Gene 95535.m00021 (T.vaginalis)

95535.m00021

Species: T.vaginalis
Alias: TvagK0508, 95535.m00021
External Links:
Annotation:

Classification

Group: CK1
Family: TTBK

Sequence

Name Sequence Type Origin Length Description Download
95535.m00021.AA Protein None 324 None Fasta, JSON
95535.m00021.kin_dom Protein Kinase Domain None 187 None Fasta, JSON

Protein domain

Protein domains of 95535.m00021.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 95535.m00021.AA CK1 10-263 25 1.7e-81 277.06 In-house 1-339 (339) Show / Hide 
Range on Protein: 10-263
Range on HMM: 1-339/339
Sequence Identity: 25% (85 aa)

YSIIQRLGSGGYG-EIYAA-----KKENDE-----TIYAIKTESIETKQKG--MELEINILKS-------------------LPQASCFATVIDSGSTAA
. ... .|.||.| .|| .     | ...      . ||.|.|..... ..  .. |....|                     ......  ... .    
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

--VNYFVMPLYGPSLAALKS--KSEIKRFSLYTALWASKQMLLILQRLHSYGFVHCDVKPSNFLLQQ--------------KSIGGLVLIDFGLSS-KFR
   || ||.|.||.|  |.   .   ..||. |.|    |||  |. .|. ||.| |.||.||..                .    ...||||..  |.|
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

NESG------------KHIENKS---SDGFRG-TLKYASINIHKLQEPTRRDDVISWFYSLVELVKGQ--LPWHDVRDKNL-----CMSCKQTITTEKLC
. .|            .|.. ..     |||| |..|.||| |. .|..||||. |||| |.|..||.  |||....|..       .  |. ...||..
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

QN------------LPPQTIEIWNHCRDLKFDEEPNYSFI
..            .|..  .|....| ||....|.| .|
STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase 95535.m00021.AA TTBKL 10-267 28 3.1e-70 236.31 In-house 1-288 (288) Show / Hide 
Range on Protein: 10-267
Range on HMM: 1-288/288
Sequence Identity: 28% (81 aa)

YSIIQRLGSGGYGEIYAAKKENDETIYAIKTESIETKQKG---MELEINILKSLP--QASCFATVIDSGSTAAVNYFVMPLYGPSLAALKSKSEIKR-FS
. |.. .|.||.|..| ..  .| . .|.. |   .. .|   |..|...|. |.   .. |.....|| .   |..|| | ||.| .|....  |. ||
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

LYTALWASKQMLLILQRLHSYGFVHCDVKPSNFLLQQK---SIG--GLVLIDFGLSSKFRNESG-----------KHIENKS---SDGFRGTLKYASINI
  |..  . | |  |. .|..||.| ||||.|. .  .   .     . |||||.. ......|           .. . ..   . .||||..|.|.|.
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

HKLQEPTRRDDVISWFYSLVELVKGQLPWHDVRDKNLCMSCKQTITTEKLCQN------LPPQTIEIWNHCRDLKFDEEPNYSFIIEQI
|  .| .| ||  ||.|...||..| |||... ||  ... |.  ..|.|...      .|..  ..  | | |.. ..|.|. |.| .
HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase 95535.m00021.AA Worm6 10-263 27 1.1e-56 194.69 In-house 1-279 (279) Show / Hide 
Range on Protein: 10-263
Range on HMM: 1-279/279
Sequence Identity: 27% (78 aa)

YSIIQRLGSGGYGEIYAAKKENDET--IYAIKTES--IETKQKGMELEINILKSLPQAS--CFATVIDSGSTAA--VNYFVMPLYGPSLAALKSKSEIKR
... . .|.||.| .| .... | .   .|.| |.   . | .   .|...|| . .     | ...| | .     || ||.|.|..|. |.  .. ..
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

FSLYTALWASKQMLLILQRLHSYGFVHCDVKPSNFLLQQ------KSIGGLVLIDFGLSS--KFRNESGKHIENK-SSDGFRGTLKYASINIHKLQEPTR
||. |.|  . |.|  .. ||. ||.| ||||.||   .      . .  . ..|||..   |..|. .. .  .    |||||..||... || ||  |
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR

RDDVISWFYSLVELVKGQLPWHDVRDKNLCM-SCKQTITTEK------LCQNLPP-QTIEIWNHCRDLKFDEEPNYSFI
.||. |||| .||...|.|||. ..|..      |... . .      . .. |. .. .|      ... ..|.| ||
KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase 95535.m00021.AA TTBK 10-263 36 2.3e-55 190.23 In-house 1-257 (257) Show / Hide 
Range on Protein: 10-263
Range on HMM: 1-257/257
Sequence Identity: 36% (93 aa)

YSIIQRLGSGGYGEIYAAKK-END-ETIYAIKTESIETKQKGMELEINILKSLPQASCFATVIDSGSTAAVNYFVMPLYGPSLAALKSKSEIKRFSLYTA
  .... | ||.|||| ||   |. | . ||| || ...   . .|. .|| |         |  |     || || | | .|| |  |     ||| |.
WKVVKKIGGGGFGEIYEAKDMINHHEQV-AIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTT

LWASKQMLLILQRLHSYGFVHCDVKPSNFL--LQQKSIGGLVLIDFGLSSKFRNESGKHIENKSSDGFRGTLKYASINIHKLQEPTRRDDVISWFYSLVE
|   .|.|  ..  || || | |.|||||   .  . .    ..||||  .. | .|      .. |||||  ||||| |. .|  |.||  | || |||
LRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVE

LVKGQLPWHDVRDKNLCMSCKQTITTEKLCQNLPPQTIEIWNHCRDLKFDEEPNYSFI
 |.|||||  ..||.   . |.   .  | ...|..     .| . |.. . |.| .|
FVQGQLPWRKIKDKDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase 95535.m00021.AA CK1-D 10-263 33 5.9e-46 158.99 In-house 1-261 (261) Show / Hide 
Range on Protein: 10-263
Range on HMM: 1-261/261
Sequence Identity: 33% (88 aa)

YSIIQRLGSGGYGEIYAAKKENDETIYAIKTESIETKQKGMELEINILKSLPQASCFATVIDSGSTAAVNYFVMPLYGPSLAALKSKSEIKRFSLYTALW
| |  ..||| .|.||  .. . .   ||| |.| ||   ...|  . | .       ..   |.    |  || | ||||  |    . ..||| | | 
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCH-RKFSLKTVLM

ASKQMLLILQRLHSYGFVHCDVKPSNFLLQQKSIGGLV-LIDFGLSSKFRNES-GKHIENKSSDGFRGTLKYASINIHKLQEPTRRDDVISWFYSLVELV
 . ||.  .. .|.  |.| |.|| |||.     | .| .|||||. ..|     .||  .      || .||||| |.  |  ||||. |  | |.   
LADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFN

KGQLPWHDV-----RDK-NLCMSCKQTITTEKLCQNLPPQTIEIWNHCRDLKFDEEPNYSFI
.| |||  .     |.| .  .  |  .  ..||. .| .  .  |.|| ||||. |.|...
RGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase 95535.m00021.AA CK1 10-261 30 1.5e-45 154.83 In-house 1-271 (271) Show / Hide 
Range on Protein: 10-261
Range on HMM: 1-271/271
Sequence Identity: 30% (84 aa)

YSIIQRLGSGGYGEIYAAKKENDETI--YAIKTESIETKQKGMELEINILKSLPQ------ASCFATVIDSGST--AAVNYFVMPLYGPSLAALKSKSEI
| .....|.|  |.|| ..  ...    .||| |.. .|.     |. |.| |        .  ..... .|       |. || | ||||  |. .   
YRVGRKIGQGSFGDIYLGINMTNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFCN-

KRFSLYTALWASKQMLLILQRLHSYGFVHCDVKPSNFLLQ--QKSIGGLVLIDFGLSSKFR-NESGKHIENKSSDGFRGTLKYASINIHKLQEPTRRDDV
..|||.| |    ||.  .. .|. .|.| |.|| |||    .|    . .|||||. ..|  ....||. .   .. ||  ||||| |   |  |||| 
RKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDM

ISWFYSLVELVKGQLPWHDVRDKNLC------MSCKQTITTEKLCQN-LPPQTIEIWNHCRDLKFDEEPNYS
 |  | |. . .|.||| ... ..        |  |.... | ||.. .| . ..  |.|| |.|.|.|.| 
ESLGYVLMYFLRGSLPWQGLKANTKKQKYEKIMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM
Kinase 95535.m00021.AA CK1-A 10-263 31 1.4e-42 147.76 In-house 1-261 (261) Show / Hide 
Range on Protein: 10-263
Range on HMM: 1-261/261
Sequence Identity: 31% (82 aa)

YSIIQRLGSGGYGEIYAAKKENDETIYAIKTESIETKQKGMELEINILKSLPQASCFATVIDSGSTAAVNYFVMPLYGPSLAALKSKSEIKRFSLYTALW
| .....||| .|.|| . . ..    ||| || . .   .  |  . . |  .  . ..   |.    | .|| | ||||  |    . .||.. | | 
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCK-RRFTMKTVLM

ASKQMLLILQRLHSYGFVHCDVKPSNFLL-QQKSIGGLVLIDFGLSSKFR-NESGKHIENKSSDGFRGTLKYASINIHKLQEPTRRDDVISWFYSLVELV
   ||.  .  .|  .|.| |.|| |||.   .    | ||||||. |.| ... .||. .      || .||||| |   | .||||. |  | ..   
LADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFN

KGQLPWHDVRDKNL------CMSCKQTITTEKLCQNLPPQTIEIWNHCRDLKFDEEPNYSFI
.|.|||  .. ..           | ... |.||.  | .   . |.||.|.|.|.|.| ..
RGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase 95535.m00021.AA CK1-Unclassified 10-235 33 3.6e-42 122.25 In-house 1-244 (244) Show / Hide 
Range on Protein: 10-235
Range on HMM: 1-244/244
Sequence Identity: 33% (81 aa)

YSIIQRLGSGGYGEIYAAKKENDETIYAIKTESIETKQKGMELEINILKSLPQAS-------CFATVIDSGST--AAVNYFVMPLYGPSLAALKSKSEIK
| .|...|.|  |||| ..  .... .||| |.  .|..    |. |.. |   .        .. .. .|       |. || | ||||  |. .   .
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMCN-R

RFSLYTALWASKQMLLILQRLHSYGFVHCDVKPSNFLLQ--QKSIGGLVLIDFGLSSKFR--NESGKHIENKSSDGFRGTLKYASINIHKLQEPTRRDDV
.|||.| |    ||.  .. ||. .|.| | || |||    .|    . .|||||| ...   . ||||. .   .. ||  ||||| |.  |  |||| 
KFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDDL

ISWFYSLVELVKGQLPWHDVRDKNLC------MSCKQTITTEKLC
 |  | |. . ||.||| ... .|        |  |.... | ||
ESLGYVLIYFLKGSLPWQNIKANNKKEKYEKIMEMKMSTPVEQLC
Kinase 95535.m00021.AA CK1-Unique 10-213 24 1.7e-24 81.83 In-house 1-232 (337) Show / Hide 
Range on Protein: 10-213
Range on HMM: 1-232/337
Sequence Identity: 24% (57 aa)

YSIIQRLGSGGYGEIYAAKKENDE------TIYAIKTESIETKQK--GMELEINILKSLPQAS-------CFATVIDSGSTAAVNYFVMPLYGPSLAALK
. .| ..|.||||  .   ..|..        |. ||| .  ..       | |..|..   .        |  |.|.. .    . || . |||.  ..
WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEECC

SKSEIKRFSLY------TALWASKQMLLILQRLHSYGFVHCDVKPSNFLLQQKS---IGGLVLIDFGLSSK----FRNESGKHIENKSSDGFRGTLKYAS
 .     | |       .|.  . | |  . . |  || | . || |. .   |      .  .|.| . .      | ... .  . .  |||...|..
MMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPRPITP--FRGCKDYCP

INIHKLQEPTRRDDVISWFYSLVELVKGQ--LPW
.  |...| .||||  ||||.|. || .   | |
CSCHQCREHGRRDDMESWFYMLYHLVHNTRGLSW
Kinase 95535.m00021.AA Pkinase 10-181 23 3e-23 83.27 Pfam 1-179 (293) Show / Hide 
Range on Protein: 10-181
Range on HMM: 1-179/293
Sequence Identity: 23% (45 aa)

YSIIQRLGSGGYGEIYAAKKENDETIYAIKTESIETKQKGME----L--EINILKSLPQASCFATVIDSGSTAAVNYFVMPLYGP-----SLA----ALK
| |....|||..|. | ... ... |.|.|. . ... ....    .  || |.|.| .  .  . .|.  .    |.||.. .      .|.    .  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--

SKSEIKRF--SLYTALWASKQMLLILQRLHSYGFVHCDVKPSNFLLQQKSIGGL----VLIDFGLSSKFRNESGKHIENKSSDGFRGTLKYAS
  .. ..|  |  ..    .|.|  |. .|| |..|.|.||.|.|. ..  | .     ..||||. .|.     .  |   ..| ||. |..
--WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNN--GHIDACVKICDFGLAKQFD-----Y-NNS-MTTFCGTPWYMA
Kinase 95535.m00021.AA CK1-G 10-263 28 9.6e-23 73.84 In-house 1-266 (266) Show / Hide 
Range on Protein: 10-263
Range on HMM: 1-266/266
Sequence Identity: 28% (77 aa)

YSIIQRLGSGGYGEIYAAKKENDETIYAIKTESIETKQKGMELEINILKSLPQAS-CFATVIDSGSTAAVNYFVMPLYGPSLAALKSKSEIKRFSLYTAL
| .  . | | .||..  |        ||| | . ..   . .|    | | ...     |   |     |  || | ||||  |    .  .||. | .
YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFDWCD-RKFSVKTVC

WASKQMLLILQRLHSYGFVHCDVKPSNFLLQQKSIGG---LVLIDFGLSSKFRN-ESGKHIENKSSDGFRGTLKYASINIHKLQEPTRRDDVISWFYSLV
  ..||.  .. .||   .  |||| |||  ..|      . .||||.  ...  | ..||         ||  | ||| |  .|  ||||  .      
MVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDMEALGHMFM

ELVKGQLPWHDVRDKNLCM------SCKQTITTEKLCQN--LPPQTIEIWNHCRDLKFDEEPNYSFI
    |.|||   .  |.          |. .  | ||||  .| |        | |.|.|.| | ..
YFLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL
Kinase 95535.m00021.AA S_TKc 10-290 17 3.5e-14 31.12 SMART 1-231 (231) Show / Hide 
Range on Protein: 10-290
Range on HMM: 1-231/231
Sequence Identity: 17% (53 aa)

YSIIQRLGSGGYGEIYAAKKENDETIYAIKTESIETKQKGMELEINILKSLPQASCFATVIDSGSTAAVNYFVMPLYGP---SLAALKSKSEIKR----F
| |.. .|.|..|. | ... ..  |.|||  .     . .. ||.|||.  .     . .|.  .    |.|| . .    .|  .  |   ..    |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

SLYTALWASKQMLLILQRLHSYGFVHCDVKPSNFLLQQKSIGGLVLIDFGLSSKFRNESGKHIENKSSDGFRGTLKYASINIHKLQEPTRRDDVISWFYS
.  .|    .|... |. .|| |..|.|.||.| || .     . ..||||. ..             . | ||. | .  .               .  
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL-------------TTFCGTPWYMAPEVL-------------GYGK

-----------LVELVKGQLPWHDVRDKNLCMSCKQTITTEKLCQNLPPQTIEIWNHCRDLKFDEEPNYSFIIEQIDSIFKENEW---TASMPLD----W
           | |.. |. |..     .. |  |.                                 ...   |. ... .     ||   |     .
CKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG-----------------------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDI

ENSTSI
 .   .
KCHPWF
Kinase 95535.m00021.AA TyrKc 10-267 17 0.000429 -156.43 SMART 1-280 (280) Show / Hide 
Range on Protein: 10-267
Range on HMM: 1-280/280
Sequence Identity: 17% (50 aa)

YSIIQRLGSGGYGEIYAAKKENDETIYAIKTESIETKQKGMELEINILKSL-PQA----SCFATVIDS-------GSTAAVNYFVMPL--YGPSLAALKS
 . .. ||.| .||.| ..     .  |.|.   .. .. .  |..|...| ..      ... ....       .      . || .  .|  .  |..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPL----MIVMEYMPHGDLKDYLRK

KSEIKRFSLYTALWASKQMLLILQRLHSYGFVHCDVKPSNFLLQQKSIGGLVLI-DFGLSSKFRNE-----SGKHIENKSSDGFR--GTLKYASINIHKL
. .   ... . |  . |     . ||| ...| |    | |.  .     | | ||||| .  ..     |.. .  |...| .    ..  ..   . 
HRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

QEPTRRDDVISWFYSLVELV-KGQLPWHDV----RDKNLCMSCKQTITTEKLCQN--------LPPQTIEIWNHCRDLKFDEEPNYSFIIEQI
 . |   || |.   . |.   || |. ..     .    . . ..    .  .|         |.   .|   | . . .. |. | |.|..
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF