GL50803_115786

Species: G.lamblia
Alias: GK225, GL50803_115786
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_115786.AA Protein None 880 None Fasta, JSON
GL50803_115786.kin_dom Protein Kinase Domain None 265 None Fasta, JSON

Protein domain

Protein domains of GL50803_115786.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_115786.AA Pkinase 179-273 24 8.4e-11 39.27 Pfam 179-293 (293) Show / Hide
Range on Protein: 179-273
Range on HMM: 179-293/293
Sequence Identity: 24% (28 aa)

SPEVLHGGPGSTQSV-MWSLGCLLYRICNGSYPFGDD-------RSQVLPAILSTLGPSALPKR-------------ASTLVEKVPLTLRPLVAQLLAYR
.|||. ||.. ...| |||.||.||  ..|  || ..         |..  |...  ..  |.              ..|.  ... ... ..  .|.. 
APEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF-HNWSEECKDFIKWCLCKD

PSDRPTPTKLLLHPKV
|..|||.. .| || .
PKKRPTAEQILQHPWF

Kinase GL50803_115786.AA Ciliate-E2 179-273 19 2.8e-09 27.99 In-house 255-365 (365) Show / Hide
Range on Protein: 179-273
Range on HMM: 255-365/365
Sequence Identity: 19% (23 aa)

SPEVLHGGP---------GSTQSVMWSLGCLLYRICNGSYPFGDDRSQVLPAILSTLGPSALPKRAST-----------LVEKVPLTLRPLVAQ----LL
.||.| |..          .... .||||..||. . | .||          .    ..  .|.  ..             .|...    |  .    .|
APEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRML

AYRPSDRPT-PTKLLLHPKV
 . |. |.| . ..| ||  
QKDPEKRITGWEQILNHPWF

Kinase GL50803_115786.AA PDK1 179-211 36 2.3e-08 21.16 In-house 207-239 (307) Show / Hide
Range on Protein: 179-211
Range on HMM: 207-239/307
Sequence Identity: 36% (12 aa)

SPEVLHGGPGSTQSVMWSLGCLLYRICNGSYPF
|||.| ... ....  |.|||..|.   | .||
SPELLTDKECTPSCDIWALGCIIYQMVAGQPPF

Kinase GL50803_115786.AA Ciliate-E2-Unclassified 178-273 21 4.8e-07 20.51 In-house 230-352 (352) Show / Hide
Range on Protein: 178-273
Range on HMM: 230-352/352
Sequence Identity: 21% (28 aa)

S---SPEVLHG-GPGS---TQSVMWSLGCLLYRICNGSYPFGD-DRSQ----------------VLPAILS--TLGPSALPKRASTLVEKVPLTLRPLVA
.   .|||| | ...     .. .||||..|| .. | |||.| .. |                ..  |.   .  |.. ..        .| .. | ..
PQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQ-------IPKHWSPEAK

--------QLLAYRPSDRPTPTKLLLHPKV
        ..| ..|. |.|. ..| ||  
DFINDLLQKMLKKNPNKRITFEQILNHPWF

Kinase GL50803_115786.AA STE 179-273 21 1e-06 19.39 In-house 230-359 (359) Show / Hide
Range on Protein: 179-273
Range on HMM: 230-359/359
Sequence Identity: 21% (28 aa)

SPEVLHG------GPGSTQSVMWSLGCLLYRICNGSYPFGD-DRSQVLPAILST--------------LGPSALPKRAS------------TLVEKVPLT
.|||. .      .. .|.. .|||||..   ..| .|. |    ... .|.                 .|  || . |            |. .|.   
APEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPE

LRPLVAQLLAYRPSDRPTPTKLLL--HPKV
..  ... | . |..|||...||   || .
FKDFINKCLQKDPNKRPTASQLLKSEHPFI

Kinase GL50803_115786.AA Ciliate-D1 193-211 47 4e-06 21.52 In-house 1-19 (19) Show / Hide
Range on Protein: 193-211
Range on HMM: 1-19/19
Sequence Identity: 47% (9 aa)

VMWSLGCLLYRICNGSYPF
 .||.||.|| ...|..||
DIWSFGCILYEMLFGQPPF

Kinase GL50803_115786.AA NEK2 179-205 48 8e-06 15.47 In-house 232-258 (319) Show / Hide
Range on Protein: 179-205
Range on HMM: 232-258/319
Sequence Identity: 48% (13 aa)

SPEVLHGGPGSTQSVMWSLGCLLYRIC
|||..|| . .  |  ||.|||.|  |
SPEQMHGQKYNEKSDIWSVGCLIYEMC

Kinase GL50803_115786.AA SCY1 194-273 23 9e-06 16.09 In-house 256-337 (337) Show / Hide
Range on Protein: 194-273
Range on HMM: 256-337/337
Sequence Identity: 23% (20 aa)

MWSLGCLLYRICNGSYPFGDDRSQ-VLPAILSTLGPSALPKRASTLVEKVPLTLRPL----VAQLLAYRPSDRPTPTKLLLHPKV
|.||||| . . || .|. .. |.   ..   .   . . .. . . ...|  |. .    .  ||.  |  ||.| ..|.|.. 
MFSLGCLIWWVYNGKKPQITCNSNPYSTFHRYM---EQWNAMSHCWWDHIPKELQEHLGHCYCHLLHQDPTCRPDPQQFLQHCYF

Kinase GL50803_115786.AA SAK 179-273 28 1.9e-05 14.22 In-house 168-254 (254) Show / Hide
Range on Protein: 179-273
Range on HMM: 168-254/254
Sequence Identity: 28% (27 aa)

SPEVLHGGPGSTQSVMWSLGCLLYRICNGSYPFGDDRSQVLPAILSTLGPSALPKRASTLVEKVPLTLRPLVAQLLAYRPSDRPTPTKLLLHPKV
|||.   ..   || .|||||.|| .  |  ||  |      |. .||    .      .   . .  . |. ..|   | .| |    | || .
SPEIATRTAHGLQSDVWSLGCMLYTLLIGRPPFDTD------AVKNTLNKVMMAEYI--MPAHLSMEAQDLIHKMLRKNPHERITLSTVLCHPFM

Kinase GL50803_115786.AA NAK 195-213 52 3.7e-05 13.09 In-house 225-243 (299) Show / Hide
Range on Protein: 195-213
Range on HMM: 225-243/299
Sequence Identity: 52% (10 aa)

WSLGCLLYRICNGSYPFGD
|.|||.||..| .  ||.|
WALGCMLYKMCFYTHPFED

Kinase GL50803_115786.AA CAMK 249-273 32 0.000621 7.77 In-house 401-425 (425) Show / Hide
Range on Protein: 249-273
Range on HMM: 401-425/425
Sequence Identity: 32% (8 aa)

LVAQLLAYRPSDRPTPTKLLLHPKV
|. ..| . |..|.| .  | || .
LIRKMLQVDPEKRMTIEQCLNHPWM

Kinase GL50803_115786.AA CAMK 179-214 31 0.018542 2.93 In-house 287-337 (425) Show / Hide
Range on Protein: 179-214
Range on HMM: 287-337/425
Sequence Identity: 31% (16 aa)

S-PEVLHG-------------GPGSTQSV-MWSLGCLLYRICNGSYPFGDD
. |||| |              |. .... |||.|..||    | .|| .|
AAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGD

S_TKc GL50803_115786.AA S_TKc 342-606 14 1.5e-05 -95.49 SMART 1-231 (231) Show / Hide
Range on Protein: 342-606
Range on HMM: 1-231/231
Sequence Identity: 14% (42 aa)

YLPIAHCGFNGMCEGFVLKNRSTGIRVFCKVYRIGDDSVLQNAITEYFAELASISHPYIVPLSFGKISSLNTYAYEAVEAASL--HRLSDVVGTLDRGG-
|  . . |  .. . .  ....|| .| .|. .       .... |         ||.|| |     .   .. |   | ..     | |.     |.| 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LCEQKVWSLLIAVVDVLCMLQTRSDGPLCHHAIRPWALYLTQEGDLRLLDTGSALRFAKKLTQPSRCGHLALDKGLD---PFTAPELRPGSAQSWVG
   . |  .....  ... |  .  .     .|  . |  . |..   . . | |.| ..                . .     . |||.         |
RFPFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL----------------TTFCGTPWYMAPEVL------GYG

GSRADLWELAQTICHLCRGDIIACSTLDDAQAHLRGHFLGLSYSDELHGVLAGMLQPDPVARTALSMLAT-------HPCI
. ..| | .  ..  .. |    . ...    ...        |.|.   . ..|| ||  |     . .       || .
KCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase GL50803_115786.AA NAK 575-594 45 0.002117 7.12 In-house 270-289 (299) Show / Hide
Range on Protein: 575-594
Range on HMM: 270-289/299
Sequence Identity: 45% (9 aa)

YSDELHGVLAGMLQPDPVAR
||...| .  .||.|||  |
YSQQMHDLIRYMLTPDPEQR

Kinase GL50803_115786.AA CAMK 576-606 28 0.024039 2.56 In-house 387-425 (425) Show / Hide
Range on Protein: 576-606
Range on HMM: 387-425/425
Sequence Identity: 28% (11 aa)

SDE--------LHGVLAGMLQPDPVARTALSMLATHPCI
|||            . .|||.||  |  ..    || .
SDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM

Kinase GL50803_115786.AA SAK 576-606 32 0.17767 0.48 In-house 224-254 (254) Show / Hide
Range on Protein: 576-606
Range on HMM: 224-254/254
Sequence Identity: 32% (10 aa)

SDELHGVLAGMLQPDPVARTALSMLATHPCI
| | . ..  ||. .|  | .||    || .
SMEAQDLIHKMLRKNPHERITLSTVLCHPFM

Kinase GL50803_115786.AA Ciliate-E2 585-606 36 0.303929 0.0 In-house 341-365 (365) Show / Hide
Range on Protein: 585-606
Range on HMM: 341-365/365
Sequence Identity: 36% (9 aa)

G--MLQPDPVARTA-LSMLATHPCI
|  ||| ||  |    . .  || .
GKRMLQKDPEKRITGWEQILNHPWF

Kinase GL50803_115786.AA Ciliate-D1 537-555 15 3.084233 0.61 In-house 1-19 (19) Show / Hide
Range on Protein: 537-555
Range on HMM: 1-19/19
Sequence Identity: 15% (3 aa)

DLWELAQTICHLCRGDIIA
|.| .  ...... |  . 
DIWSFGCILYEMLFGQPPF

Ank GL50803_115786.AA Ank 650-680 27 0.001602 16.96 Pfam 1-33 (33) Show / Hide
Range on Protein: 650-680
Range on HMM: 1-33/33
Sequence Identity: 27% (9 aa)

QGCTALFLAAQRGMHQLLNLLVG--AEADIADS
 |.|.| ||...| .. . .|..  |. .. | 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD

Ank GL50803_115786.AA Ank 681-702 27 0.021673 12.88 Pfam 1-22 (33) Show / Hide
Range on Protein: 681-702
Range on HMM: 1-22/33
Sequence Identity: 27% (6 aa)

RGRTALMAAAANNRVGCIDRLL
 |.|.|. |. .... ..  ||
DGFTPLHLACRCGHTEVVKMLL

Ank GL50803_115786.AA Ank 712-732 38 0.215806 9.28 Pfam 1-21 (33) Show / Hide
Range on Protein: 712-732
Range on HMM: 1-21/33
Sequence Identity: 38% (8 aa)

DGDTALIYAARFWATDALSLL
||.|.| .|.|   |. ...|
DGFTPLHLACRCGHTEVVKML

Ank GL50803_115786.AA Ank 742-763 36 0.011086 13.93 Pfam 1-22 (33) Show / Hide
Range on Protein: 742-763
Range on HMM: 1-22/33
Sequence Identity: 36% (8 aa)

RGETALMVAAASNYVEGVEALL
 |.|.|..|. ....| |. ||
DGFTPLHLACRCGHTEVVKMLL

Ank GL50803_115786.AA Ank 773-803 24 0.173698 9.62 Pfam 1-33 (33) Show / Hide
Range on Protein: 773-803
Range on HMM: 1-33/33
Sequence Identity: 24% (8 aa)

EGWTALMCAAVVGATAAVCQLVT--VEAGLRNN
.|.|.|..|.  | |  |  |.    .  ....
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD

Ank GL50803_115786.AA Ank 804-824 38 0.730511 7.37 Pfam 1-21 (33) Show / Hide
Range on Protein: 804-824
Range on HMM: 1-21/33
Sequence Identity: 38% (8 aa)

RGRTALIEAVLCGQMASVHVL
 |.|.|  |..||..  |  |
DGFTPLHLACRCGHTEVVKML

Ank GL50803_115786.AA Ank 835-855 33 0.085513 10.73 Pfam 1-21 (33) Show / Hide
Range on Protein: 835-855
Range on HMM: 1-21/33
Sequence Identity: 33% (7 aa)

AGRCALMYAASRGHTPAIRIL
 |. .|..|...|||  .. |
DGFTPLHLACRCGHTEVVKML