Gene GL50803_115572 (G.lamblia)

GL50803_115572

Species: G.lamblia
Alias: GK074, GL50803_115572
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: WEE
Subfamily: WEE-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_115572.AA Protein None 2528 None Fasta, JSON
GL50803_115572.kin_dom Protein Kinase Domain None 1302 None Fasta, JSON

Protein domain

Protein domains of GL50803_115572.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Pkinase GL50803_115572.AA Pkinase 67-193 25 2.8e-19 69.27 Pfam 1-144 (293) Show / Hide 
Range on Protein: 67-193
Range on HMM: 1-144/293
Sequence Identity: 25% (36 aa)

YTVLEILGQGCSGKTYKVLFQRDGRLYAMKKKRSATSEDVK--------EGILITSLKCPVCIPCYLCWIEDNSTYFVTDLAHC-----SLDSILD--YY
|......|.| .|. ||   . .|...|.|. .  . .. |        |  .  .|..|  . .| .. .... |.|.... .     .| ...   ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

HFL--IEDLIWILMADISMALEYIHANGIAHCDLKPENILVTNR
  .   |. .   |  |  .|||.|..|| |.||||||||. |.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNN
Kinase GL50803_115572.AA CMGC 67-192 15 6.8e-19 57.86 In-house 1-219 (513) Show / Hide 
Range on Protein: 67-192
Range on HMM: 1-219/513
Sequence Identity: 15% (34 aa)

YTVLEILGQGCSGKTYKVLFQRDG--------------RLYAMKKKRSATSEDV----------------KEGILITSLK-----------------CPV
|.... .|.|  |. ||   .| .              ...|.|| ...  ..                  |  .   |.                  . 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

CIPCYLCWIEDN-----------------STYFVTDLAHCSLDSILDYYHF----------------------------LIEDLIWILMADISMALE--Y
.. .| .   .|                 . |.|...  ..|  ... ..|                            ..  .|   |  |  .|.  |
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

IHANG--IAHCDLKPENILVTN
.| ..  | |.||||||||...
CHSHWGNIIHRDLKPENILINH
Kinase GL50803_115572.AA Ciliate-E2 67-202 22 1.4e-13 42.94 In-house 1-196 (365) Show / Hide 
Range on Protein: 67-202
Range on HMM: 1-196/365
Sequence Identity: 22% (47 aa)

YTVLEILGQGCSG-----KTYKV--LF----------------QRDGRLYAMKKKRSATSEDVKEGILIT-----------------SLKCPVCIPCYLC
| .....|||. |     | .||  .|                . .. .|||| ..    | .|  | |                  .|..|  | .| |
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

WI--EDNSTYFVTDLAHCSLDSILD---------------YYHFLIEDLIWILMADIS---------------MALEYIHANG-IAHCDLKPENILVTNR
..   ||. |.|...  |.  . .|               . . . |  |  .|. |                 ||||.| .. | | |.||||||.   
FQEKDDNNIYLVMEY--CQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---

IDGYNVPPK
       .|
-------IK
Kinase GL50803_115572.AA CAMK1 169-189 66 5.4e-13 34.06 In-house 120-140 (276) Show / Hide 
Range on Protein: 169-189
Range on HMM: 120-140/276
Sequence Identity: 66% (14 aa)

ALEYIHANGIAHCDLKPENIL
|.||.|..||.|.||||||.|
AVEYMHSKGIVHRDLKPENLL
Kinase GL50803_115572.AA Ciliate-C1 169-189 66 8.7e-13 28.98 In-house 141-161 (328) Show / Hide 
Range on Protein: 169-189
Range on HMM: 141-161/328
Sequence Identity: 66% (14 aa)

ALEYIHANGIAHCDLKPENIL
...||| |.|.| ||||||||
VIQYIHQNNICHRDLKPENIL
Kinase GL50803_115572.AA S_TKc 67-250 19 2.1e-12 5.04 SMART 1-231 (231) Show / Hide 
Range on Protein: 67-250
Range on HMM: 1-231/231
Sequence Identity: 19% (48 aa)

YTVLEILGQGCSGKTYKVLFQRDGRLYAMKKKRSATSEDVKEGILITSLKCPVCIPCYLCWIEDNSTYFVTDLAHC---SLDSILDYYHF------LIED
|..|...|.|  || ||.   ..||..|.|. .    |...  | | . ..|  . .| .. . .. |.|....     .| .... .        . | 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKKHHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-

LIWILMADISMALEYIHANGIAHCDLKPENILVTN--------------------------RIDGYNV-------------------PPKNCGDSYTIDT
 .. .|. |  ||||.| .|| |.||||||||...                           . ||.                    ||       ....
HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQLTTFCGTPWYMAPEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQM

SMDRLTPINDPNLK-------RSYVAQRAAALARSK--SDKAKDTYI
 ....    .| .|       .   ..|  |    .  .| ... ..
MFKKIG---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_115572.AA AGC 161-189 58 2.6e-12 26.62 In-house 158-187 (395) Show / Hide 
Range on Protein: 161-189
Range on HMM: 158-187/395
Sequence Identity: 58% (18 aa)

ILMADISMALEYIHA-NGIAHCD-LKPENIL
| .. | .||||.|  .|| | | |||||||
I-CGCIVLALEYLHSHMGIIHRDYLKPENIL
Kinase GL50803_115572.AA WEE 152-193 44 4.3e-12 36.93 In-house 106-148 (297) Show / Hide 
Range on Protein: 152-193
Range on HMM: 106-148/297
Sequence Identity: 44% (19 aa)

HFLIEDLIWILMADISMALEYIHAN-GIAHCDLKPENILVTNR
| | |..|| .  ||. .| .|| | |. | |.|||||.....
HWLPEWMIWQILVDICQGLHHIHSNCGMVHMDIKPENIFISKK
Kinase GL50803_115572.AA TKL 73-192 17 9e-12 38.67 In-house 1-175 (364) Show / Hide 
Range on Protein: 73-192
Range on HMM: 1-175/364
Sequence Identity: 17% (32 aa)

LGQGCSGKTYKVLFQR--------DGRLYAMKKKRS-------------------------------ATSEDVKEGILITSLKCPVCIPCYLCWIEDNS-
.|.| .|. ||  ..         .|.  |.|| .|                               .  . ..|  .. .|..|  .... . .. .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------TYFVTDLAHCSLDSILDYYHFLIEDLIWILMADISMALEYIHANG--------IAHCDLKPENILVTN
             ..|...  |.  | |.|.|    ...  .. ||. ...| |...        |.|.|||..|||| .
CVCMHPVGPWGQLCIVMEY--CPGGSLLHYLH---WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDE
Kinase GL50803_115572.AA CAMK 162-193 43 1.6e-11 32.69 In-house 184-215 (425) Show / Hide 
Range on Protein: 162-193
Range on HMM: 184-215/425
Sequence Identity: 43% (14 aa)

LMADISMALEYIHANGIAHCDLKPENILVTNR
..  |  |..|.| ..|.|.||||||||....
YFRQICSAVHYCHSHNIVHRDLKPENILLDDN
Kinase GL50803_115572.AA Gdt 162-191 50 1.5e-09 28.89 In-house 135-164 (289) Show / Hide 
Range on Protein: 162-191
Range on HMM: 135-164/289
Sequence Identity: 50% (15 aa)

LMADISMALEYIHANGIAHCDLKPENILVT
.| ||. . .. |.||| |.||||.|||..
IMIDIAKGCQFLHQNGIIHRDLKPDNILIF
Kinase GL50803_115572.AA NEK 67-97 38 1.7e-07 22.9 In-house 1-36 (286) Show / Hide 
Range on Protein: 67-97
Range on HMM: 1-36/286
Sequence Identity: 38% (14 aa)

YTVLEILGQGCSGKTYKVLFQRDGRL-----YAMKK
|.... .|||  || |||  ..||.      |..||
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKK
Kinase GL50803_115572.AA WEE 67-97 35 2.6e-07 20.67 In-house 1-31 (297) Show / Hide 
Range on Protein: 67-97
Range on HMM: 1-31/297
Sequence Identity: 35% (11 aa)

YTVLEILGQGCSGKTYKVLFQRDGRLYAMKK
..... .|.| .|. ||. .  ||..|| ||
FQEVQKIGEGSFGEVYKCRCRIDGCIYAIKK
Kinase GL50803_115572.AA NEK 156-192 35 1.4e-05 16.11 In-house 113-154 (286) Show / Hide 
Range on Protein: 156-192
Range on HMM: 113-154/286
Sequence Identity: 35% (15 aa)

EDLIWILMADISMALEYIHAN-----GIAHCDLKPENILVTN
|. ||  .. ...|| |.| .      | | |.|| ||  |.
EEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTK
Kinase GL50803_115572.AA TyrKc 67-337 13 0.000805 -160.85 SMART 1-280 (280) Show / Hide 
Range on Protein: 67-337
Range on HMM: 1-280/280
Sequence Identity: 13% (44 aa)

YTVLEILGQGCSGKTYKVLFQRDGRLYAMKKKRSATSED--VKEGILITSL--KCPVCIPCYLCWIED-------NSTYFVTDLA-HCSLDSILDYYH--
 | ...|| |. |. ||       .  | |. .. . .    .|  . ..|  . |  . .| . ...          . |. .. | .|.. | ...  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

FLIEDLIWILMADISMALEYIHANGIAHCDLKPENILVTNRIDGYNVPPKNCGDSYTIDTSMDRLTPINDPNLKRSYVAQRAA-ALARSKSDK-----AK
.  .||. . . .|.   ||.| ... | ||   |.||...                                    ..  .   |.|   |.     .|
LCMKDLLSF-CWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----------------------------------TVKISDFGLSRDIYDDDQQGESK

DTYINKS-QNKP----------------------------------FSVASSSHSQQ----ASATNTVPTTGVASVVSTPMH----TSIVSTAVNQKLSE
|.|  |. ...                                   |.   . .. .     |..  .           | .                  
DYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------

DTLYPIASENVTTSMDQ-LSLHTTF-PRAQVIHSDL
   ...... . . | |         |. . ||...
---FVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase GL50803_115572.AA AGC 67-97 32 0.002547 2.85 In-house 1-37 (395) Show / Hide 
Range on Protein: 67-97
Range on HMM: 1-37/395
Sequence Identity: 32% (12 aa)

YTVLEILGQGCSGKTYKVLFQ------RDGRLYAMKK
. .| ..|.|  || | |           |..||||.
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKV
Kinase GL50803_115572.AA CAMK 72-96 18 0.009519 3.88 In-house 1-37 (425) Show / Hide 
Range on Protein: 72-96
Range on HMM: 1-37/425
Sequence Identity: 18% (7 aa)

ILGQGCSGKTYKVLFQRDG------------RLYAMK
.||.|  || ...   ...            . .|.|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIK
Kinase GL50803_115572.AA WEE 1236-1302 32 6.5e-14 43.13 In-house 173-247 (297) Show / Hide 
Range on Protein: 1236-1302
Range on HMM: 173-247/297
Sequence Identity: 32% (24 aa)

LSDFGHAQEAP-----FKESNTGDSRYICPQFLR---TGIPDYSADVYSFGMTILEVMTNVNIPPNGESFECLRS
. ||||. ...     ... . |||||. |  |    . ...|.||..|.|.||.|...|.. | ||.. . .|.
IGDFGHVTDMNSNNNNPHQEQEGDSRYMAPEILQGYYHYTHLYKADIFSLGITIYELACNMDLPKNGDWWHQIRQ
Kinase GL50803_115572.AA TKL 1260-1286 33 0.000201 11.85 In-house 259-284 (364) Show / Hide 
Range on Protein: 1260-1286
Range on HMM: 259-284/364
Sequence Identity: 33% (9 aa)

PQFLRTGIPDYSADVYSFGMTILEVMT
. |.. .  . ..||||||. . |..|
E-FCKGFEYSEKCDVYSFGIVLWEILT
Kinase GL50803_115572.AA Gdt 1269-1285 52 0.000322 10.36 In-house 212-228 (289) Show / Hide 
Range on Protein: 1269-1285
Range on HMM: 212-228/289
Sequence Identity: 52% (9 aa)

DYSADVYSFGMTILEVM
..|.||||||..  |.|
QKSTDVYSFGILFYEMM
Kinase GL50803_115572.AA Ciliate-E2 1236-1287 13 0.209912 0.56 In-house 197-292 (365) Show / Hide 
Range on Protein: 1236-1287
Range on HMM: 197-292/365
Sequence Identity: 13% (13 aa)

LSDFGHAQEA--------------PFKESN----------------------TGDSRYICPQFLR-TGI--------PDYSADVYSFGMTILEVMTN
..||| ....               ... .                       |   | .|. |.  ..         ||..|..|.|... | ...
IIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG