Gene GL50803_14223 (G.lamblia)

GL50803_14223

Species: G.lamblia
Alias: GK252, GL50803_14223
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_14223.AA Protein None 302 None Fasta, JSON
GL50803_14223.kin_dom Protein Kinase Domain None 265 None Fasta, JSON

Protein domain

Protein domains of GL50803_14223.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc GL50803_14223.AA S_TKc 9-273 22 4.9e-30 107.02 SMART 1-231 (231) Show / Hide 
Range on Protein: 9-273
Range on HMM: 1-231/231
Sequence Identity: 22% (63 aa)

HGKEVVLSASEFSVTYRAIRLKDLADVAVKVTDTVKLAESGRSDYRHESRVLQNAVHPHILRAVYGYYDEETKKFLLETEYCRG--GSLWGLMAWMRKSD
  .  ..    |.. |...  |.   ||.|. .          . | | ..|..  ||.| .  . ..|   ... . .||| |  |.|  ..  ...  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

MR--FSEQEVWELFAQLVSALHYLHKTNEHIGITAHLNLRPDNVLLTQDGILKLCGFGYSATREPNKLFTLRNPGT-AYHAPEVVAFTNSQGSSEGYTE-
 |  |.| ... ...|...|| |.|. .       |  | |.|.||..   .|.| || ..             ||  | ||||.          ||.  
LRFPFPE-HARFYMYQICCALEYCHSHG-----IIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----------GYGKC

AADIWSLGCMIYELCT----FRRIENEPVSSFNPLPENLETPGYADDLLILIKACLAPNPRERITAELLMA-------SPPI
..|.||.||..||...    |.    ..   |. .          .... .|. ||  .|..|.||  ...        | .
KCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_14223.AA Ciliate-E2-Unclassified 58-221 24 3.1e-29 98.55 In-house 69-268 (352) Show / Hide 
Range on Protein: 58-221
Range on HMM: 69-268/352
Sequence Identity: 24% (51 aa)

RVLQN--AVHPHILRAVYGYYDEETKKFLLETEYCRGGSLWGLMAWM-------------RKSDMRFSEQEVW-----ELFAQLVSALHYLHKTNEHIGI
. .|.    |||... .. |... .... . .|||.||.||  .  .             .|.. .|.||..       .|||....| |||. | .|  
KIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NI--

TAHLNLRPDNVLLTQDG---ILKLCGFGYSATRE-----------------PNKLFTLR-NPGTA--YHAPEVVAFTNSQGSSEGYTEAADIWSLGCMIY
  | .. |.|.|....|    .|...|| |   .                 .... |   .|..   | ||||    |  .|.    ...||||||. .|
-IHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA---YKCDIWSLGVILY

ELCTFRR
|... ..
EMLFGYY
Kinase GL50803_14223.AA Ciliate-E2 56-273 20 4.4e-29 96.95 In-house 82-365 (365) Show / Hide 
Range on Protein: 56-273
Range on HMM: 82-365/365
Sequence Identity: 20% (59 aa)

ESRVLQNAVHPHILRAVYGYYDEETKKFLLETEYCRGGSLWGLMAWMRKSD-------MRFSEQEVWELFAQLVS---------------ALHYLHKTNE
| ..|..  ||.|.. .. .... .... | .||| ||.|. ..  ..|.         .|.|.|. ....|...               ||.|||. | 
EKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN

HIGITAHLNLRPDNVLLTQDGILKLCGFGYSAT-----------REPNKLFTLRNP----------------------GTAYHAPEVVAFTNSQG--SSE
 |    | .. |.|.|.     .|.. ||.|             .. ...   .|                          | |||..   . ..   ..
-I---IHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQK

GYTEAADIWSLGCMIYELCTFRR-----IENEPVSSFNPLPENL---------ETPGYADDLLILIKA----CLAPNPRERIT-AELLMASPPI
||....||||||...||... ..     |.. ... ..| ...          ..    ..   |||     .|  .| .||| .| ..  | .
GYDYKCDIWSLGVILYEMLFGKPPFQQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase GL50803_14223.AA CAMK 14-214 17 1.9e-25 78.36 In-house 1-325 (425) Show / Hide 
Range on Protein: 14-214
Range on HMM: 1-325/425
Sequence Identity: 17% (58 aa)

VLSASEFSVTYRAIRLKDL------------ADVAVKVTDTVKLA--------------------------ESGRSDYRHESRVLQNAV-------HPHI
.|    |.. ...|. ..               ||.|. |. ||                           .. |   |.| .....         ||.|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LRAVYGYYDEE-----------------TKKFLLET---EYCRGGSL--WGLMAWMRKSD-------------MRFSEQEVWELFAQLVSALHYLHKTNE
..    | |..                 .|.. . .   ||| || |    .    ....              ||.|.|.  .| |..||.||.|. | 
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN-

HIGITAHLNLRPDNVLLTQD-----------------GILKLCGFGYSATREP------------------------NKLFTLRNPGTAYHA-PEVVAF-
 |   .|. | |.|.||...                 . .|.. || ..  .|                        ..... .    .| | |||.   
-I---VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGK

-------TNSQGSSEGYTEAADIWSLGCMIY
         . .  ..|....|.||.|.. |
GHCNMQNA-TDEEKPYYGPKCDMWSCGVILY
Kinase GL50803_14223.AA Pkinase 20-273 22 6.2e-25 89.24 Pfam 12-293 (293) Show / Hide 
Range on Protein: 20-273
Range on HMM: 12-293/293
Sequence Identity: 22% (67 aa)

FSVTYRAIRLKDLADVAVKVTDTVKLAESGRSDYRH--ESRVLQNAVHPHILRAVYGYYDEETKKFLLETEYCRGG----SLWGLMA-WMRKSDMRFSEQ
|.. |.... ..   ||||. . ..  .. .   |.  | .....  ||.|.|  . ..|   ..  . .|||.||    .|. ..  |.... . |||.
FGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY-FSEW

EVWELFAQLVSALHYLHKTNEHIGITAHLNLRPDNVLLTQDGIL----KLCGFGYSAT--REPNKLFTLRNPGTAYHAPEVVAFTNSQGSSEGYTEAADI
|.   . |....| |.|. .   ||  |  | |.|.|. ..| .    |.| || ..     .|  .| .     | ||||.       ....|. ..|.
ECKFYMYQILRGLEYCHS-M---GI-IHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR------GGQYYGPKVDM

WSLGCMIYELCT----FRRI-----ENEPVSSFNPLPENLETPGY----------------------ADDLLILIKACLAPNPRERITAELLMASPPI
||.||..||...    |.        .. .  .. ..  |. . .                       .... .|| ||...| .|.||| .. .| .
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase GL50803_14223.AA STE 88-273 22 1.4e-22 76.63 In-house 117-359 (359) Show / Hide 
Range on Protein: 88-273
Range on HMM: 117-359/359
Sequence Identity: 22% (57 aa)

EYCRGGSLWGLMA--WMRKSD--------MRFSEQEVWELFAQLVSA-LHYLHKTNEHIGITAHLNLRPDNVLLTQDGILKLCGFGYSATREPN------
||. ||||  ..   .... .         ||.|...     |.. . |.|||. .       |  . |.|.||      ||| || ..  ...      
EYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH-----IIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQS

------------KLFTLR-NPGTAYHAPEVVAFTNSQGSSEGYTEAADIWSLGCMI-------YELCTFRRIENEPVSSFN------------------P
            |  |.   |   . ||||.   ..  .. ||.. .|||||||.|       ......   ..     ||                  |
NNIIDCIETMQQKRNTFVGTP---WMAPEVIQQNGQG-RDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPP

LPENLE--------------TPGYADDLLILIKACLAPNPRERITAELLMA--SPPI
||..|.              .  . ...   |. ||  .|..| ||. |.    | |
LPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase GL50803_14223.AA TKL 15-261 14 9.3e-18 60.53 In-house 1-354 (364) Show / Hide 
Range on Protein: 15-261
Range on HMM: 1-354/364
Sequence Identity: 14% (53 aa)

LSASEFSVTYRAIRLK--------DLADVAVKVTDTVKLAESGRSD------------------------YRHESRVLQNAV-HPHILRAVYGYYDEETK
.    |.. |...           .  |||||.  .    |. ...                         . |  .. .   ||.|..  .||  ....
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQ-FMGYCCCPPC

------------KFLLETEYCRGGSLWGLMAWMRKSDMRFSEQEVWELFAQLVSALHYLHK------TNEHIGITAHLNLRPDNVLLTQDGI--------
            .. . .||| ||||. ..            .    .  .  ....|||       |       .| .| ..|.|. ...         
GCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCT---KPPIIHRDLKSKNILVDENWTNVSNYMYN

------LKLCGFGYSATREPNKL------------------FTLRNPG--TAYHAPEVVAFTNSQGS---------SEGYTEAADIWSLGCMIYELCT--
      .|.| || | . ....                    |. ...  ... ||||   ..   .         .. |.|..|..| | ...|..|  
PNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRC

--FRRIENEPVS---------------SFNPLPENLET--------PGYADDLLILIKACLAPNPRER
  .. . ..|.                .  |.. .           |   ...  |.. | ...|..|
RPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKR
Kinase GL50803_14223.AA NEK10 92-218 30 4.6e-16 49.24 In-house 99-215 (279) Show / Hide 
Range on Protein: 92-218
Range on HMM: 99-215/279
Sequence Identity: 30% (40 aa)

GGSLWGLMAWMRKSDMRFSEQEVWELFAQLVSALHYLHKTNEHIGITAHLNLRPDNVLLTQDGILKLCGFGYSATRE--PNKLFTLRNPGTA-YHAPEVV
| .|  ..  |.     |.|. .|..| |.. || ||||    .    |  |.| |......       ||    .   | |.      ||  |  ||.|
GCPLYEHFNSMKEKHHHFEEERIWHMFIQMCLALRYLHKEKQIV----HRDLTPNNIMMGDKDRVTITDFGLAKQKQPDPSKMTSVV--GTILYSCPEIV

AFTNSQGSSEGYTEAADIWSLGCMIYELCT
        || | | ||.|. ||..|..||
Q-------SEPYGEKADVWAFGCCLYQMCT
Kinase GL50803_14223.AA MELK 35-216 32 1.1e-15 49.77 In-house 27-193 (254) Show / Hide 
Range on Protein: 35-216
Range on HMM: 27-193/254
Sequence Identity: 32% (60 aa)

VAVKVTDTVKLAESGRSDYRHESRVLQNAVHPHILRAVYGYYDEETKKFLLETEYCRGGSLWGLMAWMRKSDMRFSEQEVWELFAQLVSALHYLHKTNEH
||.|. |  .|  .     . |   |.|  | || . .| | . | | |..  ||| || ..  .     .  |..|.|   .| |.|||. |.|     
VAIKIMDKNQLG-HDLPRVKTEMDALKNLRHQHICQ-LYHYIETEDKIFMV-MEYCPGGEMFDYII----RQDRLEEEETRHFFRQIVSAIAYVHSQG--

IGITAHLNLRPDNVLLTQDGILKLCGFGYSATREPNKLFT-LRN--PGTAYHAPEVVAFTNSQGSSEGYTEAADIWSLGCMIYEL
    || .|.|.|.|...|  |||  ||  |    .|    |       || |||..   .  ||       ||.||.| ..| |
---YAHRDLKPENLLFDEDHHLKLIDFGLCAKTKGRKDYHNLQTCCGSPAYAAPELIQGKQYIGS------EADVWSMGILLYVL
Kinase GL50803_14223.AA SLK 51-273 27 1.7e-15 48.67 In-house 41-259 (259) Show / Hide 
Range on Protein: 51-273
Range on HMM: 41-259/259
Sequence Identity: 27% (64 aa)

SDYRHESRVLQNAVHPHILRAVYGYYDEETKKFLLETEYCRGGSLWGLMAWMRKSDMRFSEQEVWELFAQLVSALHYLHKTNEHIGITAHLNLRPDNVLL
.||  |  .| .  ||.|..    || ..    ..  |.| || .  .|  .   .    |. .  .  ... ||..||. .       | .|.  |.|.
EDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMI--EFCDGGAVDNIMVEL---EHPLTEDQIQYVCKHMCEALNWLHSNK-----VIHRDLKAGNILM

TQDGILKLCGFGYSATREPNKLFTLRNPGTAYH-APEVVAFTNSQGSSEGYTEAADIWSLGCMIYELCTFRRIENEPVSSFNPL----------PENLET
|.|| ..|  || ||  . .        || |  |||||.   ..   . |   |||||||  . |.    ..|  | .  ||.          |  ||.
TMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFK--DQPYDYKADIWSLGITLIEMA---QME-PPHHEMNPMRVLLKIQKSEPPTLEQ

PG-YADDLLILIKACLAPNPRERITAELLMASPPI
|  .. .   ..| ||  .|. | |.. ||  . .
PSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase GL50803_14223.AA WEE 78-218 21 1.2e-13 42.27 In-house 75-231 (297) Show / Hide 
Range on Protein: 78-218
Range on HMM: 75-231/297
Sequence Identity: 21% (37 aa)

EETKKFLLETEYCRGGS--LWGLMAWMRKSDMRFSEQEVWELFAQLVSALHYLHKTNE-HIGITAHLNLRPDNVLLTQDG--------------------
||. . .. .|||.|||  |  . .   ... ...|...| .. ... .||..|  .. ..    |. . |.|.... ..                    
EEDDHMYIQMEYCNGGSNLLQFWIQQCHNWNHWLPEWMIWQILVDICQGLHHIH--SNCGM---VHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNM

ILKLCGFGYSATRE--PNKLFTLRNPGTAYHAPEVVAFTNSQGSSE--GYTEA--ADIWSLGCMIYELCT
..|.  || . . .  .|.     .    | |||..        ..   || .  ||| |||..|||| .
MCKIGDFGHVTDMNSNNNNPHQEQEGDSRYMAPEIL--------QGYYHYTHLYKADIFSLGITIYELAC
TyrKc GL50803_14223.AA TyrKc 13-276 16 3.6e-09 -74.44 SMART 1-280 (280) Show / Hide 
Range on Protein: 13-276
Range on HMM: 1-280/280
Sequence Identity: 16% (52 aa)

VVLSAS----EFSVTYRAIRLKDLADVAVKVTDTVKLAESGRSDYRHESRVLQNA--VHPHILRAVYGYYDE-----ETKKFLLETEYCRGGSLWGLMAW
..|       .| . |...      .||||.    .     | | ..| |.. .    ||.|.| .    ..     . .  .. .||. .|.|      
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

MRKSDMRFSEQEVWELFAQLVSALHYLHKTNEHIGITAHL---NLRPDNVLLTQDGILKLCGFGYSATREPN-------KLFTLRN--PGT-----AYHA
 |.    .. ..  .   |  .   |||.         ..    |   |.|.. ... | . || |   .         .  . .    |         |
HRPK---LCMKDLLSFCWQIACGMEYLHSK--------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA

PEVVAFTNSQGSSEG-YTEAADIWSLGCMIYELCTF-----RR-----IENEPVSSFNPLPENLETPGY---------ADDLLILIKACLAPNPRERITA
||.          .| .|.. |.|| | ...|..|.            ..|. |  .    . .. | .          |..  ..| | . .| .| | 
PECI--------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTF

ELLMASPPIQAA
. .     ..  
SEI-----HECF
Kinase GL50803_14223.AA NEK 196-221 42 2e-08 26.23 In-house 197-224 (286) Show / Hide 
Range on Protein: 196-221
Range on HMM: 197-224/286
Sequence Identity: 42% (12 aa)

SSEGYTEAADIWSLGCMIYELCTF--RR
....|.. .||||||| .||.||.  ..
QNKPYNNKSDIWSLGCVLYEMCTLKPKH
Kinase GL50803_14223.AA NEK 75-130 26 2.4e-07 22.33 In-house 73-132 (286) Show / Hide 
Range on Protein: 75-130
Range on HMM: 73-132/286
Sequence Identity: 26% (16 aa)

YYDEETKKFLLETEYCR-GGSLWGL---MAWMRKSDMRFSEQEVWELFAQLVSALHYLHK
...|.  ..  . |||  || |  .       ...   |.| ..|. |.|...||.|.|.
FIEEQNNCLCIVMEYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHD
Kinase GL50803_14223.AA WEE 239-273 28 0.000327 10.11 In-house 263-297 (297) Show / Hide 
Range on Protein: 239-273
Range on HMM: 263-297/297
Sequence Identity: 28% (10 aa)

TPGYADDLLILIKACLAPNPRERITAELLMASPPI
. .. ..|  |||  . |.|. |.|.. |...| .
DNIISQELKQLIKWMMHPDPEQRPTCQQLLQHPVL
Kinase GL50803_14223.AA CAMK 249-273 32 0.002787 5.63 In-house 401-425 (425) Show / Hide 
Range on Protein: 249-273
Range on HMM: 401-425/425
Sequence Identity: 32% (8 aa)

LIKACLAPNPRERITAELLMASPPI
||. .| ..| .|.|.|  .. | .
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase GL50803_14223.AA Ciliate-E2-Unclassified 243-273 34 0.013785 4.82 In-house 321-352 (352) Show / Hide 
Range on Protein: 243-273
Range on HMM: 321-352/352
Sequence Identity: 34% (11 aa)

ADDLLI-LIKACLAPNPRERITAELLMASPPI
| |..  |.. .|  || .|||.| ..  | .
AKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase GL50803_14223.AA NEK 249-273 28 0.015753 5.19 In-house 262-286 (286) Show / Hide 
Range on Protein: 249-273
Range on HMM: 262-286/286
Sequence Identity: 28% (7 aa)

LIKACLAPNPRERITAELLMASPPI
||  .| ..| .| ... ... | |
LISQMLQKDPEQRPSCNQILEMPFI
Kinase GL50803_14223.AA NEK10 230-261 31 0.021184 3.46 In-house 237-264 (279) Show / Hide 
Range on Protein: 230-261
Range on HMM: 237-264/279
Sequence Identity: 31% (10 aa)

FNPLPENLETPGYADDLLILIKACLAPNPRER
..|..| .    . ||.  .|. ||.| |  |
YDPVNEGM----WSDDVRFTITRCLTPDPEAR