Gene GL50803_113553 (G.lamblia)

GL50803_113553

Species: G.lamblia
Alias: GK162, GL50803_113553
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_113553.AA Protein None 650 None Fasta, JSON
GL50803_113553.kin_dom Protein Kinase Domain None 267 None Fasta, JSON

Protein domain

Protein domains of GL50803_113553.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_113553.AA NEK 10-276 37 5.2e-98 331.91 In-house 1-286 (286) Show / Hide 
Range on Protein: 10-276
Range on HMM: 1-286/286
Sequence Identity: 37% (108 aa)

FEPIELLGSGSFGKVHKVRSRKDGRI-----YACKEIEYTKMSSKEVSLLQ-SEVINLRRMSHPHIIAYYSTIHDQDASVVFIINEYCG-KGDLTKY---
.| |. .|.||||||.|||...||..     |. |.| ...||.||   .| .||. |... ||.|..||  . ... .  .|. |||  .||| .    
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IRTYRQKKENIPEATIWSMFHQMALALEYCHSPNKPGFKPGEIVIHRDIKPANVLITDDDQ----LKLADFGFCRTIGLDT-MAQT-KAGSPVYCAPEVL
|  ..||.....| .|| .| ||.||| |.|.    .      ..||||||.|. .|...     .|. |||  .  . .| ||.|   | | | .|||.
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRK-GP---QRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVC

REEDYNEKADIWSLGCVIYELCCV--EYAYSSI--NEKFLLISMMQQ-KRKPIPSC--YSRDLAEVIERMLQVDFKKRPSATELLAHPKF
... ||.|.||||||||.||.|.   . .  .   | . |    |.  . .||||   ||.|| ..|..|||.| ..|||....|..|  
QNKPYNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase GL50803_113553.AA S_TKc 10-276 31 3.7e-80 273.51 SMART 1-231 (231) Show / Hide 
Range on Protein: 10-276
Range on HMM: 1-231/231
Sequence Identity: 31% (88 aa)

FEPIELLGSGSFGKVHKVRSRKDGRIYACKEIEYTKMSSKEVSLLQSEVINLRRMSHPHIIAYYSTIHDQDASVVFIINEYCGK--GDLTKYIRTYRQKK
.| ....|.|.||||.|.| .|.|||.|.|.|            ...|.  |..  ||.|. .| ...|   . .... |||.   ||| .||. .. ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

EN--IPEATIWSMFHQMALALEYCHSPNKPGFKPGEIVIHRDIKPANVLITDDDQLKLADFGFCRTIGLDTMAQTKAGSPVYCAPEVLREEDYNE-KADI
 .  .|| .......|...||||||| .         .||||.||.|.|...  ..|..|||..| .       |  |.| |.|||||    |.  |.|.
LRFPFPE-HARFYMYQICCALEYCHSHG---------IIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDW

WSLGCVIYELCCVEYAYSSINEKFLLISMMQQKRKPIPSCYSRDLAEVIERMLQVDFKKRPSATELLA-------HPKF
||.||..||..| .  ..       .  |... .       |... . |...||.| .|||.| |.|.       || |
WSCGCILYEMLCGYPPFP------QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_113553.AA Pkinase 10-276 27 1.3e-76 265.67 Pfam 1-293 (293) Show / Hide 
Range on Protein: 10-276
Range on HMM: 1-293/293
Sequence Identity: 27% (85 aa)

FEPIELLGSGSFGKVHKVRSRKDGRIYACKEIEYTKMSSKEVSLLQS--EVINLRRMSHPHIIAYYSTIHDQDASVVFIINEYCGKG----DLTKYIRTY
.. .. .||||||.| | . ...|.|.|.|.|.. . .|..   .    |.  ..|..||.|. .| . .|   . . .. |||..|    ||  ||.| 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST-

RQKKENI--PEATIWSMFHQMALALEYCHSPNKPGFKPGEIVIHRDIKPANVLITDDDQL----KLADFGFCRT--IGLDTMAQTKAGSPVYCAPEVLR-
 ... ..  .| .. ... |.. .|||||| .         .||||.||.|.|| .....    |..|||...   .  .. ..| .|.| |.||||.| 
-WRHGCFYFSEWECKFYMYQILRGLEYCHS-M--------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRG

EEDYNEKADIWSLGCVIYELCCVEYAYSSI------NEKFLLISMMQ-QKRKPIPSCYS-------------------RDLAEVIERMLQVDFKKRPSAT
 ..|  |.|.||.||..||..| .  ...       ......   |. . . ..|  .|                   ... ..|...|..| ||||.|.
GQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAE

ELLAHPKF
..| || |
QILQHPWF
Kinase GL50803_113553.AA NEK2 10-276 34 8.6e-75 251.27 In-house 1-319 (319) Show / Hide 
Range on Protein: 10-276
Range on HMM: 1-319/319
Sequence Identity: 34% (110 aa)

FEPIELLGSGSFGKVHKVRSRKDGRIYACKEIEYTKMSSKEVSLLQSEVINLRRMSHPHIIAYYSTIHDQDASVVFIINEYCGKGDLTKYIRTYRQKKEN
 |  . .|.||||.. |||   ||.| . |||.| .| .||  .| ||.  ||   || |. ||  | |  .|.. |. |||  |||   |  .|. .  
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQY

IPEATIWSMFHQMALALEYCHS------------PNKPGFKPGEIVIHRDIKPANVLITDDDQ-------------------------------------
..|  ||  . |. .||  ||               ||  . .....||||||||.    |.                                      
MEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQ

--LKLADFGFCRTIGLDTM-AQTKAGSPVYCAPEVLREEDYNEKADIWSLGCVIYELCCVEYAYSSINEKFLLISMMQQKRKPIPSCYSRDLAEVIERML
   || |||  |    ||  |.|  | | |  ||..    |||| ||||.||.|||.|         | . |     | .  .||. |||.| |.| .|.
VVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFMI

QVDFKKRPSATELLAHPKF
 || ..|||  |.|.||  
NVDHYHRPSIEEILQHPQI
Kinase GL50803_113553.AA ULK 10-276 28 2.8e-65 223.19 In-house 1-324 (324) Show / Hide 
Range on Protein: 10-276
Range on HMM: 1-324/324
Sequence Identity: 28% (96 aa)

FEPIELLGSGSFG-KVHKVR-SRKD--GRIYACKEIEYTKMSSKEVS--------LLQSEVINLRRMS---HPH--IIAYYSTIHDQDASVVFIINEYCG
.. .. ||.|||| ||.| |  ...  . ..||| |.  ||. |.          ||..|. ... .    ||.  |. .|    ...   ..|| ||| 
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

KGDLTKYIRTYRQ-----KKENIPEATIWSMFHQMALALEYCHSPNKPGFKPGEIVIHRDIKPANVLITDDD------------QLKLADFGFCRTIGLD
 ||| .|| ...      .| ...|  . . |.| . .. . |. |         .|||||||.| ||....            .||.|||||....  .
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHN---------IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNN

TMAQTKA----------GSPVYCAPEVLR----EEDYN-EKADIWSLGCVIYELCCVEYAYSS-INEKF----LLISM-------MQQKRKPIP-----S
.|.|..           |.| | ||..|     ...|.  |.|||||||..||.   .| ..| .|. .     || .       ....  ..|      
NMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDP

CYSRDLAEVIERMLQVDFKKRPSATELLAHPKF
  | .. . | ||||.| |.| | .|...|| |
KISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase GL50803_113553.AA NEK1 10-276 33 1.3e-64 220.98 In-house 1-276 (276) Show / Hide 
Range on Protein: 10-276
Range on HMM: 1-276/276
Sequence Identity: 33% (96 aa)

FEPIELLGSGSFGKVHKVRSRKDGRIYACKEIEYTKMSSKEVSLLQSEVINLRRMSHPHIIAYYSTIHDQDASVVFIINEYCGKGDLTKYIRTYRQKKEN
.. |  .|.|||||. .|... ||. |. |||  .||..|| .    ||. |..| || |..|..        . .|. |||  ||| . |   . |   
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

IPEATIWSMFHQMALALEYCHSPNKPGFKPGEIVIHRDIKPANVLIT--DDD---------------QLKLADFGFCRTIGLDTM--AQTKAGSPVYCAP
..| .| . | |. ||| . |. .         ..|||||. |.  |  ...                .||.|||  |.   .||  |.| .| | |  |
FSEDQIMHWFCQICLALNHIHDRK---------ILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLN-HTMEYACTCIGTPYYLSP

EVLREEDYNEKADIWSLGCVIYELCCVEYAYSSINEKFLLISMMQQKRKPIPSCYSRDLAEVIERMLQVDFKKRPSATELLAHPKF
|      || | |||||||| ||||    .  . |.| |     |    |||. ||..| . .  |.... . |||.. .|  |  
EICQNKPYNNKSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase GL50803_113553.AA ULK 10-276 28 8.1e-64 218.33 In-house 1-329 (329) Show / Hide 
Range on Protein: 10-276
Range on HMM: 1-329/329
Sequence Identity: 28% (95 aa)

FEPIELLGSGSFGKVHKVR-SRKD---GRIYACKEIEYTKMSSKEVS--------LLQSEVINLRRMS--------HPHIIAYYSTIHDQDASVVFIINE
.. .. ||.||||||.| |  ...   . ..||| |.  ||. |.          ||..|. .....         ||.|. .|    ...   ..|| |
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCGKGDLTKYIRTYRQ------KKENIPEATIWSMFHQMALALEYCHSPNKPGFKPGEIVIHRDIKPANVLITDDD------------QLKLADFGFCRT
||  ||| .|| ...       .| ...|  . . |.| . .. . |. |         .|||||||.|.||....            .||.|||||...
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHN---------IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKH

IGLDTM----AQTKA------GSPVYCAPEVLR----EEDYN-EKADIWSLGCVIYELCCVEYA----YSSINEKFL--LISM-------MQQKRKPIP-
.  |.|    ..|        |.| | ||..|     ...|.  |.|||||||..||.   ..     ... .....  ||         ....   .| 
VDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPK

----SCYSRDLAEVIERMLQVDFKKRPSATELLAHPKF
       | .. . | ||||.| |.| | .||..|| |
DGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase GL50803_113553.AA CAMK 15-276 19 2e-62 199.65 In-house 1-425 (425) Show / Hide 
Range on Protein: 15-276
Range on HMM: 1-425/425
Sequence Identity: 19% (84 aa)

LLGSGSFGKVHKVRSRKDG------------RIYACKEIEYTKMS--------------------------SKEVSLLQSEVINLRR-------MSHPHI
 ||.||||||.... ....            . .|.| |. .|..                           |    ...|.  ...       ..||.|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IAYYSTIHDQD-----------------ASVVFIIN---EYCGKG----DLTKYIRTYRQKKEN-----------IPEATIWSMFHQMALALEYCHSPNK
|  | .. | .                  . ....    |||  |    ||  ||.  ... |.           ..|.    .|.|.. |..||||   
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHS---

PGFKPGEIVIHRDIKPANVLITDDD-----------------QLKLADFGFCRTIGL------------------------DTMAQTKAGSPVYCA-PEV
        ..|||.|| |.|..|..                 ..|..|||| . .                          . . .|  |.| |.| |||
------HNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEV

LR--------------EEDYNEKADIWSLGCVIYELCCVEYAYSSI-------------NEKFLLISMMQQKRKPIPSCYSR------------------
|.              .. |..|.|.||.|.. | . | .. . .              |.. |.   |. |   .|.  |                   
LNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFH

-----DLAEVIERMLQVDFKKRPSATELLAHPKF
     .    | .||||| .||..... |.|| .
HFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase GL50803_113553.AA STE 10-276 24 2.3e-62 213.51 In-house 1-359 (359) Show / Hide 
Range on Protein: 10-276
Range on HMM: 1-359/359
Sequence Identity: 24% (90 aa)

FEPIELLGSGSFGKVHKVRSRK---------------DGRIYACKEIEYTKMSS---------------KEVSLLQSEVINLRRMS--HPHIIAYYSTIH
.| || .|.|.||.|.| . .|                |.|.| |.... . ..               .|.  .. |.  .....  ||.|. || .  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

-----DQDASVVFIINEYCGKGDLTKYIR-TYRQKKEN---------IPEATIWSMFHQMALA-LEYCHSPNKPGFKPGEIVIHRDIKPANVLITDDDQL
     ... . ..|. ||.. | |.. |. .|  .|..         .||  |  . .|   . |.| || .         .|||||||||.|.      
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---------IIHRDIKPANILL-----V

KLADFGFCRTIGL-----------------DTMAQTKAGSPVYCAPEVLREED------YNEKADIWSLGCVIYELCCVEYAY---SSINEKFLLISM--
||.|||.|  .                   . . .| .|.| . ||||.. ..      |..|.|||||||.| |... .. .   .     |. . .  
KLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYH

MQQ----------KRKPIPSC-------------------YSRDLAEVIERMLQVDFKKRPSATELLA--HPKF
|||          .  |.|.                    .| .. . |.. || | .|||.|..||   || .
MQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase GL50803_113553.AA Ciliate-E2 10-276 22 4.7e-62 211.8 In-house 1-365 (365) Show / Hide 
Range on Protein: 10-276
Range on HMM: 1-365/365
Sequence Identity: 22% (89 aa)

FEPIELLGSGSFGKVHKVRSRKDGR-----------------------IYACKEIEYT--KMSSKEVSLLQ---------SEVINLRRMSHPHIIAYYST
.. |...|.|.||.| |.. .|...                       ||| | ..    .. ..| ....          |  .|....||.|| .| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

IHDQDASVVFIINEYCGKGDLTKYIR---TYRQKK----ENIPEATIWSMFHQMAL---------------ALEYCHSPNKPGFKPGEIVIHRDIKPANV
  ..| . .... |||  ||| .||.   . |...    ... |  |  .. | .                ||||.|| |         .||||||| |.
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKN--------NIIHRDIKPENI

LITDDDQLKLADFGFCRTIGLD--------------------------------TMAQTKAGSPVYCAPEVLREED---------YNEKADIWSLGCVIY
|.     .|..|||... .  |                                 |..| .|.| | |||.|. ..         |..|.||||||...|
LF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILY

ELCCVEYAYSSINEKFLLISMMQQKRK-----PIPSC----------------YSRDLAEVIER----MLQVDFKKRPS-ATELLAHPKF
|... .. .            .||. .     | | .                 | .    | .    |||.| .||.. . ..| || |
EMLFGKPPF------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase GL50803_113553.AA CAMKL 10-276 26 3.2e-59 187.56 In-house 1-297 (297) Show / Hide 
Range on Protein: 10-276
Range on HMM: 1-297/297
Sequence Identity: 26% (82 aa)

FEPIELLGSGSFGKVHKVRS-RKDGRIYACKEIEYTKMSSKEVSL-------------LQSEVINLRRMS---HPHIIAYYSTIHDQDA----SVVFIIN
.. .. || ||||||   .  |  |. .| | |.  |.. .....             .. |.  .....   ||.||  | .| ...     . .... 
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYCGKGD--LTKYIRTYRQKKENIPEATIWSMFHQMALALEYCHSPNKPGFKPGEIVIHRDIKPANVLITDDD--QLKLADFGFCRTIG-L----DTMAQ
|||. |.  |  ||.  . ... .||     .| |.  |..||||           ..|||||| |.|.....  ..|..||||.  .       . .  
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHS---------HGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLK

TKAGSPVYCAPEVLRE--EDYN-EKADIWSLGCVIYELCCVEYAYS---------SINEKFLLISMMQQKRKPIPSCYSRDLAEVIERMLQVDFKKRPSA
|  ||| |.|||..    ..|.  |.||||.| . | . | ..            . . ..... | . .. ||..  | |.   | .||||. .|||..
TFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTI

TELLAHPKF
 ... || .
HQIMNHPWM
Kinase GL50803_113553.AA Ciliate-E2-Unclassified 10-276 24 6.4e-59 202.06 In-house 1-352 (352) Show / Hide 
Range on Protein: 10-276
Range on HMM: 1-352/352
Sequence Identity: 24% (87 aa)

FEPIELLGSGSFGKVHKVRSRKDGRIY-----ACKEIEYT---KMSSKEVSLLQSEVINLRR---------------MSHPHIIAYYSTIHDQDASVVFI
.. |. .|.|.||||.|.. .|..  |     ..| ..|    .|...   ... . .| .                 .|||.. ..   ..||   ..|
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

INEYCGKGDLTKYIRTY-------------RQKKENIPEATIW-----SMFHQMALALEYCHSPNKPGFKPGEIVIHRDIKPANVLITDDD---QLKLAD
. |||  ||| .||. .             ..... ..|  .       .| |  ..|||.|. |.        .||||||| |.|....    ..|..|
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNN--------IIHRDIKPENILFDNNGKNYYIKIID

FGFCRTIGLD----------------TMAQTKAGSPVYC----APEVLREEDYN----EKADIWSLGCVIYELCCVEYAYSSIN----------------
||... .. .                 |..|..|.| |     |||||... |.    .|.||||||...||..  .| ... |                
FGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAY

EKFLLISMMQQ-----KRKP--IPSCYSRDLAEVIE----RMLQVDFKKRPSATELLAHPKF
.| |.   .|.     | ..  ||   |   .. |.    .||... .||... ..| || |
RKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase GL50803_113553.AA Pkinase_Tyr 10-215 26 5.8e-21 71.61 Pfam 1-208 (270) Show / Hide 
Range on Protein: 10-215
Range on HMM: 1-208/270
Sequence Identity: 26% (58 aa)

FEPIELLGSGSFGKVHKVRSR----KDGRIYACKEIEYTKMSSK--EVSLLQSEVINLRRM-SHPHIIAYYSTIHDQDAS-VVFIINEYCGKGDLTKYIR
 . .. ||.|.||.|.| . .    ...   | | .  . |..     .... |.  .. . .||.|. .|  . ||. .  ..|. ||. .||| .| |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

TYRQKKENIPEATIWSMFHQMALALEYCHSPNKPGFKPGEIVIHRDIKPANVLITDDDQLKLADFGFCRTI-GLDTM--AQTKAGSPV-YCAPEVLREED
. |  |....  .. .| .| | ..|| .| |          ||||.   |.|.|.. . | .||| .|.|   |.   .....  |.  .|||....  
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---------CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK

YNEKADIWSLGCVIYELC
...| |.|| | ...|..
FTTKSDVWSFGVLMWEIF
Kinase GL50803_113553.AA TyrKc 10-276 22 9.5e-17 48.11 SMART 1-280 (280) Show / Hide 
Range on Protein: 10-276
Range on HMM: 1-280/280
Sequence Identity: 22% (67 aa)

FEPIELLGSGSFGKVHKVRSRKDGRIYACKEIEYTKMSSKEVSLLQSEVINLRRM--SHPHIIAYYSTIHDQ-----DASVVFIINEYCGKGDLTKYIRT
 . .. ||.| ||.|.| . .   .  | | .   .     .  . .|   ...   .||.|.. |  . .|      .  ..|. ||. .||| .|.| 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

YRQKKENIPEATIWSMFHQMALALEYCHSPNKPGFKPGEIVIHRDIKPANVLITDDDQLKLADFGFCRTIGLD--------TMA-----QTKAGSPV-YC
.| |   .. ..  |. .| |   || ||           .||||.   |.|.... . | .||| .| |. |        .       ..|.  |.  .
HRPK---LCMKDLLSFCWQIACGMEYLHSK---------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM

APEVLREEDYNEKADIWSLGCVIYELCCVEYAYSSI-----NEKFLLISMMQQK-RKPIPSC--------YSRDLAEVIERMLQVDFKKRPSATELLAHP
|||....  ...| |.|| | ...|..       .       . . .|   .|  | |.|           . .. .....  . | ..||. .|.  | 
APECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HE

KF
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CF
Ank GL50803_113553.AA Ank 471-494 50 0.003674 15.66 Pfam 1-24 (33) Show / Hide 
Range on Protein: 471-494
Range on HMM: 1-24/33
Sequence Identity: 50% (12 aa)

DGVTRLMLAAQKGLTAVVQHLLSQ
|| | |.||...| | ||. ||..
DGFTPLHLACRCGHTEVVKMLLQH
Ank GL50803_113553.AA Ank 502-525 29 0.001099 17.55 Pfam 1-24 (33) Show / Hide 
Range on Protein: 502-525
Range on HMM: 1-24/33
Sequence Identity: 29% (7 aa)

SGKTALMYAAENGQNACVRLLMDK
 | |.|..|...|.  .|..|...
DGFTPLHLACRCGHTEVVKMLLQH
Ank GL50803_113553.AA Ank 533-553 38 0.35508 8.5 Pfam 1-21 (33) Show / Hide 
Range on Protein: 533-553
Range on HMM: 1-21/33
Sequence Identity: 38% (8 aa)

KGTTALMRASIGGRFETCKIL
 | |.|. |.. |. | .| |
DGFTPLHLACRCGHTEVVKML
Ank GL50803_113553.AA Ank 564-584 38 0.002846 16.06 Pfam 1-21 (33) Show / Hide 
Range on Protein: 564-584
Range on HMM: 1-21/33
Sequence Identity: 38% (8 aa)

EGDTALTYATIRGNTEIIRLL
.|.|.| .| ..|.||....|
DGFTPLHLACRCGHTEVVKML
Ank GL50803_113553.AA Ank 595-630 36 0.000999 17.7 Pfam 1-33 (33) Show / Hide 
Range on Protein: 595-630
Range on HMM: 1-33/33
Sequence Identity: 36% (13 aa)

DGKTALMSAASRGFLEAVKILYDREGKLVDKNGRDA
|| |.|. |...| .| || | .   .  | | .| 
DGFTPLHLACRCGHTEVVKMLLQ---HGADVNAQDD