GL50803_14897

Species: G.lamblia
Alias: GL50803_14897, GK184
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_14897.AA Protein None 989 None Fasta, JSON
GL50803_14897.kin_dom Protein Kinase Domain None 282 None Fasta, JSON

Protein domain

Protein domains of GL50803_14897.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc GL50803_14897.AA S_TKc 10-291 23 1.5e-25 92.08 SMART 1-231 (231) Show / Hide
Range on Protein: 10-291
Range on HMM: 1-231/231
Sequence Identity: 23% (69 aa)

YDILGIIGHGPYATVFKCRHKATEETHIIKEYLLDAIPRQCISLLRREADLQAQVQIDSILQPCYTFVDHDSLVLYIVLPFLGA--KTLQAAIESAKT--
|.|| .||.| ...|.||||| | .   ||.             .||| ..  . . . | .  ..|.|     ||.|. ...    .|   |.. ..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

DQTYFTEDVVWSTAYSLLTILKDLASYPLREDDAPSLKPLHCNLKPTNILFLDENLSMVQLCDCSFSPDLRLTLSSTKIGLKAHKRDADHLYTTAYMAPE
 . .|.| .... .| ..  |. . |             .|. ||| |||. .     . .||  ..  |                      |  |||||
LRFPFPE-HARFYMYQICCALEYCHSHGI----------IHRDLKPENILLDE----HIKICDFGLARQL-----------------TTFCGTPWYMAPE

ILKDKKAHE-TSDIWSLGCILYEMCTMKALVSDTLDAASSESMLSAILPIRKLYGYSDVLNDFLNQMLTQNPSLRPDYDTLLN-------HSRM
.|   .     .|.||.|||||||.. . . .        . |.  |.        |. . ||....|. .|. ||    .|.       |  .
VL---GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase GL50803_14897.AA Ciliate-E2 196-291 21 2.2e-17 56.19 In-house 248-365 (365) Show / Hide
Range on Protein: 196-291
Range on HMM: 248-365/365
Sequence Identity: 21% (30 aa)

LYTTAYMAPEILKDKK---------AHETSDIWSLGCILYEMCTMKALVSDTLDAASSESMLSAILPIRKLYGYSDVLN---------------------
..|  |||||||. ||           . .||||||.|||||.. |                           .   ..                     
CGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF------------------------QQQIKQCKIDFPCPEWQKDTQCIQCKW

-----------DFLNQ----MLTQNPSLRPD-YDTLLNHSRM
           |....    ||  .|. |.. .. .|||  .
KSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF

Kinase GL50803_14897.AA Ciliate-E2-Unclassified 198-291 25 2.7e-17 56.54 In-house 225-352 (352) Show / Hide
Range on Protein: 198-291
Range on HMM: 225-352/352
Sequence Identity: 25% (33 aa)

TTAYM----APEILKDKKAHET----SDIWSLGCILYEMCTMKALVSDTLDAA------------SSESMLSAIL------PIRKL----YGYSDVLNDF
|  ||    |||.|. ..  ..    .||||||.|||||.. .   .|. .                . ... |.      |  .     .. |.   ||
TPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDF

LN----QMLTQNPSLRPDYDTLLNHSRM
.|    .||  ||. |.... .|||  .
INDLLQKMLKKNPNKRITFEQILNHPWF

Kinase GL50803_14897.AA STE 198-291 22 4.4e-17 56.97 In-house 226-359 (359) Show / Hide
Range on Protein: 198-291
Range on HMM: 226-359/359
Sequence Identity: 22% (31 aa)

TTAYMAPEILKD-----KKAH-ETSDIWSLGCILYEMCTMKALVSDTLDA-ASSESMLS---------------AILPIRK-----------------LY
|  .||||...      .| . . .||||||| . ||.| |   .|  .  |  . . .                . |.                     
TP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPH

GYSDVLNDFLNQMLTQNPSLRPDYDTLLN--HSRM
 .|. ..||.|. |. .|. ||... ||.  |.  
KWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI

Kinase GL50803_14897.AA Pkinase 201-291 21 6.8e-16 57.27 Pfam 177-293 (293) Show / Hide
Range on Protein: 201-291
Range on HMM: 177-293/293
Sequence Identity: 21% (25 aa)

YMAPEILK-DKKAHETSDIWSLGCILYEMCTMKALVSDTL----DAASSESMLSAILPIRKLYGYS-----------------------DVLNDFLNQML
|||||... ...    .|.||.|||||||.. . . .       . ..   |.  |.. .  . ..                       . . ||.. .|
YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL

TQNPSLRPDYDTLLNHSRM
...|. ||  . .|.|  .
CKDPKKRPTAEQILQHPWF

Kinase GL50803_14897.AA ULK 201-291 24 3.1e-15 50.55 In-house 213-324 (324) Show / Hide
Range on Protein: 201-291
Range on HMM: 213-324/324
Sequence Identity: 24% (28 aa)

YMAPEILK----DKKAHET-SDIWSLGCILYEMCTMK-----ALVSDTLDAASSES----------MLSAILPIR---KLYGYSDVLNDFLNQMLTQNPS
||||.||.     |. ..  .||||||||.||| . |        .|. .    .           .    ....   | .  |. . |.. .||. ...
YMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLY-IQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEK

LRPDYDTLLNHSRM
 | . . ..||  .
DRISWEEIFNHPWF

Kinase GL50803_14897.AA ULK 201-291 23 9.5e-15 47.99 In-house 217-329 (329) Show / Hide
Range on Protein: 201-291
Range on HMM: 217-329/329
Sequence Identity: 23% (27 aa)

YMAPEILK----DKKAHET-SDIWSLGCILYEMCT-------MKALVSDTLDAASSES--------MLSAILPIR---KLYGYSDVLNDFLNQMLTQNPS
||||.||.     |. ..  .||||||||.||| .       . .   . .   .           . .  | ..   . .  |. . |.. .||. ...
YMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEK

LRPDYDTLLNHSRM
 | . . |.||  .
DRISWEELFNHPWF

Kinase GL50803_14897.AA NEK2 201-230 56 6.9e-14 43.04 In-house 230-259 (319) Show / Hide
Range on Protein: 201-230
Range on HMM: 230-259/319
Sequence Identity: 56% (17 aa)

YMAPEILKDKKAHETSDIWSLGCILYEMCT
|| || ... |  | |||||.||..||||.
YMSPEQMHGQKYNEKSDIWSVGCLIYEMCA

Kinase GL50803_14897.AA NEK 201-232 58 2e-12 40.45 In-house 190-223 (286) Show / Hide
Range on Protein: 201-232
Range on HMM: 190-223/286
Sequence Identity: 58% (20 aa)

YMAPEILKDKKAHETSDIWSLGCILYEMCTM--K
||.||....|.  . ||||||||.||||||   |
YMSPEVCQNKPYNNKSDIWSLGCVLYEMCTLKPK

Kinase GL50803_14897.AA MARK 10-60 34 6.2e-10 28.83 In-house 1-52 (262) Show / Hide
Range on Protein: 10-60
Range on HMM: 1-52/262
Sequence Identity: 34% (18 aa)

YDILGIIGHGPYATVFKCRHKATEETHIIKEYLLDAIPR-QCISLLRREADL
| .|  |||| ||.| ...|| |..   || |    . . | .. ..||...
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEI

Kinase GL50803_14897.AA CAMK 198-228 34 6.6e-09 24.09 In-house 282-327 (425) Show / Hide
Range on Protein: 198-228
Range on HMM: 282-327/425
Sequence Identity: 34% (16 aa)

TTAYMA-PEILKD-------------KKAH-ETSDIWSLGCILYEM
| .||| ||.|.              |. . . .|.||.|.||| |
TPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIM

Kinase GL50803_14897.AA CAMKL 10-65 20 2e-08 22.82 In-house 1-70 (297) Show / Hide
Range on Protein: 10-65
Range on HMM: 1-70/297
Sequence Identity: 20% (14 aa)

YDILGIIGHGPYATVFKCRH-KATEETHIIKEYLLDAIPRQCISL-------------LRREADLQAQVQ
|.|.  .|.| ...|  ..| . |.|   || .  . |   ....             .|||. .. ...
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLN

Kinase GL50803_14897.AA MARK 198-228 53 1.4e-07 21.03 In-house 168-199 (262) Show / Hide
Range on Protein: 198-228
Range on HMM: 168-199/262
Sequence Identity: 53% (17 aa)

TTAYMAPEILKDKKAH-ETSDIWSLGCILYEM
| .||||||.. |.      |||||| .|| |
TPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFM

Kinase GL50803_14897.AA NEK 260-291 31 5.6e-07 21.04 In-house 255-286 (286) Show / Hide
Range on Protein: 260-291
Range on HMM: 255-286/286
Sequence Identity: 31% (10 aa)

YSDVLNDFLNQMLTQNPSLRPDYDTLLNHSRM
||. |.....|||. .|..||. . .|... .
YSQDLQNLISQMLQKDPEQRPSCNQILEMPFI

Kinase GL50803_14897.AA CAMK 15-67 14 7.2e-07 17.41 In-house 1-96 (425) Show / Hide
Range on Protein: 15-67
Range on HMM: 1-96/425
Sequence Identity: 14% (14 aa)

IIGHGPYATVFKCRHKATE------------ETHIIKEYLLDAIP--------------------------RQCISLLRREADLQAQVQ-----ID
..|.| ...|..|.|| |             .   || .  . ..                           .    .||| ..  ..|     .|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLD

Kinase GL50803_14897.AA CAMKL 198-226 46 3e-06 16.01 In-house 196-227 (297) Show / Hide
Range on Protein: 198-226
Range on HMM: 196-227/297
Sequence Identity: 46% (15 aa)

TTAYMAPEILKD--KKAH-ETSDIWSLGCILY
. .||||||...  |. .    ||||.| |||
SPPYMAPEIFQGNNKPYDGPKVDIWSCGVILY

Kinase GL50803_14897.AA TyrKc 10-291 11 9e-06 -129.62 SMART 1-280 (280) Show / Hide
Range on Protein: 10-291
Range on HMM: 1-280/280
Sequence Identity: 11% (40 aa)

YDILGIIGHGPYATVFKCRHKATEETHIIKEYLLDAIPRQCISLLRREADLQAQV--QIDSILQPCYTFVDHDS------LVLYIVLPFLGAKTLQAAIE
   . ..|.| . .|.|.. |   ..  .|    ||     .  ..||| .  ..  . . |.. .|  . ...        |.||. .     |.  . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVR-LYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

SAKTDQTYFTEDVVWSTAYSLLTILKDLASYPLREDDAPSLKPLHCNLKPTNILFLDENLSMVQLCDCSF--------------------------SPDL
. . .                                                      |.| .|.. ..                          . ..
KHRPK------------------------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH

----------RLTLSS------TKIGLKAHKRDADHLYTTAYMAPEILKDKKAHETSDIWSLGCILYEMCTMKALVSDT-----LDAASSESMLSAI--L
          |   .       ..   |. ..... .     |||| ....|  . ||.|| |  ..|..|  .          ....     . .   .
TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRM

PIRKLY-------GYSDVLNDFLNQMLTQNPSLRPDYDTLLNHSRM
|. . .         ... .    |    .|. ||   ..  |...
PQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--HECF

Kinase GL50803_14897.AA Ciliate-E2-Unclassified 10-40 35 2.5e-05 14.44 In-house 1-31 (352) Show / Hide
Range on Protein: 10-40
Range on HMM: 1-31/352
Sequence Identity: 35% (11 aa)

YDILGIIGHGPYATVFKCRHKATEETHIIKE
| |. .||.| ...|.||.|| . .  ..|.
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKY

Kinase GL50803_14897.AA NEK 10-40 27 3.3e-05 14.72 In-house 1-36 (286) Show / Hide
Range on Protein: 10-40
Range on HMM: 1-36/286
Sequence Identity: 27% (10 aa)

YDILGIIGHGPYATVFKCRHKATEET-----HIIKE
|.|.  || | . .|.|.|.| ..        ..|.
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKK

Kinase GL50803_14897.AA NEK2 10-32 34 4.1e-05 13.04 In-house 1-23 (319) Show / Hide
Range on Protein: 10-32
Range on HMM: 1-23/319
Sequence Identity: 34% (8 aa)

YDILGIIGHGPYATVFKCRHKAT
|..|. || | . .. | |.| .
YEVLYTIGNGSFGRCRKVRRKSD

Kinase GL50803_14897.AA Ciliate-E2 10-97 14 4.4e-05 13.37 In-house 1-122 (365) Show / Hide
Range on Protein: 10-97
Range on HMM: 1-122/365
Sequence Identity: 14% (18 aa)

YDILGIIGHGPYATVFKCRHKATEE------------------THIIKEYLLDAIPRQCISLLRREADLQAQVQIDS-----------------ILQPCY
|... .|| | ...|.||... . .                     ||.| .  .  . |  . .| ..  ....                   |..  .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FYKKINEKNILEQLNHPNIIKMYE

TFVDHDSLVLYIVLPFLGAKTLQ
.| . |   .|.|. ..  ..|.
CFQEKDDNNIYLVMEYCQGGDLF

Kinase GL50803_14897.AA MARK 261-291 29 4.5e-05 12.72 In-house 232-262 (262) Show / Hide
Range on Protein: 261-291
Range on HMM: 232-262/262
Sequence Identity: 29% (9 aa)

SDVLNDFLNQMLTQNPSLRPDYDTLLNHSRM
|. . ......|| ||. ||... ...|. |
SKECRNLIQRLLTVNPEERPTIEEIMKHPWM

Kinase GL50803_14897.AA Pkinase 10-105 21 7.6e-05 18.21 Pfam 1-101 (293) Show / Hide
Range on Protein: 10-105
Range on HMM: 1-101/293
Sequence Identity: 21% (22 aa)

YDILGIIGHGPYATVFKCRHKATEETHIIKEYLLDAIPRQCISLLRR--EADLQAQVQIDSILQPCYTFVDHDSLVLYIVLPFLGAK----TLQAAIE-S
| |...|| | ...|.||.|| |...  .|.  .. .  ..   .||  |. . . .. . |..  ..| |.|..   .|.....       | . |. .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIY--MVMEYCEGGLYVMDLFDYISTW

AKT
...
RHG

Kinase GL50803_14897.AA CAMKL 266-291 38 0.000398 8.9 In-house 272-297 (297) Show / Hide
Range on Protein: 266-291
Range on HMM: 272-297/297
Sequence Identity: 38% (10 aa)

DFLNQMLTQNPSLRPDYDTLLNHSRM
|.. .||. ||. ||  . ..||  |
DLIRKMLQVNPEKRPTIHQIMNHPWM

Kinase GL50803_14897.AA STE 10-30 28 0.000509 10.23 In-house 1-21 (359) Show / Hide
Range on Protein: 10-30
Range on HMM: 1-21/359
Sequence Identity: 28% (6 aa)

YDILGIIGHGPYATVFKCRHK
......||.| . ||.|....
WEGIEKIGKGAFGTVYKAMNH

Kinase GL50803_14897.AA NEK2 260-291 28 0.000513 9.28 In-house 288-319 (319) Show / Hide
Range on Protein: 260-291
Range on HMM: 288-319/319
Sequence Identity: 28% (9 aa)

YSDVLNDFLNQMLTQNPSLRPDYDTLLNHSRM
||. ||.    |.  ... ||  . .| |.. 
YSRHLNEIIHFMINVDHYHRPSIEEILQHPQI

Kinase GL50803_14897.AA CAMK 266-291 34 0.000939 7.18 In-house 400-425 (425) Show / Hide
Range on Protein: 266-291
Range on HMM: 400-425/425
Sequence Identity: 34% (9 aa)

DFLNQMLTQNPSLRPDYDTLLNHSRM
|....||. .|. |.  .  |||  |
DLIRKMLQVDPEKRMTIEQCLNHPWM

Kinase GL50803_14897.AA ULK 10-39 26 0.001301 8.76 In-house 1-34 (324) Show / Hide
Range on Protein: 10-39
Range on HMM: 1-34/324
Sequence Identity: 26% (9 aa)

YDILGIIGHGPYA-TVFKCRHKATE---ETHIIK
| .  ..|.| .. .|.| |.| |.   .   .|
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACK

Kinase GL50803_14897.AA ULK 10-41 28 0.00545 6.38 In-house 1-30 (329) Show / Hide
Range on Protein: 10-41
Range on HMM: 1-30/329
Sequence Identity: 28% (9 aa)

YDILGIIGHGPYATVFKCRHKATEETHIIKEY
| .  ..|.| ...|.| |.| |. .  ..|.
YCLNHCLGKGSFGKVYKGRNKKTK-D-YVNEK

Ank GL50803_14897.AA Ank 404-425 36 0.009695 14.14 Pfam 1-22 (33) Show / Hide
Range on Protein: 404-425
Range on HMM: 1-22/33
Sequence Identity: 36% (8 aa)

HGKTALMYAAELGRNEFILYLL
.| |.|..|.. |. | . .||
DGFTPLHLACRCGHTEVVKMLL

Ank GL50803_14897.AA Ank 434-456 26 4.068214 4.68 Pfam 1-20 (33) Show / Hide
Range on Protein: 434-456
Range on HMM: 1-20/33
Sequence Identity: 26% (6 aa)

NGATALQLAIAAGNDDGADMIAY
.| |.| ||.  |   ..... .
DGFTPLHLACRCG---HTEVVKM

Ank GL50803_14897.AA Ank 622-654 21 0.007182 14.61 Pfam 1-33 (33) Show / Hide
Range on Protein: 622-654
Range on HMM: 1-33/33
Sequence Identity: 21% (7 aa)

EGKTALMFCAESNCILMARVLLETEAGLILRDG
.| |.|.  ...... ... ||.  | . ..| 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD

Ank GL50803_14897.AA Ank 734-754 47 2.5e-05 23.49 Pfam 1-21 (33) Show / Hide
Range on Protein: 734-754
Range on HMM: 1-21/33
Sequence Identity: 47% (10 aa)

DGKTALMYAAELGNAEVVQLL
|| |.|..|.. |..|||..|
DGFTPLHLACRCGHTEVVKML

Ank GL50803_14897.AA Ank 770-792 47 0.001202 17.41 Pfam 1-23 (33) Show / Hide
Range on Protein: 770-792
Range on HMM: 1-23/33
Sequence Identity: 47% (11 aa)

KGRTALMFACRKNHLNCVFPLLQ
 |.|.|. |||..|...|  |||
DGFTPLHLACRCGHTEVVKMLLQ

Ank GL50803_14897.AA Ank 801-822 40 0.000335 19.41 Pfam 1-22 (33) Show / Hide
Range on Protein: 801-822
Range on HMM: 1-22/33
Sequence Identity: 40% (9 aa)

RGWTALMMASYLGYTQIIKALL
 |.|.|..|.. |.|...| ||
DGFTPLHLACRCGHTEVVKMLL

Ank GL50803_14897.AA Ank 837-860 33 0.002901 16.03 Pfam 1-24 (33) Show / Hide
Range on Protein: 837-860
Range on HMM: 1-24/33
Sequence Identity: 33% (8 aa)

SGATALMLAAEAGNVAAVSLLVNY
 | |.|.||.. |..  |..|...
DGFTPLHLACRCGHTEVVKMLLQH

Ank GL50803_14897.AA Ank 868-896 44 1e-06 28.25 Pfam 1-29 (33) Show / Hide
Range on Protein: 868-896
Range on HMM: 1-29/33
Sequence Identity: 44% (13 aa)

NGFTALMMAAQEGHSECVKILMKKEARLN
.|||.|..|.. || |.|| |... | .|
DGFTPLHLACRCGHTEVVKMLLQHGADVN

Ank GL50803_14897.AA Ank 899-924 42 1.3e-05 24.48 Pfam 1-26 (33) Show / Hide
Range on Protein: 899-924
Range on HMM: 1-26/33
Sequence Identity: 42% (11 aa)

DGWTALMSAVQRNRVECVKLLMAHEA
||.|.|. |......|.||.|. | |
DGFTPLHLACRCGHTEVVKMLLQHGA

Ank GL50803_14897.AA Ank 930-951 45 0.00028 19.69 Pfam 1-22 (33) Show / Hide
Range on Protein: 930-951
Range on HMM: 1-22/33
Sequence Identity: 45% (10 aa)

SGYTALMCAAQCGWEQCVRMLL
 |.|.|..|..|| ...|.|||
DGFTPLHLACRCGHTEVVKMLL