Gene GL50803_15411 (G.lamblia)

GL50803_15411

Species: G.lamblia
Alias: GK292, GL50803_15411
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_15411.AA Protein None 706 None Fasta, JSON
GL50803_15411.kin_dom Protein Kinase Domain None 271 None Fasta, JSON

Protein domain

Protein domains of GL50803_15411.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_15411.AA Ciliate-E2-Unclassified 191-280 19 1.2e-15 50.77 In-house 232-352 (352) Show / Hide 
Range on Protein: 191-280
Range on HMM: 232-352/352
Sequence Identity: 19% (24 aa)

YASPEFLNR-EYTE---CPADVWSAGACIFAMAMRRPPFNSTNVES----------------LRVEVEEGKKDGLD-------ISFSRELDDMLQ----R
|..|| | . .| .     .|.|| | ....| . ..||...| |.                |. .  ... .             | |  |...    .
YTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQK

MMTPDQGYRPTAGDLLNDPSI
|.  ....|.|. ..|| | .
MLKKNPNKRITFEQILNHPWF
Kinase GL50803_15411.AA CAMK 189-280 20 1.5e-14 42.6 In-house 283-425 (425) Show / Hide 
Range on Protein: 189-280
Range on HMM: 283-425/425
Sequence Identity: 20% (30 aa)

LAYAS-PEFLNR--------------EYTECPADVWSAGACIFAMAMRRPPFNST-------------NVESLRVEVEEGKKDGLDISFSR---------
..|.. || ||.              .|   ..|.||.|   ..|   .|||..              | . |   . .|| |  .  ||          
PEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEW

--------------ELDDMLQRMMTPDQGYRPTAGDLLNDPSI
              |  |....|...|   |.|. . ||.| .
WDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
S_TKc GL50803_15411.AA S_TKc 10-280 20 1.8e-14 35.34 SMART 1-231 (231) Show / Hide 
Range on Protein: 10-280
Range on HMM: 1-231/231
Sequence Identity: 20% (58 aa)

YRFQTTLAAGEYSMLFLAMGND-YQEVAIKSFDCTQMDDAQVSEIHRQALLLKSVNHPLVLKVYDVQMNITRTRLHVIMEPFFK---TLQNLIDECEK--
|..  ..  | ..  ...  ..  ..||||  .           | |   .||. .|| . | |||  .   ..|...||       .|  .|... .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

ADRSLLNNIVCQVAYQVIKGLHYLSTTNHVAVNEQGQEFSQDKIFHSFITPNDIVFNTSGVVKLM-----NIFPLEHRMLYEKGDASFPG-LAYASPEFL
 .. .    .. ..||....| |.    |          |. .| |  . |  | ...  ..|.       ..             .| | . | .|| |
LRFPFPE-HARFYMYQICCALEYC----H----------SH-GIIHRDLKPENILLDE--HIKICDFGLARQL------------TTFCGTPWYMAPEVL

NREYTECPADVWSAGACIFAMAMRRPPFNSTNVESLRVEVEEGKKDGLDISFSRELDDMLQRMMTPDQGYRPTAGDLLN-------DPSI
   |. |..|.|| | ... |. ..|||  .  . ... .            |.|. |....... |   |||| ..|.       .| .
--GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_15411.AA NEK10 206-269 35 5e-13 39.07 In-house 201-265 (279) Show / Hide 
Range on Protein: 206-269
Range on HMM: 201-265/279
Sequence Identity: 35% (23 aa)

ADVWSAGACIFAMAMRRPPFNSTNVESLRVEVEEGKKDGLDI-SFSRELDDMLQRMMTPDQGYRP
||||..| |.. |.  .||| |||  .|   . | . | ..   .| .. ....| .|||   ||
ADVWAFGCCLYQMCTLQPPFYSTNMLTLAMKIVEHFYDPVNEGMWSDDVRFTITRCLTPDPEARP
Kinase GL50803_15411.AA NEK 206-280 24 5.2e-13 42.54 In-house 205-286 (286) Show / Hide 
Range on Protein: 206-280
Range on HMM: 205-286/286
Sequence Identity: 24% (20 aa)

ADVWSAGACIFAMAMR--RPPFNST--NVESLRVEVEEG-KKDGLDIS--FSRELDDMLQRMMTPDQGYRPTAGDLLNDPSI
.|.|| | ... |..   ..||...  | .|| . . .| . . .     .|..| .....| ..|   ||.. ..|..| |
SDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase GL50803_15411.AA Ciliate-E2 191-280 16 2.6e-12 38.57 In-house 253-365 (365) Show / Hide 
Range on Protein: 191-280
Range on HMM: 253-365/365
Sequence Identity: 16% (22 aa)

YASPEFLNREYTE---------CPADVWSAGACIFAMAMRRPPFNSTNVESLRVEVEEGKKDGLDISFSRELD---------------------------
| .|| ||..  .           .|.||.| ... | . .|||                   ...    ..|                           
YMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQEC

-DMLQR----MMTPDQGYRPT-AGDLLNDPSI
 |....    |.  |.  |.| . ..|| | .
KDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase GL50803_15411.AA GIN4 191-280 30 4e-11 31.35 In-house 200-293 (293) Show / Hide 
Range on Protein: 191-280
Range on HMM: 200-293/293
Sequence Identity: 30% (29 aa)

YASPEFLN-REYTECPADVWSAGACIFAMAMRRPPFNST--NVESLRVEVEEGKKDGLDI-SFSRELDDMLQRMMTPDQGYRPTAGDLLNDPSI
||.||    . |   ..|||| |  .||.   . ||.    |.  | . | .|| .  .    |||  |....... |   | .  |.|  | |
YAAPEIVMGIPYHGFASDVWSCGVILFALLTGHLPFDEEDGNIRKLLLKVQKGKYEMPSDDEISREAQDLIRKILVVDPEKRIKTRDILKHPLI
Kinase GL50803_15411.AA NEK2 191-280 30 6.6e-11 32.85 In-house 230-319 (319) Show / Hide 
Range on Protein: 191-280
Range on HMM: 230-319/319
Sequence Identity: 30% (27 aa)

YASPEFLNREYTECPADVWSAGACIFAMAMRRPPFNSTNVESLRVEVEEGKKDGLDISFSRELDDMLQRMMTPDQGYRPTAGDLLNDPSI
| ||| ...       |.|| |  |. |.  .|||  ||   | . . .|. . .    ||.| .   .|.  |   ||    .| .| |
YMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFMINVDHYHRPSIEEILQHPQI
Kinase GL50803_15411.AA CAMKL 189-280 19 1e-09 27.03 In-house 197-297 (297) Show / Hide 
Range on Protein: 189-280
Range on HMM: 197-297/297
Sequence Identity: 19% (20 aa)

LAYASPEFLNR--E-YTECPADVWSAGACIFAMAMRRPPFNSTNVE-----SLRVEVEEGKKDGLDI-SF---SRELDDMLQRMMTPDQGYRPTAGDLLN
..|..|| ...  . |   ..|.||.|   .||   . ||.  ...         . .. ...   .  .   | .. |....|....  .|||. ...|
PPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMN

DPSI
.|  
HPWM
Kinase GL50803_15411.AA Pkinase 191-280 20 2e-07 27.3 Pfam 177-293 (293) Show / Hide 
Range on Protein: 191-280
Range on HMM: 177-293/293
Sequence Identity: 20% (24 aa)

YASPEFLN-REYTECPADVWSAGACIFAMAMRRPPFNST----NVESLRVEVEEGKKDGLDISFS-----------------------RELDDMLQRMMT
|..|| .. ..|   ..|.||.|  .. |. .|||| .     |  . .. ... ..  |. ...                       .|. | . .. .
YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLC

PDQGYRPTAGDLLNDPSI
.|   |||| ..|..| .
KDPKKRPTAEQILQHPWF
Kinase GL50803_15411.AA QIK 33-74 33 1e-06 22.12 In-house 25-66 (272) Show / Hide 
Range on Protein: 33-74
Range on HMM: 25-66/272
Sequence Identity: 33% (14 aa)

QEVAIKSFDCTQMDDAQVSEIHRQALLLKSVNHPLVLKVYDV
..||||. | .|.|      . |   ..|. .|| . | |.|
TKVAIKIIDKSQLDEENLQKCYREVQIMKMLYHPHIIKLYQV
Kinase GL50803_15411.AA Ciliate-E2 10-127 14 2e-06 17.78 In-house 1-176 (365) Show / Hide 
Range on Protein: 10-127
Range on HMM: 1-176/365
Sequence Identity: 14% (25 aa)

YRFQTTLAAGEYSMLFLA--MGNDYQE-----------------VAIKSFDCTQMDDAQVSEIHR--QAL--------------LLKSVNHPLVLKVYDV
| |.  .  | ..  ...    ...|.                 |.|| .   .|   |. .| .  . .              .|...||| ..| |..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

QMNITRTRLHVIMEPFFK-TLQNLIDECEKADRSLLN-------NIVCQVAYQVIK---------------GLHYL
  ..... .  .|| .   .|. .| .. |   . ..       . .... .|...               .|.||
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYL
Kinase GL50803_15411.AA SNRK 155-280 25 3e-06 16.28 In-house 129-254 (254) Show / Hide 
Range on Protein: 155-280
Range on HMM: 129-254/254
Sequence Identity: 25% (33 aa)

NDIVFNTSGVVKLMNIFPLEHRMLYEKGDASFPGLAYASPEFLNREYTECPA-DVWSAGACIFAMAMRRPPFNSTNVESLRVEVEEGKKDGLDISFSREL
| . |.  |.|||       . |  || . |   |||. || |  .  . || |.|| |  .. .   ..||.  |       . . |   .    |.| 
NVVFFEKQGMVKLTDFGFSNKFMPGEKLETSCGSLAYSAPEILLGDSYDAPAVDIWSLGVILYMLVCGQAPFQEANDSETLTMIMDCKY-TVPDHVSDEC

DDMLQRMMTPDQGYRPTAGDLLNDPSI
 |..|.|.  |   | .  .. . . .
RDLIQSMLVRDPKKRASLEEIVSHSWV
Kinase GL50803_15411.AA SNRK 10-88 30 5e-06 15.56 In-house 1-78 (254) Show / Hide 
Range on Protein: 10-88
Range on HMM: 1-78/254
Sequence Identity: 30% (24 aa)

YRFQTTLAAGEYSMLFLAMG-NDYQEVAIKSFDCTQMDDAQVSEIHRQALLLKSVNHPLVLKVYDVQMNITRTRLHVIME
|  . ||  | . .  ||      . ||.|  | |.||..  ... .    .| | || . ..|.|    | |.|..|.|
YDLEKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKMDEVSKAHLFQEVRCMKLVQHPNIVRLYEVID--TQTKLYLILE
Kinase GL50803_15411.AA TyrKc 10-278 14 3.2e-05 -138.18 SMART 1-280 (280) Show / Hide 
Range on Protein: 10-278
Range on HMM: 1-280/280
Sequence Identity: 14% (47 aa)

YRFQTTLAAGEYSMLFLAMGNDYQEVAIKSFDCTQMDDAQVSEIHRQALLLKSV--NHPLVLKVYDVQMNITR-----TRLHVIME--PFFKTLQNLIDE
 ..  .|  |..   .... .  ..||.|.          . ...| | .....  .|| ... | | .   |       | ..||  |    |.. . .
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLRK

CEKADRSLLNNIVCQVAYQVIKGLHYLSTTNHV---------AVNEQGQEFSQDKIFHSFITPNDIVFNTSGVVK-----LMNIFPLE------HRMLYE
...    | .   .. ..|. .|  ||.  | .          |.|..                        .||     |.     .      . .   
HRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH------------------------TVKISDFGLSRDIYDDDQQGESKDYYRK

KG--DAS--FPGLAYASPEFL-NREYTECPADVWSAGACIFAMAMR-RPPFNS-----TNVESLRVEVEEGKKDGLDIS--------FSRELDDMLQRMM
|.  ..   .| .   .|| .  ...|.   |||| | |.. .  .  .|         . . ..  |..|.      .         . |. .. ..  
KEHKGGKTMLP-IRWMAPECINYGKFTTK-SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCW

TPDQGYRPTAGDLLNDP
  |   |||  ..  . 
HEDPEDRPTFSEIHECF
Kinase GL50803_15411.AA CAMK 15-88 13 3.5e-05 11.87 In-house 1-140 (425) Show / Hide 
Range on Protein: 15-88
Range on HMM: 1-140/425
Sequence Identity: 13% (19 aa)

TLAAGEYSMLFLAMGNDY-------------QEVAIKSFDCTQMD--------------------------DAQVSEIHRQALLLKS-------VNHPLV
||  | ..  .|..                 |.||||  | ....                          .    .. |   ..|.       ..|| .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LKVYDVQMNIT-----------------RTRLHVIM---E
.| |.|  . .                 ..... .|   |
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIME
Kinase GL50803_15411.AA Pkinase 10-127 16 0.000142 17.25 Pfam 1-124 (293) Show / Hide 
Range on Protein: 10-127
Range on HMM: 1-124/293
Sequence Identity: 16% (21 aa)

YRFQTTLAAGEYSMLFLAMGNDYQE-VAIKSFDCTQMDDAQVSEIHR--QALLLKSVNHPLVLKVYDVQMNITRTRLHVIMEPFFKTLQNLIDEC----E
|..  .. .| ..  ....  .... ||.| ..    .. .  .  |   . ..|..||| ... ||. ..  .......||   ..|  ..| .     
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLY-VMDLFDYIST

KADRSL--LNNIVCQVAYQVIKGLHYL
......    . .. ..||...|| |.
WRHGCFYFSEWECKFYMYQILRGLEYC
Kinase GL50803_15411.AA QIK 190-280 25 0.000322 12.7 In-house 182-272 (272) Show / Hide 
Range on Protein: 190-280
Range on HMM: 182-272/272
Sequence Identity: 25% (23 aa)

AYASPE-FLNREYTECPADVWSAGACIFAMAMRRPPFNSTNVESLRVEVEEGKKDGLDISFSRELDDMLQRMMTPDQGYRPTAGDLLNDPSI
.|| || |. .||.   .|.|| |   ...     || . ....||  | .||   .  . | .....  .|.. | . | |    .. . .
PYAAPEMFEGKEYDGPKVDIWSMGVVLYVLVCGALPFDGKTLQNLRQRVLSGKFR-IPFFMSQDCEHLIRHMLVVDPEHRYTIMQICQHRWM
Kinase GL50803_15411.AA Ciliate-E2-Unclassified 10-127 11 0.019247 4.31 In-house 1-159 (352) Show / Hide 
Range on Protein: 10-127
Range on HMM: 1-159/352
Sequence Identity: 11% (19 aa)

YRFQTTLAAGEYSMLFLAMGNDYQEV-----AIKSFDCT-QMDDAQVSEIHRQALLLKS-----------------VNHPLVLKVYDVQMNITRTRLHVI
|... ..  | ..  ...  .. ...     ..|. ..  .    .  || .... ...                 .|||  ..|... .  ..  .  .
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

MEPFF-KTLQNLIDECEK-------------ADRSLLNNIVC-----QVAYQVIKGLHYL
|| .  ..|.. | ...|              .. .  . ..     . ..|...|| ||
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYL
Kinase GL50803_15411.AA CAMKL 10-88 23 0.061948 1.79 In-house 1-101 (297) Show / Hide 
Range on Protein: 10-88
Range on HMM: 1-101/297
Sequence Identity: 23% (24 aa)

YRFQTTLAAGEYSMLFLAMG-ND-YQEVAIKSFD------CTQMD--------DAQVSEIHRQALLLKSVN---HPLVLKVYDVQMNITR----TRLHVI
||.  ||  | ..   ||.      ..||||  |       ..|.        .. .  | | . ..|..|   || . | |.|  . .     . .. .
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

ME
||
ME
Kinase GL50803_15411.AA GIN4 36-74 30 0.110236 0.67 In-house 64-102 (293) Show / Hide 
Range on Protein: 36-74
Range on HMM: 64-102/293
Sequence Identity: 30% (12 aa)

AIKSFDCTQMDDAQVSEIHRQALLLKSVNHPLVLKVYDV
.| |    . |..   .| |  ...| ..|| |...|||
SIASREHSNHDQTNPYGIEREIVIMKLISHPNVMRLYDV
Ank GL50803_15411.AA Ank 511-541 32 1.031201 6.83 Pfam 4-33 (33) Show / Hide 
Range on Protein: 511-541
Range on HMM: 4-33/33
Sequence Identity: 32% (10 aa)

TALMNAVRTGKNDVVQRLVGEHSGDIGWKTP
|.|. |.| |  .||. |.. |  |.  .. 
TPLHLACRCGHTEVVKMLLQ-HGADVNAQDD
Ank GL50803_15411.AA Ank 543-563 33 0.087725 10.69 Pfam 1-21 (33) Show / Hide 
Range on Protein: 543-563
Range on HMM: 1-21/33
Sequence Identity: 33% (7 aa)

EKKTALMVAADLGNAEAVELL
.  |.|..|.  |..| |..|
DGFTPLHLACRCGHTEVVKML
Ank GL50803_15411.AA Ank 607-627 38 0.008057 14.43 Pfam 1-21 (33) Show / Hide 
Range on Protein: 607-627
Range on HMM: 1-21/33
Sequence Identity: 38% (8 aa)

DGCTPLFQAVFWNKPDCVRAL
||.|||  |.... ...|. |
DGFTPLHLACRCGHTEVVKML
Ank GL50803_15411.AA Ank 574-606 27 0.05905 11.31 Pfam 1-33 (33) Show / Hide 
Range on Protein: 574-606
Range on HMM: 1-33/33
Sequence Identity: 27% (9 aa)

DGWRAIDYAAQNGNVRAVNALLQYEGDMPIVRK
||. .  .|...|... |  |||.  |  .. .
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank GL50803_15411.AA Ank 644-664 42 0.001867 16.72 Pfam 1-21 (33) Show / Hide 
Range on Protein: 644-664
Range on HMM: 1-21/33
Sequence Identity: 42% (9 aa)

EGFTALMEAAKCCRVECVEIL
.|||.|. |..| ..|.|. |
DGFTPLHLACRCGHTEVVKML