Gene 87634.m00053 (T.vaginalis)
87634.m00053
Species: T.vaginalis
Alias: TvagK0922, 87634.m00053
External Links:
Annotation:
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
---|---|---|---|---|---|
87634.m00053.AA | Protein | None | 328 | None | Fasta, JSON |
87634.m00053.kin_dom | Protein Kinase Domain | None | 258 | None | Fasta, JSON |
Protein domains of 87634.m00053.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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S_TKc | 87634.m00053.AA | S_TKc | 55-312 | 27 | 3.8e-53 | 183.81 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 55-312 Range on HMM: 1-231/231 Sequence Identity: 27% (76 aa) YSIIRRIGDGAEAAVYEAIKNDEGISVALKRYKKVNNLRDGIPLEVEIAKMLDNDYCLKVFSHFKSVTGDFIVTMPLAQH--GALQP--SNKPE------ | |.| || || . || ..... | ||.|. | . | |..| |. . .. | . .| . ... . | .. . | | ... YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP ISISGAIQLVYQIGNGLQYMHSHRIVHRDIKPQNILLLDGNYVLCDYSVSAVLKSDDELLTGYTGSPIFMAPEVSPTLYKPRPPDLWSLGVTVYVLLFGC .. | ..||| ..|.|.|||.|.|||.||.|||| . . .|| ....| | . |.| .||||| | ... | ||.|...| .| |. FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL-------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILYEMLCGY YPYKLERGLVQVEQNYVKNVSKSLDLGDLTFPEVPSIPQELKDVIAGLLEKNPDQRMTASDICN-------NPWL |. |... . | . ..|.|| | ..|.|.|..|.|| .. . ||. PPFP------QMQMMFKKIG-----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | 87634.m00053.AA | CAMK | 60-312 | 17 | 3.1e-52 | 166.22 | In-house | 1-425 (425) | Show / Hide |
Range on Protein: 60-312 Range on HMM: 1-425/425 Sequence Identity: 17% (75 aa) RIGDGAEAAVYEAIKNDEG------------ISVALKRYKKV-----------------------------NNLRDGIPLEVEIAKM-------LDNDYC .| |. . |...| . || | ..| . |. .. |.|| |. || TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI LKVFSHFK------------SVTG--------DFIVT--MPLAQHGAL----------QPSNK-----------PEISISGAIQLVYQIGNGLQYMHSHR .| . .. . . ..|. | ... | | .... .. . | ... || ...|.||| IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN IVHRDIKPQNILLLD------------------GNYVLCDYSVSAVLKS-----------------------DDELLTGYTGSPIFMA-PEVSPT----- |||||.|| |||| | .| ..| ...... ...... . |.| .|| ||| IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN ---------LYKPRPPDLWSLGVTVYVLLFGCYPYKLE-----------------------RGLVQVEQNYVKN------------VSKSLDLGDLTFPE | ... | ||.|| |..| |..|. . .| . . |... .|.. | . MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDE-------F-H VPSIPQELKDVIAGLLEKNPDQRMTASDICNNPWL . || || | ..|...|..|||.... | ||. H-FVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM |
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Pkinase | 87634.m00053.AA | Pkinase | 55-312 | 25 | 1.7e-47 | 168.9 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 55-312 Range on HMM: 1-293/293 Sequence Identity: 25% (75 aa) YSIIRRIGDGAEAAVYEAIKNDEGISVALKRYKKVNNLRDGIPL-----EVEIAKMLDNDYCLKVFSHFKSVTGDFIVTMPLAQHG----ALQ----PSN | |.|.|| |. . ||.... ..|. ||.|. ||... . |..| |.|. .. .. . | . .. . |.....| | .. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTWR KPEI--SISGAIQLVYQIGNGLQYMHSHRIVHRDIKPQNILLL-DGNY----VLCDYSVSAVL-KSDDELLTGYTGSPIFMAPEVSP-TLYKPRPPDLWS . . | .. .||| ||.|.||..|.|||.||.|||. .|. .|| ..... .. .|...|.| .||||| | ... | || HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS LGVTVYVLLFGCYPYKLER----GLVQVEQNYVKNVSKSLDLGDLTFPEVP--------------SIPQELKDVIAGLLEKNPDQRMTASDICNNPWL .|...| .|.| |.. .. . . | .... .. |. . ... ...|.||.| ..|.|.| .| || .|.. ||. CGCILYEMLCGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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Kinase | 87634.m00053.AA | Ciliate-E2 | 55-312 | 18 | 9e-42 | 141.16 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 55-312 Range on HMM: 1-365/365 Sequence Identity: 18% (73 aa) YSIIRRIGDGAEAAVYEAIKNDEGISVALK-------------------RYKKVNNLRDGIPLEVEIAKM------------------LDNDYCLKVFSH | .|. || |. . ||.. . .. .|.| ..|... .. . .. || | |.... .| . . YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC FKS-VTGDFIVTMPLAQHGALQ---------PSNKPE----ISISGAIQLVYQIGN---------------GLQYMHSHR-IVHRDIKPQNILLLDGNYV |.. . . | ..|.| |. ...| ... .... .|| . .|.|.|| |.||||||.|||. FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IK LCDYSVSAVLKSD-------------------------------DELLTGYTGSPIFMAPEVSPTLY---------KPRPPDLWSLGVTVYVLLFGCYPY ..| | .. | ... . |.| .||||. |.|||||. | .||| .|. IIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF KLERGLVQVEQNYVKNVSKSLDLG-DLTFP----------------EVPSIPQELKDVIAG----LLEKNPDQRMT-ASDICNNPWL . .. || . ...|| || | .|.|.|..|.| ...| |.||. ------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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Kinase | 87634.m00053.AA | CAMKK | 160-312 | 28 | 1.3e-40 | 126.36 | In-house | 188-396 (396) | Show / Hide |
Range on Protein: 160-312 Range on HMM: 188-396/396 Sequence Identity: 28% (61 aa) GLQYMH-SHR-------------------IVHRDIKPQNILL-LDG---NYVLCDYSVSAVLKSDDELLTG-----------YTGSPIFMAPEVSPT-L- ||.|.| . |.||||||||||. .| . ...|..|| ....|..| . | | |||||. . GLEYLHNYQKACSYIIIYINEFIIDHFQDIIHRDIKPQNILIDEEGCGEHVKIADFGVSHIFEGQDQTLSNCESCFQRELNKTAGTPAFMAPELCSKENQ --------------YKPRPPDLWSLGVTVYVLLFGCYPYKLERGLVQVEQNYVKNVSKSLDLGDLTFPE-----------VPSIPQELKDVIAGLLEKNP |. .. | |.|||| | ..|| |.. . . . || | . .. ..||| | |. .|||.| ..||||| KENYNGYKYRFRFIYCGKAADIWALGVTLYCFVFGKCPFWHNNLMQLHH-NYMKIKNDP-----IKFPENKEMLNNVSIYCPEISEDLKDLIKRMLEKNP DQRMTASDICNNPWL ..|.|...| ..||. TKRITIPQIKVHPWV |
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Kinase | 87634.m00053.AA | ULK | 150-312 | 27 | 1.2e-38 | 132.54 | In-house | 132-329 (329) | Show / Hide |
Range on Protein: 150-312 Range on HMM: 132-329/329 Sequence Identity: 27% (55 aa) AIQLVYQIGNGLQYMHSHRIVHRDIKPQNILLLDGN-------------YVLCDYSVSAVLKSD---DELLTGYT------GSPIFMAPEVSPTL----- ||| .|| ||....|.|.|.||||||||||. .|. . ..| . .. .| ..... .. |.|..|||.. . AIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKP YKPRPPDLWSLGVTVYVLLFGCYPYKLERGLVQVEQNYVKNVSKSLDLGD------LTFP---EVPSIPQELKDVIAGLLEKNPDQRMTASDICNNPWL | |.||||. | .|.| .|.. |..|.. |.. . . ... | || . | | .|.|| | ..|......|.. .. |.||. YYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF |
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Kinase | 87634.m00053.AA | CAMKK-Unclassified | 160-312 | 24 | 1e-35 | 113.63 | In-house | 190-392 (392) | Show / Hide |
Range on Protein: 160-312 Range on HMM: 190-392/392 Sequence Identity: 24% (51 aa) GLQYMHSHR---------------------IVHRDIKPQNILL-LDGN-----YVLCDYSVSAVLKSDDEL-LTGYTGSPIFMAPEVSPTL-YKPRPPD- |||||| |.||||||||||. ..| ...|...| ...... | . | . |||||. | .. | GLQYMHNFNQACSYIIIYINEFDKIDHFQDIIHRDIKPQNILIDHEDNDKGEHFKIADFGISVIMEHEQQKKLKNNAGTYCFMAPEFWSKENFKYDYNDY --------------------------LWSLGVTVYVLLFGCYPYKLERGLVQVEQNYVKNVSKSLDLGDLTFPE--VPSIPQELKDVIAGLLEKNPDQRM |||||| | . .. |.. . . .. . ... || | .. |.|| | ....|||. | SFLPGTFNPLRKTYRIERICFYKKADIWSLGVTFYCMVYHSLPFWHKNLQE------LFH--QMICQKEINFPPQYHPHCSHEFKDLIQKMCDKNPKKRI TASDICNNPWL |.... ..||. TIDQMLVHPWF |
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Kinase | 87634.m00053.AA | CAMKL | 156-312 | 30 | 3.2e-35 | 109.73 | In-house | 135-297 (297) | Show / Hide |
Range on Protein: 156-312 Range on HMM: 135-297/297 Sequence Identity: 30% (52 aa) QIGNGLQYMHSHRIVHRDIKPQNILLL-DG--NYVLCDYSVSAVLKS----DDELLTGYTGSPIFMAPEVSPT--L-YKPRPPDLWSLGVTVYVLLFGCY || ...|.|||.|||||||| |||| .| | ..| |. . ....|. ||| .||||. | .. | ||.||. |....| . QIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYL PYKLE---RGLVQVEQNYVKNVSKSLDLGDLTFPEVPSIPQELKDVIAGLLEKNPDQRMTASDICNNPWL | . . . .. . . . | .| .... ...| | ..|..||..|.|. .| | ||. PFDDDTYNK----QGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM |
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Kinase | 87634.m00053.AA | Ciliate-E2-Unclassified | 150-312 | 26 | 4.6e-35 | 119.07 | In-house | 140-352 (352) | Show / Hide |
Range on Protein: 150-312 Range on HMM: 140-352/352 Sequence Identity: 26% (57 aa) AI-----QLVYQIGNGLQYMHSH-RIVHRDIKPQNILLLDG----NYVLCDYSVSAVLKSD---------------DELLTGYTGSPIFM----APEVS- |. .. .|| .||.|.|. |.||||||.|||. .. . ..|.. | .... ..... .|.|..| |||| AKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQ -PTLYKP--RPPDLWSLGVTVYVLLFGCYPYK--LERGLVQVEQNYVKN------VSKSLDLGDLTFPEVP------SIPQELKDVIA----GLLEKNPD ... | ||||| | .||| ||.. . |.... . | . . ... ||. | ...| || | .|.|||. GQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWI-NNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPN QRMTASDICNNPWL .|.|...|.| ||. KRITFEQILNHPWF |
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Kinase | 87634.m00053.AA | ULK | 150-312 | 27 | 3.8e-32 | 111.4 | In-house | 128-324 (324) | Show / Hide |
Range on Protein: 150-312 Range on HMM: 128-324/324 Sequence Identity: 27% (54 aa) AIQLVYQIGNGLQYMHSHRIVHRDIKPQNILLLDGN-------------YVLCDYSVSAVLKSDD---ELLTGYT------GSPIFMAPEVSPTL----- ||| .|| ||....|.| |.||||||||||. .|. . ..| . .. ... ... . |.|..|||.. . AIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKP YKPRPPDLWSLGVTVYVLLFGCYPYKLERGLVQVEQNYVKNVSK------SLDLGDLTFP---EVPSIPQELKDVIAGLLEKNPDQRMTASDICNNPWL | |.||||. | .|.| ||.. |... | . . . || . | | .|.|| | ..|......|.. .| |.||. YYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLY-IQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF |
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Kinase | 87634.m00053.AA | RSK | 155-312 | 28 | 3.5e-25 | 89.2 | In-house | 111-278 (278) | Show / Hide |
Range on Protein: 155-312 Range on HMM: 111-278/278 Sequence Identity: 28% (50 aa) YQIGNGLQYMHSHRIVHRDIKPQNILLLD----GNYVLCDYSVSAVLKSD-DELLTGYTGSPIFMAPEVSPTLYKPRP-----PDLWSLGVTVYVLLFGC ..| ....|.. |.|||.|| |||. | | .|.| . .. | ... . .. .||||. . . .. |.||||| | .|.|| AEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRAN-QQGGHDKACDWWSLGVLMYEMLTGC YPYKL-ERGLVQVEQNYVKNVSKSLDLGD--LTFPEVPSIPQELKDVIAGLLEKNPDQRMT-----ASDICNNPWL |.. .. | | ..| |. ||.|. ... || || | ..|...| .| . |..| ..||. PPFQGPND-------NNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF |
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Kinase | 87634.m00053.AA | Meta | 160-246 | 41 | 1.1e-19 | 53.41 | In-house | 135-228 (287) | Show / Hide |
Range on Protein: 160-246 Range on HMM: 135-228/287 Sequence Identity: 41% (39 aa) GLQYMHSHRIVHRDIKPQNILLLDGNYV-LCDYSVSAVLKSDDELLTG--YTGSPIFMAPEVSPTLYKP----RPPDLWSLGVTVYVLLFGCYP || | | |.|||||| | || | . | |. || . || .| . |.| ||||| .. | | |..||| | ..|| | GLEYLHYQKIIHRDIKPSNLLLNDDGHVKIADFGVSNEFEGDDAFLCNGSTAGTPAFMAPEACSEEQNHFYCGRALDVWAMGVTLYCFVFGQCP |
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Kinase | 87634.m00053.AA | Meta | 273-312 | 42 | 1.8e-14 | 38.13 | In-house | 248-287 (287) | Show / Hide |
Range on Protein: 273-312 Range on HMM: 248-287/287 Sequence Identity: 42% (17 aa) LTFPEVPSIPQELKDVIAGLLEKNPDQRMTASDICNNPWL ..||| | | .|||.| ..|.||| .| . ..| || VMFPEQPEISEDLKDCIKRMLDKNPEHRIMIPEIKTHPWV |
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Kinase | 87634.m00053.AA | TyrKc | 55-316 | 19 | 1.4e-09 | -67.57 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 55-316 Range on HMM: 1-280/280 Sequence Identity: 19% (57 aa) YSIIRRIGDGAEAAVYEAIKNDEGISVALKRYKKVNNLRDGIPLEVEIAKML--DNDYCLKVFSHFKSVT------GDFIVTMPLAQHGALQ---PSNKP . .. .| || ||... . | || | |. | . | .| ..| ... .. . . . . | .. ||.|. ...| ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP EISISGAIQLVYQIGNGLQYMHSHRIVHRDIKPQNILLLDGNYV-LCDYSVSAVLKSD-------DELLT----GYTG-SPIF-MAPEVSPTLYKPRPP- ... . .. .|| .| .| ||....|||. |.|. ... | .| | ...| | . | . || ||||. .| . KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFTTKS DLWSLGVTVYVLLFGCYPYKLE-----RGLVQVEQNYVKNVSKSLDLGDL----TFPEVPSIPQELKDVIAGLLEKNPDQRMTASDICNNPWLVSEY | || ||. . .. . . . .| .. . . .. . | . |.|. ... . .|..| | |.| ... DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQG--YRMPQPPNDYPMSF---VCCPDEMYQIMKQCWHEDPEDRPTFSEI------HECF |
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Kinase | 87634.m00053.AA | ULK | 55-120 | 18 | 3e-06 | 18.45 | In-house | 1-86 (324) | Show / Hide |
Range on Protein: 55-120 Range on HMM: 1-86/324 Sequence Identity: 18% (16 aa) YSIIRRIGDGAEA-AVYEAIKNDE---GISVALKRYK-----KVNNLRD------GIPLEVEIAKMLD------NDYCLKVFSHFKS |......| |. . ||...... . || | | .|... . |..| |.|. . .. | . |.. YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNH-HIVKLYDWFET |
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Kinase | 87634.m00053.AA | ULK | 55-120 | 15 | 0.0001 | 12.52 | In-house | 1-89 (329) | Show / Hide |
Range on Protein: 55-120 Range on HMM: 1-89/329 Sequence Identity: 15% (14 aa) YSIIRRIGDGAEAAVYEAIKNDE----GISVALKRYK---KVNNLRD--------GIPLEVEIAKMLD--------NDYCLKVFSHFKS |......| |. . ||...... .. || | . ... . . |..| |.|. . .. | . |.. YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFET |
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Kinase | 87634.m00053.AA | Pkinase_Tyr | 140-174 | 28 | 0.000234 | 15.38 | Pfam | 103-137 (270) | Show / Hide |
Range on Protein: 140-174 Range on HMM: 103-137/270 Sequence Identity: 28% (10 aa) SNKPEISISGAIQLVYQIGNGLQYMHSHRIVHRDI ..|. .... .| .|| .|..| .|....|||. EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL |
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Kinase | 87634.m00053.AA | CAMKL | 55-118 | 21 | 0.000387 | 8.94 | In-house | 1-84 (297) | Show / Hide |
Range on Protein: 55-118 Range on HMM: 1-84/297 Sequence Identity: 21% (18 aa) YSIIRRIGDGAEAAVYEAIK-NDEGISVALKRYKKVNNLRDGIPL----------------EVEIAKMLD---NDYCLKVFSHF | |.. .| |. . | |. |. || | ..| | . . |..| |||. | . .. YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVI |
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Kinase | 87634.m00053.AA | Ciliate-E2-Unclassified | 55-91 | 32 | 0.000679 | 9.42 | In-house | 1-37 (352) | Show / Hide |
Range on Protein: 55-91 Range on HMM: 1-37/352 Sequence Identity: 32% (12 aa) YSIIRRIGDGAEAAVYEAIKNDEGISVALKRYKKVNN | ||. || |. . ||........ |.| ||... YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQI |