Gene GL50803_11311 (G.lamblia)

GL50803_11311

Species: G.lamblia
Alias: GK169, GL50803_11311
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-GL2

Sequence

Name Sequence Type Origin Length Description Download
GL50803_11311.AA Protein None 367 None Fasta, JSON
GL50803_11311.kin_dom Protein Kinase Domain None 267 None Fasta, JSON

Protein domain

Protein domains of GL50803_11311.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_11311.AA NEK 27-293 43 1.5e-129 436.72 In-house 1-286 (286) Show / Hide 
Range on Protein: 27-293
Range on HMM: 1-286/286
Sequence Identity: 43% (128 aa)

YIFLNIIGSGSFGKVHKVQSRTNGRI-----FACKEIDYAKMSEKEKKLLV-HEVNTLKELSHENIVSYIDRFVERENAKMFIVMEYCE-NGDLAKY---
|  .  ||.||||||.||... .|..     .. |.|.. .||||||. .. .||. ||.| |.|||.|.|.|.|..| ...||||||| .|||..    
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IKRHKTDRRYIAEEKIWSVFVQLLHALNYCHSI--HSEDESGVHKVIHRDIKPGNVFLTQDGS----IKLGDFGLCRTLGED-SVAQT-NVGTPLYMAIE
||..|  . |. ||.|| .|.|.. ||.|.|.           .|..|||||| |.||| ...    .|.||||. . |. . . |.|  |||| ||. |
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGP------QRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPE

VLQKQSYTEKADIWSLGCVIYELCALQP--PFVAS--NIESLKTKVKQG-ARPAIPSH--YSSDLSAAIDLMLNPNPSARPSATDILQHSRI
|.| ..|..|.||||||||.||.|.|.|  || |.  |..|| .|...|   | ||||  ||.||.  | .||...|. |||...||... |
VCQNKPYNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase GL50803_11311.AA NEK2 27-293 41 2.7e-120 405.96 In-house 1-319 (319) Show / Hide 
Range on Protein: 27-293
Range on HMM: 1-319/319
Sequence Identity: 41% (131 aa)

YIFLNIIGSGSFGKVHKVQSRTNGRIFACKEIDYAKMSEKEKKLLVHEVNTLKELSHENIVSYIDRFVERENAKMFIVMEYCENGDLAKYIKRHKTDRRY
|  |  ||.||||.. ||     |.|.. |||.| .| |||. .|| |.| |..| |.||| | |. . |.|    ||||||| |||.  ||. . .|.|
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQY

IAEEKIWSVFVQLLHALNYCHS------------IHSEDESGVHKVIHRDIKPGNVFLTQDGS-------------------------------------
. || || .. ||. ||  ||                    | | ..||||||.|.|| .|..                                     
MEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQ

--IKLGDFGLCRTLG-EDSVAQTNVGTPLYMAIEVLQKQSYTEKADIWSLGCVIYELCALQPPFVASNIESLKTKVKQGARPAIPSHYSSDLSAAIDLML
  .||||||| | |  . | |.| |||| ||  |... |.| || ||||.||.|||.||| ||| | |   | .|.|||    ||. ||..|.. | .|.
VVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFMI

NPNPSARPSATDILQHSRI
| ... |||   ||||..|
NVDHYHRPSIEEILQHPQI
Kinase GL50803_11311.AA NEK1 27-293 40 5.3e-95 321.91 In-house 1-276 (276) Show / Hide 
Range on Protein: 27-293
Range on HMM: 1-276/276
Sequence Identity: 40% (114 aa)

YIFLNIIGSGSFGKVHKVQSRTNGRIFACKEIDYAKMSEKEKKLLVHEVNTLKELSHENIVSYIDRFVERENAKMFIVMEYCENGDLAKYIKRHKTDRRY
|. . .||.|||||. .|...  |. .. |||   ||.|||.   . ||. |. . |.|||.| . |.|. .   .||||||..|||.. |.| |     
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

IAEEKIWSVFVQLLHALNYCHSIHSEDESGVHKVIHRDIKPGNVFLT--QDG---------------SIKLGDFGLCRTLGE-DSVAQTNVGTPLYMAIE
. |  | . |.|.  |||. |.          |..|||||. |.|||  ..|                .||||||  |.| . .. |.| .||| |   |
FSEDQIMHWFCQICLALNHIHD---------RKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPE

VLQKQSYTEKADIWSLGCVIYELCALQPPFVASNIESLKTKVKQGARPAIPSHYSSDLSAAIDLMLNPNPSARPSATDILQHSRI
  |.. |. | |||||||| ||||.|  || | |   |  |. ||  | ||.||| .|.  .  |.. ||. |||...||.   |
ICQNKPYNNKSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase GL50803_11311.AA S_TKc 27-293 33 2.5e-87 297.35 SMART 1-231 (231) Show / Hide 
Range on Protein: 27-293
Range on HMM: 1-231/231
Sequence Identity: 33% (94 aa)

YIFLNIIGSGSFGKVHKVQSRTNGRIFACKEIDYAKMSEKEKKLLVHEVNTLKELSHENIVSYIDRFVERENAKMFIVMEYCEN--GDLAKYIKRHKTDR
| .|..||.|.||||.|.. .  |||.|.|.|.         . .  |.. ||.  |.||| ..| |..    ....|||||..  ||| .|||.... .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

--RYIAEEKIWSVFVQLLHALNYCHSIHSEDESGVHKVIHRDIKPGNVFLTQDGSIKLGDFGLCRTLGEDSVAQTNVGTPLYMAIEVLQKQSYTE-KADI
  ... |  ..... |.. ||.||||         |..||||.|| |..|..   ||..||||.| |       | .||| ||| |||   .|.  |.|.
LRFPFPE-HARFYMYQICCALEYCHS---------HGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDW

WSLGCVIYELCALQPPFVASNIESLKTKVKQGARPAIPSHYSSDLSAAIDLMLNPNPSARPSATDILQ-------HSRI
||.||..||... .|||   ... .  |..           |...   |. .|. .|. ||.| ..||       |  .
WSCGCILYEMLCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_11311.AA Pkinase 27-293 29 7e-80 276.48 Pfam 1-293 (293) Show / Hide 
Range on Protein: 27-293
Range on HMM: 1-293/293
Sequence Identity: 29% (92 aa)

YIFLNIIGSGSFGKVHKVQSRTNGRIFACKEIDYAKMSEKEKKLLVH--EVNTLKELSHENIVSYIDRFVERENAKMFIVMEYCENG----DLAKYIKRH
| .. .|||||||.| | . . .|.|.|.|.|.. . ...... ...  |.  .|.|.|.||| ..| | .  . .. .||||||.|    ||. ||.. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST-

KTDRRYI--AEEKIWSVFVQLLHALNYCHSIHSEDESGVHKVIHRDIKPGNVFLTQDGSI----KLGDFGLCRT--LGEDSVAQTNVGTPLYMAIEVLQ-
  ... .   |. . ... |.| .|.||||          ..||||.|| |... ..| |    |..||||..   .  .| ..| .||| ||| ||.. 
-WRHGCFYFSEWECKFYMYQILRGLEYCHSM---------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRG

KQSYTEKADIWSLGCVIYELCALQPPFVAS----NIESLKTKVKQGARPAIPSHYS-----------------------SDLSAAIDLMLNPNPSARPSA
 | |. |.|.||.||..||..  .|||  .    |  . . ....  .| ......                       ...   |. .|...|. ||.|
GQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTA

TDILQHSRI
..||||  .
EQILQHPWF
Kinase GL50803_11311.AA STE 27-293 23 6.5e-75 255.2 In-house 1-359 (359) Show / Hide 
Range on Protein: 27-293
Range on HMM: 1-359/359
Sequence Identity: 23% (88 aa)

YIFLNIIGSGSFGKVHKVQSRT---------------NGRIFACKEIDYAKMS---------------EKEKKLLVHEVNTLKELS--HENIVSYIDRFV
. .. .||.|.||.|.|   .                .|.|.| |.... . .               ..|.. . .|....|...  |.||| |.. ..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

-----ERENAKMFIVMEYCENGDLAKYIK-RHKTDR---------RYIAEEKIWSVFVQLLHA-LNYCHSIHSEDESGVHKVIHRDIKPGNVFLTQDGSI
     . .. . .|.|||...| | . || .... .          .. |. |  . .|.|.. |.| || |         .|||||||.|..|     .
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---------IIHRDIKPANILL-----V

KLGDFGLCRTLGE-----------------DSVAQTNVGTPLYMAIEVLQK------QSYTEKADIWSLGCVIYELCALQPPFVA-SNIESLKTKVKQ--
|| |||.|  | .                 ..  .| |||| .|| ||.|.      . |..|.|||||||.| |..  .||.   .. . .  . .   
KLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYH

------------GARPAIPS-------------------HYSSDLSAAIDLMLNPNPSARPSATDILQ--HSRI
            |  | .|.                   ..|...   |.. |. .|. ||.|.. |.  |. |
MQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase GL50803_11311.AA CAMK 32-293 20 1.3e-71 229.76 In-house 1-425 (425) Show / Hide 
Range on Protein: 32-293
Range on HMM: 1-425/425
Sequence Identity: 20% (89 aa)

IIGSGSFGKVHKVQSR-TNGRI-----------FACKEIDYAKMS--------------------------EKEKKLLVHEVNTLKELS-------HENI
..|.||||||.... . |.|..           .|.| ||  |..                          .| .| . .|.. .| |.       |.||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VSYIDRFVERE-----------------NAKMFIVM---EYCENG----DLAKYIKRH------------KTDRRYIAEEKIWSVFVQLLHALNYCHSIH
.. .. .  ..                 . .|..||   |||..|    ||  ||..|              .|... |.    .| |.. |..||||  
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHS--

SEDESGVHKVIHRDIKPGNVFLTQD-----------------GSIKLGDFGLCRTLGE------------------------DSVAQTNVGTPLYMA-IE
       |...|||.|| |. |...                 . ||. |||. . . .                        .   .| .||| |||  |
-------HNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPE

VLQKQS--------------YTEKADIWSLGCVIYELCALQPPFVAS-------------NIESLKTKVKQGARPAIPSHYSS-----------------
||....              |..|.|.||.|.. | .    ||| ..             |.. |. |...|    .|.. |                  
VLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEF

------DLSAAIDLMLNPNPSARPSATDILQHSRI
      .    |  ||...|. |......|.|  .
HHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase GL50803_11311.AA ULK 27-293 28 2.9e-68 233.12 In-house 1-329 (329) Show / Hide 
Range on Protein: 27-293
Range on HMM: 1-329/329
Sequence Identity: 28% (96 aa)

YIFLNIIGSGSFGKVHKVQ-SRTN---GRIFACKEIDYAKMSEKEKK--------LLVHEVNTLKELS--------HENIVSYIDRFVERENA-KMFIVM
|.  ...|.||||||.|    .|.   . ..||| ||  ||..|..         ||  |. ..|.|         |.||| ..| . |  |    .|.|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYD-WFETSNHNNIYIIM

EYCENGDLAKYIKRHKT------DRRYIAEEKIWSVFVQLLHALNYCHSIHSEDESGVHKVIHRDIKPGNVFLTQD------------GSIKLGDFGLCR
|||. ||| .|||..|.        ... |... ..| |.| .. . |.         |..||||||| |. .. .            | .|..|||...
EYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHK---------HNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAK

TLGED----SVAQTNV------GTPLYMAIEVLQ----KQSYT-EKADIWSLGCVIYELCALQPPFVASNIESLK-----TKVKQGARPA---------I
.. .|     ...| |      ||||||| ..||    .. |.  |.|||||||..||.   .|||.|. .....       .... ...         .
HVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQF

P-----SHYSSDLSAAIDLMLNPNPSARPSATDILQHSRI
|      . |...   |  ||  ... | | .....|  .
PKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase GL50803_11311.AA ULK 27-293 28 3.7e-68 232.74 In-house 1-324 (324) Show / Hide 
Range on Protein: 27-293
Range on HMM: 1-324/324
Sequence Identity: 28% (96 aa)

YIFLNIIGSGSFG-KVHKVQ-SRTN--GRIFACKEIDYAKMSEKEKK--------LLVHEVNTLKELS---HEN--IVSYIDRFVERENA-KMFIVMEYC
|.  ...|.|||| ||.|    .||  . ..||| ||  ||..|...        ||  |....|.|    |.|  || ..| . |  |    .|.||||
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYD-WFETSNHNNIYIIMEYC

ENGDLAKYIKRHKT-----DRRYIAEEKIWSVFVQLLHALNYCHSIHSEDESGVHKVIHRDIKPGNVFLTQD------------GSIKLGDFGLCRTLGE
. ||| .|||..|.       ... |... ..| |.. .. . |.         |..||||||| |  .. .            | .|..|||..... .
NGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHK---------HNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDN

D----SVAQTNV------GTPLYMAIEVLQ----KQSYT-EKADIWSLGCVIYELCALQPPFVASNIESLK----TKVKQG---------ARPAIP----
.     . || |      ||||||| ..||    .. |.  |.|||||||..||.   ..||... .....      ...|             .|    
NNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPK

-SHYSSDLSAAIDLMLNPNPSARPSATDILQHSRI
  . |...   |  ||  ... | | ..|..|  .
DPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase GL50803_11311.AA NEK4 27-293 36 5e-66 225.67 In-house 1-257 (257) Show / Hide 
Range on Protein: 27-293
Range on HMM: 1-257/257
Sequence Identity: 36% (97 aa)

YIFLNIIGSGSFGKVHKVQSRTNGRIFACKEIDYAKMSEKEKKLLVHEVNTLKELSHENIVSYIDRFVERENAKMFIVMEYCENGDLAKYIKRHKTDRRY
| ..  .| ||.| |  |..|  .. .  | ..  . | .|.|   ||.. |  | | |||.| . .   ..  ..||| .|| ||| .  |. | .   
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKNQ--F

IAEEKIWSVFVQLLHALNYCHSIHSEDESGVHKVIHRDIKPGNVFLTQDGSIKLGDFGLCRTLG-EDSVAQTNVGTPLYMAIEVLQKQSYTEKADIWSLG
. |. .   |||   || | |           ...||| |  |.|||.   ||.||||. | |     .|.| .||| ||  |.   . |  | ||||||
LEEYQVVEWFVQIAMALQYMHE---------KHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLG

CVIYELCALQPPFVASNIESLKTKVKQGARPAIPSHYSSDLSAAIDLMLNPNPSARPSATDILQHSRI
| .||.  |   | | .. ||  .. ||  | .|  || ||   .  ||.  |  |||  ||.|   |
CCVYEMITLKHAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase GL50803_11311.AA Ciliate-E2 27-293 24 9e-63 214.31 In-house 1-365 (365) Show / Hide 
Range on Protein: 27-293
Range on HMM: 1-365/365
Sequence Identity: 24% (93 aa)

YIFLNIIGSGSFGKVHKVQSRTNGRIFACKEIDYAK-------------------MSEKEKKLLVHEVNTLK----------------ELSHENIVSYID
|.|...||.|.||.| |.. . ... || | ||  |                   |...... .  | . ..                .|.| ||. ...
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

RFVERENAKMFIVMEYCENGDLAKYIK--RHKT------DRRYIAEEKIWSVFVQLLH---------------ALNYCHSIHSEDESGVHK-VIHRDIKP
 | |  . ....|||||. ||| .|||  ..|       |  |. |..|  .. |.|                ||.|.||          . .|||||||
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHS---------KNNIIHRDIKP

GNVFLTQDGSIKLGDFGLCRTLGED--------------------------------SVAQTNVGTPLYMAIEVLQKQS---------YTEKADIWSLGC
 |...     ||. ||||.. . .|                                 ...| .||| ||| |.|....         |..|.||||||.
ENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGV

VIYELCALQPPFVASNIESLKTKVK-QGARPA-----------IPSHYSSDLSAAIDL----MLNPNPSARPS-ATDILQHSRI
..||..  .|||    .. .. |.. . . .            .. . | .    |      ||. .|. |.. . .||.|  .
ILYEMLFGKPPF---QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase GL50803_11311.AA Ciliate-E2-Unclassified 27-293 24 1.7e-61 210.64 In-house 1-352 (352) Show / Hide 
Range on Protein: 27-293
Range on HMM: 1-352/352
Sequence Identity: 24% (88 aa)

YIFLNIIGSGSFGKVHKVQSRTNGRIF-----ACKEIDYA-KMSEKEKKLLVHEVNTLKELSHENIVS------------------YIDRFVERENAKMF
|... .||.|.||||.|.| . ..  .     ..| ..|. |  ....  .. | ........ ....                  . . ....   ...
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIY

IVMEYCENGDLAKYIK-------------RHKTDRRYIAEEKIW-----SVFVQLLHALNYCHSIHSEDESGVHK-VIHRDIKPGNVFLTQDG---SIKL
|||||||.||| .|||             ...  |. . |...        | |.| .|.|.|.          . .||||||| |......|    ||.
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHH---------KNNIIHRDIKPENILFDNNGKNYYIKI

GDFGLCRTLGED----------------SVAQTNVGTPLYM----AIEVLQKQSYT----EKADIWSLGCVIYELCALQPPFVASNIES-----------
 |||... ....                  ..|..||| ||    | ||||.| |     .|.||||||...||..  ..|| . | |.           
IDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINN

-----LKTKVKQG---ARPAIP--SHYSSDLSAA--ID----LMLNPNPSARPSATDILQHSRI
     |. . ||.    ... .   .. .. .|.  |      ||. ||. |... .||.|  .
AYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase GL50803_11311.AA TyrKc 27-293 22 4.6e-25 90.5 SMART 1-280 (280) Show / Hide 
Range on Protein: 27-293
Range on HMM: 1-280/280
Sequence Identity: 22% (69 aa)

YIFLNIIGSGSFGKVHKVQSRTNGRIFACKEID-YAKMSEKEKKLLVHEVNTLKEL--SHENIVSYIDRFVER-EN----AKMFIVMEYCENGDLAKYIK
  .. ..|.| ||.|.| . .   .  | | .  .|      .. . .| . ...|  .|.|||  .   ..  .|      ..|||||...||| .|..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

RHKTDRRYIAEEKIWSVFVQLLHALNYCHSIHSEDESGVHKVIHRDIKPGNVFLTQDGSIKLGDFGLCRTLGED-----SVAQTNV----GTP--L---Y
.|. .   .  ..  |  .|     .| ||          ..||||.   |. .. .. .| .||||.| ...|     |     .    |.   |    
KHRPK---LCMKDLLSFCWQIACGMEYLHSK---------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW

MAIEVLQKQSYTEKADIWSLGCVIYELCAL-QPPFVA-----SNIESLKTKVKQGARPAIPSH--------YSSDLSAAIDLMLNPNPSARPSATDILQH
||.|....  .|.| |.|| | ...|.. . |.|         . . .  .|||| |. .| .         ....   .    . .|. ||. ..|  |
MAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--H

SRI
...
ECF
Kinase GL50803_11311.AA Pkinase_Tyr 169-293 23 5.6e-13 44.58 Pfam 141-270 (270) Show / Hide 
Range on Protein: 169-293
Range on HMM: 141-270/270
Sequence Identity: 23% (31 aa)

NVFLTQDGSIKLGDFGLCRTLGEDSVA-QTNVGTPL---YMAIEVLQKQSYTEKADIWSLGCVIYELCAL-QPP-FVASNIESLKTKV-KQGARPAIPSH
|. .| .. .| .||||.|.. .|.   ..  |..|    || |...   .|.| |.|| | ...|.. . . | .     | .. .. ..| | ..| .
NCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPEN

YSSDLSAAIDLMLNPNPSARPSATDILQHSRI
 . ..   . .  ...|. ||. ..|  |...
CPDEIYDLMKQCWHYDPEDRPTFSEI--HEQL
Kinase GL50803_11311.AA Pkinase_Tyr 27-121 27 3.1e-11 38.68 Pfam 1-105 (270) Show / Hide 
Range on Protein: 27-121
Range on HMM: 1-105/270
Sequence Identity: 27% (29 aa)

YIFLNIIGSGSFGKVHKVQSR----TNGRIFACKEIDYAKMSEKE--KKLLVHEVNTLKEL-SHENIVSYIDRFV-ERE-NAKMFIVMEYCENGDLAKYI
 .|.  .|.|.||.|.|   .     ..   | | .   . ....  .. . .|....|.| .|.|||...   . ..| | ...|||||...||| .| 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGDLLDYL

KRH---K
..|   |
RKHREDK