Gene GL50803_101866 (G.lamblia)

GL50803_101866

Species: G.lamblia
Alias: GL50803_101866, GK226
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_101866.AA Protein None 809 None Fasta, JSON
GL50803_101866.kin_dom Protein Kinase Domain None 264 None Fasta, JSON

Protein domain

Protein domains of GL50803_101866.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_101866.AA NEK8 187-274 32 1.7e-18 49.32 In-house 191-278 (278) Show / Hide 
Range on Protein: 187-274
Range on HMM: 191-278/278
Sequence Identity: 32% (29 aa)

PEVFTSNIYNEQSEVWALGCILYEALAARRCFSAETGAILRHNIINC-KYAPLPSSVSEGMKLLISEMLKPDYNSRPTLLDVRLSLQLL
||   .  ||. | .|||||.||| .  .| | |.    |   |. | .|.|... .| .|. |... |. |   ||..  . ..  |.
PEMCEGKPYNQKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQI-MAMPLC
Kinase GL50803_101866.AA NEK 184-274 32 2.3e-18 61.63 In-house 190-286 (286) Show / Hide 
Range on Protein: 184-274
Range on HMM: 190-286/286
Sequence Identity: 32% (32 aa)

YTAPEVFTSNIYNEQSEVWALGCILYEALAA--RRCFSAE--TGAILRHNIINC-KYAPLPSS--VSEGMKLLISEMLKPDYNSRPTLLDVRLSLQLL
| .|||. .  ||. | .|.|||.|||  .   .. | |.      |  .|... .|.|.||    |. .. ||| ||..|  .||.  .. |.. ..
YMSPEVCQNKPYNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQI-LEMPFI
Kinase GL50803_101866.AA Ciliate-E2-Unclassified 180-267 25 7e-16 51.59 In-house 228-346 (352) Show / Hide 
Range on Protein: 180-267
Range on HMM: 228-346/352
Sequence Identity: 25% (30 aa)

YMISYTAPEVFTSNIYNEQ----SEVWALGCILYEALAARRCFSAETGAI----------------LRHNIINCKYAPLP-------SSVSEGMKLLIS-
||..||||||. .. |...    . .|.||.|||| |  ...|....  .                |. ||.....   .         .|.  | .|. 
YMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFIND

---EMLKPDYNSRPTLLDV
    ||| . |.|.|. ..
LLQKMLKKNPNKRITFEQI
Kinase GL50803_101866.AA AGC 184-263 21 3e-13 29.13 In-house 273-375 (395) Show / Hide 
Range on Protein: 184-263
Range on HMM: 273-375/395
Sequence Identity: 21% (23 aa)

YTAPEVFTSNIYNEQSEVWA--LGCILYEALAARRCFSAETGA----------ILRHNIINC-----KYAPLP----------SSVSEGMKLLISEMLKP
| |||..    |. .   |.  |||..|| |. .  |....             . ..|.|.     .  ..|          ...|.  | ||. .|..
YMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCK

DYNSRPT
| . |..
DPEKRLG
S_TKc GL50803_101866.AA S_TKc 18-274 17 1.8e-12 5.96 SMART 1-231 (231) Show / Hide 
Range on Protein: 18-274
Range on HMM: 1-231/231
Sequence Identity: 17% (52 aa)

NRPSERL--------LKVRGKTSGAYYACRQIDVSKLKQEQQQMLEAEIHLFQQLDGKLTTRYLRVLRNNKPSVIHLIMEYCDD--GTLEDLFVRTRERR
 .  . .         |.| | .| ..|. .|.         .... || . .. . .   ... | ..   . ....|||||   |.| |. .. . ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

--IPCTEEKTRAIGSQIAHALSALRS-------------------------SACGLDGATVMGALTPKSVLLLSTGKIRLKGLCSWHSSGQISISTRADY
   | .|  .| .  ||. ||  . |                         .|. |                                       |    
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQL---------------------------------------TTFCG

MISYTAPEVFTSNIYNE-QSEVWALGCILYEALAARRCFSAETGAILRHNIINCKYAPLPSSVSEGMKLLISEMLKPDYNSRPTLLDVRL------SLQL
   | ||||.    |.   . .|..|||||| |. .  |.  . . . ..|            |. .| .|. .|. | . |||  ..        . . 
TPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPW

L
.
F
Kinase GL50803_101866.AA NEK4 184-267 30 2.9e-12 40.54 In-house 168-251 (257) Show / Hide 
Range on Protein: 184-267
Range on HMM: 168-251/257
Sequence Identity: 30% (26 aa)

YTAPEVFTSNIYNEQSEVWALGCILYEALAARRCFSAETGAILRHNIINCKYAPLPSSVSEGMKLLISEMLKPDYNSRPTLLDV
|  ||.| .  |.  | .|.||| .||    .  | |     | . ||. .  |.|   |. .. |. .||.   . || . |.
YMSPECFGNRPYDYKSDIWSLGCCVYEMITLKHAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDI
Kinase GL50803_101866.AA NEK10 182-276 29 4.2e-12 35.97 In-house 184-279 (279) Show / Hide 
Range on Protein: 182-276
Range on HMM: 184-279/279
Sequence Identity: 29% (28 aa)

ISYTAPEVFTSNIYNEQSEVWALGCILYEALAARRCFSAETGAILRHNIINCKYAPLPS-SVSEGMKLLISEMLKPDYNSRPTLLDVRLSLQLLSN
| |  ||.  |  | |   ||| ||.||.    .  |       |   |   .| |..    |. .. .|.  | || . || ...|   |. .. 
ILYSCPEIVQSEPYGEKADVWAFGCCLYQMCTLQPPFYSTNMLTLAMKIVEHFYDPVNEGMWSDDVRFTITRCLTPDPEARPDIVKVSSVLRMIQD
Kinase GL50803_101866.AA NEK2 184-262 31 1.7e-11 34.88 In-house 230-308 (319) Show / Hide 
Range on Protein: 184-262
Range on HMM: 230-308/319
Sequence Identity: 31% (25 aa)

YTAPEVFTSNIYNEQSEVWALGCILYEALAARRCFSAETGAILRHNIINCKYAPLPSSVSEGMKLLISEMLKPDYNSRP
|  ||.     ||| | .|..||..||  | .  | |   | |   | . .. ..|.  |..   .|. |.. |  .||
YMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFMINVDHYHRP
Kinase GL50803_101866.AA Ciliate-E2 180-267 21 1.1e-10 32.88 In-house 249-359 (365) Show / Hide 
Range on Protein: 180-267
Range on HMM: 249-359/365
Sequence Identity: 21% (26 aa)

YMISYTAPEVFT---------SNIYNEQSEVWALGCILYEALAARRCFSAETGAILRHNIINCKYAPL-----------------PSSVSEGMKLLISE-
..  | |||..          .. |.... .|.||.|||| |  .. |          .|..||.                    . ..|. .| ||.  
GTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKF

---MLKPDYNSRPT-LLDV
   ||. | . |.|   ..
GKRMLQKDPEKRITGWEQI
Kinase GL50803_101866.AA CAMK 183-267 20 3.5e-10 28.28 In-house 284-419 (425) Show / Hide 
Range on Protein: 183-267
Range on HMM: 284-419/425
Sequence Identity: 20% (28 aa)

SYTA-PEVFTSNI--------------YNEQSEVWALGCILYEALAARRCFSAE-------------TGAILRHNIINCKYAPLPSS-------------
.| | |||. ..               |.... .|..|.|||  |  .  | ..             .   | ..|...||   |.              
EYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWW

----------VSEGMKLLISEMLKPDYNSRPTLLDV
          ||.  | ||. ||..| . |.|. ..
DDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQC
Kinase GL50803_101866.AA ULK 30-131 20 9.7e-09 26.73 In-house 22-148 (329) Show / Hide 
Range on Protein: 30-131
Range on HMM: 22-148/329
Sequence Identity: 20% (26 aa)

KTS---GAYYACRQIDVSKLKQEQQQ--------MLEAEIHLFQQLD----GKL----TTRYLRVLRNNKPSVIHLIMEYCDDGTLEDLFVRTRE-----
||    . ..|| .|| .|..|....        .|. || . ..|.    .|     . ... .... .   | .|||||..|.||..  . ..     
KTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDT

-RRIPCTEEKTRAIGSQIAHALSALRS
 .    .|.... .  ||. .. .|..
EEKKRLSEQEAIQFFKQILNGFKELHK
Kinase GL50803_101866.AA Pkinase 201-273 21 8e-08 28.75 Pfam 195-293 (293) Show / Hide 
Range on Protein: 201-273
Range on HMM: 195-293/293
Sequence Identity: 21% (21 aa)

VWALGCILYEALAARRCFSAE----TGAILRHNIINCKYAPLPSSVS-----------------------EGMKLLISEMLKPDYNSRPTLLDVRLSLQL
.|..|||||| |  |  |. .    . .  .. | . ...||... .                       | .| .|. .|..| ..|||  ..  .  .
MWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
TyrKc GL50803_101866.AA TyrKc 22-271 14 5e-07 -109.08 SMART 1-280 (280) Show / Hide 
Range on Protein: 22-271
Range on HMM: 1-280/280
Sequence Identity: 14% (44 aa)

ERLLKVRGK------TSGAYYACRQIDVS--KLKQEQQQMLEAEIHLFQQL--DGKLTTRYLRVLRNNKP-----SVIHLIMEYCDDGTLEDLFVRTRER
 .|.|. |         | ..    |.|   .|| . ....  |. .  .|  . .   | . | .  .        . ..|||.. | | |   ..|..
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

RIPCTEEKTRAIGSQIAHALSALRSSACGLDGATVMGALTPKSV--------LLLSTGKIRLK----GLCSWHSSG--------QISIST--RAD--YMI
    . ..   .  |||   . | |                . .         |.. .. . |    ||.  . ..         .. ..   ..    |
---LCMKDLLSFCWQIACGMEYLHSK---------------NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI

SYTAPEVFTSNIYNEQSEVWALGCILYEALAARRCFSAE------TGAILRHNIINCKYAPLPSS--------VSEGMKLLISEMLKPDYNSRPTLLDVR
  .|||..  ......| ||. |  ..| .        .      . . ..... . .. | | .         .. |  ....  . | ..|||  ...
RWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIH

LSL
  .
ECF
Kinase GL50803_101866.AA CAMK 33-127 17 3e-06 15.49 In-house 31-193 (425) Show / Hide 
Range on Protein: 33-127
Range on HMM: 31-193/425
Sequence Identity: 17% (29 aa)

GAYYACRQIDVSKLK--------------------------QEQQQMLEAEIHLFQQ-------LDGKLTTRYLRVLRNNK-----------------PS
|  .|.  || .|||                          .. ..... ||.. ..       || .   . . |  ...                 ..
GQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDK

VIHLIM---EYCDDGTL-EDLFVRTRER--------------RIPCTEEKTRAIGSQIAHALS
 ....|   |||. | | .||| . .|.              |   ||. .| .  ||. |. 
HMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVH
Kinase GL50803_101866.AA NEK 26-99 22 3.4e-05 14.69 In-house 17-97 (286) Show / Hide 
Range on Protein: 26-99
Range on HMM: 17-97/286
Sequence Identity: 22% (18 aa)

KVRGKTSGAY-----YACRQIDVSKLKQEQQQMLE-AEIHLFQQLDGKLTTRYLRVLRNNKPSVIHLIMEYCD-DGTLEDL
||| |  |       |.  .|..........|..   |... .||.     .|      .. . .. .||||.  |.|...
KVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQK
Kinase GL50803_101866.AA ULK 184-257 25 6.7e-05 13.13 In-house 217-313 (329) Show / Hide 
Range on Protein: 184-257
Range on HMM: 217-313/329
Sequence Identity: 25% (25 aa)

YTAPEVFTSN----IYNEQ-SEVWALGCILYEALAARRCFSAETGAILRHNIINCK------------YAPLPSS-------VSEGMKLLISEMLKPD
| ||... ..     |..  . .| ||||.|| |  .  |.|     . ..||.                ||          .|. .| ||. ||. |
YMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYD
Kinase GL50803_101866.AA Pkinase 30-129 21 7.6e-05 18.21 Pfam 21-124 (293) Show / Hide 
Range on Protein: 30-129
Range on HMM: 21-124/293
Sequence Identity: 21% (23 aa)

KTSGAYYACRQIDVSKLKQEQQQMLEA--EIHLFQQLDGKLTTRYLRVLRNNKPSVIHLIMEYCDDG----TLEDLFVRTRERRIPC--TEEKTRAIGSQ
| .|  .|. .|.... | ...| .    ||.. . |. .   |.... ..  .. |...||||. |     | |.  .  .|. .   .|.  . .  |
KGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQ

IAHALSAL
|. .|  .
ILRGLEYC
Kinase GL50803_101866.AA Ciliate-E2 40-99 21 0.000473 9.78 In-house 49-124 (365) Show / Hide 
Range on Protein: 40-99
Range on HMM: 49-124/365
Sequence Identity: 21% (16 aa)

QIDVSKLKQEQQQMLEAEIHLFQ----------------QLDGKLTTRYLRVLRNNKPSVIHLIMEYCDDGTLEDL
.. .  .|. | .... |||...                ||. .   ..  .  ... . | |.||||. |.|.|.
IYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDY
Kinase GL50803_101866.AA Ciliate-E2-Unclassified 84-132 20 0.0075 5.75 In-house 96-162 (352) Show / Hide 
Range on Protein: 84-132
Range on HMM: 96-162/352
Sequence Identity: 20% (14 aa)

IHLIMEYCDDGTLEDLFV-------------RTRERRIPCTEEKTR-----AIGSQIAHALSALRSS
| ..||||..|.|..                .....|   ||....      .  ||  .|. | ..
IYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHK
Kinase GL50803_101866.AA NEK8 88-104 41 0.012313 3.21 In-house 79-95 (278) Show / Hide 
Range on Protein: 88-104
Range on HMM: 79-95/278
Sequence Identity: 41% (7 aa)

MEYCDDGTLEDLFVRTR
|||.| |||... ....
MEYADGGTLYQMIQHQQ
Kinase GL50803_101866.AA NEK2 26-94 28 0.071937 1.94 In-house 17-85 (319) Show / Hide 
Range on Protein: 26-94
Range on HMM: 17-85/319
Sequence Identity: 28% (20 aa)

KVRGKTSGAYYACRQIDVSKLKQEQQQMLEAEIHLFQQLDGKLTTRYLRVLRNNKPSVIHLIMEYCDDG
||| |  |   .   |.  ..     ||| .|. . .||      ||   . . . |.. ..||||  |
KVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGG
Ank GL50803_101866.AA Ank 551-569 31 58.52869 0.5 Pfam 1-19 (33) Show / Hide 
Range on Protein: 551-569
Range on HMM: 1-19/33
Sequence Identity: 31% (6 aa)

CGTTDLMIAAVKGNASLVE
.| | |..|. .|... |.
DGFTPLHLACRCGHTEVVK
Ank GL50803_101866.AA Ank 582-603 45 0.000139 20.79 Pfam 1-22 (33) Show / Hide 
Range on Protein: 582-603
Range on HMM: 1-22/33
Sequence Identity: 45% (10 aa)

NGMTALMLAAERDHEAVVLLLL
.|.|.|.||....|. || .||
DGFTPLHLACRCGHTEVVKMLL
Ank GL50803_101866.AA Ank 649-671 47 0.000136 20.82 Pfam 1-23 (33) Show / Hide 
Range on Protein: 649-671
Range on HMM: 1-23/33
Sequence Identity: 47% (11 aa)

NGNTALMLAVKHRFTDVVKQLVQ
.|.|.|.||...  |.||| |.|
DGFTPLHLACRCGHTEVVKMLLQ
Ank GL50803_101866.AA Ank 618-648 33 0.00047 18.88 Pfam 1-33 (33) Show / Hide 
Range on Protein: 618-648
Range on HMM: 1-33/33
Sequence Identity: 33% (11 aa)

KGKTALMFAAINNHTSTVQRLLE--TEAGQQDE
 | |.|. |....||. |. ||.   .   || 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank GL50803_101866.AA Ank 680-702 30 0.069269 11.06 Pfam 1-23 (33) Show / Hide 
Range on Protein: 680-702
Range on HMM: 1-23/33
Sequence Identity: 30% (7 aa)

RGETALMMAAATGDVTSVGLLID
 |.|.|..|.  |..  | .|..
DGFTPLHLACRCGHTEVVKMLLQ
Ank GL50803_101866.AA Ank 711-731 28 1.855284 5.91 Pfam 1-21 (33) Show / Hide 
Range on Protein: 711-731
Range on HMM: 1-21/33
Sequence Identity: 28% (6 aa)

YGWTALCFAVMNHHALAAEAL
.|.|.|  |... |.  .. |
DGFTPLHLACRCGHTEVVKML
Ank GL50803_101866.AA Ank 746-776 18 0.003053 15.95 Pfam 1-33 (33) Show / Hide 
Range on Protein: 746-776
Range on HMM: 1-33/33
Sequence Identity: 18% (6 aa)

SGVTAFMIAAEAGYVDIASLLVE--KEVFLRNK
 | |. ..|.. |.......|..   .| ....
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank GL50803_101866.AA Ank 777-797 23 4.448501 4.54 Pfam 1-21 (33) Show / Hide 
Range on Protein: 777-797
Range on HMM: 1-21/33
Sequence Identity: 23% (5 aa)

NGEKALDIAIKAGQADMIAFL
.|. .| .|.. |..... .|
DGFTPLHLACRCGHTEVVKML