Gene GL50803_12240 (G.lamblia)
GL50803_12240
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
---|---|---|---|---|---|
GL50803_12240.AA | Protein | None | 519 | None | Fasta, JSON |
GL50803_12240.kin_dom | Protein Kinase Domain | None | 252 | None | Fasta, JSON |
Protein domains of GL50803_12240.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | GL50803_12240.AA | Ciliate-E2 | 61-271 | 16 | 7.7e-23 | 75.22 | In-house | 58-361 (365) | Show / Hide |
Range on Protein: 61-271 Range on HMM: 58-361/365 Sequence Identity: 16% (54 aa) KQIEDSDKLVQAIK-------------------HDNIVTWRKVIK--DDKCICIVMDRYDC-SLDVFLRERRHKG-------VPMDEDMVLDFSRQICS- .||| . . .. |.||. . . ||..| .||. .. .| .......| ...| ......||.. NQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQG --------------AFAYIHNLNKELPNGLPILSVVHGDVKPANILVADQGKKFSIADFAF-----------------------GDRNMASS-------- |. |.|. | ...| | || |||. |.|| . .|.. .. FKTKAEFYIACIILALEYLHSKN----------NIIHRDIKPENILF------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQ --------VAYYEAPEVRSGGA---------PTSASDMWSIGVILYELAVGNITIIRTIDFTKCNRDFQLNLN-AVTYPSIR------------------ ..| |||. .|. . ..|.||.||||||. |. .| ... . .|. NMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKW -----AIISR----LLVLNPSSRIT-AKELCD .|.. .|. .|. ||| .... . SQECKDLIKKFGKRMLQKDPEKRITGWEQILN |
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Kinase | GL50803_12240.AA | Ciliate-E2-Unclassified | 22-220 | 17 | 1.5e-20 | 67.99 | In-house | 1-267 (352) | Show / Hide |
Range on Protein: 22-220 Range on HMM: 1-267/352 Sequence Identity: 17% (50 aa) SCMGTELGKGIHGSVFAIKGHDNLVF--------------KEVQYSTPNEPVVKQIEDSDK-------------LVQAIKHDNIVTWRKVIKDDKCICIV .. .|.| .|.|. . .. . | .... .. .... . | . . ..| .|| . .|...|.|| YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV MDRY-DCSLDVFLR-------------ERRHKGVPMDEDMVL-----DFSRQICSAFAYIHNLNKELPNGLPILSVVHGDVKPANILVADQGK--KFSIA |. . .| ... ...... .| .. .. .||.... |.| |. ..| | || |||. ..|| . |. MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNN----------IIHRDIKPENILFDNNGKNYYIKII DFAF---------------------GDRNMASSV--AYYE----APEVRSGGAPT----SASDMWSIGVILYELAVGN || . . .| . . .| |||| | . ..|.|| ||||||. |. DFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGY |
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Kinase | GL50803_12240.AA | S_TKc | 22-278 | 21 | 8.5e-17 | 63.05 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 22-278 Range on HMM: 1-231/231 Sequence Identity: 21% (59 aa) SCMGTELGKGIHGSVFAIKGHD---NLVFKEVQYSTPNEPVVKQIEDSDKLVQAIKHDNIVTWRKVIKDDKCICIVMDRYDC---SLDVFLRERRHKG-- .. ..||| |.|. . .. |.. ..|. .. . .|.|||. |. | .....||. | .| ....|...| YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR VPMDEDMVLDFSRQICSAFAYIHNLNKELPNGLPILSVVHGDVKPANILVADQGKKFSIADFAFGDRNMASSV--AYYEAPEVRSGGAPTS-ASDMWSIG .|..| .. . .|||.| .|.|... ..| |.||.|||. . |.|| . . . . .| |||| . ..|.||.| FPFPE-HARFYMYQICCALEYCHSHG-----------IIHRDLKPENILLDE---HIKICDFGLARQL-TTFCGTPWYMAPEVL---GYGKCKCDWWSCG VILYELAVGNI---TIIRTIDFTKCNRDFQLNLNAVTYPSIRAIISRLLVLNPSSRITAKELCD----VLASKDV .||||...| .. .... . |. . .|...|. .|. |.|| |. . . . CILYEMLCGYPPFPQMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | GL50803_12240.AA | CMGC | 70-219 | 15 | 2.8e-16 | 49.1 | In-house | 92-331 (513) | Show / Hide |
Range on Protein: 70-219 Range on HMM: 92-331/513 Sequence Identity: 15% (38 aa) VQAIKHDNIVTWRKVIKDDK-----------------CICIVMDRYDCSLDVFLRERRH-----KGVPMDEDM------------VLDFS------RQIC ... .| |||. . ...... ....|.. |..| .... .. ...|..| . |. .||. PDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQIL SAFA--YIHNLNKELPNGLPILSVVHGDVKPANILVADQGKKF-------------------SIADF----AFGDR-----------------------N . . |.| .. ...| | ||.|||. .... . |.|| ..... RGLKLKYCHSHWG---------NIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRP MASSVA--YYEAPEV--RSG--------GAPTSASDMWSIGVILYELAVG . . |. .| |||. ... . |.. ||||.| |..|. | YTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTG |
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Kinase | GL50803_12240.AA | CAMK | 68-271 | 17 | 2e-13 | 38.92 | In-house | 86-421 (425) | Show / Hide |
Range on Protein: 68-271 Range on HMM: 86-421/425 Sequence Identity: 17% (59 aa) KLVQA----IKHDNIVTWRKVIKD-------------------DKCICIVM---DRYDC-----SLDVFLRERRHKG-----------VPMDEDMVLDFS |..|. ..| ||. |. | ||....|| . . | ...|....| ..|. . . KKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYF RQICSAFAYIHNLNKELPNGLPILSVVHGDVKPANILVADQG----------------KKFSIADFAFGDRNMASSV----------------------- |||||| .|.|. . .|| | || |||. | . . |.|| | . . .. RQICSAVHYCHS-----------HNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQ --------AYYEA-PEVRSG-------------GAP-TSASDMWSIGVILYELAVG--------NITIIR------TIDFTKCN---RDFQLNLNAVTYP .| | ||| .| . . ..||||.||||| . .| . |. .. .. . ... .. . KMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPI S----------------------IRAIISRLLVLNPSSRITAKELCD | . |...|. .|. |.|... . SCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLN |
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Kinase | GL50803_12240.AA | Pkinase | 74-175 | 22 | 4.2e-13 | 47.42 | Pfam | 58-156 (293) | Show / Hide |
Range on Protein: 74-175 Range on HMM: 58-156/293 Sequence Identity: 22% (25 aa) KHDNIVTWRKVIKDDKCICIVMDRYDC-----SLDVFLRERRHKGVPM--DEDMVLDFSRQICSAFAYIHNLNKELPNGLPILSVVHGDVKPANILVADQ .|.|||. . . |.. |..||. .. .| ... ... .. .|. . .. .||... .|.|. ...| |.||.|||. .. NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHSM-----------GIIHRDLKPENILIDNN GKK---FSIADF | . |.|| GHIDACVKICDF |
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Kinase | GL50803_12240.AA | ULK | 68-265 | 19 | 7.1e-13 | 42.07 | In-house | 62-314 (324) | Show / Hide |
Range on Protein: 68-265 Range on HMM: 62-314/324 Sequence Identity: 19% (52 aa) KLVQAIK---HDN--IVTWRKVIKDD--KCICIVMDRYDC-SLDVFLRERRHKGVPM------DEDMVLDFSRQICSAFAYIHNLNKELPNGLPILSVVH .... .| | | || .. ... . |.|.|. .. |. .. ....... |. .. | .|||..| ..|. | ..| QIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHN-----------IIH GDVKPANILVAD-QGKK----------FSIADFAFGDR----NMASSVA-------------YYEAPEVRS----GGAPT-SASDMWSIGVILYELAVGN | ||.|||. . |.|. . |||| |. ||. . .| ||.. . . .. . .|.||.|.|.||. | RDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGK IT----IIRTI-------------DFTKCNRDFQLNLNA---VTYPSIRAIISRLLVLNPSSRIT . .. .. .|. .| ... . | .. .|.|.|. ... ||. YPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRIS |
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Kinase | GL50803_12240.AA | TKL | 101-219 | 14 | 5.5e-12 | 39.46 | In-house | 124-285 (364) | Show / Hide |
Range on Protein: 101-219 Range on HMM: 124-285/364 Sequence Identity: 14% (27 aa) S-LDVFLRERRHKGVPMDEDMVLDFSRQICSAFAYIHNLN----KELPNGLPILSVVHGDVKPANILVADQGK-------------KFSIADF------- | |.... . ......|... .| |. | . ..| | |..|||| . .. . |.|| SLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCT-------KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMS ------------------AFGDRNMASSVA---YYEAPEVRSGG----------------APTSASDMWSIGVILYELAVG . |.. ... .. |||| | . ..|..| |..|.|.. . QSGNMNDTMTTMMESAEHQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTR |
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Kinase | GL50803_12240.AA | NEK | 73-175 | 25 | 3.7e-11 | 35.94 | In-house | 61-167 (286) | Show / Hide |
Range on Protein: 73-175 Range on HMM: 61-167/286 Sequence Identity: 25% (29 aa) IKHDNIVTWRKVIKDDK--CICIVMDRYD--CSLDVF---LRERRHKGVPMDEDMVLDFSRQICSAFAYIHNL-NKELPNGLPILSVVHGDVKPANILVA .||.|||. . . ... |.||||. . |. . . ....|| ...|....|. |.|.| |.|. . ..| | ||.|| LKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGP-------QRKILHRDIKPQNIFLT DQGK---KFSIADF .... | || KNNNDYHNVKIGDF |
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Kinase | GL50803_12240.AA | ULK | 68-265 | 18 | 6.7e-11 | 34.37 | In-house | 62-319 (329) | Show / Hide |
Range on Protein: 68-265 Range on HMM: 62-319/329 Sequence Identity: 18% (51 aa) KLVQAIK----HDN----IVTWRKVIKDD--KCICIVMDRYDC-SLDVFLRERRHKGVPM------DEDMVLDFSRQICSAFAYIHNLNKELPNGLPILS |. . .| | | || .. ... ..| |.|. . |. .. ...... . |. .. | .||...| ..| | KIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHN----------- VVHGDVKPANILVAD-QGKK----------FSIADFAFGDR---N------MASSV--------AYYEAPEVRS----GGAPT-SASDMWSIGVILYELA ..| | ||.|||. . |.|. . |||| |. . | . | .| ||.. . . .. . .|.||.|.|.||. IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEML VGNIT----IIRTIDFTKCNR------------DFQLNLN-----AVTYPSIRAIISRLLVLNPSSRIT .| . ... . . ...|. . . | .. .|.|.|. ... ||. YGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRIS |
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Kinase | GL50803_12240.AA | TyrKc | 22-273 | 18 | 1.1e-08 | -81.91 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 22-273 Range on HMM: 1-280/280 Sequence Identity: 18% (58 aa) SCMGTELGKGIHGSVFAIKGHDNLVFKEVQYSTPNEPV-VKQIEDSD--------KLVQAI--KHDNIVTWRKVIKDD-------KCICIVMDRYDC-SL .| .|| | | |. . ..| || . .. .. . .|.||| |. .. . ..||| . .| ITLGKKLGEGAFGEVYKGTWK--------------IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL DVFLRERRHKGVPMDEDMVLDFSRQICSAFAYIHNLNKELPNGLPILSVVHGDVKPANILVADQGKKFSIADFAFGDRNMAS------SVAYYE------ . .||..|.| . |.|. ||.. .|.| ..| | |.||.... |.|| . | KDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSK-----------NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGG ---------APEVRSGGAPTSASDMWSIGVILYELA--------------VGNITIIRTIDFTKCNRDFQLNL--NAV----TYPSIRAIISRLLVLNPS |||. | |..|| || || ..|. . |. .|. .. . .| | . . . |... .|. KTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVK--QGYRMPQPPNDYP-MSFVCCPDEMYQIMKQCWHEDPE SRITAKELCDVL .| | .|... . DRPTFSEIHECF |
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Kinase | GL50803_12240.AA | Pkinase | 188-273 | 19 | 9.6e-08 | 28.46 | Pfam | 176-293 (293) | Show / Hide |
Range on Protein: 188-273 Range on HMM: 176-293/293 Sequence Identity: 19% (23 aa) YYEAPEVRS-GGAPTSASDMWSIGVILYELAVG-----NI----TIIRTIDFTKCNRDFQLNLNAVTY---------------------PSIRAIISRLL .| |||| | ....||||.|.||||.. | . . .. . . ... .| . . .. . .|...| WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL VLNPSSRITAKELCDV--L ..|..|.||.... . CKDPKKRPTAEQILQHPWF |
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Kinase | GL50803_12240.AA | CDC2 | 69-175 | 25 | 4.7e-07 | 17.15 | In-house | 53-147 (301) | Show / Hide |
Range on Protein: 69-175 Range on HMM: 53-147/301 Sequence Identity: 25% (28 aa) LVQAIK-HDNIVTWRKVIKDDKCICIVMDRYDCSLDVFLRERRHKGVPMDEDMVLDFSRQICSAFAYIHNLNKELPNGLPILSVVHGDVKPANILVADQG . ...| |.|||. . ||. . . .| ...|. | .... |. .|... | .. ||... .. | ..| | || |||. ..| CLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQRR-----------IMHRDLKPQNILIDKKG KKFSIADF . |||| N-IKIADF |
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Kinase | GL50803_12240.AA | MLK | 191-216 | 37 | 1e-06 | 19.36 | In-house | 201-229 (291) | Show / Hide |
Range on Protein: 191-216 Range on HMM: 201-229/291 Sequence Identity: 37% (11 aa) APEVR---SGGAPTSASDMWSIGVILYEL ||||. .. . ..|.||.||.|.|. APEVIQQFRCEKYSEKCDVWSWGVVLWEM |
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Kinase | GL50803_12240.AA | MLK | 68-175 | 20 | 7e-06 | 16.58 | In-house | 57-177 (291) | Show / Hide |
Range on Protein: 68-175 Range on HMM: 57-177/291 Sequence Identity: 20% (27 aa) KLVQAIKHDN----IVTWRKVIKDD-KCICIVMDRYDC-SLDVFLRERRHKGV----------PMDEDMVLDFSRQICSAFAYIHNLNKELPNGLPILSV ... ..| | |. . |.... .. |||| .. || .|...| |. .| | ..... |. .. .| |.. . . . RHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKP--------I VHGDVKPANILVAD-----QGKKFSIADF .| | |. |||... .... |.|| IHRDLKSHNILIDEICHDMHHGTLKICDF |
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Kinase | GL50803_12240.AA | NEK | 204-217 | 57 | 0.000125 | 12.67 | In-house | 205-218 (286) | Show / Hide |
Range on Protein: 204-217 Range on HMM: 205-218/286 Sequence Identity: 57% (8 aa) SDMWSIGVILYELA ||.||.|..|||.. SDIWSLGCVLYEMC |
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Kinase | GL50803_12240.AA | CDC2 | 251-268 | 38 | 0.002022 | 5.79 | In-house | 277-294 (301) | Show / Hide |
Range on Protein: 251-268 Range on HMM: 277-294/301 Sequence Identity: 38% (7 aa) IISRLLVLNPSSRITAKE .....|...|. ||.||| LLMQMLQYDPQKRISAKE |
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Kinase | GL50803_12240.AA | CMGC | 252-271 | 30 | 0.002757 | 5.62 | In-house | 490-509 (513) | Show / Hide |
Range on Protein: 252-271 Range on HMM: 490-509/513 Sequence Identity: 30% (6 aa) ISRLLVLNPSSRITAKELCD ....|...|. ||||.. .. LKKMLQYDPDKRITAEQALQ |
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Kinase | GL50803_12240.AA | CDC2 | 205-217 | 50 | 0.006858 | 4.13 | In-house | 188-203 (301) | Show / Hide |
Range on Protein: 205-217 Range on HMM: 188-203/301 Sequence Identity: 50% (8 aa) DMWSIGVILYEL---A |||||| |..|. . DMWSIGCIFAEMFMDV |
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Kinase | GL50803_12240.AA | Ciliate-E2-Unclassified | 251-270 | 30 | 0.151249 | 1.16 | In-house | 328-347 (352) | Show / Hide |
Range on Protein: 251-270 Range on HMM: 328-347/352 Sequence Identity: 30% (6 aa) IISRLLVLNPSSRITAKELC .....|. ||..|||..... LLQKMLKKNPNKRITFEQIL |
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Ank | GL50803_12240.AA | Ank | 376-406 | 24 | 4.7e-05 | 22.48 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 376-406 Range on HMM: 1-33/33 Sequence Identity: 24% (8 aa) KGMTALMYAAEADRFQIVELLLE--HEKCIRDK |.|.|..|.. .. ..|..||. . ...|. DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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Ank | GL50803_12240.AA | Ank | 407-437 | 21 | 0.000299 | 19.59 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 407-437 Range on HMM: 1-33/33 Sequence Identity: 21% (7 aa) NGWTALMRAAQKNSVNSVRLLIK--VEAGMQSN .|.|.|. |....... |..|.. . .| . DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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Ank | GL50803_12240.AA | Ank | 348-375 | 32 | 0.004743 | 15.26 | Pfam | 6-33 (33) | Show / Hide |
Range on Protein: 348-375 Range on HMM: 6-33/33 Sequence Identity: 32% (9 aa) LMTAVQSNNIETVRMILSSGVSMGKQDN |. |......| |.| |. | . ||. LHLACRCGHTEVVKMLLQHGADVNAQDD |
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Ank | GL50803_12240.AA | Ank | 438-461 | 20 | 0.056469 | 11.38 | Pfam | 1-24 (33) | Show / Hide |
Range on Protein: 438-461 Range on HMM: 1-24/33 Sequence Identity: 20% (5 aa) NGRTALMEAVAKKSLNSAVELIEC .|.|.|. |. . ... . .|... DGFTPLHLACRCGHTEVVKMLLQH |
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Ank | GL50803_12240.AA | Ank | 469-492 | 41 | 0.000234 | 19.97 | Pfam | 1-24 (33) | Show / Hide |
Range on Protein: 469-492 Range on HMM: 1-24/33 Sequence Identity: 41% (10 aa) SGCTALMYAAEKGLTEIVTRLLDY |.|.|..|...| ||.|. ||.. DGFTPLHLACRCGHTEVVKMLLQH |