Gene 94291.m00051 (T.vaginalis)

94291.m00051

Species: T.vaginalis
Alias: TvagK0765, 94291.m00051
External Links:
Annotation:

Classification

Group: CMGC
Family: GSK

Sequence

Name Sequence Type Origin Length Description Download
94291.m00051.AA Protein None 322 None Fasta, JSON
94291.m00051.kin_dom Protein Kinase Domain None 276 None Fasta, JSON

Protein domain

Protein domains of 94291.m00051.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 94291.m00051.AA GSK 26-301 35 1.9e-94 288.86 In-house 1-328 (328) Show / Hide 
Range on Protein: 26-301
Range on HMM: 1-328/328
Sequence Identity: 35% (117 aa)

YRVIEKIGSGTFGNIYAIEYY----DRRRL-----ALKKVLQDPKYK-NRELTMIQAL---RHPNCLKL-----HQYELKREGDQEFL-YIFTDLLPTDL
|. ...||.|.||. |         .  .      | |||.||..|| |||| ... |   .|||. .|     ..|| | |..   . ... . .| .|
YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIKKVWQDKRYKCNRELQIMKMLGKLDHPNIVRLKYFFYMHYEKKDENHVYCNCLVM-EYMPQTL

HKYLR-----KNKITTSLAKIFGYQLFNGLDYLHKINITHRDIKSSNILVDPDTGILKICDFGSAKELKI--NEASVSYISTRSYRAPELLYESQFYTSK
....|     | .... . |.. ||.| || |||...| ||||| .|||||||||.|||||||||| |.   ||...||| .| ||||||.  .. ||..
YQVIRHYVKNKQQMPIIHIKLYMYQMFRGLAYLHSHGICHRDIKPQNILVDPDTGVLKICDFGSAKQLEPNKNEPNISYICSRYYRAPELIFGCTNYTCQ

IDVWAAGCVLSEMFKGGDEIFHADSNQSLKQIILNFIGTPTISDFHDMNLQLQPQFYHP------GIG------------------------IEHAFNEP
|||| .|||. ||.||.  .|  ||       | . .||||  ... || . .|.| .|        .                        . ......
IDVWSCGCVMAEMLKGQ-PLFPGDSSVDQLVEIIKMLGTPTKEQIQSMNPS-YPEFKFPYWSFQQIKPHPWQKNDTKYEYQTYYHKKYRTVYMFKWCHTD

LDPLLLDLLKKIFVYSPVLRYTAEQAKYHPFF
 .  ..||..|..|| |  | .. .|  ||||
MQ-DWIDLISKCLVYDPKKRLSPLEACAHPFF
Kinase 94291.m00051.AA CMGC 26-301 18 1.2e-84 278.0 In-house 1-513 (513) Show / Hide 
Range on Protein: 26-301
Range on HMM: 1-513/513
Sequence Identity: 18% (98 aa)

YRVIEKIGSGTFGNIYAIEY---------------YDRRRLALKKVLQDPKYKN----------------RELTMIQALR-----------------HPN
| .|.|||.||.|. |                    . .. |.||. ... |..                ||. . . |.                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

CLKLHQYELKRE--GDQE-----------FLYIFTDLLPTDLHKYLRKNK-----------------------------ITTSLAKIFGYQLFNGLD--Y
..||. .   ..  |...            ||. ......||..|...|.                             ..  . . . ||...||.  |
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

LHKIN--ITHRDIKSSNILVDPDT-------------------GILKICDFGSAKELKIN----------------------EASVSYISTRSYRAPELL
.|. .  | |||.| .|||.....                   |.|||||||.|. . ..                      ..  .|..|| |||||.|
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

YES---------QFYTSKIDVWAAGCVLSEMFKG-------GDEIFHADSN-----------QSLKQIILNFIGTPT---------------ISDFHDM-
  .         . ||..||.|..||.. ||. |       |. .|. .|.           .   . | . .||||                 .. .| 
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI

-------------------------------NLQLQPQFYHPGIGIEHAFNE-------------------------------PLDPLLLDLLKKIFVYS
                               |...... ..|   ..  ...                                .||...|||||...| 
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYD

PVLRYTAEQAKYHPFF
|  | |||||  ||.|
PDKRITAEQALQHPYF
Kinase 94291.m00051.AA S_TKc 26-301 26 1e-68 235.51 SMART 1-231 (231) Show / Hide 
Range on Protein: 26-301
Range on HMM: 1-231/231
Sequence Identity: 26% (78 aa)

YRVIEKIGSGTFGNIYAIEYYD-RRRLALKKVLQDPKYKNRELTMIQALRHPNCLKLHQYELKREGDQEFLYIFTDLLPT---DLHKYLRKNK-------
|....|||.|.||  |     .  |. |.|..    .   ||. . .  .|||  ||. .        ..||........   ||..|..|..       
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

ITTSLAKIFGYQLFNGLDYLHKINITHRDIKSSNILVDPDTGILKICDFGSAKELKINEASVSYISTRSYRAPELLYESQFYTS-KIDVWAAGCVLSEMF
..   |. . ||....|.|.|. .| |||.| .|||.|     .||||||.|..|       ... |. |.|||.|     |.  |.|.|. ||.| ||.
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEML

KGGDEIFHADSNQSLKQIILNFIGTPTISDFHDMNLQLQPQFYHPGIGIEHAFNEPLDPLLLDLLKKIFVYSPVLRYTAEQAKY-------HPFF
  |   |.        | ... ||                                 .| ..|...|.... |  |.|| .|         ||.|
C-GYPPFP------QMQMMFKKIG---------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 94291.m00051.AA Pkinase 26-301 27 8.5e-61 213.09 Pfam 1-293 (293) Show / Hide 
Range on Protein: 26-301
Range on HMM: 1-293/293
Sequence Identity: 27% (83 aa)

YRVIEKIGSGTFGNIY-AIEYYDRRRLALKKVLQDPKYKNR--------ELTMIQALRHPNCLKLHQYELKREGDQEFLYIFTDLLPT-----DLHKYLR
|....|||||.||  | ...  .... |.|..  . . ..         |. . . |.||| ..|. .          .|. .....      ||. |..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYIS

---KNKI--TTSLAKIFGYQLFNGLDYLHKINITHRDIKSSNILVDPDTGI---LKICDFGSAKE--LKINEASVSYISTRSYRAPELLYESQFYTSKID
   ....  .   .| . ||.. ||.|.|. .| |||.|..|||.| .  |   .||||||.||   .  |.   ..  |. |.|||.. ..| |..|.|
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

VWAAGCVLSEMFKGGDEIFHAD----SNQSLKQIILNFIGTPTISDFHDMNL-QLQPQFYHPGIGIEHAFNEPLDPLLLDLLKKIFVYSPVLRYTAEQAK
.|..||.| ||.  |  .|  .    .  . .|.| .  |.|. .|.   .   . . |.|    . | ..  ... ..|..|... . |  |.||||..
MWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWTFHNWSEECKDFIKWCLCKDPKKRPTAEQIL

YHPFF
 ||.|
QHPWF
Kinase 94291.m00051.AA CDK 26-301 30 3.9e-54 171.5 In-house 1-284 (284) Show / Hide 
Range on Protein: 26-301
Range on HMM: 1-284/284
Sequence Identity: 30% (98 aa)

YRVIEKIGSGTFGNIY-AIEYYDR-----RRLALKKV-LQD----------PKYKNRELTMIQALRHPNCLKLHQYELKREGD-------QEFLYIFTDL
|  .|||| ||.|  | |.   .      .  ||||. ..           |    || .. . | |||  |||   .  . |       .  ||.  . 
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

LPTDLHKYLRKNKITTSLAKIFGYQLFNGLDYLHKINITHRDIKSSNILVDPDT----GILKICDFGSAKELKI-------NEASVSYISTRSYRAPELL
...|| ||..         | . .|| .||.|.|. .| |||.| .|||.. .     | ||| ||| |..  |       | .  . . |. |||||||
MDHDLKKYMD--------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELL

YESQFYT--SKIDVWAAGCVLSEMFK--GGDEIFHADSNQSLKQI--ILNFIGTPTISDFH-DMNLQLQPQFYHPGIGIEHAFNEPLDPLLLDLLKKIFV
  |. |.    ||.|..||...|||    .  .|. ||   . |.  | ...|||| ..      |..                        ||| | ..
LGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSE--IDQLFKIFRICGTPTEDNWPGVTKLPDY-----------------------DLLNKMLC

YSPVLRYTAEQAKYHPFF
| |  | .||||  ||.|
YDPKKRISAEQALQHPYF
Kinase 94291.m00051.AA CDC2 26-301 30 1.9e-50 152.95 In-house 1-301 (301) Show / Hide 
Range on Protein: 26-301
Range on HMM: 1-301/301
Sequence Identity: 30% (95 aa)

YRVIEKIGSGTFGNIY-AIEYYDRRRLALKKVLQDPKYKN--------RELTMIQALR-HPNCLKLHQYELKREGDQEFLYIFTDLLPTDLHKYLR----
|  ||||| ||.| .| ...  . .  ||||.  .             ||.  ...|. |||  |||    .       ||.... |  || ||..    
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-----NKLYMVFEYLDMDLKKYMDMSIP

K-NKITTSLAKIFGYQLFNGLDYLHKINITHRDIKSSNILVDPDTGILKICDFGSAKELKINEASVS---YISTRSYRAPELLYESQFYTSKIDVWAAGC
|  ... .| | . ||. .|....|   | |||.| .|||.| ..| .|| ||| |.   |.         . |. |||||.|  ...|.  .|.|. ||
KNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILID-KKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGC

VLSEMFKG--GDEIFHADSNQSLKQI--ILNFIGTPTISDFHDMNLQLQ------PQFYHPGIGIEHAFNE--------PLDPLLLDLLKKIFVYSPVLR
...|||       .||.||     |.  |  ..|||. ... ..  ||.      |..  . ..... .           |||  .|||... .| |  |
IFAEMFMDVTKKPLFHGDSE--IDQLFKIFRILGTPNEQTWPGVT-QLPDYKNTFPRW--KPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKR

YTAEQAKYHPFF
 .|..|  ||.|
ISAKEALQHPYF
Kinase 94291.m00051.AA Ciliate-E2 26-301 20 2.7e-43 146.45 In-house 1-365 (365) Show / Hide 
Range on Protein: 26-301
Range on HMM: 1-365/365
Sequence Identity: 20% (80 aa)

YRVIEKIGSGTFGNIYAI-EYYDRRRLALK----------------------KVL--QDPKYKNRELTMIQALR----------------HPNCLKLHQY
| .|.|||.|.|| .|    . .... |.|                      |..  .. .....|. ... ..                ||| .|.  |
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKM--Y

ELKREGDQEFLYIFTDLLPT-DLHKYLRKN------------KITTSLAKIFGYQLFN---------------GLDYLHKIN-ITHRDIKSSNILVDPDT
|   | |.. .|. ....   || .|...|            ..|   .| . .|...               .| |||. | | ||||| .|||.    
ECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

GILKICDFGSAKELKIN-------------------EASVSYIS-------------TRSYRAPELLY--------ESQFYTSKIDVWAAGCVLSEMFKG
  .||.||| .|.....                   . . .|..             |  | ||| |         ... |. |.|.|..|..| ||  |
--IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG

GDEIFHADSNQSLKQIILNFIGTPTISDFHDMNLQLQPQFYHPGIGIEHAF--------NEPLDPLLLDLLKK----IFVYSPVLRYT-AEQAKYHPFF
                              . ..| . .|  |  . . .         .. ...   ||.||    .... |  |.| .||.. ||.|
KPPF-------------------------QQQIKQCKIDFPCPEWQKD-TQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 94291.m00051.AA ERK7 26-301 31 8.7e-40 133.56 In-house 1-292 (292) Show / Hide 
Range on Protein: 26-301
Range on HMM: 1-292/292
Sequence Identity: 31% (95 aa)

YRVIEKIGSGTFGNIY-AIEYYDRRRLALKKVLQ------DPKYKNRELTMIQALR-HPNCLKLHQYELKREGDQEFLYIFTDLLPTDLHKYLRKNKITT
| .....| | .| .  |.    .  .||||.        |     || ...|... ||| ..|    .. . |. .  .| . . ||||   || .|  
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINV-IRADNDRDIYLVF-EFMETDLHAVIRKGNILK

SLAKIF-GYQLFNGLDYLHKINITHRDIKSSNILVDPDTGILKICDFGSAKELKINE-------ASVSYISTRSYRAPELLYESQFYTSKIDVWAAGCVL
   | .  |||.. . |.|  |. |||.| ||||.| .   .|.|||| |  .   |       .   |. || ||||| |  |. ||  .| |  ||.|
DIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSEC-MVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCIL

SEMFKGGDEIFHADSNQSLKQI--ILNFIGTPTISDFHDMNLQLQPQFYHPGIGIEHAFNEPLDPLL-------LDLLKKIFVYSPVLRYTAEQAKYHPF
 || . |  .|   |   . ||  ||. |. ||  | .... ..  .  .  .   .   ..|| ..       .||||.. |. |  | |||||  ||.
GEMLR-GKPMFPGTS--TMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMN---QQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPY

F
 
V
Kinase 94291.m00051.AA CDK-Unclassified 26-215 28 1.4e-38 124.43 In-house 1-235 (324) Show / Hide 
Range on Protein: 26-215
Range on HMM: 1-235/324
Sequence Identity: 28% (67 aa)

YRVIEKIGSGTFGNIY-AIEYYDRRRLALKKVLQDPKY----------------KNRELTMIQALRHPNCLKLHQYELKREGDQ---------EFLYIFT
|| ..|.|.||||  . ||     .. | ||.    |                  .||..  | . | | .|. .   .. ..            .|. .
YRMQCKYGEGTFGCVCKAIDFQTQKHVAIKKIMVNNKKGNKCKHILPLLNSKITDQREISCLQNCNHMNIIKFMDMHYDHDRCSKNPYYDNLHPSFYMVM

DLLPTDLHKYLRKNKITTSLAKI--FGYQLFNGLDYLHKINITHRDIKSSNILVDPDTG-----ILKICDFGSAKELK----------INEASVSY---I
.  | ..   |  | .  |   |  |  |.. |. |||   | ||||| .||... ...     .||| |||.|                . . .|   .
EYMPYTWYNQLHNNRYNLSMCQIRNFMHQMLEGIAYLHCNKIMHRDIKPQNIMIT-NNNSTVSPMLKIADFGQACFYMNCPPNLNYQTPADPMQQYSTQV

STRSYRAPELLYESQFYTSKIDVWAAGCVLSEMFKG
||| |||||||  |. |.  .|.|..||...|.|.|
STRWYRAPELLFGSKCYDTGVDIWSFGCIYAEWFQG
Kinase 94291.m00051.AA STE 26-301 19 2.7e-37 129.28 In-house 1-359 (359) Show / Hide 
Range on Protein: 26-301
Range on HMM: 1-359/359
Sequence Identity: 19% (74 aa)

YRVIEKIGSGTFG-NIYAIEYY---------------DRRRLALKKVL---QDP---------------KYKN---RELTMIQALR--HPNCLKLHQYEL
.. |||||.|.||   .|.                    .. | |..    ...               . ..   .|. . . ..  |||  | . ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KR---EGDQEFLYIFTDLLP-TDLHKYLRKNKIT---------------TSLAKIFGYQLFNG-LDYLHKINITHRDIKSSNILVDPDTGILKICDFGSA
|    ... . |.|.  ...   | . .......                |. ... .|.  | |.|||. .| |||||..|||.       |.|||| .
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFGVC

KELKI---------------NEASV--SYISTRSYRAPELLYE-----SQFYTSKIDVWAAGCVLSEMFKGGDEIFHADSNQSLKQIILNF---------
. |                 . ..   . . |  . ||| .       .. |. | |.|  ||.. ||  |  . .     . . .|. |.         
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

----IGTPTISDFHDMNLQLQPQFYHPGIGIEHAFNEPLD---------PLLLDLLKKIFVYSPVLRYTAEQAKY--HPFF
     . |.. |  ..| .  .. |  | |                   | . | ..| ... |  | ||.|     |||.
CIVNGPPPPLPDHLSQNEM--IS-Y--G-G---------SGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 94291.m00051.AA MAPK 26-240 27 7.7e-37 124.82 In-house 1-255 (328) Show / Hide 
Range on Protein: 26-240
Range on HMM: 1-255/328
Sequence Identity: 27% (71 aa)

YRVIEKIGSGTFGNIYAIEYYD-------RRRLALKKV---LQDPKYKN---RELTMIQAL-RHPNCLKLHQYELKR-----EGDQEF--LYIFTDLLPT
|. ...||.| .|   .             .. |.||.    |.| .     ||. . . . .|.|  ||            .  .||  .|| ..|  |
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLHKYLRKNK-ITTSLAKIFGYQLFNG--LDYLHKINITHRDIKSSNILVDPDTGILKICDFGSAKELKINEASV---------------SYISTRSYRA
|||. .. ..  .    . | ||. .|  | |.|  |. |||.| |||||.   . ||||||| |  .  ..                   |..|| |||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVN-ENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRA

PELLYE--SQFYTSKIDVWAAGCVLSEMFKGGDEIFHADSNQSLKQIILNFIGTPT
||..    .. || ..|.|..|| . || ...  .|  .. .   . |....|||.
PEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPS
Kinase 94291.m00051.AA MAPK-Unclassified 26-164 32 3.4e-20 69.34 In-house 1-154 (575) Show / Hide 
Range on Protein: 26-164
Range on HMM: 1-154/575
Sequence Identity: 32% (50 aa)

YRVIEKIGSGTFGNIY-AIEYYD-RRRLALKKVL------QDPKYKNRELTMIQALRHPNCLKLHQYELKREGDQE--F--LYIFTDLLPT---DLHKYL
| ... |||| .|  . |..     .  | |||       .| |   ||.     | ||| ...    . .....   |  .|| .|. .|   |||. .
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDI-FYNKELHNQEFDDIYIVMDYMQTSLFDLHQII

RKNK--ITTSLAKIFGYQLFNGLDYLHKINITHRDIKSSNILVDPDTGILKICDFG
. |       . ..| ||. .|| |||  .| ||| | ||.|.. | . ..|||||
KSNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQD-CSVRICDFG
Kinase 94291.m00051.AA TyrKc 26-301 22 1.4e-14 13.12 SMART 1-280 (280) Show / Hide 
Range on Protein: 26-301
Range on HMM: 1-280/280
Sequence Identity: 22% (69 aa)

YRVIEKIGSGTFGNIYAIEYYDRRRLALKKVLQDPKYKN--RELTMIQAL--RHPNCLKLHQYELKREGDQ---EFLYIFTDLLPT-DLHKYLRKNK--I
 . ..|.|.| || .|  ...  .  | |..  |   .   ||. .   |  .||| ..|. . .. ..     | |.| . . |  ||..||||..  .
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKL

TTSLAKIFGYQLFNGLDYLHKINITHRDIKSSNILVDPDTGILKICDFGSAKELKIN----EASVSYISTR--SYR--------APELLYESQFYTSKID
...    | .|  .| .|||. |. |||.   |.||. .  . ||.||| .....      |..  | ..   . .        ||| .     .|.| |
CMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFTTKSD

VWAAGCVLSEMFKGGDEIFHA-----DSNQSLKQIILNFIGTPTISD----FHDMNLQLQPQFYHPGIGIEHAFNEPLDPLLLDLLKKIFVYSPVLRYTA
||. | .. |.|  |..          ||| . . . .    |   .                          |     . . .. |.   . |  | | 
VWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS---------------------F-VCCPDEMYQIMKQCWHEDPEDRPTF

EQAKYHPFF
..   | .|
SEI--HECF
Kinase 94291.m00051.AA MAPK-Unclassified 178-212 42 4.1e-11 35.92 In-house 408-442 (575) Show / Hide 
Range on Protein: 178-212
Range on HMM: 408-442/575
Sequence Identity: 42% (15 aa)

YISTRSYRAPELLYESQFYTSKIDVWAAGCVLSEM
|..|| |||||..  .. |. ..| |..||.. ||
YVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEM
Kinase 94291.m00051.AA Pkinase_Tyr 26-164 26 3.2e-10 35.26 Pfam 1-156 (270) Show / Hide 
Range on Protein: 26-164
Range on HMM: 1-156/270
Sequence Identity: 26% (42 aa)

YRVIEKIGSGTFGNIYAIEYY-----DRRRLALKKVLQDPKYKN-------RELTMIQAL-RHPNCLKLHQYELKREGDQEFLYIFTDLLPT-DLHKYLR
 . ..|.|.| ||..|  ...     ..   | |.. ..   ..       ||. .   | .||| ..|.   ..... .  .|| . . |  ||..|||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGDLLDYLR

KN-----KITTSLAKIFGYQLFNGLDYLHKINITHRDIKSSNILVDPDTGILKICDFG
|.     ..|..    . .|  .|..||. .|. |||.   |.||. .... ||||||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVT-ENNVVKICDFG
Kinase 94291.m00051.AA MAPK 271-301 45 1.8e-08 25.13 In-house 298-328 (328) Show / Hide 
Range on Protein: 271-301
Range on HMM: 298-328/328
Sequence Identity: 45% (14 aa)

DPLLLDLLKKIFVYSPVLRYTAEQAKYHPFF
.|. .|||.|  | .|  |.|.|.|  ||.|
NPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 94291.m00051.AA MAPK-Unclassified 275-301 40 1e-07 23.46 In-house 549-575 (575) Show / Hide 
Range on Protein: 275-301
Range on HMM: 549-575/575
Sequence Identity: 40% (11 aa)

LDLLKKIFVYSPVLRYTAEQAKYHPFF
.|...| ....|  |.||.||  ||.|
IDFVQKMLQFNPWKRITADQALEHPYF
Kinase 94291.m00051.AA CDK-Unclassified 275-301 22 0.020049 3.63 In-house 298-324 (324) Show / Hide 
Range on Protein: 275-301
Range on HMM: 298-324/324
Sequence Identity: 22% (6 aa)

LDLLKKIFVYSPVLRYTAEQAKYHPFF
....    .|.|  | ...... || |
NNCEFQMVMYQPYNRWKCMEILQHPWF
Kinase 94291.m00051.AA Pkinase_Tyr 186-218 36 6.284032 0.38 Pfam 182-213 (270) Show / Hide 
Range on Protein: 186-218
Range on HMM: 182-213/270
Sequence Identity: 36% (12 aa)

APELLYESQFYTSKIDVWAAGCVLSEMFKGGDE
||| . ..  .|.| |||. | .. |.|  |..
APECINYGK-FTTKSDVWSFGVLMWEIFTYGEQ