Gene GL50803_16167 (G.lamblia)

GL50803_16167

Species: G.lamblia
Alias: GK158, GL50803_16167
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-GL1

Sequence

Name Sequence Type Origin Length Description Download
GL50803_16167.AA Protein None 546 None Fasta, JSON
GL50803_16167.kin_dom Protein Kinase Domain None 256 None Fasta, JSON

Protein domain

Protein domains of GL50803_16167.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc GL50803_16167.AA S_TKc 24-285 21 2.9e-14 32.24 SMART 1-231 (231) Show / Hide 
Range on Protein: 24-285
Range on HMM: 1-231/231
Sequence Identity: 21% (58 aa)

NAMGSPCGQGACSVIYTLDALP-GEV--LKEIRTDMLPSHVLEGMEAALCTLSRLKHPNLPECKRAFRVSDYLYLQVTRYHG---SLESLMRLYRRRK--
  .. . |.|| .. |       |..  .|.|.         | ..  .  |.. .|||.  .. .|.  |.||.      |   .| .... ..|..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

QSMPRRLILEVVHQISSALAYLHDPDKTDPTGAYLPMLVHGGIKPANILVDRAETHFVLADTCVSTEAFRRHL---SMYAPPEVLLGEEPTP-ASDLWSL
. .|   .  ...|| .||.|.|.          .   .|  .||.|||.|.   |  ..|  ....   ...     | .||||     .. ..| ||.
FPFPE-HARFYMYQICCALEYCHS----------H-GIIHRDLKPENILLDE---HIKICDFGLARQL--TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GAVLYEMSTGSKPVAPDGRRVNELLEKGLTPDLSGVKDVVIRGILEHILVLDPRERISARELAC-IVDLDAKELA
| .|||| .|  |       ......| .        .   . .....|. ||..|..| |.    .|  . .  
GCILYEMLCGYPPFP----QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_16167.AA Ciliate-E2 154-273 15 1.9e-12 39.06 In-house 183-359 (365) Show / Hide 
Range on Protein: 154-273
Range on HMM: 183-359/365
Sequence Identity: 15% (32 aa)

VHGGIKPANILVDRAETHFVLADTCVST----------------EAFRRH------------------------LSMYAPPEVLLGEE---------PTP
.|  ||| |||.        ..|   |.                .    .                          .| .||.| |..          . 
IHRDIKPENILF------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDY

ASDLWSLGAVLYEMSTGSKPVAPDGRRVNELLEKGLTPDLSGVKDVVIR----------------------------GILEH----ILVLDPRERIS-AR
..|.|||| .|||| .|  |                   .   |.  |.                             ..      .|. || .||. . 
KCDIWSLGVILYEMLFGKPPF------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWE

EL
..
QI
Kinase GL50803_16167.AA RSKL 190-221 54 2e-12 24.89 In-house 343-374 (436) Show / Hide 
Range on Protein: 190-221
Range on HMM: 343-374/436
Sequence Identity: 54% (18 aa)

MYAPPEV-LLGEEPTPASDLWSLGAVLYEMSTG
||  |||     |.|.|.| ||.||||||. .|
MYCAPEVGQI-WELTEACDWWSYGAVLYELLCG
Kinase GL50803_16167.AA Ciliate-E2-Unclassified 154-279 18 8.5e-12 37.22 In-house 166-352 (352) Show / Hide 
Range on Protein: 154-279
Range on HMM: 166-352/352
Sequence Identity: 18% (35 aa)

VHGGIKPANILVDRAET--HFVLADTCVSTEA------------------FRRHLSM-----YA----PPEVLLGEEPT----PASDLWSLGAVLYEMST
.|  ||| |||.|      .  ..|   | .                   . .  ..     |     .|||| |...      ..| |||| .|||| .
IHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLF

GSKPVAPDGRRVN--------------ELLEKGLT--------------PDLSGVKDVVIRGILEHILVLDPRERISARELACIVDL
|  |     .  .              .|... .                ..|      |. .|  .|. .| .||.. .. .   .
GYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase GL50803_16167.AA ULK 190-269 21 1.6e-11 37.25 In-house 212-314 (324) Show / Hide 
Range on Protein: 190-269
Range on HMM: 212-314/324
Sequence Identity: 21% (23 aa)

MYAPPEVLL----GEEPTPA-SDLWSLGAVLYEMSTGSKP-VAPDGRRVN----ELLEKG-----------LTPDLSGVKDVVI----RGILEHILVLDP
.|  |..|     ..... . .|.|||| ..||| .|. | ...  .  .    .|...|           . ... . ||..|    . ..   |. |.
LYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPP-KDPKISPECKDLIRRMLQYDE

RERIS
..|||
KDRIS
Kinase GL50803_16167.AA AGC 191-221 45 2e-11 24.29 In-house 273-301 (395) Show / Hide 
Range on Protein: 191-221
Range on HMM: 273-301/395
Sequence Identity: 45% (15 aa)

YAPPEVLLGEEPTPASDLWS--LGAVLYEMSTG
| .||.|     ..| | ||  ||...||| ||
YMAPEIL----YGKACDWWSFGLGCLMYEMLTG
Kinase GL50803_16167.AA Pkinase 191-273 20 8.5e-11 39.25 Pfam 177-287 (293) Show / Hide 
Range on Protein: 191-273
Range on HMM: 177-287/293
Sequence Identity: 20% (23 aa)

YAPPEVLL-GEEPTPASDLWSLGAVLYEMSTGSKPVAPD----GRRVNELLEKGLTPDLSGVKD-----------------------VVIRGILEHILVL
|..|||.. |.. .|..| ||.| .|||| .|  |   .    ... ...... . |.|.   .                          . ... .| .
YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCK

DPRERISAREL
|| .|..|...
DPKKRPTAEQI
Kinase GL50803_16167.AA TKL 72-224 18 1.4e-10 34.34 In-house 79-288 (364) Show / Hide 
Range on Protein: 72-224
Range on HMM: 79-288/364
Sequence Identity: 18% (42 aa)

LSRLKHPNLPECKRAFRVSDY------------LYLQVTRYH--GSLESLMRLYRRRKQSMPRRLILEVVHQISSALAYLHD--P-DKTDPTGAYLPMLV
.|||.|||.  .. .   ...             .  |. |.  |||....             ...  ...|.....|||   |   |       | ..
MSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCT------KPPII

HGGIKPANILVDRAETH-------------FVLADTCVSTEAF-----------------------RRHLSM----YAPPEVLLGE--------------
|  .|..|||||.  |.               ..|   |.. .                       ...       . .|||| |.              
HRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCK

--EPTPASDLWSLGAVLYEMSTGSKP
  | ....| .| | ||.|. |. .|
GFEYSEKCDVYSFGIVLWEILTRCRP
Kinase GL50803_16167.AA ULK 190-269 20 1.8e-10 32.87 In-house 216-319 (329) Show / Hide 
Range on Protein: 190-269
Range on HMM: 216-319/329
Sequence Identity: 20% (21 aa)

MYAPPEVLL----GEEPTPA-SDLWSLGAVLYEMSTGSKP-VAPDGRRVN-----ELLEKGLTPD-------LS-------GVKDVVIRGILEHILVLDP
.|  |..|     ..... . .|.|||| ..||| .|  | .|.  .  .     .|.......        |         .    .. ..   |. |.
LYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDE

RERIS
..|||
KDRIS
Kinase GL50803_16167.AA CAMK 191-272 19 1.6e-08 22.82 In-house 285-418 (425) Show / Hide 
Range on Protein: 191-272
Range on HMM: 285-418/425
Sequence Identity: 19% (26 aa)

YAP-PEVLLG-------------EEP-TPASDLWSLGAVLYEMSTGSKPVAPD-----------GRRVNELLEKGLTPDLSGVKDVV-------------
|.. ||||.|             ... .|..| ||.| .|| | .|  |   |           |   .||.|| .. . .   . .             
YMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWD

-------------IRGILEHILVLDPRERISARE
              .  . ..|. || .|... .
DISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQ
Kinase GL50803_16167.AA MSK 191-224 41 2e-08 24.55 In-house 171-209 (277) Show / Hide 
Range on Protein: 191-224
Range on HMM: 171-209/277
Sequence Identity: 41% (16 aa)

YAPPEVLLG--EEPT---PASDLWSLGAVLYEMSTGSKP
|..||.| .  ....   .| |.||||..||.| ||  |
YMAPEMLRRGYAQDGGYDEACDWWSLGVILYTMLTGQVP
Kinase GL50803_16167.AA Pkinase 72-176 25 2.9e-08 30.31 Pfam 54-155 (293) Show / Hide 
Range on Protein: 72-176
Range on HMM: 54-155/293
Sequence Identity: 25% (29 aa)

LSRLKHPNLPECKRAFRVSDYLYLQVTRYH-GSLESLMRLY----RRRKQSM--PRRLILEVVHQISSALAYLHDPDKTDPTGAYLPMLVHGGIKPANIL
. ||.|||  .....|. .|..|  |. |. | |. .| |.    ..|. ..  . . .  .. || ..|.|.|.              .|  .||.|||
MKRLNHPNIVRLYDWFEDKDHIY-MVMEYCEGGLY-VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM-----------GIIHRDLKPENIL

VDRAETHF----VLAD
.|  . |      ..|
ID-NNGHIDACVKICD
TyrKc GL50803_16167.AA TyrKc 24-277 17 2.1e-07 -102.94 SMART 1-280 (280) Show / Hide 
Range on Protein: 24-277
Range on HMM: 1-280/280
Sequence Identity: 17% (51 aa)

NAMGSPCGQGACSVIYTLDALPGEVL-KEIRTDMLPSHVLEGMEAALCTLSRL--KHPNLPECKRAFRVS-------DYLYLQVTRY-HGSLESLMRLYR
  .|   | ||  ..|   .   .|  | .. |      .| .   .  ...|  .|||.  .  . . .       . |.. .    ||.| .  | .|
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

RRKQSMPRRLILEVVHQISSALAYLHDPDKTDPTGAYLPMLVHGGIKPANILVDRAE----THFVLADTCVST-------EAFRRH---LSM------YA
..    . .  |.  .||..  .|||.             ..|  .   |.||..      . | |.    .        .  |      .         
PK---LCMKDLLSFCWQIACGMEYLHSK-----------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM

PPEVLLGEEPTPASDLWSLGAVLYEM-STGSKPVAP------DGRRVNELLEKGLTPDLSGV--------KDVVIRGILEHILVLDPRERISARELACIV
.||..   . |..|| || | ...|. . | .|         . ..| |....|  ..                .  | .     || .| . .|.  . 
APECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase GL50803_16167.AA CMGC 193-224 32 6.4e-07 17.79 In-house 293-341 (513) Show / Hide 
Range on Protein: 193-224
Range on HMM: 293-341/513
Sequence Identity: 32% (16 aa)

PPEVLLGEE----------PTPASDLWSLGAVLYEMSTG-------SKP
.||.||| .           |.. | ||.| ...|| ||        ||
APEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKP
Kinase GL50803_16167.AA Ciliate-E2 72-138 20 0.017832 4.29 In-house 86-177 (365) Show / Hide 
Range on Protein: 72-138
Range on HMM: 86-177/365
Sequence Identity: 20% (19 aa)

LSRLKHPNLPECKRAFR--VSDYLYLQVTRYHG-SLESLMR---LYRRRK----QSMPRRLILEVVHQISS---------------ALAYLH
|..|.|||. ... .|     ...||    . | .|.....   . |  .    ...  . |...  || .               || |||
LEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLH
Kinase GL50803_16167.AA CMGC 72-138 11 0.019447 2.78 In-house 75-199 (513) Show / Hide 
Range on Protein: 72-138
Range on HMM: 75-199/513
Sequence Identity: 11% (15 aa)

LSRLK-----------------HPNLPECKRAFRVSD-----------------YLYLQVTRYHGSLESLMRLYRRR-----------------------
| .|.                 |.|.  ..  |. ..                 .|||       .|  ... ....                       
LKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPH

-KQSMPRRLILEVVHQISSALA--YLH
 .....  .|    .||  .|.  |.|
NIKYFMI-HIR-YMYQILRGLKLKYCH
Kinase GL50803_16167.AA CMGC 256-272 41 0.031694 2.07 In-house 490-506 (513) Show / Hide 
Range on Protein: 256-272
Range on HMM: 490-506/513
Sequence Identity: 41% (7 aa)

LEHILVLDPRERISARE
|. .|..|| .||.| .
LKKMLQYDPDKRITAEQ
Kinase GL50803_16167.AA CAMK 72-139 11 0.033433 2.09 In-house 85-197 (425) Show / Hide 
Range on Protein: 72-139
Range on HMM: 85-197/425
Sequence Identity: 11% (13 aa)

LSR-------LKHPNLPECKRAFR------------VSDY--------LYLQV--TRYHGSL----ESLMRLYRRRK-------------QSMPRRLILE
...       |.|||.  .  ..               ..        .|.    . |        . . .. ....               .. |    
MKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARR

VVHQISSALAYLHD
...|| ||..|.|.
YFRQICSAVHYCHS
Ank GL50803_16167.AA Ank 360-390 36 1.1e-05 24.77 Pfam 1-33 (33) Show / Hide 
Range on Protein: 360-390
Range on HMM: 1-33/33
Sequence Identity: 36% (12 aa)

SGMTALMHASSHGHVAVVRLLVD--HEAQMQDD
 |.|.|. |...||. ||..|..   .  .|||
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank GL50803_16167.AA Ank 327-359 33 0.000104 21.25 Pfam 1-33 (33) Show / Hide 
Range on Protein: 327-359
Range on HMM: 1-33/33
Sequence Identity: 33% (11 aa)

LGMTELMQASANGDTNAVRALVDAGSDLRAKGP
 |.| |. |. .|.|. |. |...| |. |.  
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank GL50803_16167.AA Ank 391-414 37 0.000769 18.11 Pfam 1-24 (33) Show / Hide 
Range on Protein: 391-414
Range on HMM: 1-24/33
Sequence Identity: 37% (9 aa)

KSRTALMLAAQNGRVNVLRILLEH
  .|.|.||...|...|.. ||.|
DGFTPLHLACRCGHTEVVKMLLQH
Ank GL50803_16167.AA Ank 422-447 46 2e-06 27.53 Pfam 1-26 (33) Show / Hide 
Range on Protein: 422-447
Range on HMM: 1-26/33
Sequence Identity: 46% (12 aa)

DGWTALMYAAHWGHLEAAQLLLRHEA
||.|.|..|...||.| ...|| | |
DGFTPLHLACRCGHTEVVKMLLQHGA
Ank GL50803_16167.AA Ank 453-473 33 0.041831 11.85 Pfam 1-21 (33) Show / Hide 
Range on Protein: 453-473
Range on HMM: 1-21/33
Sequence Identity: 33% (7 aa)

RCQTALMLAAGNGNIPLVRLL
  .|.|.||. .|..  |..|
DGFTPLHLACRCGHTEVVKML
Ank GL50803_16167.AA Ank 484-507 41 0.000438 18.99 Pfam 1-24 (33) Show / Hide 
Range on Protein: 484-507
Range on HMM: 1-24/33
Sequence Identity: 41% (10 aa)

AGQTALMRAASKGHVGAVQLLLEH
 |.|.|. |...||.  |..||.|
DGFTPLHLACRCGHTEVVKMLLQH
Ank GL50803_16167.AA Ank 515-535 28 7.800889 3.66 Pfam 1-21 (33) Show / Hide 
Range on Protein: 515-535
Range on HMM: 1-21/33
Sequence Identity: 28% (6 aa)

TGKTALGWASEFNRSDAVRIL
 | |.| .|.. .. . |. |
DGFTPLHLACRCGHTEVVKML