Gene 82588.m00127 (T.vaginalis)

82588.m00127

Species: T.vaginalis
Alias: 82588.m00127, TvagK0156
External Links:
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: CAMKL-Tvag1

Sequence

Name Sequence Type Origin Length Description Download
82588.m00127.AA Protein None 315 None Fasta, JSON
82588.m00127.kin_dom Protein Kinase Domain None 242 None Fasta, JSON

Protein domain

Protein domains of 82588.m00127.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 82588.m00127.AA CAMKL 19-206 33 7.3e-71 225.33 In-house 1-236 (297) Show / Hide 
Range on Protein: 19-206
Range on HMM: 1-236/297
Sequence Identity: 33% (80 aa)

YVIKEHIGKGGFGSVYRVYH-ETTNQTCVCKILSQFGSFSN--------------------ELQTLVMLN---HPNIIKLYEQFDENDK------FYLIL
| | . .|||.|| |    |  ||..    ||.  ..   .                    | | . |||   ||||||||| ..  ..      .||..
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EDCCEGD--IINYMKTHNC-----SQEQIASFCYQIISALYYLHSQNISHRDIKPSNILVDKNG--TIKLADFGLS-------DNTFGYSKSCSGTKFYM
| |. |.    .| . | .     . ..   .  ||.||..|.||..| |||||| |||.|.||  .||..|||.|       ...    | . |.  ||
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEIFDK--RPYNAYKADVWSLGITLYFIIFQKFPF
||||| .  .||...|.|.||.|..||.... ..||
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPF
Kinase 82588.m00127.AA CAMK 24-206 21 5.9e-66 211.25 In-house 1-334 (425) Show / Hide 
Range on Protein: 24-206
Range on HMM: 1-334/425
Sequence Identity: 21% (72 aa)

HIGKGGFGSVYRVYHETTN------------QTCVCKILS---------------------------------QFGSFSNELQTLVM-------LNHPNI
 .|.|.|| |....|  |.            | . .||..                                    .. .|.. . .       |.||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKLYEQFDE-------------------NDKFYLIL---EDCCEG----DIINYMKTHNC----------------SQEQIASFCYQIISALYYLHSQNI
||||| ..                    ....|...   | |  |    |. .| . | |                . .. . .  ||.||. |.||.||
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

SHRDIKPSNILVDKN-----------------GTIKLADFGLSDNTFG--------------------------YSKSCSGTKFYMA-PEIFDK------
 |||.|| |||.|.|                 ..||..|||..   ..                            | . ||  ||| ||.. .      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-------RPYNAYKADVWSLGITLYFIIFQKFPF
       .||  .|.|.||.|. ||.    ..||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPF
Kinase 82588.m00127.AA S_TKc 19-264 32 1.7e-65 224.86 SMART 1-231 (231) Show / Hide 
Range on Protein: 19-264
Range on HMM: 1-231/231
Sequence Identity: 32% (84 aa)

YVIKEHIGKGGFGSVYRVYHETTNQTCVCKILSQFGSFSNELQTLVMLNHPNIIKLYEQFDENDKFYLILEDCCEG---DIINYMKTHNC-------SQE
| | ..||||.||.||...|  |.. . .||..   .. .|.| | . .||||.|||. |.. |..|...| .|.|   |   |.| ...       .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVME-YCDGDLGDLFDYIKKRGRHGLRFPFPE-

QIASFCYQIISALYYLHSQNISHRDIKPSNILVDKNGTIKLADFGLSDNTFGYSKSCSGTKFYMAPEIFDKRPYNAYKADVWSLGITLYFIIFQKFPFSN
......|||..|| |.||..| |||.||.|||.|.  .||..||||.       ... || .|||||..   .|.  |.|.||.|..||  .  . ||. 
HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-

SMEWVKFVQYGIGQNTFPEIIDGNLDQVLRMSIIPQPHLRHTVAELLS---EISKCPLL
  . . | . |          .  . . .|      |  | |. |.|    .| . | .
-QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 82588.m00127.AA ULK 19-209 29 7.6e-62 211.77 In-house 1-259 (329) Show / Hide 
Range on Protein: 19-209
Range on HMM: 1-259/329
Sequence Identity: 29% (76 aa)

YVIKEHIGKGGFGSVYRVYHETT----NQTCVCKILS-----QFG----------SFSNELQTLVMLN--------HPNIIKLYEQFDEN--DKFYLILE
|.... .||| || ||. ... |    |. ..||...     |.           .. || ... .|.        ||||.|||. | .   . .|.|.|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

DCCEGDIINYMKTH-----------NCSQEQIASFCYQIISALYYLHSQNISHRDIKPSNILVDKN------------GTIKLADFGLSDNTFGY-----
 |  ||  .|.|..           . |.... .|..||.... .||..|| ||||||.|||....            |..|.||||..           
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

-SKSCS------GTKFYMAPEIFD----KRPYNAYKADVWSLGITLYFIIFQKFPFSNS
  ..|.      ||  ||||.|.     . ||. ||.|.||||. .| ... | ||...
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW
Kinase 82588.m00127.AA AGC 19-197 22 4.9e-60 152.89 In-house 1-296 (395) Show / Hide 
Range on Protein: 19-197
Range on HMM: 1-296/395
Sequence Identity: 22% (68 aa)

YVIKEHIGKGGFGSVYRVYHE------TTNQTCVCKILS-----------QFGSFSNE------------LQTLVMLN----------HPNIIK-LYEQF
. .. .||||.|| || | .       .|.. . .|.|.           .     .|             . |...|          ||.|.| |.  |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

DENDK--FYLILE---------DCCEG-DIINYMK---THNCSQEQIASFCYQ--------IISALYYLHS-QNISHRD-IKPSNILVDKNGTIKLADFG
  .|.   |...|          |. | .   ...      .  |. | |           |..|| |||| ..| ||| .|| ||| |..| |||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSDNTFGY-----------------------------------------------------SKSCSG--TKFYMAPEIFDKRPYNAYKADVWS--LGITL
|.    ..                                                      ..  |  |  ||||||.       . .| ||  ||. .
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL-----YGKACDWWSFGLGCLM

Y
|
Y
Kinase 82588.m00127.AA Ciliate-E2-Unclassified 19-207 27 9e-60 204.89 In-house 1-271 (352) Show / Hide 
Range on Protein: 19-207
Range on HMM: 1-271/352
Sequence Identity: 27% (76 aa)

YVIKEHIGKGGFGSVYRVYHETTNQTCVCKILSQFGSFS-----------------NELQ-------------TLVMLNHPNIIKLYEQFDENDKFYLIL
| | . ||.||||.||...|. ..|  . |..... ...                 |...              |....||.|.|....|   ...|...
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EDCCEGDIINYMKT------------------HNCSQEQIA-----SFCYQIISALYYLHSQN-ISHRDIKPSNILVDKNG---TIKLADFGLS------
| |  || ..|.|                   .  . .|..      ...||...| |||..| | ||||||.|||.|.||    ||..|||.|      
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

---DNTFG----------YSKSCSGTKFYM----APEIFDKRPYNA---YKADVWSLGITLYFIIFQKFPFS
   | |..           .....||  ||    |||....  |.    ||.|.||||. ||...|...||.
NNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFY
Kinase 82588.m00127.AA MARK 19-206 38 7.7e-59 191.03 In-house 1-206 (262) Show / Hide 
Range on Protein: 19-206
Range on HMM: 1-206/262
Sequence Identity: 38% (79 aa)

YVIKEHIGKGGFGSVYRVYHETTNQTCVCKILS---QFG-----SFSNELQTLVMLNHPNIIKLYEQFD--ENDK-FYLILEDCCEGDIINYMKTH--NC
| ..  ||.|... |. . |  |..    ||.     .      ..  |.. . .|.|||||||.. ..  .. . .|||.| ...|.  .|.| |   .
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

SQEQIA-SFCYQIISALYYLHSQNISHRDIKPSNILVDKNG--TIKLADFGLSDNT--FGYSKSCSGTKFYMAPEIFDKRPYNAYKADVWSLGITLYFII
 .|  |  .. ||.||..|.||.|| |||||| |||.|.||   ||..|||.|         ... ||. ||||||| |.||...|.|.||||. |||..
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMV

FQKFPF
  .|||
CGYFPF
Kinase 82588.m00127.AA Pkinase 19-209 35 3e-57 201.3 Pfam 1-215 (293) Show / Hide 
Range on Protein: 19-209
Range on HMM: 1-215/293
Sequence Identity: 35% (77 aa)

YVIKEHIGKGGFGSVYRVYHETTNQTCVCKILSQFGSFS---------NELQTLVMLNHPNIIKLYEQFDENDKFYLILEDCCEG----DIINYMK--TH
|.|.. ||.|.||.||. .|  |... ..||..  .  |         .|.| . .||||||..||. | ..|. |...| |  |    |   |..   |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

NC---SQEQIASFCYQIISALYYLHSQNISHRDIKPSNILVDKNGTI----KLADFGLS----DNTFGYSKSCSGTKFYMAPEIFDKRPYNAYKADVWSL
.|   | ... ...|||...|.|.||..| |||.||.|||.|.||.|    |..||||.        .  ..  || .|||||.  ...|  .|.|.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GITLYFIIFQKFPFSNS
|..||  .. ..||...
GCILYEMLCGRPPFPGH
Kinase 82588.m00127.AA Ciliate-E2 19-214 27 1.1e-56 193.1 In-house 1-301 (365) Show / Hide 
Range on Protein: 19-214
Range on HMM: 1-301/365
Sequence Identity: 27% (86 aa)

YVIKEHIGKGGFGSVYRVYH-----------------------ETTNQTCVCKIL--SQFGSFSNELQTLV----------------MLNHPNIIKLYEQ
| . . ||.|.|||||.. .                       .....    ||.  .|  ....|.. .                  ||||||||.|| 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FD--ENDKFYLILEDCCEGDIINYMK--THNCSQE----------QIASFCYQIIS---------------ALYYLHSQN-ISHRDIKPSNILVDKNGTI
|    ....||..| |  ||   |.|   ... .|          .|. . .||..               || ||||.| | ||||||.|||.     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLADFGLSDN-------------------------TFGYS---------KSCSGTKFYMAPEIFDKRPYNA--------YKADVWSLGITLYFIIFQKFP
|..||||| .                         |.||.         ... ||  ||||||. . .|.         ||.|.||||..||. .| |.|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FSNSMEWVK
|   ..  |
F---QQQIK
Kinase 82588.m00127.AA ULK 19-209 30 1.1e-55 191.3 In-house 1-255 (324) Show / Hide 
Range on Protein: 19-209
Range on HMM: 1-255/324
Sequence Identity: 30% (77 aa)

YVIKEHIGKGGFG-SVYRVYHETT---NQTCVCKILSQFG---------------SFSNELQTLVMLN---HPN--IIKLYEQFDEN--DKFYLILEDCC
|.... .||| ||  ||. ... |   ||   ||. ....               .. || |.. .|.   |||  |.|||. | .   . .|.|.| | 
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

EGDIINYMKTH----------NCSQEQIASFCYQIISALYYLHSQNISHRDIKPSNILVDKN------------GTIKLADFGLSDNTFG------YSKS
 ||  .|.|..          . |.... .|..||.... .||..|| ||||||.|||. ..            |..|.||||..   .         ..
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

CS------GTKFYMAPEIFD----KRPYNAYKADVWSLGITLYFIIFQKFPFSNS
|       ||  ||||.|.     . ||. ||.|.||||. .| ... | ||...
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW
Kinase 82588.m00127.AA STE 19-208 24 3.4e-52 179.74 In-house 1-270 (359) Show / Hide 
Range on Protein: 19-208
Range on HMM: 1-270/359
Sequence Identity: 24% (67 aa)

YVIKEHIGKGGFGSVYRVYHET---------------TNQTCVCKILS----------------------QFGSFSNELQTLVMLN--HPNIIKLYEQFD
. . | ||||.||.||. ..                 |.. .  |...                      .. .. .|....  .|  ||||.| |  . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EN-------DKFYLILEDCCEGDIINYMK---THNCS------------QEQIASFCYQIISA-LYYLHSQNISHRDIKPSNILVDKNGTIKLADFGLSD
 .       |. ....| .  | .   .|    ....             .||| .|.||. . ||||||..| ||||||.|||.     .||.|||.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

------------------NTFG-YSKSCSGTKFYMAPEIFDKRP---YNAY--KADVWSLGITLYFIIFQKFPFSN
                  .| .  .... ||  .||||. ...     . |  |.|.||||.|.   .  | |...
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHD
Kinase 82588.m00127.AA Ciliate-E2b 19-206 32 2.6e-51 154.23 In-house 2-210 (272) Show / Hide 
Range on Protein: 19-206
Range on HMM: 2-210/272
Sequence Identity: 32% (68 aa)

YVIKEHIGKGGFGSVYRVYH-ETTNQT----CVCKI-LSQFG---SFSNELQTLVMLNHPNIIKLYEQFDENDKFYLILEDCCEGDIINYMKTHN---CS
 .||.  |.| ||||| |    .|.|     |. |  ..|..   .  .| ..| ..|||.|.|..  |  ... |...| | ....  ..   .    |
IYIKK-LGFGQFGSVYLVWNTKNTKQYYAMKCISKNQIIQQNMEKHMLQEKNVLEKCNHPFIMKFIRSFKDDQHMYFMMEFCNGMELFDVIREIGRLLLS

QEQIASFCYQIISALYYLHSQNISHRDIKPSNILVDKNGTIKLADFGLSDNTFGYSK------SCSGTKFYMAPEIFD-----KRPYNAYKADVWSLGIT
...   .  .|. .| |||.||| .|||||.||.||..| .||.|.|..    . .       .  || .||||||        ..|. ||.|.||.||.
TYDSQFYIASICLCLEYLHNQNIIYRDIKPENIMVDHKGYMKLIDMGTAKHMYKKNEQMTRTFTIIGTPHYMAPEIIQSLQPGGKGYT-YKVDIWSVGIC

LYFIIFQKFPF
||.... . |.
LYEFMCGYVPW
Kinase 82588.m00127.AA Pkinase_Tyr 19-197 28 3.7e-21 72.3 Pfam 1-205 (270) Show / Hide 
Range on Protein: 19-197
Range on HMM: 1-205/270
Sequence Identity: 28% (58 aa)

YVIKEHIGKGGFGSVYRVYHE----TTNQTCVCKIL------SQ--FGSFSNELQTLVML-NHPNIIKLYEQFD-ENDK--FYLILEDCCEGDIINYMKT
 .. . .|.| ||.||. .       |....  |.|      .|    .| .|....  | .||||..||     . .    |...| .. ||  .| ..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

H-----NCSQEQIASFCYQIISALYYLHSQNISHRDIKPSNILVDKNGTIKLADFGLSDNT--FGYS-KSCSGTKF---YMAPE-IFDKRPYNAYKADVW
|     . . ... ..|.|| ... ||.|.|. |||.   |.||..|...| .||||.      .|  .. .|.|.    |||| |....     | |||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK--FTTKSDVW

SLGITLY
| |....
SFGVLMW
Kinase 82588.m00127.AA TyrKc 19-258 24 1.1e-15 31.03 SMART 1-280 (280) Show / Hide 
Range on Protein: 19-258
Range on HMM: 1-280/280
Sequence Identity: 24% (70 aa)

YVIKEHIGKGGFGSVYR-VYHETTNQTCVCKILSQ--FGSFSNELQTLVML--NHPNIIKLY---EQFDEN----DKFYLILEDCCEGDIINYMKTHN--
 . .. .| | || ||. ..     ...  | |       | .|.. . .|  .||||..||    |  .|    .  ....| .. ||  .| . |   
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

CSQEQIASFCYQIISALYYLHSQNISHRDIKPSNILVDKNGTIKLADFGLSDNTFGY--------SKSCS---GTK-----FYMAPEIFDKRPYNAYKAD
 . ..  |||.|| .   ||||.|. |||.   |.||..|.|.| .||||| .   .         .. .   |.|       |||| .... ..  | |
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT-TKSD

VWSLGITLYFII-FQKFPFSNS----MEWVKFVQYGIGQNTFPEIIDG-----------NLDQVLRMSIIPQPHLRHTVAELLSEI
||| |.... |  . . | ..     |..   ..| . |   ... .             . |. ..    .|. | | .|. ...
VWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEY-VKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF