Gene GL50803_113030 (G.lamblia)
GL50803_113030
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| GL50803_113030.AA | Protein | None | 680 | None | Fasta, JSON |
| GL50803_113030.kin_dom | Protein Kinase Domain | None | 254 | None | Fasta, JSON |
Protein domains of GL50803_113030.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | GL50803_113030.AA | Pkinase | 181-302 | 20 | 1.1e-16 | 60.14 | Pfam | 136-293 (293) | Show / Hide |
Range on Protein: 181-302 Range on HMM: 136-293/293 Sequence Identity: 20% (33 aa) PDNIMFAGDGRR---VVLADFGFCE---GISSGAAK--AGDPAYMAPETLL-RGDVTPASAVWSLGAVAYELATLRKPDFLRGK------EPAEVFVTEW |.||.. .| | ..|||... ... .. .| | ||||| .. . . .|.. .||.| . ||... ..| | |. .. .... PENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFP-GHCWHDNHDQMQMICRIM RPDLSGIAD-----------------------DLARSVLEKMLVLDPAERPTAKGLAHL--I .|.|. . . ........| .||..||||. . . . GPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| S_TKc | GL50803_113030.AA | S_TKc | 49-302 | 21 | 8.2e-15 | 40.29 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 49-302 Range on HMM: 1-231/231 Sequence Identity: 21% (58 aa) ECKDEPLGTGGFYTIHASNERP---KFTMRKIQLDGLDQHRVDAIKRRLAALLSASHPGVLKYHQVLTDGNTILVVTDRCCG---DLRQFITDHRD--IH . ...| |.| . . .. .. . .| . |.| .. | . || . |.. | | . . .|.. | | ||...| ... . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR ESVPNELVLSLLGQLAGALAYLHGLGGDVDDDLLPRAI----LEPDNIMFAGDGRRVVLADFGFCEGISSGAAKAGDPAYMAPETLLRGDVTP-ASAVWS | . ... |.. ||.|.| .| | | |.||.. .. ..|||.. . | | ||||| | .. .. .|| FPFPE-HARFYMYQICCALEYCHSHG-----------IIHRDLKPENILLDE---HIKICDFGLARQL---TTFCGTPWYMAPEVL---GYGKCKCDWWS LGAVAYELATLRKPDFLRGKEPAEVFVTEWRPDLSGIADDLARSVLEKMLVLDPAERPTAKGLAH---------LI .| . ||... ..| | .....| .. |.. ..|.|. ||..|||| . . . CGCILYEMLC-GYPPFP---QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | GL50803_113030.AA | AGC | 181-245 | 20 | 9.5e-13 | 27.79 | In-house | 183-300 (395) | Show / Hide |
Range on Protein: 181-245 Range on HMM: 183-300/395 Sequence Identity: 20% (25 aa) PDNIMFAGDGRRVVLADFGFCEGISSGA----------------------------------------------------AK--AG--DPAYMAPETLLR |.||.. | . |.|||.| . .. .. | | ||||| | PENILLDED-GHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL-- GDVTPASAVWS--LGAVAYELAT ..| || ||.. ||. | --YGKACDWWSFGLGCLMYEMLT |
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| Kinase | GL50803_113030.AA | STE | 181-296 | 20 | 2e-11 | 36.76 | In-house | 180-349 (359) | Show / Hide |
Range on Protein: 181-296 Range on HMM: 180-349/359 Sequence Identity: 20% (37 aa) PDNIMFAGDGRRVVLADFGFCEGISSGAA----------------K----AGDPAYMAPETLLR------GDVTPASAVWSLGAVAYELATLRKP----D |.||.. | |.|||.| ... | | .| | .|||| ... .. . . .|||| .. |.|| . | PANILL------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMH FLRGKEPAE------------VFVTEWRPDLSGIAD-------------------DLARSVLEKMLVLDPAERPTAK .| .. | . | | . . . ..| |. || .||||. PMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTAS |
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| Kinase | GL50803_113030.AA | Ciliate-E2 | 181-296 | 16 | 8.2e-11 | 33.33 | In-house | 189-357 (365) | Show / Hide |
Range on Protein: 181-296 Range on HMM: 189-357/365 Sequence Identity: 16% (31 aa) PDNIMFAGDGRRVVLADFGFCEGISS--------GAAK---------------------------AGDPAYMAPETLLRGD---------VTPASAVWSL |.||.| . ..|||.. .. .| .| | ||||| | ... . .. .||| PENILF------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSL GAVAYELATLRKPDFLRGKEPAEVFVTEWRPDLS------------------GIADDLARSVLEK----MLVLDPAERPT-AK | . ||. . . | . . |.. .. . . | ||. || .|.| .. GVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWE |
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| Kinase | GL50803_113030.AA | Ciliate-E2-Unclassified | 179-296 | 20 | 3e-10 | 31.77 | In-house | 170-344 (352) | Show / Hide |
Range on Protein: 179-296 Range on HMM: 170-344/352 Sequence Identity: 20% (35 aa) LEPDNIMFAGDGR--RVVLADFGFCEGISS-------------------GAAKAGDPAYM----APETLLRGDVT----PASAVWSLGAVAYELATLRKP . |.||.| .|. .. ..|||.. . . ..| | || ||| | . .. .|||| ..||. . . | IKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYP DF----------------------LRGKEPAEVFVTEWRP------DLSGIADDLARSVLEKMLVLDPAERPTAK . |. . . . . | ..| | |. . | |||. .| .|.|.. FYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFE |
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| Kinase | GL50803_113030.AA | CAMK | 181-241 | 17 | 2.5e-09 | 25.46 | In-house | 207-325 (425) | Show / Hide |
Range on Protein: 181-241
Range on HMM: 207-325/425
Sequence Identity: 17% (21 aa)
PDNIMFAGDG----------------RRVVLADFGFCEGISSGA---------------------------AKAGDPAYMA-PETLLR------------
|.||.. .. . ..|||| . .| | |.||| || |..
PENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDE
--GDVTPASAVWSLGAVAY
..|.. .||.| . |
EKPYYGPKCDMWSCGVILY
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| TyrKc | GL50803_113030.AA | TyrKc | 49-302 | 17 | 4.1e-09 | -75.24 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 49-302 Range on HMM: 1-280/280 Sequence Identity: 17% (53 aa) ECKDEPLGTGGFYTIHASNERPKF-----TMRKIQLDGLDQHRVDAIKRRLAALLSA--SHPGVLKYHQVLTDG-------NTILVVTDRCC-GDLRQFI ... || | | ... . .... . .. | . . . .|| ... . | |.. ...|. .. |||.... ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL TDHRDIHESVPNELVLSLLGQLAGALAYLHGLGGDVDDDLLPRAI---LEPDNIMFAGDGRRVVLADFGFCEGISSG--------AAKA----GDP---- .||. .... || | | .||| . | | |.. . .. .| .||| . | .. .. | RKHRPK---LCMKDLLSFCWQIACGMEYLHSK----------NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLP -AYMAPETLLRGDVTPASAVWSLGAVAYELATLRKPDF-------LRGKEPAEVFVTEWRPDLSGI---------ADDLARSVLEKMLVLDPAERPTAKG ||||.. | |..| ||| | . .|. |. .. . .| | . |.. |.. . . .. ||..||| . IRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSE LAHLI . ... IHECF |
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| Kinase | GL50803_113030.AA | TK-Unique | 215-246 | 42 | 2.5e-08 | 24.95 | In-house | 201-235 (294) | Show / Hide |
Range on Protein: 215-246 Range on HMM: 201-235/294 Sequence Identity: 42% (15 aa) AYMAPETLL--RGDV-TPASAVWSLGAVAYELATL ..|||| |. .| |. | |||.| . .|..|| RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTL |
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| Kinase | GL50803_113030.AA | NEK6 | 86-249 | 28 | 4.6e-08 | 22.36 | In-house | 43-202 (252) | Show / Hide |
Range on Protein: 86-249 Range on HMM: 43-202/252 Sequence Identity: 28% (49 aa) RVDAIKRRLAALLSASHPGVLKYHQVLTDGNTILVVTDRC-CGDLRQFITDHRDIHESVPNELVLSLLGQLAGALAYLHGLGGDVDDDLLPRAILEPDNI | | || . | . || |.|| . . | . .| . ||. . | . .| . ||. ||. .| .. | | | |. RQDCIK-EIDLLKQLNHPNVIKYYASFIENNELNIVLELADAGDMSRMIKHFKKQKRLIPERTIWKYFVQLCSALEHMH------SKRVMHRDI-KPANV MFAGDGRRVVLADFGFCEGISSGAAKA----GDPAYMAPETLLRGDVTPASAVWSLGAVAYELATLRKP ..| | | | | || | | | ||.|| . | .|||| . ||.| | | FITANG-IVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSP |
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| Kinase | GL50803_113030.AA | MSK | 181-243 | 32 | 6.9e-08 | 22.74 | In-house | 129-203 (277) | Show / Hide |
Range on Protein: 181-243 Range on HMM: 129-203/277 Sequence Identity: 32% (24 aa) PDNIMFAGD--GRRVVLADFGFCEGISSGAAKAGDP-----AYMAPETLLR---GDV--TPASAVWSLGAVAYEL | ||.|... ...|.| |||| .. .. . ||||| | | .|. .| .||||.. |.. PENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVILYTM |
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| Kinase | GL50803_113030.AA | TKL | 181-302 | 14 | 2.2e-07 | 22.65 | In-house | 168-364 (364) | Show / Hide |
Range on Protein: 181-302 Range on HMM: 168-364/364 Sequence Identity: 14% (28 aa) PDNIMFAGDGR-------------RVVLADFGFCEGISSGAA-----------------------KAGDPAYMAPETLL----------------RGDVT ..||. ... .. ..|||.. .| . | |..|||| | .. . SKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYS PASAVWSLGAVAYELATLRKPDF-LRGKEPA------EVFVT----EWRPDLS------------GIADDLARSVLEKMLVLDPAERPTAKGLAHLI ... |.| | | .|..| ..| . . .. | |. || . ... .. ... || .||... . . . EKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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| Kinase | GL50803_113030.AA | TK | 186-302 | 17 | 6.1e-07 | 18.49 | In-house | 283-486 (486) | Show / Hide |
Range on Protein: 186-302 Range on HMM: 283-486/486 Sequence Identity: 17% (35 aa) FAGDGRRVVLADFGFC---------------EGISSGAAKAGDPA-----------------------YMAPETLL---------RGDVTPASAVWSLGA | |.|. . .|||| . . ... ..|.|. .||||.|. | |..| |||.| FDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGV VAYELATLRKPDFLR----------GKEPAEVFVTEWR------------------PDLSGIAD-------------DLARSVLEKMLVLDPAERPTAKG . .|. |. . . | ...||. | | . | .. .. . .||..||| . LMWEIFTYGQEPYYGGMSNQDVWKDG-DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQ LAHLI | . . LHEQL |
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| Kinase | GL50803_113030.AA | CAMK | 88-166 | 14 | 0.000456 | 8.21 | In-house | 76-199 (425) | Show / Hide |
Range on Protein: 88-166 Range on HMM: 76-199/425 Sequence Identity: 14% (18 aa) DAIKRRLAALLSAS-------HPGVLKYHQVLTDGNT-------------------ILVVT---DRCCG-----DLRQFITDHRD----------IHES- . ..| .. . . . || ..| ..| |.. . |. . | | || ..|..|.. . |. KNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERG -VPNELVLSLLGQLAGALAYLHGLG .. . . . |.. |..|.| .. RFTEREARRYFRQICSAVHYCHSHN |
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| Kinase | GL50803_113030.AA | TK | 93-163 | 11 | 0.000579 | 8.33 | In-house | 90-251 (486) | Show / Hide |
Range on Protein: 93-163
Range on HMM: 90-251/486
Sequence Identity: 11% (18 aa)
RLAALLS---ASHPGVLKYHQVLTDGNT------------ILVVTDRCC-GD----LRQFITDHR-----------------------------------
. ..... || ... . | |.| . ...|. .. || ||.. ..|
EEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHE
-----------------DIHESVPNELVLS-------------------LLGQLAGALAYLH
|. .... |. |.| ...|||
SNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLH
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| Kinase | GL50803_113030.AA | Ciliate-E2 | 97-163 | 20 | 0.001327 | 8.22 | In-house | 86-177 (365) | Show / Hide |
Range on Protein: 97-163 Range on HMM: 86-177/365 Sequence Identity: 20% (19 aa) LLSASHPGVLKYHQVLT--DGNTILVVTDRCCG-DLRQFITDHRDIHESVPN-------ELVLSLLGQLAG---------------ALAYLH | . .|| ..|.. . | |.| |.. | | ||...| ... . . .. . .. . |.. || ||| LEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLH |
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| Kinase | GL50803_113030.AA | CAMK | 270-296 | 26 | 0.002258 | 5.93 | In-house | 384-417 (425) | Show / Hide |
Range on Protein: 270-296 Range on HMM: 384-417/425 Sequence Identity: 26% (9 aa) SGIADD-------LARSVLEKMLVLDPAERPTAK ..| |. ... . |||. || .|.|.. DDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIE |
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| Kinase | GL50803_113030.AA | AGC | 277-297 | 33 | 0.013195 | 0.96 | In-house | 358-378 (395) | Show / Hide |
Range on Protein: 277-297 Range on HMM: 358-378/395 Sequence Identity: 33% (7 aa) ARSVLEKMLVLDPAERPTAKG |.. ..|.|. ||..|....| AKDLIKKLLCKDPEKRLGCGG |
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| Kinase | GL50803_113030.AA | Pkinase | 94-166 | 20 | 0.017416 | 9.87 | Pfam | 51-128 (293) | Show / Hide |
Range on Protein: 94-166 Range on HMM: 51-128/293 Sequence Identity: 20% (16 aa) LAALLSASHPGVLKYHQVLTDGNTILVVTDRC-CG----DLRQFIT--DHRDIHESVPNELVLSLLGQLAGALAYLHGLG .. ... .|| ..... . .|.. | .|.. | .| || .|. .|. . . . . . . |.. .|.|.| | IQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY--FSEWECKFYMYQILRGLEYCHSMG |
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| Kinase | GL50803_113030.AA | Ciliate-E2-Unclassified | 97-163 | 23 | 0.059717 | 2.58 | In-house | 75-160 (352) | Show / Hide |
Range on Protein: 97-163 Range on HMM: 75-160/352 Sequence Identity: 23% (20 aa) LLSASHPGVLKYHQVLTDGNTILVVTDRC-CGDLRQFITD------------HRDIH-ESVPNELVL-----SLLGQLAGALAYLH ||. || ..|.. . .| ..| |.. | |||.|.|.. |. . . .. . .. .. |. .| ||| LLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLH |
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| Ank | GL50803_113030.AA | Ank | 406-422 | 35 | 22.641373 | 1.99 | Pfam | 6-22 (33) | Show / Hide |
Range on Protein: 406-422 Range on HMM: 6-22/33 Sequence Identity: 35% (6 aa) LMRAVDRNDVEAVKALI |. |. ....| || |. LHLACRCGHTEVVKMLL |
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| Ank | GL50803_113030.AA | Ank | 442-462 | 38 | 1.256871 | 6.52 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 442-462 Range on HMM: 1-21/33 Sequence Identity: 38% (8 aa) YEGTALIRAAVYGYTEIVELL . |.| |. .|.||.|..| DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_113030.AA | Ank | 473-496 | 37 | 4.7e-05 | 22.49 | Pfam | 1-24 (33) | Show / Hide |
Range on Protein: 473-496 Range on HMM: 1-24/33 Sequence Identity: 37% (9 aa) NGWTALMYTARTGHADCLKLLLEK .|.|.|.. .| ||....|.||.. DGFTPLHLACRCGHTEVVKMLLQH |
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| Ank | GL50803_113030.AA | Ank | 504-534 | 39 | 1e-06 | 28.52 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 504-534 Range on HMM: 1-33/33 Sequence Identity: 39% (13 aa) KGRTALMSAASAGHLECIKLLLK--NEVGMQDN |.|.|. |.. ||.|..|.||. .| .||. DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_113030.AA | Ank | 535-565 | 36 | 1e-05 | 24.91 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 535-565 Range on HMM: 1-33/33 Sequence Identity: 36% (12 aa) DGETALMAAAGNGHRDCVELLLE--REGGIQDN ||.|.|. |. .|| ..|..||. . .||. DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_113030.AA | Ank | 566-589 | 33 | 0.000784 | 18.08 | Pfam | 1-24 (33) | Show / Hide |
Range on Protein: 566-589 Range on HMM: 1-24/33 Sequence Identity: 33% (8 aa) SKWTALMIAAEQGYTDCAKLLLER .|.|..|.. |.|...|.||.. DGFTPLHLACRCGHTEVVKMLLQH |
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| Ank | GL50803_113030.AA | Ank | 597-620 | 37 | 2e-06 | 27.64 | Pfam | 1-24 (33) | Show / Hide |
Range on Protein: 597-620 Range on HMM: 1-24/33 Sequence Identity: 37% (9 aa) DGWTALMWAAKNGHAGCVRLLVEK ||.|.|..|...||. .|..|... DGFTPLHLACRCGHTEVVKMLLQH |
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| Ank | GL50803_113030.AA | Ank | 628-657 | 24 | 0.004928 | 15.2 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 628-657 Range on HMM: 1-33/33 Sequence Identity: 24% (8 aa) HGWPALTVAAQSGYIECARLLVR---EKNIRDN .|. .| .|...|..|....|. . |..|. DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_113030.AA | Ank | 658-678 | 23 | 41.491427 | 1.04 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 658-678 Range on HMM: 1-21/33 Sequence Identity: 23% (5 aa) MDETALDMAKLWRRHEIIALL . .|.| .| .. ..|.. .| DGFTPLHLACRCGHTEVVKML |
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