Gene GL50803_15035 (G.lamblia)
GL50803_15035
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| GL50803_15035.AA | Protein | None | 533 | None | Fasta, JSON |
| GL50803_15035.kin_dom | Protein Kinase Domain | None | 260 | None | Fasta, JSON |
Protein domains of GL50803_15035.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | GL50803_15035.AA | NEK | 229-298 | 28 | 1.5e-09 | 30.25 | In-house | 209-286 (286) | Show / Hide |
Range on Protein: 229-298 Range on HMM: 209-286/286 Sequence Identity: 28% (22 aa) SLGVVIYTLVML--RKPFSLH--TAENLLQSMKVR-EYTPIC-G--VSEELTTLIEDLLNPQIDERPSLDYLLSLPQV |||.|.| ...| ..|| . ..| . .| || |..| ||. .|.. ..||| . .|..|.. SLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI |
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| Kinase | GL50803_15035.AA | Ciliate-E2-Unclassified | 212-298 | 19 | 4.3e-08 | 24.19 | In-house | 234-352 (352) | Show / Hide |
Range on Protein: 212-298 Range on HMM: 234-352/352 Sequence Identity: 19% (23 aa) APELFDSFIPD----VRSDLYSLGVVIYTLVMLRKPFSLHTAEN----------------LLQSMKVREYTPIC--------GVSEELTTLIE----DLL |||.... .| .| .||||..| ... . ||. . | |.| | ... . ..|.| .|. .| APEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKML NPQIDERPSLDYLLSLPQV . ....|.... .| | KKNPNKRITFEQILNHPWF |
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| Kinase | GL50803_15035.AA | PLK1 | 226-298 | 24 | 4.4e-08 | 22.38 | In-house | 181-253 (253) | Show / Hide |
Range on Protein: 226-298 Range on HMM: 181-253/253 Sequence Identity: 24% (18 aa) DLYSLGVVIYTLVMLRKPFSLHTAENLLQSMKVREYTPICGVSEELTTLIEDLLNPQIDERPSLDYLLSLPQV |..|.| ..|.|.. . || .. .. . .| ||. .|. ||. .|.|. ..|| . .|. . DIWSIGCIMYILLFGQPPFETKCLKETYSRIKKNEYRIPSHISQPAAQLIRKMLDPDPTRRPTIEQVLNDEFF |
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| Kinase | GL50803_15035.AA | SAK | 223-298 | 32 | 4.8e-08 | 23.19 | In-house | 179-254 (254) | Show / Hide |
Range on Protein: 223-298 Range on HMM: 179-254/254 Sequence Identity: 32% (25 aa) VRSDLYSLGVVIYTLVMLRKPFSLHTAENLLQSMKVREYTPICGVSEELTTLIEDLLNPQIDERPSLDYLLSLPQV ..||..||| ..|||.. | || . .| | . . || .| | ||. .| . || .|. | | . LQSDVWSLGCMLYTLLIGRPPFDTDAVKNTLNKVMMAEYIMPAHLSMEAQDLIHKMLRKNPHERITLSTVLCHPFM |
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| S_TKc | GL50803_15035.AA | S_TKc | 35-298 | 11 | 6.8e-07 | -75.85 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 35-298
Range on HMM: 1-231/231
Sequence Identity: 11% (36 aa)
YSIETVLSENSIKTELLLAAVDGDDRVAVHAFKLGSLQDAIMTEIRRTAQDLSGVSLEGFLPISEIVWDESSSQLYILQNINKL--VPLSVLVEASEK--
| | .. . . . . .. . .||. | . |. ||. . . . .. | . ||. | . . .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-----HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG
----LPEDYLWAVVSQVVQAIKTL----------------------------SRQQEALGAHMSISITNIFVTDTRGTDDPSAEFLVFLGLPCLDQALHP
.|| . .. |...|.. . .||
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQL--------------------------------------------
CMLSGDVFQKSMC------APELFDSFIPDV-RSDLYSLGVVIYTLVMLRKPFSLHTAENLLQSMKVREYTPICGVSEELTTLIEDLLNPQIDERPSLDY
...| |||.. . ..| .|.|...| .. . ||. . . ... .. |.|. .|. .|. ..||.
---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-E
LLS-------LPQV
.| | .
ALQDEWDIKCHPWF
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| Kinase | GL50803_15035.AA | Ciliate-E2 | 212-298 | 17 | 1e-06 | 18.57 | In-house | 255-365 (365) | Show / Hide |
Range on Protein: 212-298 Range on HMM: 255-365/365 Sequence Identity: 17% (21 aa) APELFD---------SFIPDVRSDLYSLGVVIYTLVMLRKPFSLHTAENLLQSMK-VREYTPIC----------------GVSEELTTLIED----LLNP ||| . . | .|..||||..| ... . || . | .. .. . . .|.| || .|. APEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQK QIDERPS-LDYLLSLPQV . ..|.. . .| | DPEKRITGWEQILNHPWF |
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| Kinase | GL50803_15035.AA | MARK | 226-298 | 33 | 2e-06 | 16.9 | In-house | 188-262 (262) | Show / Hide |
Range on Protein: 226-298 Range on HMM: 188-262/262 Sequence Identity: 33% (25 aa) DLYSLGVVIYTLVMLRKPFSLHT--AENLLQSMKVREYTPICGVSEELTTLIEDLLNPQIDERPSLDYLLSLPQV | .||||| |..| . || | ..| . . .|. | || |. || ||.. .|||... ... | . DIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM |
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| Kinase | GL50803_15035.AA | NEK4 | 213-298 | 26 | 4e-06 | 18.38 | In-house | 171-257 (257) | Show / Hide |
Range on Protein: 213-298 Range on HMM: 171-257/257 Sequence Identity: 26% (23 aa) PELFDSFIPDVRSDLYSLGVVIYTLVMLRKPFSLHTAENLLQSMKVREYTPICGV-SEELTTLIEDLLNPQIDERPSLDYLLSLPQV ||.| . | .||..||| .| .. |. | |. . |. . |..| |. .|. | ..|||. .. | . PECFGNRPYDYKSDIWSLGCCVYEMITLKHAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI |
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| Kinase | GL50803_15035.AA | NEK1 | 225-298 | 33 | 4e-06 | 17.42 | In-house | 202-276 (276) | Show / Hide |
Range on Protein: 225-298 Range on HMM: 202-276/276 Sequence Identity: 33% (25 aa) SDLYSLGVVIYTLVMLRKPFSLHTAENLLQSMKVREYTPICGV-SEELTTLIEDLLNPQIDERPSLDYLLSLPQV || |||.| | |. | || . || |.|| |.|| |. ... ||| .|. | . SDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI |
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| Kinase | GL50803_15035.AA | PASK | 226-298 | 27 | 4e-06 | 14.6 | In-house | 192-260 (260) | Show / Hide |
Range on Protein: 226-298 Range on HMM: 192-260/260 Sequence Identity: 27% (20 aa) DLYSLGVVIYTLVMLRKPFSLHTAENLLQSMKVREYTPICGVSEELTTLIEDLLNPQIDERPSLDYLLSLPQV .. .||| |||. || | | ... . ||||. || .||.. . |. .. . | . EMWALGVTLYTLMFKENPF-CNIEETLEAEIHFPN---AEHVSEECMSLIKSMLNRCPEKRCTMHQIITDPWL |
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| Kinase | GL50803_15035.AA | SNRK | 226-298 | 32 | 6e-06 | 15.09 | In-house | 182-254 (254) | Show / Hide |
Range on Protein: 226-298 Range on HMM: 182-254/254 Sequence Identity: 32% (24 aa) DLYSLGVVIYTLVMLRKPFSLHTAENLLQSMKVREYTPICGVSEELTTLIEDLLNPQIDERPSLDYLLSLPQV |..||||..| || . || . | . || ||.| ||. .| . | ||. . | . | DIWSLGVILYMLVCGQAPFQEANDSETLTMIMDCKYTVPDHVSDECRDLIQSMLVRDPKKRASLEEIVSHSWV |
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| Kinase | GL50803_15035.AA | Pkinase | 222-298 | 17 | 8.7e-05 | 18.01 | Pfam | 190-293 (293) | Show / Hide |
Range on Protein: 222-298 Range on HMM: 190-293/293 Sequence Identity: 17% (18 aa) DVRSDLYSLGVVIYTLVMLRKPFSLH----TAENLLQSMKVREYTPICGVS------------------------EELTTLIEDLLNPQIDERPSLDYLL . ..| .|.|...| .. | ||. | . . .| .. . ..|. . ||. .|...|.. .||. . .| GPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQIL SLPQV | . QHPWF |
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| Ank | GL50803_15035.AA | Ank | 375-395 | 47 | 0.00232 | 16.38 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 375-395 Range on HMM: 1-21/33 Sequence Identity: 47% (10 aa) EGVTALMLAARLGFVNIVKEL .| |.|.||.| | ...||.| DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_15035.AA | Ank | 441-462 | 45 | 8.7e-05 | 21.52 | Pfam | 1-22 (33) | Show / Hide |
Range on Protein: 441-462 Range on HMM: 1-22/33 Sequence Identity: 45% (10 aa) VGRTALMLAAANSHLECIKLLL |.|.|.||. . |.|..|.|| DGFTPLHLACRCGHTEVVKMLL |
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| Ank | GL50803_15035.AA | Ank | 410-440 | 21 | 0.000268 | 19.76 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 410-440 Range on HMM: 1-33/33 Sequence Identity: 21% (7 aa) EGYTAMMFAVQRNSPECVRLLMD--AESGLVTK .|.|. . |......|.|..|.. |. .... DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_15035.AA | Ank | 472-492 | 23 | 17.767721 | 2.37 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 472-492 Range on HMM: 1-21/33 Sequence Identity: 23% (5 aa) EGWTSLMNAVIVCSLDAIDVL .|.| |. |.. ... . | DGFTPLHLACRCGHTEVVKML |
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