Gene 90729.m00118 (T.vaginalis)

90729.m00118

Species: T.vaginalis
Alias: 90729.m00118, TvagK0685
External Links:
Annotation:

Classification

Group: Other
Family: NEK
Subfamily: NEK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
90729.m00118.AA Protein None 436 None Fasta, JSON
90729.m00118.kin_dom Protein Kinase Domain None 255 None Fasta, JSON

Protein domain

Protein domains of 90729.m00118.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 90729.m00118.AA NEK 4-258 41 1.6e-134 453.18 In-house 1-286 (286) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-286/286
Sequence Identity: 41% (120 aa)

YTLQHELGEGAYGKVYLAIDKETNEK-----VALKKVKLSKMTDEEKEKAL-AEVDLLSKLKHPNIVAYKGSWTTGN--HLYIAMEYVD-GGDLNDK---
|... ..|.|..||||.. .|... .     ...||.....|...||..|.  || .|..|||||||.|. |.   .  .|.| ||| . |||| .|   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

LLRQN--GQLLPVQTVLDIFVQITMALQYIHGQ-----LVLHRDLKPQNIFLTKNDV----VKLGDFGVAKSLANSFELAHT-MIGTPYYLAPELWRGDP
. .|   |....  ...|.|.|. .||.|.| .      .||||.||||||||||.     ||.||||..| | .. ..|.| ..|||||..||.... |
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YNEKADIYSLGVLLYEMCTL--RKPFEGN--NTAQLFNNLMKG-HYKPIPSS--YPQEIRRLVDGMLSKNPMERPSTAQILKLPFV
||.|.|| |||..|||||||  ..|||..  |  .|... ||| .|.||||   | |. ..|.  || |.| .|||. |||..||.
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 90729.m00118.AA NEK1 4-258 45 2.8e-121 409.23 In-house 1-276 (276) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-276/276
Sequence Identity: 45% (125 aa)

YTLQHELGEGAYGKVYLAIDKETNEKVALKKVKLSKMTDEEKEKALAEVDLLSKLKHPNIVAYKGSWTTGNH--LYIAMEYVDGGDLNDKLLRQ--NGQL
|. .  .|||..||..|. .|| .   ..|  ...|| ..|.|... || .|.|.||||||.|| |   . .  ||| ||| |||||. |  ||   |.|
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

LPVQTVLDIFVQITMALQYIHGQLVLHRDLKPQNIFLT--KND---------------VVKLGDFGVAKSLANSFELAHTMIGTPYYLAPELWRGDPYNE
 .  . .. |.|| .||..|| . .||||.|.||||||  ||.               .|||||||.|. | .. |.| | ||||||| ||..   ||| 
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNN

KADIYSLGVLLYEMCTLRKPFEGNNTAQLFNNLMKGHYKPIPSSYPQEIRRLVDGMLSKNPMERPSTAQILKLPFV
| || |||. ||| |||  |||.||  .| .   .|.| |||. | .|.. ||  |...||  |||. |||. ||.
KSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase 90729.m00118.AA NEK8 10-258 36 1.6e-105 302.28 In-house 7-278 (278) Show / Hide 
Range on Protein: 10-258
Range on HMM: 7-278/278
Sequence Identity: 36% (99 aa)

LGEGAYGKVYLAIDKETN--EKVALKKVKLSKMTDEEKEKALAEVDLLSKLKHPNIVAYKGSWTTGNHLYIAMEYVDGGDLNDKLLRQNG-QLLPVQ---
.| || | . |   || .   .| .| . .. |. .|   |. |...||.| ||||..| ..    | | |.||| ||| | .....| .  ...     
VGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDNTLMIEMEYADGGTLYQMIQHQQNKLFEEERQLK

-------------TVLDIFVQITMALQYIHGQLVLHRDLKPQNIFLTKN-DVVKLGDFGVAKSLANSFELAH--TMIGTPYYLAPELWRGDPYNEKADIY
             ..|. |.|.  |. ..|  ..||||||.||||.|.   |||.|||| .| .      .   | .|||||. ||.  | |||.| |. 
QVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPYNQKSDMW

SLGVLLYEMCTLRKPFEGNNTAQLFNNLMKG-HYKPIPSSYPQEIRRLVDGMLSKNPMERPSTAQILKLPFV
.||  |||||.|.. ||. |   | .  | .  | ||.. |  | | ||   |.. |  ||| .||.. | .
ALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase 90729.m00118.AA S_TKc 4-258 31 2.7e-101 343.72 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-231/231
Sequence Identity: 31% (85 aa)

YTLQHELGEGAYGKVYLAIDKETNEKVALKKVKLSKMTDEEKEKALAEVDLLSKLKHPNIVAYKGSWTTGNHLYIAMEYVDG--GDLNDKLLRQNG----
|..  ..|.||.||||....|.|...||.|..|         |... |...|.| .||||| ..... . .|||. |||.||  ||| | . ....    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

QLLPVQTVLDIFVQITMALQYIHGQLVLHRDLKPQNIFLTKNDVVKLGDFGVAKSLANSFELAHTMIGTPYYLAPELWRGDPYNE-KADIYSLGVLLYEM
. .|  ..  .. ||  ||.|.| . ..||||||.||.|..  ..|..|||.|. |       .|..|||.|.|||.    .|.  |.|..|.|..||||
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

CTLRKPFEGNNTAQLFNNLMKGHYKPIPSSYPQEIRRLVDGMLSKNPMERPSTAQILK-------LPFV
.. . ||.  . ...|....           ..| . .....| |.| .||.  ..|.        |..
LCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 90729.m00118.AA NEK4 4-258 44 8.2e-100 337.9 In-house 1-257 (257) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-257/257
Sequence Identity: 44% (114 aa)

YTLQHELGEGAYGKVYLAIDKETNEKVALKKVKLSKMTDEEKEKALAEVDLLSKLKHPNIVAYKGSWTTGNH--LYIAMEYVDGGDLNDKLLRQNGQLLP
|      | | || |.|   .    .  .||..| .   .|.  |. |. |||.||||||| || ||  .|   ||| | . .||||  || .| .|.|.
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKNQFLE

VQTVLDIFVQITMALQYIHGQLVLHRDLKPQNIFLTKNDVVKLGDFGVAKSLANSFELAHTMIGTPYYLAPELWRGDPYNEKADIYSLGVLLYEMCTLRK
 . |.. |||| |||||.| . .|||||| |||||||  ..|.||||... | |. ..| ||||||||. ||..   ||. | ||.|||  .||| ||. 
EYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITLKH

PFEGNNTAQLFNNLMKGHYKPIPSSYPQEIRRLVDGMLSKNPMERPSTAQILKLPFV
 |.  .   |   ...|.  |.|  | |..  ||  ||.| | .|||  .|.. |..
AFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase 90729.m00118.AA Pkinase 4-258 29 5e-89 306.87 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-293/293
Sequence Identity: 29% (86 aa)

YTLQHELGEGAYGKVYLAIDKETNEKVALKKVKLSKMTDEEKEKALA--EVDLLSKLKHPNIVAYKGSWTTGNHLYIAMEYVDGG----DLNDKLL-RQN
|..   .|.|..|.||....| |...||.|..|...  ..... ..   |. .. .|.||||| .........|.|. |||..||    || | .  ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GQL-LPVQTVLDIFVQITMALQYIHGQLVLHRDLKPQNIFLTKNDVV----KLGDFGVAKSL-ANSFELAHTMIGTPYYLAPELWR-GDPYNEKADIYSL
| . .. ... ... ||  .|.|.| . ..||||||.||.. .|...    |..|||.|| .   . . ..|  |||.|.|||. | | .|  |.|..|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVLLYEMCTLRKPFEGN------NTAQLFNNLMKGHYKPI-PSSYP-------------------QEIRRLVDGMLSKNPMERPSTAQILKLPFV
|..||||.. | || |       .  |.... |.. ..   | ...                   .| . .....| |.| .||. .|||. |..
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 90729.m00118.AA CAMK 9-258 21 5.2e-83 267.21 In-house 1-425 (425) Show / Hide 
Range on Protein: 9-258
Range on HMM: 1-425/425
Sequence Identity: 21% (92 aa)

ELGEGAYGKVYLAIDKETN------------EKVALKKVKLSKMT--------------------------DEEKEKALAEVDLLSK-------LKHPNI
.||.|..|||.|.|.|.|.            .||| | .. .|..                          .. ... . |.....|       |.||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VAYKGSWT------------TGNH--------LYIAM---EYVDGG----DLNDKLLRQNG-------------QLLPVQTVLDIFVQITMALQYIHGQL
.     .             | ..        .|. |   ||..||    || |.. .. .               .. . .  .| ||  |..|.| . 
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

VLHRDLKPQNIFLTKND-----------------VVKLGDFGVAKSLANS-----------------------FELAHTMIGTPYYLA-PELWRG-----
. |||||| || |..|.                  .|. ||| |. .  .                        .. .|. |||.| | ||. .|     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------DPYNEKADIYSLGVLLYEMCTLRKPFEGN-------------NTAQLFNNLMKGHYKPIPSSYP-----------------------QEIR
         ..|..|.|. |.||.|| | . . ||.|              |  .|| . ||| |  .|.  .                       || .
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

RLVDGMLSKNPMERPSTAQILKLPFV
 |. .|| ..| .|.. .|.|. |..
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 90729.m00118.AA CAMKL 4-258 30 5.7e-80 254.88 In-house 1-297 (297) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-297/297
Sequence Identity: 30% (92 aa)

YTLQHELGEGAYGKVYLAID-KETNEKVALKKVKLSKMTDEEKEKALA-------------EVDLLSKLK---HPNIVAYKGSWTTGNH------LYIAM
|..  .||.|..||| ||.. . |.|||| | .. .|...... |.               |. ....|.   ||||.     ..| .|      .|. |
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYVDGGD--LNDKLLRQNGQL--LPVQTVLDIFVQITMALQYIHGQLVLHRDLKPQNIFLTKND--VVKLGDFGVAKS---L-ANSFELAHTMIGTPYYL
||..||.  | |.. .. .    .|      .| ||  |..|.| . . |||.|| || |..|.  ..|. ||| .        .. .. .|  |.| | 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APELWRG--DPYN-EKADIYSLGVLLYEMCTLRKPFEGN--------NTAQLFNNLMKGHYKP-IPSSYPQEIRRLVDGMLSKNPMERPSTAQILKLPFV
|||.  |  .||.  |.|| |.||.|| | . . ||..         |.  |..  |.| |.| |... . . |.|  .|| .||..||.  ||.. |..
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 90729.m00118.AA STE 4-258 24 5.9e-77 261.97 In-house 1-359 (359) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-359/359
Sequence Identity: 24% (91 aa)

YTLQHELGEGAYGKVYLAIDK------ETNEK---------VALKKVKLSKMT---------------DEEKEKALAEVDLLSKLK--HPNIVAYKGSWT
.... ..|.||.|.||.|...      .|.|.         .| |...|.. .               .||... | |.....|..  ||||| | |.  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TG-------NHLYIAMEYVDGGDLNDKLLR-------------QNGQLLPVQTVLDIFVQITMA-LQYIHGQLVLHRDLKPQNIFLTKNDVVKLGDFGVA
 .       ..|.|.|||.||| | | . .             . .. .| . .  | .||  . |.|.| . . |||.||.||.|     ||| ||||.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQH-QHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVC

KSLANS----------------FELAHTMIGTPYYLAPELWRG------DPYNEKADIYSLGVLLYEMCTLRKPF-EGNNTAQLFNNLMK----------
..|..|                 .   |..||| . |||  ..      ..|..|.||.||| .. ||.| . |. .....  .|. ...          
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

----GHYKPIPS-------------------SYPQEIRRLVDGMLSKNPMERPSTAQILK--LPFV
    |.  |.|.                   .. .| .  ..  | |.| .||.. | ||   ||.
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 90729.m00118.AA ULK 4-258 28 7.3e-74 251.7 In-house 1-329 (329) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-329/329
Sequence Identity: 28% (93 aa)

YTLQHELGEGAYGKVYLAIDKET----NEKVALKKVKLSKMTDEEKE--------KALAEVDLLSKLK--------HPNIVAYKGSWTTG--NHLYIAME
| | |.||.|..|||| ...|.|    ||||| |.. ..||  ...|            |.... |||        ||||| ..    |   |..|| ||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YVDGGDLNDKLLRQ--------NGQLLPVQTVLDIFVQITMALQYIHGQLVLHRDLKPQNIFLTKND------------VVKLGDFGVAKSLANS---FE
| .|||| . . ..        ... |. | .. .| ||  .....| . . |||.||||| .....            |.|..||| ||.. |.    .
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

LAHTMI------GTPYYLAPELWRGD----PYN-EKADIYSLGVLLYEMCTLRKPFEGNNTAQLFNNLMKGHYKP----------IPSSYP---------
...|.       |||.| ||... |     ||.  |.||.|||...||| . . ||...   ..... ..  ..           .|  .|         
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

QEIRRLVDGMLSKNPMERPSTAQILKLPFV
.|.. |  .|| ... .| |  .... |..
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 90729.m00118.AA ULK 4-258 28 7.7e-74 251.62 In-house 1-324 (324) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-324/324
Sequence Identity: 28% (94 aa)

YTLQHELGEGAYG-KVYLAIDKET---NEKVALKKVKLSKMTDEEKE-------KALA-EVDLLSKLK---HPN--IVAYKG-SWTTG-NHLYIAMEYVD
| | |.||.|..| ||| ...|.|   |..|| |.. ..|| . ..|       . |  |. .. |||   |||  || ..  ..|.  |..|| ||| .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGDLNDKLLRQ-------NGQLLPVQTVLDIFVQITMALQYIHGQLVLHRDLKPQNIFLTKND------------VVKLGDFGVAKSLAN---SFELAHT
|||| . . ..       ... |. | .. .| ||  .....| . . |||.||||| .....            |.|..||| ||.. |   .  . .|
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

MI------GTPYYLAPELWRGD----PYN-EKADIYSLGVLLYEMCTLRKPFEGNNTAQLFNNLMKGH----------YKPIPSSYP---------QEIR
.       |||.| ||... |     ||.  |.||.|||...||| . . ||...   ..... .. .           |  |  .|         .|..
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLY-IQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECK

RLVDGMLSKNPMERPSTAQILKLPFV
 |  .|| ... .| |  .|.. |..
DLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 90729.m00118.AA NEK2 4-258 31 4e-73 245.57 In-house 1-319 (319) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-319/319
Sequence Identity: 31% (99 aa)

YTLQHELGEGAYGKVYLAIDKETNEKVALKKVKLSKMTDEEKEKALAEVDLLSKLKHPNIVAYKGSW--TTGNHLYIAMEYVDGGDLND--KLLRQNGQL
|   ...|.| .|...  ..|.. .  . |  .  .|.  |.    .|. .|..||||||| |       .   ||| |||  ||||    |  |.  | 
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQY

LPVQTVLDIFVQITMALQYIHG---------------------QLVLHRDLKPQNIFLTKNDV-------------------------------------
.. . .. |. |.. ||| .|                      . .||||.|| ||||  ..                                      
MEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQ

--VKLGDFGVAKSLANSFELAHTMIGTPYYLAPELWRGDPYNEKADIYSLGVLLYEMCTLRKPFEGNNTAQLFNNLMKGHYKPIPSSYPQEIRRLVDGML
  ||||||| |..|  .   ||| .|||||  ||.  | .|||| || |.| |.||||.|. ||.. | |||     .||. .||. | ..   ..  |.
VVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFMI

SKNPMERPSTAQILKLPFV
  ..  |||.  ||. |..
NVDHYHRPSIEEILQHPQI
Kinase 90729.m00118.AA Pkinase_Tyr 4-234 30 3.2e-43 147.02 Pfam 1-248 (270) Show / Hide 
Range on Protein: 4-234
Range on HMM: 1-248/270
Sequence Identity: 30% (77 aa)

YTLQHELGEGAYGKVYLAIDK----ETNEKVALKKVKLSKMTDEE--KEKALAEVDLLSKL-KHPNIVAYKGSWT-TGNH--LYIAMEYVDGGDLNDKLL
 |. ..|||||.|.||... |    .|. .|| |..   . ..|.  .|. ..|. ....| .||||| . |  |  | .  .|| |||. .||| | | 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

RQ--NGQLLPVQTVLDIFVQITMALQYIHGQLVLHRDLKPQNIFLTKNDVVKLGDFGVAKSL-ANSFE-LAHTMIGTPY-YLAPELWRGDPYNEKADIYS
..  ..| |.... |.. .|| ....| . .   ||||   |. .|.| ||| .||| |. .   .    ...    |   .||| ..   ...| |..|
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

LGVLLYEMCTL-RKP-FEGNNTAQLFNNL-MKGHYKPIPSSYPQEIRRL
 |||..|..|. ..| ..|   ..... .  .|.  |.|   |.|| .|
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDL
Kinase 90729.m00118.AA TyrKc 4-256 25 5.6e-40 140.04 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-256
Range on HMM: 1-280/280
Sequence Identity: 25% (75 aa)

YTLQHELGEGAYGKVYLAIDKETNEKVALKKVKLSKMTDEEKEKALAEVDLLSKL--KHPNIVAYKGSWTTG-------NHLYIAMEYVDGGDLNDKLLR
 || ..|||||.|.||... |   ..|| |..| ..     .|  . |  ...||  .|||||.  |  |..         |.| |||...|||.| | .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

QNGQLLPVQTVLDIFVQITMALQYIHGQLVLHRDLKPQNIFLTKNDVVKLGDFGVAKSLANS----FELAHTMI----GTP-----YYLAPELWRGDPYN
  .. |.... |.. .||    .|.| . . ||||   |. ...| .|| .||| .. . .      .    .     |.        .||| ..   ..
HRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

EKADIYSLGVLLYEMCTL-RKPFEG-----NNTAQLFNNLMKGHYKPIPSS--------YPQEIRRLVDGMLSKNPMERPSTAQILKLP
.| |..| ||...|..|.  .| .|      . .........|.. |.| .         |.|. ..       .| .||. ..| .. 
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF