RRPVKLPN--------------------YSAQ
||| ... .      .. |  |||||| . ||.  .  .   .   .. .|..                 | .||.                    .|  
APEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPE

LEEVVNSLLEPSPDKRLSAAELLK--HPTI
. . .|  |.  |.|| .| .|||  || |
FKDFINKCLQKDPNKRPTASQLLKSEHPFI
Pkinase GL50803_16251.AA Pkinase 10-129 21 1e-10 38.96 Pfam 1-124 (293) Show / Hide 
Range on Protein: 10-129
Range on HMM: 1-124/293
Sequence Identity: 21% (28 aa)

LQLEQVLATGEHSVIYQCADLRTGSTYACKKICYSRFDQLKEDALNH--ELAVVHRANHGNVVAYLDVIHDKPCQTYYIIMPFYRFYDLGT----QICKK
.......  |  .. |.| .  || ..|.|.|.... .  |. .. .  |... .| || |.| ..|. .|   . .|..|.. .    |.      .  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCE----GGLYVMDLFDY

IE--EGGRF--EEACVWLILVQCLLALDYL
|.  ..|.|  .|  .  .. | | .|.|.
ISTWRHGCFYFSEWECKFYMYQILRGLEYC
Kinase GL50803_16251.AA CAMK 188-277 18 1.7e-10 29.33 In-house 284-425 (425) Show / Hide 
Range on Protein: 188-277
Range on HMM: 284-425/425
Sequence Identity: 18% (26 aa)

PYWA-PEQLMNYS--------------HSSKIEIWSLGCIVYEMCLLHSLFRG--------------TCEDVLEQIQKLRRPVKLPN-------------
.| | || |   .              .. |. .||.|.| | |   .. |.|              . .. .|.|.| .     |              
EYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWW

----------YSAQLEEVVNSLLEPSPDKRLSAAELLKHPTI
           |..    ....|.. |.||..... |.|| .
DDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase GL50803_16251.AA ULK 10-129 20 7.8e-09 27.55 In-house 1-142 (324) Show / Hide 
Range on Protein: 10-129
Range on HMM: 1-142/324
Sequence Identity: 20% (29 aa)

LQLEQVLATGEHS-VIYQCADLRT---GSTYACKKICYSRFDQLKED--------ALNHELAVVHRAN---HGN--VVAYLDVIHDKPCQTYYIIMPFYR
 .| ..|  |    . |.  . .|   .  .|||.|  . . . | .         |. |  ..   .   | |  .| ..|.  .. .  .|||| .  
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

FYDLGTQICKKIE-----EGGRFEEACVWLILVQCLLALDYL
  || . | |. .     |..|..|  .  .. | . .. .|
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKEL
Kinase GL50803_16251.AA ULK 10-129 20 1.3e-08 26.25 In-house 1-146 (329) Show / Hide 
Range on Protein: 10-129
Range on HMM: 1-146/329
Sequence Identity: 20% (30 aa)

LQLEQVLATGEHSVIYQCADLRT----GSTYACKKICYSRFDQLKED--------ALNHELAVVHRAN--------HGNVVAYLDVIHDKPCQTYYIIMP
 .| ..|  |   . |.  . .|    .  .|||.|. . ..| . .         |. |  . .. .        | |.| ..|.  .. .  .|||| 
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

FYRFYDLGTQICKKIE------EGGRFEEACVWLILVQCLLALDYL
.    || . | |. .      |..|..|  .  .. | | .. .|
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKEL
Kinase GL50803_16251.AA ULK 206-277 28 1.4e-08 26.19 In-house 239-329 (329) Show / Hide 
Range on Protein: 206-277
Range on HMM: 239-329/329
Sequence Identity: 28% (26 aa)

IWSLGCIVYEMCLLHSLFRGT-CEDVLEQIQKL------------RRPVKLP------NYSAQLEEVVNSLLEPSPDKRLSAAELLKHPTI
||||||| |||      |..  ....| .||||             .| . |      . | ....    .|.  ...| |  ||..|| .
IWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase GL50803_16251.AA NEK 11-129 22 1e-07 23.71 In-house 2-130 (286) Show / Hide 
Range on Protein: 11-129
Range on HMM: 2-130/286
Sequence Identity: 22% (29 aa)

QLEQVLATGEHSVIYQCADLRTGST-----YACKKICYSRFDQLKEDALN-HELAVVHRANHGNVVAYLDVIHDKPCQTYYIIMPFYR-FYDLGTQ---I
.. ...  | ... | . . ..|.      |. ||| ... .. . ...  .|  .  . .| |.|.| | . ..  .. .|.| .     ||  .   |
EIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKSI

CKKIEEGGRFEEACVWLILVQCLLALDYL
 |. ..|  |||  .| ...| .|||.|.
KKQKQKGKYFEEEQIWDWFIQMCLALKYM
Kinase GL50803_16251.AA NEK2 32-126 31 1.3e-07 21.52 In-house 23-117 (319) Show / Hide 
Range on Protein: 32-126
Range on HMM: 23-117/319
Sequence Identity: 31% (30 aa)

TGSTYACKKICYSRFDQLKEDALNHELAVVHRANHGNVVAYLDVIHDKPCQTYYIIMPFYRFYDLGTQICKKIEEGGRFEEACVWLILVQCLLAL
.|   . | |||   .  . ..|  |  .     | |.| | | | |.. .| ||.| .    ||.  | |   |  ..||  .| |. | ..||
DGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQYMEEEFIWRIMFQLCTAL
Kinase GL50803_16251.AA ULK 206-277 27 1.4e-07 23.04 In-house 235-324 (324) Show / Hide 
Range on Protein: 206-277
Range on HMM: 235-324/324
Sequence Identity: 27% (25 aa)

IWSLGCIVYEMCLLHSLFRGT-CEDVLEQIQKL------------RRPVKLP------NYSAQLEEVVNSLLEPSPDKRLSAAELLKHPTI
||||||| |||      |..  ....|  ||||             .|.. |      . | ....    .|.  ...| |  |...|| .
IWSLGCIFYEMLYGKYPFFSWFNDQYLY-IQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase GL50803_16251.AA STE 10-129 15 2.3e-07 22.17 In-house 1-168 (359) Show / Hide 
Range on Protein: 10-129
Range on HMM: 1-168/359
Sequence Identity: 15% (26 aa)

LQLEQVLATGEHSVIYQCADLR---------------TGSTYACKKICYSRFDQ---------------LKEDALNHELAVVHRAN--HGNVVAYLDVIH
... ...  |   . |....                 ||  .| |.. ... ..                ... . .|. . .. |  | |.| |..   
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DKP-----CQTYYIIMPFYRFYDLGTQICK---KIEEG--------GRFEEACVWLILVQCLLA-LDYL
..      ... .|.| .     | ..| |   .. ..        .||.|  .  |..|.| . |.||
KEGHNHKNDDELWICMEYMDGGSL-DDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYL
Kinase GL50803_16251.AA TyrKc 10-283 13 3e-06 -121.52 SMART 1-280 (280) Show / Hide 
Range on Protein: 10-283
Range on HMM: 1-280/280
Sequence Identity: 13% (43 aa)

LQLEQVLATGEHSVIYQCADLRTGSTYACKKICYSRFDQLKEDALNHELAVVHRA--NHGNVVAYLDVIHDK-----PCQTYYIIMPFYRFYDLGTQICK
..|...|  |.  ..|..       . | |..  .      . .. .|. . ..   .| |.|. . |. ..       . ..|.| .    ||   . |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

KIEEGGRFEEACVWLILVQCLLALDYLDTELSDVDADARPTNKLVFGNIRPTSIYVDLQGNTYI-----------NTFR--------LSKYPSLL-----
. ..   .  .    . .|     .||                                   .|           .  .        ||..         
HRPK---LCMKDLLSFCWQIACGMEYLHSK-------------------------------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGE

---NGTA----APK--LAPYW-APEQLMNYSHSSKIEIWSLGCIVYEMCLL-HSLFRG------TCEDVLEQIQKLRRPVKLPN--------YSAQLEEV
     ..      |  |   | ||| .. .  ..|  .|| |   .|.. .  .   |      . ..|.|.... .|. . ||         .. . ..
SKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQI

VNSLLEPSPDKRLSAAELLKHPTILEYKRF
  .  .  |..| . .|.        ...|
MKQCWHEDPEDRPTFSEI--------HECF
Kinase GL50803_16251.AA STE11 247-277 35 5e-06 17.96 In-house 273-303 (303) Show / Hide 
Range on Protein: 247-277
Range on HMM: 273-303/303
Sequence Identity: 35% (11 aa)

SAQLEEVVNSLLEPSPDKRLSAAELLKHPTI
|... . ..  .|. | || .|..||.|| |
SEECRDFLRHCFEHDPKKRPTANQLLQHPFI
Kinase GL50803_16251.AA STE11 10-88 19 1.5e-05 16.32 In-house 1-92 (303) Show / Hide 
Range on Protein: 10-88
Range on HMM: 1-92/303
Sequence Identity: 19% (18 aa)

LQLEQVLATGEHSVIYQCADLRTGSTYACKKICYSRFDQL------KEDA------LNHELAVVHRANHGNVVAYLDVIHDKP-CQTYYIIM
 |. ... .|  .. |.| .. ||  .| |.| . . .|.      . ..      . .|...    || | | |... ....   ...|.|
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFM
Kinase GL50803_16251.AA CAMK 15-88 10 1.6e-05 12.94 In-house 1-136 (425) Show / Hide 
Range on Protein: 15-88
Range on HMM: 1-136/425
Sequence Identity: 10% (14 aa)

VLATGEHSVIYQCADLRTG------------STYACKKICYSRFD--------------------------QLKEDALNHELAVVHR-------ANHGNV
.| .|  .. . | . .|.              .|.| |  .. .                          . ... . .|...  .        .| |.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VAYLDVIHDK----------PCQT--------YYIIM
.  ..|. |.            ..        .|..|
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVM
Kinase GL50803_16251.AA STE11 191-217 43 2.7e-05 15.41 In-house 203-232 (303) Show / Hide 
Range on Protein: 191-217
Range on HMM: 203-232/303
Sequence Identity: 43% (13 aa)

APEQLMNYS---HSSKIEIWSLGCIVYEMC
||| ...     .. |  ||||||.|.||.
APEVIKQEGRDGYGRKADIWSLGCTVIEMA
Kinase GL50803_16251.AA Ciliate-E2 10-129 15 0.005461 6.08 In-house 1-176 (365) Show / Hide 
Range on Protein: 10-129
Range on HMM: 1-176/365
Sequence Identity: 15% (27 aa)

LQLEQVLATGEHSVIYQCADLRTG-----------------------STYACKKICYSRFDQL-KEDALN----------HELAVVHRANHGNVVAYLDV
  . ... .| ....|.| . ...                       . || | .  .   |. .|. ..           |. .  . || |.. . ..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

IHDKPCQTYYIIMPFYRFYDLGTQICKK---------IEEGGRFEEACVWLILVQCLL---------------ALDYL
  .|  ...|..| ..   ||   | ..         . . ..| |  .  |  | |                || ||
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYL