Gene GL50803_15514 (G.lamblia)
GL50803_15514
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
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GL50803_15514.AA | Protein | None | 527 | None | Fasta, JSON |
GL50803_15514.kin_dom | Protein Kinase Domain | None | 260 | None | Fasta, JSON |
Protein domains of GL50803_15514.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | GL50803_15514.AA | STE20 | 16-275 | 41 | 1.2e-114 | 387.16 | In-house | 1-288 (288) | Show / Hide |
Range on Protein: 16-275 Range on HMM: 1-288/288 Sequence Identity: 41% (123 aa) FELLSPIGSGSYGAVWQAFSVL-TSEI----VAVKRIPLESD------TSALILEIQLMKKLNHPNIVKYLGSFVDKVD--DELWIILEFCSAGAISDLM .||| ||.||||.| | | |. ||.|...||.. .. ||. ||...|||||||.||.. . . |||||. |.|..| ..|.| YELLEKIGQGSYGKVYKA-YHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIM R---GCHK-----TLTEEQCSYTLASTLLGLRYLHKQHVIHRDIKANNLLISEDASVRIADFGVSAEMQN----SFA-QRNSTIGTPYWLSPQQIKG--- . | | ...||| .| . .| || |||..|.|||||||.| |..||..| .|||||.| ... ... .||. .|||||..| |.. KHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEG --EPYGFKADVWALGITAIELTEGKPPHSELTSMRAMIVIP--RQPPMKLKGRTNPFTKQPHSDVFADFVDRCLQHAEEDRATVEELLQHEFI .|..|.|.|.|||||||. ||.||.... |||| || . || .||.. . |. | ||||.||| |.|.|...||.|.|| PDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDD-K---PHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI |
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Kinase | GL50803_15514.AA | MST | 16-275 | 44 | 7.29999999999e-112 | 356.86 | In-house | 1-254 (254) | Show / Hide |
Range on Protein: 16-275 Range on HMM: 1-254/254 Sequence Identity: 44% (116 aa) FELLSPIGSGSYGAVWQAFSVLTSEIVAVKRIPLESDTSALILEIQLMKKLNHPNIVKYLGSFVDKVDDELWIILEFCSAGAISDLMRGCHKTLTEEQCS |... .| |||| | .| |..|||.| .| ..| ...| || |. . ..|||| ||. | . ..||. |.| .| ..|.|. .||.|.| . FDIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPVNEDLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNEQQIA YTLASTLLGLRYLHKQHVIHRDIKANNLLISEDASVRIADFGVSAEMQNSFAQRNSTIGTPYWLSPQQIKGEPYGFKADVWALGITAIELTEGKPPHSEL | .||.|| |||. . ||||||| | |.... ||||||.. . | ||. ||||||..| .| | ||| |.|||||||. ||.|| |.. CILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQEIKYDCKADIWSLGITAIEMAEGMPPYSDI TSMRAMIVIPRQPPMKLKGRTNPFTKQPHSDVFADFVDRCLQHAEEDRATVEELLQHEFI ||||. || || ..| .| . |. | ||| .||| |.|.| |.||||.|| HPMRAMFMIPQKPPPTFK---DP---EQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI |
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Kinase | GL50803_15514.AA | STE | 16-275 | 30 | 4.3e-102 | 345.47 | In-house | 1-359 (359) | Show / Hide |
Range on Protein: 16-275 Range on HMM: 1-359/359 Sequence Identity: 30% (112 aa) FELLSPIGSGSYGAVWQAFSVL---------------TSEIVAVKRIPLESDTS-------------------ALILEIQLMKKLN--HPNIVKYLGSFV .|... ||.|..| | .| . | ||.|.|...||.... .. ||..|||.| |||||||.|... WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF -----DKVDDELWIILEFCSAGAISDLMR---GCHKTLT----------EEQCSYTLASTLLG-LRYLHKQHVIHRDIKANNLLISEDASVRIADFGVSA .| ||||||..|....| ..|... || |.|. |.| .| . ..| | | |||..|.||||||. | |. | ..||||.. KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG EMQNSFA----------------QRNSTIGTPYWLSPQQIKG------EPYGFKADVWALGITAIELTEGKPPHSELTSMRAMIVIPRQ----------- ...| | .||. .||| | .| |.. .|..|.|.| ||.|.||. .||||..... |||| ||. QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC ----PPMKLKGR-------------TNPFTKQPHSDVFADFVDRCLQHAEEDRATVEELLQ--HEFI || .|. . | . . |. | ||...||| ..|.|...||. |.|| IVNGPPPPLPDHLSQNEMISYGGSGT-T-YPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI |
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Kinase | GL50803_15514.AA | PAKL | 16-275 | 44 | 8.7e-94 | 317.88 | In-house | 1-256 (256) | Show / Hide |
Range on Protein: 16-275 Range on HMM: 1-256/256 Sequence Identity: 44% (118 aa) FELLSPIGSGSYGAVWQAFSVLTSEIVAVKRIPL-ES-DTSALILEIQLMKKLNHPNIVKYLGSFVDKVDDELWIILEFCSAGAISDLMRGCHKTLTEEQ ||. | ||||.|. | | |.| |.. || . . |||. || . |||| | || |. ...|| ...||.| | |.| | |||.|.| FEFQEKLGQGSYGSVYKAIHKDTNFPLAIKVIEIKESNEIKDIEKEIQILKKCKCPNIVSYFGSIQQKL-NHYWILMDYCSLGSINDMMESCCKTLNEKQ CSYTLASTLLGLRYLHKQHVIHRDIKANNLLISEDASVRIADFGVSAEMQNSFA-QRNSTIGTPYWLSPQQIKGEPYGFKADVWALGITAIELTEGKPPH | | ||.|| ||| . .||||||| | |..||. | ||||||| .| .. | |. |||||| | |. .| |.|.| |||||||. .| ||| ISVILQQTLKGLHYLHSKNIIHRDIKAANILLNEDCQVKIADFGVSQQLQDEYDGQANQMIGTPYWMAPEIINKQNYNNKCDIWSLGITAIEMADGFPPH SELTSMRAMIVIPRQPPMKLKGRTNPFTKQPHSDVFADFVDRCLQHAEEDRATVEELLQHEFI ... .|||| ||. || ... || | | ||...|.. | |. . .|| | || YDMPPMRAMYMIPNWPPPTFS---NP---KHWSPCFNDFLAQCCVKDPEKRWSPIDLLCHPFI |
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Kinase | GL50803_15514.AA | YSK | 16-275 | 39 | 3.1e-88 | 265.72 | In-house | 1-257 (257) | Show / Hide |
Range on Protein: 16-275 Range on HMM: 1-257/257 Sequence Identity: 39% (105 aa) FELLSPIGSGSYGAVWQAFSVLTSEIVAVKRIPLESDTSALIL---EIQLMKKLNHPNIVKYLGSFVDKVDDELWIILEFCSAGAISDLMRG-CHKTLTE | .. || ||.| |. . . | ..||.| | ||.. . ||| . |.| ||.||. . |||| |.| | ..|||. . | FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDT--KLWIIMEYCGGGSCLDLMKPKYVGQFDE EQCSYTLASTLLGLRYLHKQHVIHRDIKANNLLISEDASVRIADFGVSAEMQNSFAQRNSTIGTPYWLSPQQIKG--EPYGFKADVWALGITAIELTEGK .. . | |.|| |||.. .||||||| | |.||. | ..||||.. .. || .||||| | |. | ||||.| |||||.|. | KYIAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKGE PPHSELTSMRAMIVIPRQPPMKLKGRTNPFTKQPHSDVFADFVDRCLQHAEEDRATVEELLQHEFI ||.... ||.| || ..| ||.|| ..|. | .||. || |.| . .||| |.|| PPYCDYHPMRVMFLIPKNNPPKLEGR-------SYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI |
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Kinase | GL50803_15514.AA | S_TKc | 16-275 | 28 | 1e-84 | 288.67 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 16-275 Range on HMM: 1-231/231 Sequence Identity: 28% (77 aa) FELLSPIGSGSYGAVWQAFSVLTSEIVAVKRIPLESDTSALILEIQLMKKLNHPNIVKYLGSFVDKVDDELWIILEFCSA--GAISDLMRGCHK-----T .|.| .||.|..| |... . | .|||.|.|. .. |||..|| .||||||....|.| |.|....|.|. | |... . . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP LTEEQCSYTLASTLLGLRYLHKQHVIHRDIKANNLLISEDASVRIADFGVSAEMQNSFAQRNSTIGTPYWLSPQQIKGEPYGF-KADVWALGITAIELTE ..| .. . .. ....| |.|....||||.| |.|..| . |.|||..... .. .|||....| . .||. |.|.|..|.. .|. FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC GKPPHSELTSMRAMIVIPRQPPMKLKGRTNPFTKQPHSDVFADFVDRCLQHAEEDRATVEELLQ-------HEFI |.|| . | .|. . . |. . ||...||| |.| |. |.|| |... GYPPFP---QMQMMFKKIG------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | GL50803_15514.AA | PAKA | 16-275 | 35 | 2.8e-81 | 276.34 | In-house | 1-260 (260) | Show / Hide |
Range on Protein: 16-275 Range on HMM: 1-260/260 Sequence Identity: 35% (97 aa) FELLSPIGSGSYGAVWQAFSVLTSEI--VAVKRIPLESDTSA--LILEIQLMKKLNHPNIVKYLGSFVDKVDDELWIILEFCSAGAISDLMRGCHK---- .. .. || |. |.| | .. | . ||.|.. .. . . .| || .||. .|.|||.|. |.. |||||...|. ..| |. | . YKFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLV--DDELWVVMEYMEGGCLTDVITQCCNIQCN TLTEEQCSYTLASTLLGLRYLHKQHVIHRDIKANNLLISEDASVRIADFGVSAEMQNSFAQRNSTIGTPYWLSPQQIKGEPYGFKADVWALGITAIELTE ...|.| .| . .| || ..|..|.|||||| | |. |.|| |.||| |... . .||. ||||| .| |.. |. | |.| ||| |||. | YMDEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIRRKQYDEKVDIWSLGIMAIEMIE GKPPHSELTSMRAMIVIPRQ--PPMKLKGRTNPFTKQPHSDVFADFVDRCLQHAEEDRATVEELLQHEFI | ||. . . ||| | . |..| . . |. | ||.|.||. ..||...|||.|.|. GEPPYLNEPPLRAMYLIATNGKPDIKDPDKW--------SQEFCDFLDKCLCVDVDRRASAQELLHHPFL |
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Kinase | GL50803_15514.AA | Pkinase | 16-275 | 28 | 1.6e-75 | 262.02 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 16-275 Range on HMM: 1-293/293 Sequence Identity: 28% (84 aa) FELLSPIGSGSYGAVWQAFSVLTSEIVAVKRIPLESDTS----ALIL--EIQLMKKLNHPNIVKYLGSFVDKVDDELWIILEFCSAG----AISDLMR-G ......|||||.| |... . |..|||||.|..... | .... |||.||.|||||||.....| | .|......|.| | .|... YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTW CHKTL--TEEQCSYTLASTLLGLRYLHKQHVIHRDIKANNLLISEDASV----RIADFGVSAEM-QNSFAQRNSTIGTPYWLSPQQIK-GEPYGFKADVW |... .|..| . .| || |.|.. .||||.| |.||... . .|.|||... . . .. |||....| |. |..|| |.|.| RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW ALGITAIELTEGKPPHSEL----TSMRAMIVIPRQPPMKLKGRTNPFTKQPHS---------------DVFADFVDRCLQHAEEDRATVEELLQHEFI ..|.. .|. |.|| .. . .. | .| | . .|. . . . . ||...||. ..| | |..|||... SCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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Kinase | GL50803_15514.AA | MSN | 16-275 | 38 | 2.7e-74 | 244.7 | In-house | 1-265 (265) | Show / Hide |
Range on Protein: 16-275 Range on HMM: 1-265/265 Sequence Identity: 38% (104 aa) FELLSPIGSGSYGAVWQAFSVLTSEIVAVKRIPLESD-TSALILEIQLMKKL-NHPNIVKYLGSFVDKV----DDELWIILEFCSAGAISDLMRGCH-KT ||| .| | || |.. | |....|.| . .. | . .|| ..|| .| ||. | | |. | |. ||...|||.||.. ||.. . .. FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVREDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGHDHQLWMVMEFCGAGSVTDLVKMTKGQS LTEEQCSYTLASTLLGLRYLHKQHVIHRDIKANNLLISEDASVRIADFGVSAEMQNSFAQRNSTIGTPYWLSPQQIKGE-----PYGFKADVWALGITAI | |. | | || .||...||||||| | |. ..| |.. |||||| .. ||. ||||||. | |. . | ...|.|..||||| LKEDWIAYICREILRGLAHLHQHKVIHRDIKGQNVLLTHNAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSVGITAI ELTEGKPPHSELTSMRAMIVIPRQPPMKLKGRTNPFTKQPHSDVFADFVDRCLQHAEEDRATVEELLQHEFI |. ||.|| .. |||...|||.|| ||| ..|. | .|...|| . | . |..|.| || EMAEGQPPLCDMHPMRALFLIPRNPPPKLK--SKKWSKK-----FHNFMEKCLIKNYHQRPYTEQMLKHPFI |
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Kinase | GL50803_15514.AA | KHS | 16-275 | 42 | 9e-73 | 244.07 | In-house | 1-258 (258) | Show / Hide |
Range on Protein: 16-275 Range on HMM: 1-258/258 Sequence Identity: 42% (113 aa) FELLSPIGSGSYGAVWQAFSVLTSEIVAVKRIPLES--DTSALILEIQLMKKLNHPNIVKYLGSFVDKVDDELWIILEFCSAGAISDLMRGCHKTLTEEQ .||| .||| || |..| . ..|..||| | .| | . . || .||. ||||| | ||.. . | |||..|.| .|.. |. . |.| | YELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRR--DKLWICMEYCGGGSLQDIYH-VTGPLSELQ CSYTLASTLLGLRYLHKQHVIHRDIKANNLLISEDASVRIADFGVSAEMQNSFAQRNSTIGTPYWLSPQ----QIKGEPYGFKADVWALGITAIELTEGK .| || ||.||| . .||||| |.|.... |..|||||||.. . |.| | ||||||. | . || |. |.||.|||||||.| . IAYVCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGG-YNQLCDIWAVGITAIELAELQ PPHSELTSMRAMIVIPR---QPPMKLKGRTNPFTKQPHSDVFADFVDRCLQHAEEDRATVEELLQHEFI || .| |||.... . ||| ||| |. |. | .|| .| | | | ||||.|. PPMFDLHPMRALFLMTKSNFQPP-KLK------DKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV |
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Kinase | GL50803_15514.AA | SLK | 16-275 | 35 | 4.7e-71 | 238.94 | In-house | 1-259 (259) | Show / Hide |
Range on Protein: 16-275 Range on HMM: 1-259/259 Sequence Identity: 35% (94 aa) FELLSPIGSGSYGAVWQAFSVLTSEIVAVKRIPLESDT--SALILEIQLMKKLNHPNIVKYLGSFVDKVDDELWIILEFCSAGAISDLMRGCHKTLTEEQ .|.. .| | .| | .| . .. . | | | .... . . ||... ...|||||| .... .|..||...||| ||. .| ...|||.| WEIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECKHPNIVKLYEAYY--YDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQ CSYTLASTLLGLRYLHKQHVIHRDIKANNLLISEDASVRIADFGVSAEMQNSFAQRNSTIGTPYWLSP-----QQIKGEPYGFKADVWALGITAIELTEG | .. .|..||...|||||.|| |.|. | ||.||||||| .. .| . ||||||. | .| .|| .|||.|.|||| ||. .. IQYVCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMAQM KPPHSELTSMRAMIVIPRQPPMKLKGRTNPFTKQPHSDVFADFVDRCLQHAEEDRATVEELLQHEFI |||.|. || .. | . | .|. . | | ||. .||. . | | ..|.||... EPPHHEMNPMRVLLKIQKSEPPTLE------QPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV |
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Kinase | GL50803_15514.AA | NinaC | 16-275 | 36 | 5.1e-63 | 215.69 | In-house | 1-267 (267) | Show / Hide |
Range on Protein: 16-275 Range on HMM: 1-267/267 Sequence Identity: 36% (99 aa) FELLSPIGSGSYGAVWQAFSVLTSEIVAVKRIPLESDTSALI-LEIQLMKKL-NHPNIVKYLGSFVDK---VDDELWIILEFCSAGAISDLMRG---CHK .| || | || |... .|.||| .| | | . .... .|||.|.. | . | . |.||...|.|. | . |. .| | . WEIYETIGKGTYGKVFKVKNKDNGQIAAVKIQHYIHDHDEEIEAEYNILRDYCDHPNVVRFYGMYYKKDKCNGDQLWFVMEYCNGGSVTDMVKGLLKCGR TLTEEQCSYTLASTLLGLRYLHKQHVIHRDIKANNLLISEDASVRIADFGVSAEMQNSFAQRNSTIGTPYWLSPQQIKGE-----PYGFKADVWALGITA . || .| | ...|| ||. ||||||.| || | . |. |||||| .. .|| .|||.|. | | . | .|||.||||| RMREEHIAYILHEACMGLQHLHCNHVIHRDVKGNNILLTTEGGVKLCDFGVSAQLDSTRHRRNTCVGTPCWMAPEVIACMQQYDPDYDARCDVWSLGITA IELTEGKPPHSELTSMRAMIVIPRQPPMKLKGRTNPFTKQPHSDVFADFVDRCLQHAEEDRATVEELLQHEFI ||| |.|| .. |||| ||| || .| .| .. | ||. .|| | | .. ..|.| || IELGDGDPPFADMHPMRAMFKIPRNPPPTLMHPEN------WCQEFNDFISQCLEKDYEKRPMMVHMLEHPFI |
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Kinase | GL50803_15514.AA | Pkinase_Tyr | 16-159 | 26 | 3.5e-24 | 82.51 | Pfam | 1-158 (270) | Show / Hide |
Range on Protein: 16-159 Range on HMM: 1-158/270 Sequence Identity: 26% (43 aa) FELLSPIGSGSYGAVWQAFSV----LTSEIVAVKRIPLESDTSA------LILEIQLMKKL-NHPNIVKYLGSFVDKVDDE--LWIILEFCSAGAISDLM ... .|.|..| |... | |||| . |. .. .. |...||.| .|||||...| . . .. ..|..|.. | | ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCT-DQGEPNQIYIVMEYMPHGDLLDYL RGC---HKTLTEEQCSYTLASTLLGLRYLHKQHVIHRDIKANNLLISEDASVRIADFGVS | . || .. . |. ||. .. ||||. | | |..|. |.|.||| . RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA |
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Kinase | GL50803_15514.AA | TyrKc | 16-275 | 23 | 4e-20 | 74.1 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 16-275 Range on HMM: 1-280/280 Sequence Identity: 23% (69 aa) FELLSPIGSGSYGAVWQAFSVLTSEIVAVKRIPLESDTSALILEIQLMKKL--NHPNIVKYLGSFVDK-----VDDELWIILEFCSAGAISDLMRGCHKT .|. .|.| .| |... . |||| . .. ... |...|.|| .|||||. .| ... .. |.|..|... |. | | .... ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK LTEEQCSYTLASTLLGLRYLHKQHVIHRDIKANNLLISEDASVRIADFGVSAEMQNS-------FAQRNST-IGTP-----YWLSPQQIKGEPYGFKADV |. .. . | .|||....||||. | | |..|. |.|.||| | . . | .. |. |..| |. . .| || LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDV WALGITAIEL-TEGKPPHSELTSMRAMIVIPRQPPMKLKGRTNPFTKQ--------PHSDVFADFVDRCLQHAEEDRATVEELLQHEFI |. |.. |. | |..|... . . |. . .|. | . ..... .| .. ||| | .|. ||.. WSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--HECF |