Gene GL50803_16049 (G.lamblia)
GL50803_16049
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| GL50803_16049.AA | Protein | None | 686 | None | Fasta, JSON |
| GL50803_16049.kin_dom | Protein Kinase Domain | None | 229 | None | Fasta, JSON |
Protein domains of GL50803_16049.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| S_TKc | GL50803_16049.AA | S_TKc | 9-287 | 17 | 1.1e-11 | -5.68 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 9-287 Range on HMM: 1-231/231 Sequence Identity: 17% (50 aa) LEICTTMQKSHGSATYQVMDVSVKKHRALRVLTPRCTPSRMIFPCITDGHMYTLLQTQTLACYYRAFQCPGSGTIYLIRELCKE---PLGHLIQSYRDSC || . | . |.. ... ... |. .. . . . . .| .|| . .|.. |.| | ..|.... YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG LD--MSEYTVLKIAKQILEGLHYLHEFKHRSTTGISPKTAAPASTLPRVNELIHGRLHLNNVMLRWDGSVALCD--MAYLFPNSTPYSSSKYSFASNMDV |. ..| .. ....||...| |.|. . || | |..| . .|| .| .. ..| . LRFPFPE-HARFYMYQICCALEYCHSHG-----------------------IIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPW- FIAPEALEKGTWST-KSDMWSLGMLIYTMCTLQAPEGISLDTLVNTLQDNPLLSHYSPQLRETLFSLLSLLPDSRPAAGDLLK-------SSLF ..||| | ... |.|.||.| ..| |.. . | .... . . ||.... . .| |. || | ..|. | YMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | GL50803_16049.AA | NEK | 216-287 | 31 | 1.7e-11 | 37.09 | In-house | 204-286 (286) | Show / Hide |
Range on Protein: 216-287 Range on HMM: 204-286/286 Sequence Identity: 31% (26 aa) KSDMWSLGMLIYTMCTLQA--P-EGI--SLDTLV-NTLQD---NPLLSH--YSPQLRETLFSLLSLLPDSRPAAGDLLKSSLF |||.|||| ..| ||||. | |. .. |. . . .|. || ||..|.. . ..| |..|| . ..|. .. KSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI |
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| Kinase | GL50803_16049.AA | NEK1 | 216-287 | 31 | 1.3e-10 | 33.22 | In-house | 201-276 (276) | Show / Hide |
Range on Protein: 216-287 Range on HMM: 201-276/276 Sequence Identity: 31% (24 aa) KSDMWSLGMLIYTMCTLQAP-EGISLDTLVNTLQD---NPLLSHYSPQLRETLFSLLSLLPDSRPAAGDLLKSSLF |||.|||| | ||| | |. .. .||. |. .||| |.. ...... | .|| . ..|.. KSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI |
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| Kinase | GL50803_16049.AA | STE-Unique | 203-287 | 20 | 1.1e-09 | 30.0 | In-house | 515-616 (616) | Show / Hide |
Range on Protein: 203-287 Range on HMM: 515-616/616 Sequence Identity: 20% (21 aa) IAPEALEKG-----TWSTKSDMWSLGMLIYTMCTLQAP-----EGISLDTLVNTLQDNPL-------LSHYSPQLRETLFSLLSLLPDSRPAAGDLLKSS ..|| ... .||.|.||||... ||.. | .... . . . |. . ..|.... . ..|.. | || | .||.. MCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPWHQRYHMQAYIEMCIHIHCQPPQCPIENIPPKCQPEQQQFIEKCLERNPHHRPSAHQLLHHF LF . WL |
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| Kinase | GL50803_16049.AA | Pkinase | 202-287 | 16 | 1.3e-09 | 35.12 | Pfam | 177-293 (293) | Show / Hide |
Range on Protein: 202-287 Range on HMM: 177-293/293 Sequence Identity: 16% (20 aa) FIAPEALE-KGTWSTKSDMWSLGMLIYTMCT----LQAP----EGISLDTLVNTLQDNPLLSHYS-----------------------PQLRETLFSLLS ..||| . ...|.||||.| ..| |.. . . .. . ... . || .... . ... . ..| YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLC LLPDSRPAAGDLLKSSLF . | .|| | ..|.. | KDPKKRPTAEQILQHPWF |
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| Kinase | GL50803_16049.AA | NEK8 | 216-287 | 35 | 2.2e-09 | 22.85 | In-house | 202-278 (278) | Show / Hide |
Range on Protein: 216-287 Range on HMM: 202-278/278 Sequence Identity: 35% (27 aa) KSDMWSLGMLIYTMCTLQ-APEGISLDTLVNTLQD----NPLLSHYSPQLRETLFSLLSLLPDSRPAAGDLLKSSLF |||||.|| .| ||.| | |. | ||. .|. .|||. .| ..|.. |. ||.| ... | KSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC |
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| Kinase | GL50803_16049.AA | Ciliate-E2 | 202-287 | 17 | 1.3e-08 | 25.69 | In-house | 253-365 (365) | Show / Hide |
Range on Protein: 202-287 Range on HMM: 253-365/365 Sequence Identity: 17% (20 aa) FIAPEALEKGT---------WSTKSDMWSLGMLIYTMCTLQAPEGISLDTLVNTLQDNPL--------------LSHYSPQLRETLFS----LLSLLPDS . ||| |... ...|.|.||||...| |.. . | . . ..| . |.. . .| |. YMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEK RPA-AGDLLKSSLF |. . ..|. | RITGWEQILNHPWF |
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| Kinase | GL50803_16049.AA | NEK-Unclassified | 202-287 | 23 | 2.1e-08 | 23.62 | In-house | 163-258 (258) | Show / Hide |
Range on Protein: 202-287 Range on HMM: 163-258/258 Sequence Identity: 23% (23 aa) FIAPEALEKGTWSTKSDMWSLGMLIYTMCTLQ-APEGISLDTLVNTLQ--DN-------PLLSHYSPQLRETLFSLLSLLPDSRPAAGDLLKSSLF ...|| ... . .|| |||| .|| ||| . .. . || | . || | . . .| .. || | ... WMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCEPFFDTHNMGEVYMKIKQDDNRLEEALEPVSKTYSTDLQQVIRFMLRRNFQQRPSATEIVEQDYI |
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| Kinase | GL50803_16049.AA | SRM | 204-231 | 50 | 4.1e-08 | 23.06 | In-house | 166-193 (253) | Show / Hide |
Range on Protein: 204-231 Range on HMM: 166-193/253 Sequence Identity: 50% (14 aa) APEALEKGTWSTKSDMWSLGMLIYTMCT ||||. .. .|.||| || | | . | | APEAANYRHYSQKSDVWSFGILLHEMFT |
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| Kinase | GL50803_16049.AA | STE | 164-287 | 18 | 4.4e-07 | 21.2 | In-house | 182-359 (359) | Show / Hide |
Range on Protein: 164-287 Range on HMM: 182-359/359 Sequence Identity: 18% (34 aa) NVMLRWDGSVALCD---MAYLFPNST------------PYSSSKYSFASNMDVFIAPEALEK------GTWSTKSDMWSLGMLIYTMCTLQAPEGISLDT |..| | ||| . | .... .. ..|. . ||| ... . .||.|.|||| .| |.| . | .. NILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP--WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPM --LVNTL----------------QDNPLLS--------------------HYSPQLRETLFSLLSLLPDSRPAAGDLLK--SSLF . ... .. | | ..|| ... . | |. || | .||| . . RAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI |
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| Kinase | GL50803_16049.AA | PEK | 204-287 | 21 | 1e-06 | 18.58 | In-house | 557-655 (655) | Show / Hide |
Range on Protein: 204-287 Range on HMM: 557-655/655 Sequence Identity: 21% (21 aa) APEALEKG-----TWSTKSDMWSLGMLIYTMCTLQAPEGISLDTLVNTLQD----------NPLLSHYSPQLRETLFSLLSLLPDSRPAAGDLLKSSLF .|| |... .|.||.||| .. |. . .. . . |.| .... |.... . .||. |. || | ..|.. .| SPEQLSGQHYQKSHYNHKVDMYSLGIIFFEMWYPFFTTMMERVKTLTDLRDESIQFPGDFPPKWFDNKYPKQADFIQWMLSHDPQQRPSAQQILQHEFF |
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| Kinase | GL50803_16049.AA | Ciliate-E2a | 202-235 | 30 | 3e-06 | 14.3 | In-house | 176-215 (275) | Show / Hide |
Range on Protein: 202-235 Range on HMM: 176-215/275 Sequence Identity: 30% (12 aa) FIA------PEALEKGTWSTKSDMWSLGMLIYTMCTLQAP ..| .| |.. .|| ||||.| .|.... . | YVAPEVLNNKEVLKHKQYDTKCDMWSCGVIFYILLCGKPP |
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| Kinase | GL50803_16049.AA | Ciliate-E2 | 71-129 | 25 | 4e-06 | 17.05 | In-house | 97-178 (365) | Show / Hide |
Range on Protein: 71-129 Range on HMM: 97-178/365 Sequence Identity: 25% (21 aa) YYRAFQCPGSGTIYLIRELCKEP-LGHLIQ---SYRDSCLD----MSEYTVLKIAKQILE---------------GLHYLHE .| .|| .|||. |.|. | ..|. |..... ..|. ...| ||||. .|.|||. MYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHS |
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| Kinase | GL50803_16049.AA | NEK | 71-129 | 18 | 1.4e-05 | 16.04 | In-house | 69-132 (286) | Show / Hide |
Range on Protein: 71-129 Range on HMM: 69-132/286 Sequence Identity: 18% (12 aa) YYRAFQCPGSGTIYLIRELCKE--PLGHL---IQSYRDSCLDMSEYTVLKIAKQILEGLHYLHE || .|. ...... . | | | . |. .... ..| ..... |.. .|.|.|. YYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHD |
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| Pkinase | GL50803_16049.AA | Pkinase | 71-129 | 26 | 5.5e-05 | 18.72 | Pfam | 65-126 (293) | Show / Hide |
Range on Protein: 71-129 Range on HMM: 65-126/293 Sequence Identity: 26% (17 aa) YYRAFQCPGSGTIYLIRELCKE-----PLGHLIQ-SYRDSCLDMSEYTVLKIAKQILEGLHYLHE .|..|. .. ||.. |.| | ..|. ... . . .|| .. ....|||.|| |.|. LYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHS |
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| TyrKc | GL50803_16049.AA | TyrKc | 13-286 | 13 | 0.000103 | -146.42 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 13-286
Range on HMM: 1-280/280
Sequence Identity: 13% (45 aa)
TTMQKSHGS--------ATYQVMDVSVKKHRALRVLTPRCTPSRMIFPCITDGHMYTLLQ-TQTLACY---------YRAFQCPGS------GTIYLIRE
|. | |. .|. ..| ||. .. . ... . . . . .. . .... |
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA--------------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVME
LCKE-PLGHLIQSYRDSCLDMSEYTVLKIAKQILEGLHYLHEFKHRSTTGISPKTAAPASTLPRVNELIHGRLHLNNVMLRWDGSVALCDMA---YLFPN
... | . ....|. . . |... || .| |||. .|| | |... .. | .| ..
YMPHGDLKDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSK-----------------------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDD
-----STPYSSSKYSFASN--MDVF-IAPEALEKGTWSTKSDMWSLGMLIYTMCTL--QAPEG-----ISLDTLVNTLQDN---PLLSH--------YSP
|. | ..| . .. . . |||.. .|. .|||| || | ... ..|. | ..| .| . ... ... | . ..
DQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPD
QLRETLFSLLSLLPDSRPAAGDLLKSSL
. . . |..|| .. .. .
EMYQIMKQCWHEDPEDRPTFSEI-HECF
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| Kinase | GL50803_16049.AA | STE-Unique | 108-128 | 52 | 0.000503 | 9.53 | In-house | 400-420 (616) | Show / Hide |
Range on Protein: 108-128 Range on HMM: 400-420/616 Sequence Identity: 52% (11 aa) MSEYTVLKIAKQILEGLHYLH . | |.....|||||| ||| FPETEVIWYTYQILEGLEYLH |
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| Kinase | GL50803_16049.AA | Ciliate-E2a | 109-128 | 40 | 0.000928 | 6.97 | In-house | 98-119 (275) | Show / Hide |
Range on Protein: 109-128 Range on HMM: 98-119/275 Sequence Identity: 40% (9 aa) SE-YTVLKIAKQIL-EGLHYLH .| . . .| .|.| .||||.| EEIQEICDIMQQLLWQGLHYMH |
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| Kinase | GL50803_16049.AA | STE | 115-129 | 56 | 0.003888 | 7.07 | In-house | 155-170 (359) | Show / Hide |
Range on Protein: 115-129 Range on HMM: 155-170/359 Sequence Identity: 56% (9 aa) KIAKQILEG-LHYLHE .|..|||.| |.|||. YICRQILKGLLYYLHS |
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| Kinase | GL50803_16049.AA | PEK | 112-129 | 50 | 0.00456 | 5.66 | In-house | 428-445 (655) | Show / Hide |
Range on Protein: 112-129 Range on HMM: 428-445/655 Sequence Identity: 50% (9 aa) TVLKIAKQILEGLHYLHE ....|..|||||| |.|. QCWRIFRQILEGLNYIHS |
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| Ank | GL50803_16049.AA | Ank | 342-364 | 34 | 0.003536 | 15.72 | Pfam | 1-23 (33) | Show / Hide |
Range on Protein: 342-364 Range on HMM: 1-23/33 Sequence Identity: 34% (8 aa) LGKTALMYAAQHGHAALIPFLLS | |.|..|...||. . .||. DGFTPLHLACRCGHTEVVKMLLQ |
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| Ank | GL50803_16049.AA | Ank | 378-399 | 36 | 0.000144 | 20.73 | Pfam | 1-22 (33) | Show / Hide |
Range on Protein: 378-399 Range on HMM: 1-22/33 Sequence Identity: 36% (8 aa) RGKTALMYAASNNHVSVVSQLI | |.|..|....|..||. |. DGFTPLHLACRCGHTEVVKMLL |
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| Ank | GL50803_16049.AA | Ank | 409-429 | 38 | 0.0002 | 20.22 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 409-429 Range on HMM: 1-21/33 Sequence Identity: 38% (8 aa) RGKTALMMAAEKGHVQVIELL | |.|..|...||..|...| DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_16049.AA | Ank | 440-461 | 36 | 24.598648 | 1.86 | Pfam | 1-22 (33) | Show / Hide |
Range on Protein: 440-461 Range on HMM: 1-22/33 Sequence Identity: 36% (8 aa) IGLTSLMLAIIRRKWTSVEMLV | | |.||... |.||. DGFTPLHLACRCGHTEVVKMLL |
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| Ank | GL50803_16049.AA | Ank | 471-492 | 40 | 0.006957 | 14.66 | Pfam | 1-22 (33) | Show / Hide |
Range on Protein: 471-492 Range on HMM: 1-22/33 Sequence Identity: 40% (9 aa) SGSTALMVAARRNMPESLKYLL | |.|..|.|.. .| .|.|| DGFTPLHLACRCGHTEVVKMLL |
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| Ank | GL50803_16049.AA | Ank | 502-520 | 47 | 0.005023 | 15.17 | Pfam | 1-19 (33) | Show / Hide |
Range on Protein: 502-520 Range on HMM: 1-19/33 Sequence Identity: 47% (9 aa) NGRTALMLAAAAGAVEFVK .|.|.|.||. | .| || DGFTPLHLACRCGHTEVVK |
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| Ank | GL50803_16049.AA | Ank | 543-573 | 24 | 0.004713 | 15.27 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 543-573 Range on HMM: 1-33/33 Sequence Identity: 24% (8 aa) RGYTALIHAARNGKATCMSVLID--VEHDIVDN |.|.| |.|.| . ... |.. . ...|. DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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